Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk (Fiziol Z Im M Sechenova)

Publisher: Rossijskaja Akademija Nauk

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Other titles Sechenov physiological journal, Fiziologic̆eskij z̆urnal
ISSN 0869-8139
OCLC 73087465
Material type Periodical
Document type Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: It is known that stress changes state and reactivity of humoral systems of stress, particularly the hypothalamic-pituitary-adrenal system (HPA) and the dynorphin-K-opioid system (DKOS) in any age periods, including ones of early postnatal development. Supposedly these changes are underlying some disorders. Difference in state and reactivity of the HPA system is well established. But the role of DKOS is not clear. Further study of this requires summarizing of the literature data on physiology of DKOS activation and ethological features of the activation in different periods of postnatal development. It is possible to conclude that the mode of reaction to stimulation of the DKOS differs in the early development in contrast to adult animals. The mode of reaction can be changed in relation to the periods of development of the system of stress-reactivity and can depend on prior activation of the stress system in a particular period.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 03/2015; 101(3):268-78.
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    ABSTRACT: The changes of chronotropic function of the heart and of the myocardium in the implementation of the diving response in humans were studied by the electrocardiographic method. The study involved 80 students aged 18-20 years. Diving simulation was performed by immersing the face in cold water during breath-hold exhale. When the water temperature was 12.3 +/- 2.3 degrees C, average duration of apnea was 31 +/- 11 s. The oxygen content in the exhaled air after apnea was 98.8 +/- 8.7 mm Hg, carbon dioxide--49.1 +/- 3.5 mm Hg. It was observed slowing of the heart rate, mainly due to the increasing of diastole in 41 of the 80 surveyed during simulating diving. But it also can be observed symptoms of conduction deterioration: atrioventricular block type I (22% of reactive type and 29% of the highly reactive type subjects), and exceeds standards QTc-interval prolongation (at 7.5% of the subjects). These responses are adaptive in nature and disappear in the recovery process. But the fact abnormalities of conduction in the myocardium must be considered when using the diving reflex in medical practice, as may be due to a predisposition to a certain pathology of the cardiovascular system.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 03/2015; 101(3):337-48.
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    ABSTRACT: By laser Doppler flowmetry investigated tissue microhemodynamics rats kept hypokinesia under 10 days. Investigation of the structure of rhythms blood flow oscillations in microvasculature revealed that chronic hypokinetic stress leads to a significant reduction of the oscillator and nonoscillation microhemodynamics indicators, reflected in the development of vasoconstriction, reducing the metabolic function of the endothelium and the allocation to them of nitric oxide, a violation of inflow and outflow of blood, the dominance of shunt blood flow, decreasing the number of functioning capillaries.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 03/2015; 101(3):316-25.
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    ABSTRACT: The article is devoted to investigation of mechanisms of salicylates influence on electric potentials in neurons of mollusk Helix albescens Rossm. It is shown that adenosinetriphosphate (5 x 10(-4) M) at the combined bath application with salicylates substantially modifies their neurotropic effects. It removes nonselective inhibition of impulse activity of neurons by acetylsalicylic acid and strengthens activating effects of cobalt and zinc acetylsalicylates. It is shown that at the blockade of Ca2+ entry by CdCl2 or BaCl2 (5 x 10(-5) and 5 x 10(-4) M) in a neuron from extracellular space or from intracellular depot do not change significantly neuronal responses to salicylates, what suggests that calcium mechanisms did not participate in these responses.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 03/2015; 101(3):326-36.
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    ABSTRACT: It is known that intracranial hemorrhage (ICH) is accompanied by the development of neurogenic pulmonary edema and insufficiency of surfactant function. The present study was undertaken for evaluation of the role of vagal afferents in the mechanisms of ICH effects on pulmonary surfactant and water balance of the lung. We explored the surface activity and biochemical composition of surfactant, as well as blood supply, total, intravascular and extravascular fluid content in lung after ICH, simulated by intraventricular administration of autologous blood against the background of bilateral blockade of capsaicin-sensitive vagal affere its. The blockade was caused by the capsaicin application (50 mcmol) on the cervical part of the nerves. Intracerebralhemorrhage was accompanied by the decrease of surfactant activity which appeared by the enhancement of minimal, maximal and static surface tension of bronchoalveolar lavage fluid (BAL), the reduction of total phospholipids including their main fraction phosphatidylcholine, the increase of lysophosphatidyicholine content and hyperhydration of the lung. The level of total proteins in BAL elevated, confirmed the enhanced permeability of the alveolar-blood barrier. The exhaustion of neuropeptides in capsaicin-sensitive vagal afferents led to the partial restoration of surface active properties of lung, normalization of phospholipids and protein contents and water balance parameters. The obtained results suggest that capsaicin-sensitive vagal afferents play a pivotal role in the disturbances of surfactant function and water balance of the lung after ICH.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 03/2015; 101(3):308-15.
