Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk (Fiziol Z Im M Sechenova)

Publisher: Rossijskaja Akademija Nauk

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Other titles Sechenov physiological journal, Fiziologic̆eskij z̆urnal
ISSN 0869-8139
OCLC 73087465
Material type Periodical
Document type Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the work is to analyze the relationship between consumption of glucose solution by rats and its absorption, and to use this fact for assessment of the absorptive capacity of the small intestine in non anesthetized animals in vivo. Consumption of glucose solution (200 g/l) by fasted rats was recorded in the control, and after administration of phloridzin--inhibitor of glucose active transport- or 3 hours after the restriction stress. On the mathematical model we studied the relative role of factors that can influence the temporal dynamics of glucose consumption by rats. The rate of glucose consumption was observed being decreased in the presence of phloridzin (1 mM), and be increased after the stress. The results of modeling are consistent with the experimental data and show that the rate of consumption of glucose solutions considerably more depends on the transport activity of the small intestine than on glucose concentration in the solution, or on the substrate regulation of the stomach emptying. Analysis of dynamics of consumption of glucose solution by intact rats may be considered as one of promising approaches to assessing the absorptive capacity of the small intestine under natural conditions.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 10/2015; 101(6):708-20.
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    ABSTRACT: Catalepsy--passive defense freezing reaction in response to the threatening stimuli. In hypertrophic form, it is a symptom of brain dysfunction. In mice, the major gene that determines predisposition to catalepsy localized in the distal fragment 111.35-116.16 m. p. n. of chromosome 13. This chromosome fragment using backcrossing was transferred from the cataleptic CBA mouse stain to the genome of catalepsy resistant mouse strain C57BL/6. It was obtained two recombinant lines C57BL6.CBA-Dl3Mit76C and C57BL6.CBA-D13Mit76B, carrying the fragment of CBA and C57BL/6, respectively. It has been shown that in C57BL6.CBA-D13Mit76C mice the number of cataleptic higher compared with the control line C57BL6.CBA-Dl3Mit76B. In tests "startle reflex reaction" and "social interaction" differences in behavior were not found. At the same time reduction of exploratory behavior in the "open field" test of C57BL6.CBA-D13Mit76C mice compared with C57BL6.CBA-D13Mit76B mice was shown. Immobility time of C57BL6.CBA-D13Mit76C mice in the "forced swimming" test was also significantly lower compared to control mice C57BL6.CBA-D13Mit76B.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 10/2015; 101(6):670-7.
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    ABSTRACT: The damage of dorsal hippocampus in mice F1 from DBA/2J and C57BL/6J on the learning in conditions of free choice in a complex multialternative maze was studied. It was revealed that the HPC-mice were able to form a 4-links food-getting habit in the cyclic form. The main differences affected the conjugation of the investigate activity, behavioral efficiency and inhibition of mistakes. While these processes developed by the same exponential types in control, this conjugation were absent in HPC-mice. The main defects were found in stage of habit stabilization: motivational state stability reduced sharply and duration of transition from disorganization to organizing behavior increased. It is supposed that the hippocampus involved in learning and memory indirectly because its main role is organization of the dominant state providing the stability of attention for habit realization.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 10/2015; 101(6):678-88.
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    ABSTRACT: The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b. w. on lipid peroxidation and functional hepatocyte state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated. It was observed that 120 mcg/kg peptide normalized the elevation of malondialdehyde (MDA) level in the liver homogenate caused by acute foot-shock stress and also significantly decreased catalase activity in all investigated doses. In serum the injection of DSIP up to 40 mcg/kg increased aminotransferase activity. Peptide in all doses provided the normalization of protein synthetic hepatocyte function, increased catalase and superoxide dismutase activity in chronic stress. In addition malondialdehyde content in the liver homogenate was significantly decreased in the dose of 40 mcg/kg and in other cases it was significantly increased against the background of the common antioxidative activity reduction. The stress-induced increase in serum alanine aminotransferase activity was normalized by peptide administration in the doses of 120, 360, and 1080 mcg/kg.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 10/2015; 101(6):700-7.
