Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk (Fiziol Z Im M Sechenova )

Publisher: Rossijskaja Akademija Nauk

Description

  • Impact factor
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  • 5-year impact
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  • Other titles
    Sechenov physiological journal, Fiziologic̆eskij z̆urnal
  • ISSN
    0869-8139
  • OCLC
    73087465
  • Material type
    Periodical
  • Document type
    Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: The effect of bacterial lipopolysaccharide (LPS) from E. coli on the viability of the cells of PC12 neuronal cell line was studied. LPS of 0111:B4 serotype was shown to have the most toxic effect on PC12 cells in the medium not containing serum, LPS of 055:B5 serotype was also found to be toxic. But the toxic effect of LPS of 0127:B8 serotype was not revealed in such medium. Preincubation of PC12 cells with GM1 and GD1a gangliosides at concentrations 50 or 100 μM diminishes significantly the death of the cells and the formation of reactive oxygen species induced by LPS of 0111:B4 and 055:B5 serotypes, but these gangliosides at nanomolar concentrations are not active. It was shown that the protective effect of GM1 and GD1a does not depend on the presence of the inhibitor of Trk receptor tyrosine kinase in the medium, their effect is similar to the effect of methyl-beta-cyclodextrin, which is known to disturb cell membrane raft structure. The data obtained suggest that the alteration of structural organization of lipid rafts in PC12 cell plasma membranes due to the incorporation of exogenous gangliosides in them prevents or diminishes the translocation and TLR4 receptor into rafts and their activation induced by LPS, it results in pronounced diminution of toxic effect of LPS on cells.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 07/2013;
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    ABSTRACT: In the experiments on the isolated perfused rat heart the effects of liposomes, containing different concentrations (0.25 and 0.1 mg/mL) of emoxipine, on coronary flow restoration after total normothermic ischemia and reperfusion were studied. The coronary flow, levels of nitrates and nitrites in the outflowing perfusate from heart and level of free radical processes were assessed, The obtained results showed that 0.1 mg/mL liposomal emoxipine provide with stronger increase coronary flow during reperfusion mostly due to the increase concentration of endothelial nitric oxide compare with treatments at 0.25 mg/mL.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):756-62.
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    ABSTRACT: Enzyme AMPK is a part of the family of serine/threonine specific protein kinases. AMPK plays important role in the transfer extracellular signals through phosphorylation of multiple substrates in different metabolic reactions of skeletal muscles. AMPK is geterotrimetric complex, consisting of the catalytic subunit (AMPKalpha) and two regulatory subunits (AMPKbeta and AMPKgamma), which are encoded by seven different high-homologous genes (alpha1, alpha2, beta1, beta2, gamma1, gamma2, gamma3). AMPK regulates skeletal muscle metabolism through phosphorylation of various enzymes such as carbohydrate, lipid and protein metabolism, as well as factors of transcription and initiation. The AMPK expression occurs in response to a changing metabolic requests muscle cells and it leads to increased energy metabolism. The data of recent studies suggest the important role of AMPK in the regulation of intracellular metabolism and point to the need to study the molecular mechanisms involved in the regulation of gene expression in skeletal muscle.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):657-73.
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    ABSTRACT: It was demonstrated in experiments on rats, that increase of immobilization stress duration causes more prolonged activation of lipid peroxidation, however significant differences of both malonic dialdehyde and acylhydroperoxides content were not established in early period after stress in rats, which were exposed to the immobilization of different duration. It was shown, that increase of superoxiddismutase activity is observed in early period of 3-hour and 6-hour stress, but it was decreased in 12-hour immobilization. Catalase activity was decreased in 6-hour and 12-hour stress. These results confirm the literature data about dependence between the expression of stress manifestations and the strength and duration of stress factor action.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):751-5.
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    ABSTRACT: Spatial organization of teta, alfa, beta-1, beta-2 in EEG potentials in humans who quickly an with a high accuracy performed task to learn and reproduce on PC monitor a definite sequence o accuracy performed task to learn and reproduce on PC monitor a definite sequence of circles wer studied. It was found that geometric images of coherent interrelations of teta, alfa, beta-1, beta-2 in EEG potentials were dynamically changed on the different stages of goal-directed the humans activity. The studies give the grounds to consider dynamically changed geometrical images of coherent links of different EEG potentials as an objective index of external projection of intracerebral processes of system architectonics of goal-directed behavior on brain cortex.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):706-18.