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    ABSTRACT: This study examines the effects of meditation on cardiovascular activity during affective image processing. 22 meditators and 20 controls were shown affective images and were asked either to attend to the images or to down-regulate negative affect (for negative images) or to up-regulate positive affect (for positive images) while continuous cardiovascular activity were recorded. During natural viewing meditators manifested identical pre-stimulus total peripheral resistance (TPR) for all images, whereas controls exhibited greatest,pre-stimulus TPR for negative images and reduced it only in the emotion regulation condition. No between-group differences were revealed for natural viewing of positive images, whereas up-regulation was associated with greater cardiac activation in meditators. The results provide a contribution to the understanding of the mechanisms responsible for the beneficial influence of meditation on cardiovascular risk factors.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 03/2015; 101(3):360-73.
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    ABSTRACT: The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied. The efficiency of emoxipine, reamberin and mexidol was compared to alpha-lipoic acid, which is considered a "golden standard" in treatment of diabetic neuropathies. Emoxipine, reamberin and mexidol after seven administrations in single doses, that are equivalent to therapeutic range in humans, corrected the anxiety-depressive disorders in rats with alloxan diabetes. Unlike reamberin and alpha-lipoic acid, emoxipine and mexidol corrected the affective status concurrently with the decrease in hyperglycemia. At the same time, emoxipine outperformed mexidol in tranquilizing action (in maximal doses) but yielded mexidol in the antidepressant effect (in minimal doses).
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 03/2015; 101(3):258-67.
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    ABSTRACT: The most common complication of diabetes mellitus of the type 1 (DM1) is a cognitive deficiency, which develops as a result of neurodegenerative changes in the brain. The aim of this work was to study the learning and spatial memory in rats with streptozotocin DM1 with different duration (1.5 and 6 months), as well as the activity of adenylyl cyclase signaling system (ACSS) sensitive to agonists of the serotonin and the dopamine receptors in the brain of diabetic rats. Our experiments demonstrated that rats with 1.5-months DM1 has no changes in spatial memory which were evaluated in a Morris water maze whereas in rats with 6-months DM1 the spatial memory and learning ability were decreased. The alterations of the regulation of adenylyl cyclase by agonists of types 1 and 6 serotonin receptors and type 2 dopamine receptors were found in both the 1.5- and 6-months DM1 which indicates their importance in the development of cognitive deficiency. Abnormalities in the. brain ACSS can be considered as key factors in the etiology and pathogenesis of cognitive dysfunctions in DM1. Hypothesized that cognitive deficiency occurs only in the later stages of DM1 due to alterations in the serotonin and dopamine signaling systems of the brain.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 03/2015; 101(3):279-90.
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    ABSTRACT: Chronic imipramine intake (7.5 mg/kg) leads to the stable decrease of excitable reactions to sound stimulant in Wistar rats and induced phase behavioral response in catatonic GC rats. Increased noradrenaline level in frontal cortex and striatum in Wistar animals was shown, whereas it didn't reveal noradrenaline level differences in any brain structures in GC rats. The higher blood corticosterone concentration was decreased under antidepressant reaction in GC rats. Differences between intact GC animals were found out: reduced triglyceride level, lesser body weight, and greater weight index of adrenals in comparison with Wistar rats. Various mechanisms of imipramine action in two rat strains were shown: influence on adrenergic brain system, taking part in the control of exiting behavior in Wistar rats and reaction in adrenals in GC rats.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 03/2015; 101(3):249-57.