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    ABSTRACT: The study presents a comprehensive of the metabolism and the fractional composition of li- pids surfactant, water balance, hemostatic activity of the lungs in neyrodegeneration substantia nigra of the brain induced by stereotaxic microinjection of 6--hydroxydopamine and systemic administration of haloperidol. It is shown that a breach of dopaminergic neurotransmission leads to deterioration of surface-active properties of the alveolar lining of the complex against a decrea- se of phospholipids, cholesterol, phosphatidylcholine and lysophospholipids enhance the pulmo- nary surfactant in the activation of phospholipase hydrolysis and lipid peroxidation. Intranigral introduction neurotoxin accompanied by increased blood supply to the lungs and the blood coagu- lation potential of the pulmonary circulation, the blockade D2-receptors--hyporhydration lung tissue. The results obtained indicate the formation of dysregulation pneumopathy dysfunction nigrostriatal dopaminergic system.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 10/2015; 101(6):721-30.
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    ABSTRACT: The relative gene expressions of glucose-6-phosphatase (G6P), phosphoenolpyruvate carbo- xykinase (PEPCK)--markers of gluconeogenesis, glucokinase (GK)--a marker of glycolysis, glucose transporter type 2 (GLUT2)--a marker of input and output of glucose in the liver were measured during the development of melanocortin (MC) obesity in male mice of C57BL/6J strain with mutation yellow in the Agouti locus (Ay/a mice). The mutation decreases MC receptor activity and induces hyperphagia and MC obesity. The males of the same line with mutation nonagouti were used as control. Tissue samples were taken at age 10 (before obesity), 15 (moderate obesity) and 30 (developed obesity) weeks. It has been shown that Ay/a mice had decreased glucose tolerance since 10-week age. There were age-related changes in mRNA levels in the liver of Ay/a mice, unlike a/a mice. In Ay/a mice the mRNA GLUT2 levels at the age of 10 weeks, mRNA GK levels at the age of 15 weeks, and mRNA G6P levels at the age of 3O weeks were higher than those in Ada mice of other ages. InAYfa mice the mRNA GK levels at the age of 15 weeks and mRNA G6F levels at the age of 30 weeks were increased relatively to those in a/a mice. Thus, Ay/a mice before the development of MK obesity had changes in the mRNA levels genes of proteins that regulate hepatic glucose metabolism, which may contribute to the compensation of glucose metabolism disorders caused by a hereditary decrease of MK system activity
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 10/2015; 101(6):689-99.
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    ABSTRACT: The results of the socio-psychological and psycho-physiological study of children and adolescents rural secondary school in a remote area of the Arkhangelsk region were studied. It was found that the poor situation of children in families at social risk leads to a decrease in their school performance, motivation to succeed and, in some cases, to reduce their personal social and psychological adaptation. However, in general, the level of personal social and psychological adaptation in the majority of surveyed students is high enough. As complementary social institutions, the family and the school, in some cases, can compensate for a number of adverse social and psychological factors. Pupils from social risk groups functional state of the central nervous system has been significantly reduced compared with children who are brought up in affluent families. In the North adverse social factors may increase the effects of the harsh climatic conditions and are an important risk factor for children's health.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 10/2015; 101(6):731-44.
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    ABSTRACT: Beyond the well-known role of p53 as a tumor suppressor, an increasing number of data demonstrated the multiple roles of p53 in the regulation of various aspects of normal life. Diverse effects ofp53 based on different mechanisms its action, such as regulation of genes' transcription, protein-protein interactions and post-translation modifications. In this review, it was summarized recent studies on the mechanisms underlying the p53-dependent regulation of neuronal differentiation.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 10/2015; 101(6):633-46.
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    ABSTRACT: Since the volume of the blood passing the lungs is great in the norm and especially during stressed muscle activity the question arises about the rate of the blood oxygenation. In the norm, when about 6 1 of the blood passes the lungs per minute, each 500 ml of the blood, which comprises the blood capacity of the lungs, is oxygenated during approximately 5 seconds. During muscle work, when the minute volume of the blood increases to 18-20 1, each 500 ml of the blood are oxygenated during 1-1.5 seconds. It is necessary to reveal the mechanisms of accelerating the blood oxygenation in the alveoli.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 100(12):1382-90.