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    ABSTRACT: We researched influence of original wound-healing composite, including chitosan and nanoparticles of copper and zinc, on specific of reparative regeneration of an experimental soft tissue full layer rat's wounds, which were conditionally aseptic and infected. The composite stimulation of reparative regeneration is related both to its antibacterial effect, and to the influence on the state of structural biopolymers of the connecting tissue.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):737-44.
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    ABSTRACT: Post-conflict interactions between victims and non-involved group members was investigated in the troop of hamadryas baboons, Papio hamadryas. Observations were done in the Russian Primate Center, Adler in 1996-1997. Redirected aggression, initiation of affiliation from the side of victims towards third parties and consolation were registered during this study. The analyses was done on 445 PC-MC pairs of animals, represented different social classes (harem male-female pairs, harem females, relations, females from different harems, male-male pairs, female-subadult pairs). The attracted-pairs method and the time-rule method were used. Redirected aggression was practiced mainly by male aggressees. It was typical for victims, both males and females, to initiate affiliative interactions with third parties soon after the conflict. Consolation was practiced by hamadryas baboons, but it was limited to harem male-female pairs only. Special affiliative patterns were used by male-consoler. This is the first case, when consolation was demonstrated in baboons.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):697-705.
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    ABSTRACT: We carried out a prolonged investigation of thymic cells, melatonin and corticosterone biorhythms in male Wistar rats. The total number ofthymic cells, lymphocyte numbers in the peripheral blood and percentrage of CD3+ lymphocyte had a 6-days period of fluctuation. The other period of fluctuation in 4 days was found in the dynamics width of subcapsular layer of the thymus and inclusion of the thymidine label. Biorhythms of the melatonin and corticosterone levels were in on antiphase and had a 4-days period.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):729-36.
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    ABSTRACT: Alzheimer's disease is the most common cause of the declarative memory disorder: 30-40% cases of dementia among all of age groups, and 50-60% among the people older 65 years. In addition, disorder of declarative memory is the genuine symptom of the disease, which certainly appears on early stage of the disease and it is an obligate diagnostic symptom. Proponents of the "cholinergic theory" of pathogenesis of Alzheimer's disease suggest that the basis disorder of declarative memory is cholinergic dysfunction. Several neurodynamic mechanisms associated with declarative memory depend on the level of acetylcholine in hippocampus and neocortex. It is believed that dysfunction of the basal cholinergic system in Alzheimer's disease leads to the impairment of these mechanisms. In this review, we summarize available literature data concerning the mechanisms of Alzheimer's disease.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):674-81.
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    ABSTRACT: An overview of current approaches to interpreting the results of spectral analysis of heart rate variability and blood pressure is demonstrated. The analysis of own obtained results were done using the method of assessment of heart rate variability and blood pressure in a variety of functional tests (mental load, moderate exercise, cold test, the restriction of pulmonary ventilation, controlled breathing at a frequency of 6 cycles per minute) in healthy adults. It was shown that all tests induced pronounced changes in the spectral indices of heart rate variability as well as the blood pressure, which were interpreted as changes in the state of autonomous regulation of subject's cardiovascular system. The direction and the degree of changes depend on the form of action.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):682-96.
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    ABSTRACT: The influence of constant lightening on biomarkers of ageing and rates of male rats aging was studied. It was revealed that the maintenance of rats in the constant lightening regime starting from the age of one month results in accelerated ageing of the organism, the reduction of the phases progressive and stable growth, early occurrence of presenile and senile periods, to the earlier occurrence of water-and-salt metabolism imbalance, accelerate the process of "aging" of the antioxidant system in comparison with the rates of the control group. On the contrary, the maintenance of rats in the constant lightening regime starting from the age of fourteen months slows ageing of the organism, increases body growth, delays appearance of pathological changes in the urine, slows down the "aging" of the enzymatic components of the antioxidant system.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):719-28.
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    ABSTRACT: A comparative analysis of rat mesentery micro vascular reactions on thermal impact during radiation to the focused laser irradiation in UV and visible regions of spectrum is made. Local intravascular temperature rise during laser irradiation both impulse (lambda = 337 nm) and continuous (lambda = 532 nm) states causes thrombus formation. The thrombus development that determined by laser irradiation parameters gives a possibility to modulate different degrees of microvessel endothelium damage.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2013; 99(6):745-50.
