Acta médica portuguesa (Acta Med Port)
- WebsiteActa Medica Portuguesa website
Other titlesActa médica portuguesa (Online), Acta médica portuguesa
Material typePeriodical, Internet resource
Document typeInternet Resource, Computer File, Journal / Magazine / Newspaper
Publications in this journal
Article: Muscle tissue changes with aging[show abstract] [hide abstract]
ABSTRACT: Sarcopenia is characterized by a progressive generalized decrease of skeletal muscle mass, strength and function with aging. Recently, the genetic determination has been associated with muscle mass and muscle strength in elderly. These two phenotypes of risk are the most commonly recognized and studied for sarcopenia, with heritability ranging from 30 to 85% for muscle strength and 45-90% for muscle mass. It is well known that the development and maintenance of muscle mass in early adulthood reduces the risk of developing sarcopenia and leads to a healthy aging. For that reason it seems important to identify which genetic factors interact with aging and in particular with the musculoskeletal response to exercise in such individuals. This review is designed to summarize the most important and representative studies about the possible association between certain genetic polymorphisms and muscle phenotypes in older populations. Also we will focuses on nutrition and some concerns associated with aging, including the role that exercise can have on reducing the negative effects of this phenomenon. Some results are inconsistent between studies and more replication studies underlying sarcopenia are needed, with larger samples and with different life cycles, particularly in the type and level of physical activity throughout life. In future we believe that further progress in understanding the genetic etiology and the metabolic pathways will provide valuable information on important biological mechanisms underlying the muscle physiology. This will enable better recognition of individuals at higher risk and the ability to more adequately address this debilitating condition.Acta médica portuguesa 01/2013; (in press).
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ABSTRACT: Doente do sexo masculino de 86 anos de idade, minei-ro reformado, com história conhecida de doença pulmonar obstrutiva crónica (DPOC), com enfisema pulmonar, car-diopatia isquémica, hipertensão arterial e dislipidémia. Internado por agudização infecciosa da sua DPOC (Figura 1), tendo iniciado antibioterapia empírica. Ao 4º dia de inter-namento, na sequência de acesso de tosse, dor retroester-nal e episódio de hemoptise, repetiu telerradiografia (Figura 2), que revelou imagem cavitada no terço médio do pulmão direito com nível hidroaéreo. Realizou TC torácico (Figura 3), que a par de instalação aguda de imagem cavitada e de estar em continuidade com a cisura interlobar (Figura 4), foi diagnóstica de hemopneu-motórax. O hemopneumotórax espontâneo decorre da ruptura de um pequeno vaso localizado nas aderências entre a pleu-ra visceral e parietal ou de folhetos adjacentes da pleura visceral, como no presente caso. É uma rara complicação do pneumotórax espontâneo (1) e pode resultar de vários me-canismos(2). Tendo em conta as comorbilidades e a estabilidade clínica do doente, optou-se por manter terapêutica conservadora. REFERÊNCIAS 1. Kim eS, Kang JY, Pyo CH, Jeon eY, Lee WB. 12-year experience of spontaneous hemopneumothorax. Ann Thorac Cardiovasc Surg 2008;14(3):149-153. 2. Migliore M, Lombardo G. An unusual clinical case of haemoptysis in spontaneous pneumothorax: blood clots within emphysematous bulla. BMJ Case Rep 2009; 2009: bcr08.2008.0796.Acta médica portuguesa 01/2012; 25(1):59.
Article: [The man and the mirror].Acta médica portuguesa 01/2012; 4(1):51.
Article: A Artrite e a História ClínicaActa médica portuguesa 01/2011;
- Acta médica portuguesa 01/2011; 24:339-348.
- Acta médica portuguesa 01/2011; 24:431-438.