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    ABSTRACT: In the present study, we investigated whether corticotropin-releasing factor (CRF) injected into the brain induces protection against indomethacin-caused gastric injury and the role of glucocorticoids in the protection. Gastric injury was caused by indomethacin (35 mg/kg, s.c.) in preliminary (24 h) fasted rats. CRF (10 microgram/rat, i.c.v.) was injected 30 min before administration of indomethacin. The participation of glucocorticoids was studied by metyrapone pretreatment (30 mg/kg, i.p., 30 min before CRF). Pretreatment by metyrapone, the inhibitor of glucocorticoid synthesis was the most suitable approach because of a short-lasting inhibiting effect of the drug. Metyrapone pretreatment allowed us to prevent the acute corticosterone response to CRF and avoid the lasting effects of glucocorticoid deficiency. Intracerebroventricular injection of CRF caused fast increase in plasma corticosterone levels and significantly suppressed the occurrence of gastric erosion induced by indomethacin. Metyrapone administration prevented CRF-induced corticosterone rise and significantly attenuated the protective effect of CRF on the gastric mucosa against indomethacin-produced injury. The results suggest that CRF injected into the brain may induce protection against indomethacin-caused gastric injury through the participation of glucocorticoids.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 100(12):1421-30.
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    ABSTRACT: Bioelectrical activity and refractoriness in ventricular myocardium of the hibernator--ground squirrel Citellus undulatus were investigated during hypothermia. Experiments were performed with use of isolated, perfused preparations of papillary muscle from right ventricular. Preparations were obtained from hibernating (HS), summer active (SAS) squirrels and from rats. Bioelectrical activity was registered using the standard microelectrode technique at 37-17 degrees C. Action potentials duration (APD), refractoriness duration (RD) and the velocity of the action potential wave front (dV/dt) were estimated. Hypothermia induced APD and RD prolongation were demonstrated in all groups of experimental animals. However, normalized RD was significantly longer in the HS group during hypothermia than in SAS and rats. Ratio of RD to APD in HS group exceeds unity at 17 degrees C, which allows to suggest so called "postrepolarization refractoriness" during hypothermia. Also, HS reveal more prominent preservation of dV/dt during hypothermia than SAS and rat. Significant prolongation of RD and maintenance of normal excitation conduction during hypothermia probably plays essential role in hibernators resistivity to cold induced arrhythmias.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 100(12):1399-408.
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    ABSTRACT: A set of physiological studies proves that conscious perception of affective stimuli influence on respiratory activity. Less is known about the effect of unconscious perception of emotional information on human breathing. The aim of current research is to compare time characteristics of respiration during unconscious and conscious perception of emotional stimuli. As emotionally provocative stimuli we used natural vocalizations of 3-month-old infants in different emotional state. Both ways of acoustic presentation--first-order unconscious and second-order conscious stimuli--were applied to the one subject within one experiment with a brief inter-trial interval. A comparative data analysis revealed significant changes in time characteristics of respiration in response to acoustic emotional stimuli perceived either consciously or unconsciously. The differences in respiratory dynamics during two conditions of emotional stimuli perception are discussed.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 100(12):1443-52.
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    ABSTRACT: The effects of immobilization stress from 15th to 19th days of gestation on hypothalamic-pituitary-adrenal (HPA) axis activity in the model of posttraumatic stress disorder (stress-restress paradigm) in adult female offspring were studied. The results showed that prenatal stressed female rats demonstrated enhanced stress reactivity and hypersensitive glucocorticoid feedback of HPA in response to the restress procedure. Moreover, decrease in basal level of corticosterone was detected only in prenatal stressed female rats. Immunocytochemical staining revealed that the effects of stress-restress procedure in control female rats were accompanied by the rise in corticotropin-releasing hormone immunoreactivity in the hypothalamic paraventricular nucleus, although over-expression of hypothalamic vasopressin was founded only in prenatal stressed rats. These data suggest that hypothalamic vasopressin was involved predominantly in posttraumatic stress disorder-like state in prenatal stressed female rats.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 100(12):1409-20.
