Journal of Biomaterials Science Polymer Edition Impact Factor & Information

Publisher: Taylor & Francis

Journal description

The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins, and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.

Current impact factor: 1.65

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.648
2013 Impact Factor 1.357
2012 Impact Factor 1.7
2011 Impact Factor 1.691
2010 Impact Factor 1.842
2009 Impact Factor 2.505
2008 Impact Factor 2.158
2007 Impact Factor 1.862
2006 Impact Factor 1.607
2005 Impact Factor 1.409
2004 Impact Factor 1.255
2003 Impact Factor 1.593
2002 Impact Factor 1.401
2001 Impact Factor 1.234
2000 Impact Factor 1.669
1999 Impact Factor 1.192
1998 Impact Factor 1.228
1997 Impact Factor 0.901
1996 Impact Factor 1.431
1995 Impact Factor 1.213
1994 Impact Factor 1.418

Impact factor over time

Impact factor

Additional details

5-year impact 1.85
Cited half-life 8.10
Immediacy index 0.27
Eigenfactor 0.00
Article influence 0.35
Website Journal of Biomaterials Science, Polymer Edition website
Other titles Journal of biomaterials science. Polymer ed., Polymer edition
ISSN 0920-5063
OCLC 21171173
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

Taylor & Francis

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Some individual journals may have policies prohibiting pre-print archiving
    • On author's personal website or departmental website immediately
    • On institutional repository or subject-based repository after either 12 months embargo
    • Publisher's version/PDF cannot be used
    • On a non-profit server
    • Published source must be acknowledged
    • Must link to publisher version
    • Set statements to accompany deposits (see policy)
    • The publisher will deposit in on behalf of authors to a designated institutional repository including PubMed Central, where a deposit agreement exists with the repository
    • STM: Science, Technology and Medicine
    • Publisher last contacted on 25/03/2014
    • This policy is an exception to the default policies of 'Taylor & Francis'
  • Classification
    ​ green