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ABSTRACT: Antibiomania, or mania induced by antibiotics, is a rare, but important side effect of clarithromycin and others antibiotics. Although underestimated due to low clinical incidence, this phenomenon is being reported in a growing number of cases of mania associated with administration of antibiotics, in patients without a previous diagnosis of Bipolar Affective Disorder. The importance of Antibiomania in current clinical practice is associated with the increasing introduction and prescription of new antibiotics, and to the need for awareness of the phenomenon as a possible differential diagnosis of secondary mania. There are several theories that may explain Antibiomania, one of the most studied is related to the interaction of antibiotics with neurotransmitters, including the gamma butyric acid (GABA). However, the mechanism is still unknown. The authors present a case of a manic episode triggered by clarithromycin in a patient with no clinical history of disturbance of mood, followed by a brief literature review of the subject, including treatment strategiesActa médica portuguesa 01/2011; 24(5-24 (5)):827-83.
- Acta médica portuguesa 09/2010; 23(5):745-54.
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ABSTRACT: Chronic Myeloid Leukemia (CML) is a clonal stem cell disease characterized by the expression of the fusion protein bcr-abl1, which has deregulated tirosine-kinase activity. Tyrosine kinase inhibitors (TKIs), and in particular imatinib, introduced fundamental changes in the treatment of CML, becoming, in most cases, the first-line treatment of choice in the chronic phase of this disease. Compared to other available therapies imatinib results in a marked increase in overall survival, tolerability and quality of life. The introduction of second generation TKI, with increased potency against bcr-abl1, expanded the number of therapeutic options for this disease and offers an alternative for patients resistant or intolerant to imatinib or who have progressed to the accelerated phase under this therapy. In order to achieve optimal outcomes, TKI therapy must be managed rigorously, requiring a careful monitoring of treatment response in pre-established time periods, thus permitting disease evaluation and safe decision of the most adequate option. Despite the definition of the criteria for imatinib treatment response, the therapeutic strategies to adopt according to the responses obtained are less clear. The objective of this paper is to review the criteria for CML diagnosis, treatment and monitoring, with recommendations as to the most adequate therapeutic choice according to the response to TKI therapy. The paper also focuses the current lines of investigation and debate areas that in the short term can significantly change the therapeutic scenario in this disease. These recommendations, supported by published scientific evidence and by the clinical practice of the expert panel involved in their elaboration, may constitute an important instrument for a better understanding and standardisation of the treatment and monitoring of CML in Portugal.Acta médica portuguesa 09/2009; 22:537-544.
Article: Frontotemporal dementia[show abstract] [hide abstract]
ABSTRACT: Frontotemporal dementia (FTD), although less common than Alzheimer's, constitutes a significant percentage of the degenerative dementias, making up 8 to 17% of patients who die with dementia before the age of 70. Several clinical presentations have been described for many authors, which are included in classical behaviour disorder of frontal lobe dementia and in language alterations of progressive aphasias. Classification and diagnosis criteria's of FTP are sometime controversial in literature. So, the authors give an overview of principal's aspects in this area, with focus on clinical, imagiological, patghological and genetic perspective. Furthermore, taken in account this revision was also made a characterization of the patients followed in Dementia Outpatient Clinical Care of our hospital. In these patient characteristics review the follow parameters were analysed: FDT clinical diagnosis; demographics, clinical, imagiological, neuropsychological aspects; and disease evolution. An retrospective study that allowed correlation between some aspects, namely clinical presentation with imagiological and neuropsychological findings. With this revision work, the authors pretend to alert for the relevance of FTD diagnosis, probably misdiagnosticated.Acta médica portuguesa 03/2007; 19(4):319-324.
Article: [Gangrenous cystitis].[show abstract] [hide abstract]
ABSTRACT: Gangrenous cystitis is a rare condition, there are no typical symptoms or clinical findings, which hampers diagnosis and may worsen the prognosis. The authors report the case of a diabetic male patient, hospitalized because of poor general condition, dehydration and diffuse abdominal pain. The diagnosis was made by typical pelvic CT findings. Medical treatment must be intensive and begun as soon as possible. As in the present case, the situation may have a favorable outcome.Acta médica portuguesa 01/2007; 14(3):357-9.
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ISSN: 1984-8250, Impact factor: 0.37
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American College of Chest Physicians
ISSN: 1931-3543, Impact factor: 5.85
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ISSN: 1877-9603, Impact factor: 2.35
ISSN: 1876-861X, Impact factor: 2.55
ISSN: 1876-7737, Impact factor: 5.07