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    ABSTRACT: The translation and transcription processes involved in mechanisms of synaptic plasticity during the development of conditional taste aversion were studied in command neurons LP11 and PP11 of defensive behavior in snail Helix lucorum. In control snails it was found that the combined presentation of gustatory (carrot juice) and supporting (concentrated solution of quinine) stimulus led to a change in neuron's responses to sensory stimulus, which are typical as to conditioning and also to the corresponding sensitization. 1 h after the start of training it was occurred facilitation of the responses to sensory chemical stimulus (weak solution of quinine) whereas 1.5 hour--reactions to the conditioned food stimulus. Application of the protein synthesis inhibitor cycloheximide during conditioning led to the suppression of response facilitation to both stimulus--weak solution of quinine and the conditioned food stimulus. However, application of the RNA synthesis inhibitor actinomycin D to the neurons caused selective suppression of synaptic facilitation in responses to sensory stimulation with a weak solution of quinine, but it had no effect on synaptic facilitation in the responses to the conditioned stimulus. It has been suggested that the development of conditioned taste aversion in snails causes a long-term synaptic facilitation in nerve cells LP11 and PP11 typical to the process of conditioning and sensitization, for the induction of which the variety of molecular genetic mechanisms are necessary.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2013; 99(5):599-611.
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    ABSTRACT: The action of non-competitive glutamate receptor antagonists on the effects of sleep deprivation has been studied on Krushinskii-Molodkina rats having an inherited predisposition to audiogenic seizures and Wistar rats deprived to this respond. Two types of glutamate receptor open channels blockers were used: the selective blockers of NMDA-receptors (memantine and IEM-1921) and blockers of mixed type, impacting both on the NMDA- and presumably Ca(2+)-permeable AMPA/kainate receptors (IEM-1754 and IEM 1925). Rats were subjected to 12 hours long sleep deprivation. Immediatly after that memantine and IEM-1921 were injected, and during the first 3 hours the total or partial reduction of fast-wave (paradoxical) sleep and a significant increase of the representation of wakefulness at the cost of reducing the total time of slow-wave sleep were observed. These effects are most likely to be a consequence of the blockade of NMDA-receptors functioning in the systems of the rat brain responsible for the launch and maintenance of fast-wave sleep. Injection of IEM-1754 and IEM-1925 on background of sleep deprivation did not affect the organization of sleep during the first 3 hours of their action. During the second three-hour period the rebound effect was observed. The obtained results indicate the involvement of NMDA glutamate receptors in the functioning of various parts of the sleep system of both rat lines.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2013; 99(5):575-85.
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    ABSTRACT: In order to evaluate relative roles of various mechanisms of glucose transport in the small intestine at high substrate loads in chronic experiments on rats, we investigated kinetics of glucose absorption in isolated part (-20 cm) of the intestine after its perfusion for 6 and 14 days during 1.5 h per day with 125 mM glucose solution (gr. 1--increased substrate load) or during 45-60 min per day with 25 mM glucose solution (gr. 2--reduced substrate load). The results of the experiments were analyzed by means of mathematical simulation. It was found that in the rats of gr. 1 the regular substrate load was more effective in maintaining a high level of glucose absorption in the isolated part of the intestine. Adaptation of glucose absorption to the increased local glucose load occurs due to enhancement of the secondary active transport via SGLT1. This component in many times exceeds the "unsaturated" component of glucose absorption, which is mainly determined by the facilitated diffusion via GLUT2, both at high and low glucose concentrations in the intestinal lumen.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2013; 99(5):630-41.
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    ABSTRACT: The analysis of the literature and our own results indicates that a nitric oxide carries out a role the allosteric effector of hemoglobin, changing its affinity to oxygen and defining a condition of oxygen transport blood function. It is important point for modification of functional properties of hemoglobin and its participation in the flow of oxygen in tissues, which plays an important role in development of disadaption reactions at stress and decreased bioactivity of the nitric oxide at the endothelial dysfunction. These findings give possiblity to creat the new ways to correct hypoxical conditions through influence on oxygen-binding properties of the blood and activity of L-arginin-NO system.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2013; 99(5):537-54.
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    ABSTRACT: Analysis of literature source indicates that main pretenders to the role of end-effectors of ischemic postconditioning of the heart are: 1) Ca(2+)-dependent K+ channel of BK-type (big conductance K+ channel), 2) mitoK(ATP) channel (mitochondrial ATP-sensitive K(+)-channel), 3) MPT pore (mitochondrial permeability transition pore). At the same time, some investigators consider that mitoK(ATP) channel is only an intermediate link in the series of signaling events ensured an increase in cardiac tolerance to impact of ischemia-reperfusion. The most likely end-effector of the three structures is MPT pore. Alternatively, it is possible, that unique molecular complex appearing a single end-effector of postconditioning does not exist. Perhaps, that there are several effectors ensured cardioprotective effect of adaptive phenomenon of postconditioning.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 05/2013; 99(5):555-74.