Publications in this journal

  • Journal of Biomaterials Science Polymer Edition 09/2015; DOI:10.1080/09205063.2015.1101259
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    ABSTRACT: Tissue engineering opens up a new area to restore the function of damaged tissue or replace a defective organ. Common strategies in tissue engineering to repair and form new tissue containing a functional vascular network include the use of cells, growth factors, extracellular matrix proteins, and biophysical stimuli. Yet, formation of well-distributed, interconnected, and stable vascular network still remains challenging. In addition, anastomoses with host vasculature upon implantation and long-time survival of the new blood vessel in vivo are other critical issues to be addressed. This paper presents a brief review of recent advances in vascularization in vitro as well as in vivo for tissue engineering, along with suggestions for future research.
    Journal of Biomaterials Science Polymer Edition 08/2015; 26(12):683-734. DOI:10.1080/09205063.2015.1059018
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    ABSTRACT: Functional polymeric micelles play an important role in the efficient delivery of therapeutic drugs into tumours. In this study, a functional drug delivery platform with ligands for targeting and fluorescent imaging was designed based on Pluronic F127 (PF127). Using folic acid (FA) and fluorescein isothyocyanate (FITC) to chemically conjugate with PF127, two functional polymers, Pluronic F127-FA (PF127-FA) and Pluronic F127-FITC (PF127-FITC), were synthesized. Solasodine-loaded micelles were then prepared via the thin-film hydration method. By employing A549 and HeLa cells, the results of in vitro cell assays performed using confocal laser scanning microscopy (CLSM) and flow cytometry suggested that the proposed micelles could provide the desired specific targeting and fluorescent imaging functions. In addition, the results of in vitro cytotoxicity experiments showed that the growth inhibition rates of A549 and HeLa cells treated with solasodine-loaded micelles were remarkably higher than those of cells treated with free solasodine. Solasodine-loaded micelles exhibited a more distinct inhibitory effect against HeLa cells than against A549 cells. Thus, an effective drug delivery system for targeting and imaging cancer cells was developed.
    Journal of Biomaterials Science Polymer Edition 03/2015; 26(8):1-30. DOI:10.1080/09205063.2015.1030136
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    ABSTRACT: Affinity binding peptides were examined for surface fabrication of synthetic polymeric materials. Peptides possessing strong binding affinities toward polyurethane (PU) were discovered via biopanning of M13 phage peptide library. The apparent binding constant (Kapp) was as high as 2.68×10(9) M(-1) with surface peptide density exceeded 1.8 μg/cm(2). Structural analysis showed that the ideal peptide had a high content (75%) of H-donor amino acid residues, and that intensified hydrogen bond interaction was the key driving force for the highly stable binding of peptides on PU. PU treated with such affinity peptides promises applications as low-fouling materials, as peptides increased its wettability and substantially reduced protein adsorption and cell adhesion. These results demonstrated a facile but highly efficient one-step strategy for surface property modification of polymeric materials for biotechnological applications.
    Journal of Biomaterials Science Polymer Edition 03/2015; 26(8):1-22. DOI:10.1080/09205063.2015.1023242
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    ABSTRACT: In this presented work, poly(HEMA-GMA) cryogel was synthesized and used for the immobilization of alcohol dehydrogenase. For this, synthesized cryogels were functionalized with IDA and chelated with Zn(2+). This metal chelated cryogels were used for the alcohol dehydrogenase immobilization and their kinetic parameters were compared with free enzyme. Optimum pH was found to be 7.0 for both immobilized and free enzyme preparations, while temperature optima for free and immobilized alcohol dehydrogenase was 25 °C. Kinetic constants such as Km, Vmax and kcat for free and immobilized form of alcohol dehydrogenase were also investigated. kcat value of free enzyme was found to be 3743.9 min(-1), while kcat for immobilized enzyme was 3165.7 min(-1). Thermal stability of the free and immobilized alcohol dehydrogenase was studied and stability of the immobilized enzyme was found to be higher than free form. Also, operational stability and reusability profile of the immobilized alcohol dehydrogenase was investigated. Finally, storage stability of the free and immobilized alcohol dehydrogenase was studied and at the end of the 60 days storage it was demonstrated that, immobilized alcohol dehydrogenase was exhibited high stability than that of free enzyme.
    Journal of Biomaterials Science Polymer Edition 02/2015; 26(7):1-23. DOI:10.1080/09205063.2015.1023241