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    ABSTRACT: This study was aimed at revealing the features condition of thermal, pain sensitivity and morphological pattern of the skin of the human back at the apex of spinal deformity in the thoracic area in patients with idiopathic scoliosis with stage III-IV. The study included 41 adolescent with idiopathic scoliosis with stage III-IV. Temperature-pain sensitivity was studied in Th6-Th10 dermatomes on the right and the left. Biopsies (skin) for histological examination were taken intraoperatively in projection corresponding to the apex of the arc scoliosis of the spine. Significant disorders of the sensitivity to temperature and pain were found in the dermatomes to the apex of the thoracic spine deformity that were hyperesthesia, hypoesthesia, or absent thermal sensitivity. Histostrukturnye changes of the skin are significantly decreasing the thickness of the epidermis and dermis, reduction of capillaries and changing the structure of the small vessels, destruction of individual nerve fibers and free nerve endings.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 03/2015; 101(3):349-59.
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    ABSTRACT: The aims of the work were the study of cardiorespiratory coupling by method of paced breathing and the analysis of heart rate variability in men. Heart rhythm of 14 athletes and 12 non-athletes, 21 ± 1.4 years old, was registered in 3 minute sessions during spontaneous and paced breathing 14, 10, 9, 8, 7, 6, 5, 4 times/minute. The subjects were following breathing rate from a display. Initial heart rate being more slow in athletes (p < 0.05) was retained during episodes of controlled breathing. The power of FFT spectra peaks of RR-intervals was growing quasilinearly during reduction of breathing rate, reaching its peak value at 5-4 breaths/minute in athletes. More pronounced modulations of RR intervals were observed in HF spectral band (p < 0.05) of athletes breathing 14-10 times/minute compared to non-athletes. The power of LF band of the spectrum in athletes breathing 8-4 times/minute was 2 times higher: variability of RR-intervals "shrinked" accordingly to paced breathing rate. The dominant role in slow oscillations of heart rate manifested by paced respirations with involvement of vagus baroreflex afferentations of lungs and chest is hypothesized to be the consequence of breathing under attentional control.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 02/2015; 101(2):238-48.
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    ABSTRACT: There are several difficulties that impede medical support of space missions. We can assume that the long-term space missions will be accompanied by functional changes in the organism. These changes will be a natural reaction to the factors of space flight. Complex action of factors can lead to the development of both non-specific changes (general adaptation syndrome), and specific changes. We analyzed the physiological changes after long space flights and carried out the correlation of these changes with previously identified proteins in the urine. It is possible to determine the mechanisms of adaptation of the human organism to the conditions of life on Earth after a long stay in Earth orbit.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 02/2015; 101(2):222-37.
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    ABSTRACT: In vitro and in vivo studies were performed to investigate the effects of M1-, M2-, M3-cholinoreceptors (M-AChR) blockade on the chronotropic and inotropic cardiac function in the rats of 1, 3, 6, 8 and 20 weeks old. These age groups were selected according to the development level of the autonomic regulation of the heart. It was found that the prior blockade of all three subtypes M-AChR did not prevent inhibitory effect of carbacholin on contractility of the atria and ventricles the animals of all studied age groups. The presence of the positive chronotropic response was found after blockade of M3-cholinoreceptor in 20 weeks-old rats. The absence of cardiac chronotropic response to the blockade of M2-receptor was revealed. In 3, 6, 8 weeks-old rats the selective blockade of M-AChR does not change of the heart chronotrope. At the same time, the effect of the M1- and M2-AChR blockade on myocardial contractility was revealed.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 02/2015; 101(2):189-99.
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    ABSTRACT: In our work it was studied the metabolic reactions in adolescent girls representatives the two small nationalities (Tofalars and Evenki) and alien (Caucasians) of the population living in different areas of the Irkutsk region. It is found the hypothalamo-thyroid adaptive response development (increase in free T3 concentration, and decrease of TSH in Tofalars; and higher levels of total T4 and T3 in Evenki) in comparison with Caucasians. The study of antioxidant defense system demonstrated the increased content of a-tocopherol and retinol in Tofalars and only retinol in Evenki. The analysis of these two systems relationships revealed the correlation between the thyroid status and antioxidants (T3-α-tocopherol axis) in Evenki and Tofalars. This data proposed that indicated metabolic changes revealed in Tofalars and Evenki may be the result of genetically-determined long-term adaptation to the region environment conditions.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 02/2015; 101(2):214-21.