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    ABSTRACT: The present study aims to perform the comparative assessment of stimulation and blockade for D2-dopaminergic receptors in depression-like behavior in male rats with deficiency of androgen hormones. Two weeks after surgery, GDX rats began 14 days of treatment with vehicle, a low dose of testosterone propionate (0.5 mg/kg, s.c.), quinpirole (0.1 mg/kg, i.p.), sulpiride (10.0 mg/kg, i.p.), quinpirole plus testosterone propionate or sulpiride plus testosterone propionate. The animals were then tested in forced swimming test (FST) and the open field test (OFT). Quinpirole administered alone or in a combination with a low dose of testosterone propionate resulted in antidepressant-like effect in GDX rats in the FST. Repeated treatment of quinpirole and testosterone propionate profoundly increased antidepressant-like effect of the single substances they exert per se. Application of neither quinpirole nor quinpirole plus testosterone propionate led to any changes of behavioral reactions in GDX rats in the OFT, except increased grooming behavior. On the contrary, sulpiride treatment failed to alter depression-like behavior in GDX rats in the FST. In addition, sulpiride blocked the antidepressant-like effect of testosterone propionate in GDX rats and its combination with a low dose of testosterone propionate induced prodepressant-like effect in GDX rats. Co-administration of sulpiride with testosterone propionate or its single application increased frequency of rearing and grooming in GDX rats in the OFT. In summary, the results of the present study suggest that stimulation of D2-dopaminergic receptors results in antidepressant-like effect at androgen deficiency in male rats, while blockade of D2-dopaminergic receptors resulted in prodepressant-like effect.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 100(12):1374-81.
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    ABSTRACT: Investigated the involvement of the endogenous opioid agonists attack in the implementation of the cardioprotective effect of postconditioning, playing with the model of isolated perfused on Langendorf rat heart. It is established that this phenomenon occurs when using three sessions reperfusion (30 s) and ischemia (30 s) played at the end of the period 45-min global ischemia. Using the selective blocker of different subtypes of opioid receptors, which was added in perfusion solution in early reperfusion period, found that the stability of the heart to action ischemia-reperfusion in ischemic postconditioning is implemented through the activation of the Delta-1 opioid receptor. Suggests that the mechanism cardioproteguoe phenomenon of postconditioning significant role belongs synthesized in the myocardium of endogenous opioids.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 100(12):1391-8.
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    ABSTRACT: In the review mechanisms of protective action of a hyperthermia, light and low-intensity ultrasonic radiation are considered. These physical factors don't cause oxygen starvation, however promote the increase of organ's tolerance to an ischemia/hypoxia. On materials of original articles the analysis of preconditioning mechanisms cause by high temperatures, low-intensive ultrasonic and laser irradiation was carried out at ischemia. By comparison of processes in tissues at influence by physical factors the general triggers--active forms of oxygen (O2*, H2O2, HO*) were revealed.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 100(12):1361-73.
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    ABSTRACT: p53 is a transcription factor and then induced by cellular stress regulates ageing, cell cycle arrest and apoptosis. Published data also demonstrated that p53 participates in the regulation of neuronal differentiation. However, the data concerning the mechanisms of neuronal differentiation by p53 is very limited. In the present work we have studied a role and mechanisms of p53 activated by Nutlin-3 in the differentiation of PC12 cells. In our experiments Nutlin-3 stimulated the cell differentiation by significantly increasing of the neuritis upgrowth and upregulation of tyrosine hydroxylase (TH) expression, the catecholamine main rate-limited ferment. We have also analyzed MAPK signaling cascade that tightly participate in the neuronal differentiation. Obtained data demonstrated that activation of p53 by Nutlin-3 injections increased the activity of cRaf and ERK1/2, as well as transcription factor CREB, which is one of the targets for ERK pathway and regulates transcription of TH. Thus, we demonstrated that p53 activation lead to increased differentiation of PC12 cells and this effect is mediated by cRaf/ERK/CREB pathway.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 100(12):1431-42.
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    ABSTRACT: The ability to voluntary control severity of alpha- and beta-2 frequency bands in the parietal and frontal cortical areas was investigated at 17 volunteers using biofeedback. The impact of different personality traits on the effectiveness of control was evaluated. According to the data, it was easier task to decrease expression beta-2 frequency in the frontal cortex than to decline the power of alpha frequency in the parietal cortex. The effectiveness of voluntary control of brain activity is influenced by personality features as extraversion, psychoticism, neuroticism, mobility and steadiness of nerve processes, level of person anxiety.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 101(5):599-613.
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    ABSTRACT: In this article we review and discuss the advantages of two proliferative vitreoretinopathy models in rats: intravitreal injection of proteolytic enzyme dispase and proinflammatory lectin concanavalin A. For the first time we selected clear morphological criteria for the retina evaluation during the inflammatory response. We also compared the effects of the injection of dispase and concanavalin on the 7th day after the drugs administration. We conclude that different doses of dispase can be used to get a stable model of PVR on different periods after the injection procedure.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2015; 101(5):572-85.