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    ABSTRACT: Electrospun fiber mesh has been a candidate for guided bone regeneration (GBR) membrane. However, its poor mechanics property has been limited in clinical application. In this study, various star-shaped PCLs are successfully synthesized by ring-opening polymerization and mixed with PLLA to be made into blended membranes through electrospinning. Their corresponding properties are evaluated including morphology, thermodynamics, mechanics and cytotoxicity. The blended fibers show smooth surface and well-distributed structure, which have slight differences in morphology with the change of arm number of star-shaped PCL. Crystallization of the fibrous membrane is influenced by star-shaped PCLs. Glass temperature drops from 64.23 ℃for pure PLLA membrane to 53.62-49 ℃for the blended membranes. The membranous tensile strength is depended strongly on star-shaped PCLs. The tensile strength goes up with arm number increasing; on the contrary, at the same arm number, the mechanics strength decreases with molecular weight increasing. And the fibrous membrane containing 20 wt% star-shaped PCL shows better mechanics property compared to the other membranes. The star-shaped PCL/PLLA fiber membrane is not cytotoxicity.
    Journal of Biomaterials Science Polymer Edition 02/2015; 26(7):1-26. DOI:10.1080/09205063.2015.1015865
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    ABSTRACT: In this study, Poly(e-caprolactone)/Polyglycolic acid (PCL/PGA) scaffolds for repairing articular cartilage were fabricated via solid-state cryomilling along with compression molding and porogen leaching. Four distinct scaffolds were fabricated using this approach by four independent cryomilling times. These scaffolds were assessed for their suitability to promote articular cartilage regeneration with in vitro chondrocyte cell culture studies. The scaffolds were characterized for pore size, porosity, swelling ratio, compressive and thermal properties. Cryomilling time proved to significantly affect the physical, mechanical and morphological properties of the scaffolds. In vitro bovine chondrocyte culture was performed dynamically for 1, 7, 14, 28 and 35 days. Chondrocyte viability and adhesion were tested using MTT assay and scanning electron microscopy (SEM) micrographs. GAG and DNA assays were performed to investigate extra cellular matrix (ECM) formation and cell proliferation respectively. PCL/PGA scaffolds demonstrated high porosity for all scaffold types. Morphological analysis and PEO continuity demonstrated existence of co-continuous network of interconnected pores with pore sizes appropriate for tissue engineering and chondrocyte ingrowth. While mean pore size decreased, water uptake and compressive properties increased with increasing cryomilling times. Compressive modulus of 12, 30 and 60 minutes scaffolds matched the compressive modulus of human articular cartilage. Viable cells increased besides increase in cell proliferation and ECM formation with progress in culture period. Chondrocytes exhibited spherical morphology on all scaffold types. The pore size of the scaffold affected chondrocyte adhesion, proliferation and GAG secretion. The results indicated that the 12 minutes scaffolds delivered promising results for applications in articular cartilage repair.
    Journal of Biomaterials Science Polymer Edition 02/2015; 26(7):1-31. DOI:10.1080/09205063.2015.1015864
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    ABSTRACT: Ionizing radiation effectively cross-links collagen into network with enhanced anti-degradability and biocompatibility, while radiation-cross-linked collagen scaffold lacks flexibility, satisfactory surface appearance, and performs poor in cell penetration and ingrowth. To make the radiation-cross-linked collagen scaffold to serve as an ideal artificial dermis, dextran was incorporated into collagen. Scaffolds with the collagen/dextran (Col/Dex) ratios of 10/0, 7/3, and 5/5 were fabricated via (60)Co γ-irradiation cross-linking, followed by lyophilization. The morphology, microstructure, physicochemical, and biological properties were investigated. Compared with pure collagen, scaffolds with dextran demonstrated more porous appearance, enhanced hydrophilicity while the cross-linking density was lower with the consequence of larger pore size, higher water uptake, as well as reduced stiffness. Accelerated degradation was observed when dextran was incorporated in both the in vitro and in vivo assays, which led to earlier integration with cell and host tissue. The effect of dextran on degradation was ascribed to the decreased cross-linking density, looser microstructure, more porous and hydrophilic surface. Considering the better appearance, softness, moderate degradation rate due to controllable cross-linking degree and good biocompatibility as well, radiation-cross-linked collagen/dextran scaffolds are expected to serve as promising artificial dermal substitutes.
    Journal of Biomaterials Science Polymer Edition 02/2015; 26(3):162-80. DOI:10.1080/09205063.2014.985023
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    ABSTRACT: Abstract In our study, a silica-polymer composite nano system (MB-NSi/p53/CS ternary complexes) composed of methylene blue-encapsulated amine-terminated silica nanoparticles (MB-NSi) and chondroitin sulfate (CS) was successfully developed for tumor-targeted imaging and p53 gene therapy of lung cancer. MB was employed as a NIR probe for in vivo imaging, MB-NSi nanoparticles were served as gene vector, while CS was applied to be a coating and targeting polymer. MB-NSi/p53/CS ternary complexes displayed nano-sized diameter, effective p53 condensation ability, efficient p53 protection profile and superior BSA stability in vitro. Experiments on A549 cell line further revealed low cytotoxicity, high p53 transfection and anti-cancer efficacy of MB-NSi/p53/CS ternary complexes. In vivo imaging and tumor targetability assays demonstrated that MB-NSi/p53/CS ternary complexes was a preferable system with desirable imaging and tumor targeting properties.