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    ABSTRACT: It was persuasively shown that norepinephrine released from sympathetic nervous endings plays an important role in the adaptation to cold and epinephrine secreted by adrenal medulla. After acclimatization calorigenic effect of norepinephrine is enhanced. Catecholamines stimulate nonshivering thermogenesis in brown adipose tissue and apparently in white adipose tissue and in skeletal muscles. Adrenergic enhancement of tolerance to cold is depended upon an increase in UCP expression in tissues. In realization of calorigenic effect of catecholamines during long-term cold exposures it is participated following signaling pathway: catecholamines --> β-adrenergic receptors (AR) --> adenylyl cyclase --> cAMP --> protein kinase A --> p38 kinase --> transcription factors --> enhancement of UCP expression. At acute cold exposure it was realized catecholamines --> β-AR --> adenylyl cyclase --> cAMP --> protein kinase A --> hormone sensitive lipase --> free fatty acids --> UCP --> uncoupling oxidative phosphorylation. Calorigenic effect of α1--AR stimulation is realized by following mechanism: norepinephrine --> α1-AR --> phospolipase C --> inositol 1,4,5-triphosphate -->[Ca2+]i --> enhancement of calorigenic effect of catecholamines.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 02/2015; 101(2):145-62.
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    ABSTRACT: The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated. It was observed that peptide at the doses of 50 and 450 μg/kg normalized malondialdehyde (MDA) level elevation in the liver homogenate caused by acute foot-shock stress. On the contrary, at the doses of 5 and 150 μg/kg Semax significantly increased MDA content without essential changes of antioxidant defense activity (catalase, superoxide dismutase, common antioxidative activity). In serum peptide at the all doses decreased stress-induced asparate aminotransferase activity elevation. In chronic stress peptide provided the normalization of protein synthetic hepatocytes function and the serum alanine aminotransferase activity with less effect on lipid peroxidation.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 02/2015; 101(2):171-9.
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    ABSTRACT: The aim of this work was the investigation of nitric oxide (NO) inhalations action on some parameters of energy and oxidative metabolism of healthy rats blood. Wistar rats were randomly divided into two groups: control group (without any manipulations; n = 10) and main group (n = 10) with inhalations by NO-containing gas flow (20 ppm). Activity of pro- and antioxidant systems, superoxide dismutase, lactate dehydrogenase and lactate level were estimated in rats blood samples. We observed stimulation of adaptive reserves of rats organism after course of NO (20 ppm) inhalations. First component of these changes was a modulation of pro- and antioxidant systems, including intensification of lipid peroxidation with prevalent activation of superoxide dismutase. Second component was a positive modification of lactate dehydrogenase functioning.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 02/2015; 101(2):180-8.
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    ABSTRACT: The experiments has been designed to study unpredictable chronic mild stress effect on anti-depressive activities of amitriptyline (10 mg/kg) and fluoxetine (20 mg/kg) in forced swim test in male outbred mice. It is shown that acute treatment with fluoxetine does not produce any antidepressant effects in mice following stress of 14 days while the sub-chronic injections of fluoxetine result in more deep depressive-like behavior. In 28 daily stressed mice, antidepressant effect of fluoxetine is observed independently of the injection rates. Amitriptyline demonstrates the antidepressant activity regardless of the duration of stress or administration scheduling, but at the same time the severity of anti-immobilization effect of amitriptyline in stressed mice is weaker in compare to non-stressed trails. Thus, the injection rates and duration of unpredictable mild chronic stress are the parameters that determine the efficiency of antidepressants in the mouse forced swimming test.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 02/2015; 101(2):163-70.
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    ABSTRACT: A group of mice with preliminary implanted (under general anesthesia) electrodes for cortical EEG and nuchal EMG was subjected to continuous baseline 24-hr video and digital polysomnographic recording with the 12/12 light/dark schedule, and then injected subcutaneously with 24 or 48 mg/kg of MPTP toxin or (the control group) saline. The recordings were continued for 2 weeks more. A significant increase in activity and the waking percentage as well as decrease in REM sleep and NREM sleep (tendency) during the dark period as compared to the baseline and control recordings was found. The effect was seen just on the 7th day following MPTP administration and became significant by the 14th day. The effect was more pronounced after 48 mg/kg injection than after 24. There were no changes during the light period. Morphological control revealed a 70% and 35% decreases in the amount of tyrosine hydroxylase positive neurons in substancia nigra/pars compacta after 48 and 24 mg/kg of MPTP, respectively, as compared to the saline group.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 11/2014; 100(11):1252-60.