    Journal of Biomaterials Science Polymer Edition 01/2015; 26(6):1-23. DOI:10.1080/09205063.2015.1012035
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    ABSTRACT: Abstract A lipopeptide (LP) containing KKGRGDS as the hydrophilic heads and lauric acid (C12) as the hydrophobic tails has been designed and prepared by standard solid-phase peptide synthesis (SPPS) technique. LP can self-assemble into spherical micelles with the size of ~ 30 nm in PBS (pH7.4). Curcumin-loaded LP micelles were prepared in order to increase the water solubility, sustain the releasing rate and improve the tumor targeted delivery of curcumin. Water solubility, cytotoxicity, in vitro release behavior and intracellular uptake of curcumin-loaded LP micelles were investigated. The results showed that LP micelles can increase the water solubility of curcumin 1.1×10(3) times and sustain the release of curcumin in a low rate. Curcumin-loaded LP micelles showed much higher cell inhibition than free curcumin on HeLa and HepG2 cells. When incubating these curcumin-loaded micelles with HeLa and COS7 cells, due to the over-expression of integrins on cancer cells, the micelles can efficiently use the tumor-targeting function of RGD sequence to deliver the drug into HeLa cells and better efficiency of the self-assembled LP micelles for curcumin delivery than crude curcumin was also confirmed by LCSM assays. Combined with the enhanced solubility and higher cell inhibition, LP micelles reported in this study may be promising in clinical application for targeted curcumin delivery.
    Journal of Biomaterials Science Polymer Edition 01/2015; 26(6):1-26. DOI:10.1080/09205063.2015.1012034
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    ABSTRACT: Abstract Growth factors [basic fibroblast growth factor (bFGF) and/or nerve growth factor (NGF)]-immobilized polycaprolactone (PCL)/Pluronic F127 microspheres were prepared using an isolated particulate-melting method and the sequential binding of heparin and growth factors (GFs) onto the microspheres. The GFs immobilized on the microspheres were released in a sustained manner over 28 days, regardless of GF type. From the in vitro culture of muscle-derived stem cells, it was observed that the NGF-immobilized microspheres induced more neurogenic differentiation than the bFGF-immobilized microspheres, as evidenced by a quantitative real time polymerase chain reaction using specific neurogenic markers (Nestin, GFAP, β-tubulin, and MAP2) and Western blot (markers, Nestin and β-tubulin)] analyses. The dual bFGF/NGF-immobilized microspheres showed better neurogenic differentiation than the microspheres immobilized with single bFGF or NGF. From the preliminary animal study, the dual bFGF/NGF-immobilized microsphere group also showed effective nerve regeneration, as evaluated by immunocytochemistry using a marker, β-tubulin. The dual bFGF/NGF-immobilized PCL/Pluronic F127 microspheres may be a promising candidate for nerve regeneration in certain target tissues (i.e., muscles) leading to sufficient reinnervation.
    Journal of Biomaterials Science Polymer Edition 01/2015; 26(5):1-36. DOI:10.1080/09205063.2015.1008882
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    ABSTRACT: Abstract Amphiphilic polymers bearing hydrophobic alkyl groups are expected to be applicable both to ligand presentation on the cell surface and intercellular crosslinking. To explore the optimum design for each application, we synthesized eight different acyl-modified dextrans with varying molecular weight, alkyl length, and alkyl modification degree. We found that the behenate-modified polymers retained on the cell surface longer than the palmitate-modified ones. Since the polymers were also modified with biotin, streptavidin can be presented on the cell surface through biotin-streptavidin recognition. The duration of streptavidin on the cell surface is longer in the behenate-modified polymer than the palmitate-modified one. As for the intercellular crosslinking, the palmitate-modified polymers were more efficient than the behenate-modified polymers. The findings in this research will be helpful to design the acyl-modified polymers for the cell surface engineering.
    Journal of Biomaterials Science Polymer Edition 01/2015; 26(6):1-37. DOI:10.1080/09205063.2015.1007414
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    ABSTRACT: To treat the osteoporosis and regulate the biological behaviors of both osteoblasts and osteoclasts, we prepared a natural polysaccharide-derived nanocomposite, containing alendronate-grafted hyaluronate (HA-Aln) and bone morphogenetic protein 2 (BMP-2) and investigated its synergistic regulation on the behaviors of osteoblasts and osteoclasts in vitro. The HA-Aln/BMP-2 nanocomposite was fabricated through the electrostatic interactions between the HA-Aln molecule and BMP-2 molecule. Here, BMP-2 was used to improve the osteoblast-mediated bone formation. Alendronate (Aln), a targeting ligand to bone matrix, was used to inhibit the osteoclast-mediated bone resorption. In vitro results showed that HA-Aln/BMP-2 nanocomposite could effectively maintain the bioactivity of loaded drugs. The osteoblasts that treated with the HA-Aln/BMP-2 nanocomposite presented a higher level of cell motility, alkaline phosphatase (ALP) activity, mineralization capacity, and osteoblast-related gene expressions (runt-related transcription factor 2, osterix, ALP, collagen type I, osteocalcin, and osteopontin), as compared to that of control group. Besides, the RAW264.7 cells that were treated with HA-Aln/BMP-2 nanocomposite showed a lower level of osteoclastic differentiation. Overall, the HA-Aln/BMP-2 nanocomposite exhibits promising potential as an efficient carrier for co-delivery of anti-osteoporotic drug and growth factors to promote osteoblastic differentiation and bone formation while suppressing osteoclastic activity.
    Journal of Biomaterials Science Polymer Edition 01/2015; 26(5):1-21. DOI:10.1080/09205063.2014.998588
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    ABSTRACT: Many investigations of wound dressings equipped with drug delivery systems have recently been conducted. Chitosan is widely used not only as a material for wound dressing by the efficacy of its own, but also as a nanoparticle for drug delivery. In this study, an electrospun polycaprolactone nanofiber composite with chitosan nanoparticles (ChiNP-PCLNF) was fabricated and then evaluated for its drug release and biocompatibility to skin fibroblasts. ChiNP-PCLNF complexes showed no cytotoxicity and nanoparticles adsorbed by van der Waals force were released into aquatic environments and then penetrated into rat primary fibroblasts. Our studies demonstrate the potential for application of ChiNP-PCLNF as a wound dressing system with drug delivery for skin wound healing without side effects.
    Journal of Biomaterials Science Polymer Edition 01/2015; 26(4):1-12. DOI:10.1080/09205063.2014.996699
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    ABSTRACT: Efficient delivery of small interfering RNA (siRNA) is crucially required for cancer gene therapy. Herein, a thermo-sensitive copolymer with a simple structure, poly (ethylene glycol) methyl ether acrylate-b-poly (N-isopropylacrylamide) (mPEG-b-PNIPAM) was developed. A novel kind of thermo-sensitive nanoparticles (DENPs) was constructed for the cold-shock triggered release of siRNA by double emulsion-solvent evaporation method using mPEG-b-PNIPAM and a cationic lipid, 3β [N-(N', N'-dimethylaminoethane)-carbamoyl] cholesterol [DC-Chol]. DENPs were observed by transmission electron microscopy and dynamical light scattering before and after 'cold shock' treatment. The encapsulation efficiency (EE) of siRNA in DENPs, which was measured by fluorescence spectrophotometer was 96.8% while it was significantly reduced to be 23.2% when DC-Chol was absent. DENPs/siRNA NPs exhibited a thermo-sensitive siRNA release character that the cumulatively released amount of siRNA from cold shock was approximately 2.2 folds higher after 7 days. In vitro luciferase silencing experiments indicated that DENPs showed potent gene silencing efficacy in HeLa-Luc cells (HeLa cells steadily expressed luciferase), which was further enhanced by a cold shock. Furthermore, MTT assay showed that cell viability with DENPs/siRNA up to 200 nM remained above 80%. We also observed that most of siRNA was accumulated in kidney mediated by DENPs instead of liver and spleen in vivo experiments. Thus, DENPs as a cold shock responsive quick release model for siRNA or hydrophilic macromolecules delivery provide a new way to nanocarrier design and clinic therapy.
    Journal of Biomaterials Science Polymer Edition 01/2015; 26(4):1-13. DOI:10.1080/09205063.2014.997559
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    ABSTRACT: In this study, poly (methyl methacrylate-glycidyl methacrylate) [poly(MMA-GMA)] cryogels were prepared by radical cryocopolymerization of MMA with GMA as a functional comonomer. Reactive Green 19 dye was then attached to the cryogel by nucleophilic substitution reaction, and this dye-attached cryogel column was used for lysozyme adsorption. Characterization of the cryogel was performed by Fourier transform infrared spectroscopy, environmental scanning electron microscopy, Brunauer-Emmett-Teller, and energy dispersive X-ray analysis. Pore size of the cryogels was 15-30 μm and pores were interconnected structure. Attached amount of Reactive Green 19 to cryogel support was calculated as 106.25 μmol/g cryogel. Lysozyme adsorption studies were carried out by using a continuous system. It was found that the maximum amount of lysozyme adsorption (32 mg/g cryogel) obtained from experimental results was found to be approximately same with the calculated Langmuir adsorption capacity (33 mg/g cryogel). Desorption of adsorbed lysozyme was carried out by using 1.5 M NaCl in pH 4.5 acetate buffer, and desorption yield was found to be 97.4%. Cryogels were very stable, and it was found that there was no remarkable reduction in the adsorption capacity at the end of ten adsorption-desorption cycles. As a result, Reactive Green 19-attached cryogels have great advantages such as easy preparation, rapid adsorption, and desorption, being economic and allowing the direct separation of proteins.
    Journal of Biomaterials Science Polymer Edition 01/2015; 26(5):1-13. DOI:10.1080/09205063.2014.997560