Magnetic Resonance in Medicine (MAGN RESON MED )

Publisher: Society of Magnetic Resonance in Medicine (U.S.); International Society for Magnetic Resonance in Medicine, John Wiley & Sons


Magnetic Resonance in Medicine is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications.

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  • 5-year impact
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  • Website
    Magnetic Resonance in Medicine website
  • Other titles
    Magnetic resonance in medicine (Online), Magnetic resonance in medicine
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  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

John Wiley & Sons

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    • Author can archive a pre-print version
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    • Author can archive a post-print version
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    • See Wiley-Blackwell entry for articles after February 2007
    • On personal web site or secure external website at authors institution
    • Not allowed on institutional repository
    • JASIST authors may deposit in an institutional repository
    • Non-commercial
    • Pre-print must be accompanied with set phrase (see individual journal copyright transfer agreements)
    • Published source must be acknowledged with set phrase (see individual journal copyright transfer agreements)
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • 'John Wiley and Sons' is an imprint of 'Wiley-Blackwell'
  • Classification
    ​ green

Publications in this journal

  • Magnetic Resonance in Medicine 09/2014; 72(3).
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    ABSTRACT: Purpose: To estimate the value of PRF shift coefficient of explanted Thiel embalmed animal and human tissue used as a pre-clinical model for treatment with MR-guided Focused Ultrasound (MRgFUS). Methods: Thiel embalmed human liver, ovine liver and porcine muscle were heated with two methods: bulk heating and FUS-induced heating. Phase-referenced PRF thermometry was applied during cooling of the tissue, to obtain a series of phase difference, ΔΦ maps. A fibre optical thermocouple was inserted in the tissue to measure the temperature difference, ΔΤ. The PRF shift coefficient was calculated from the measured ΔΦ,ΔΤ. Results: In the case of bulk heating, average values of PRF coefficient (±SD): 0.017 (5×10-4) ppm/0C, 0.015(6×10-4) ppm/0C and 0.012(6×10-4) ppm/0C were found for Thiel embalmed ovine liver, porcine muscle and human liver, respectively. Very similar values of PRF coefficient were found in tissues heated with FUS. Conclusion: The values of PRF coefficient measured for the Thiel embalmed tissue were higher than the values for fresh tissue. This lead to the assumption that embalming a tissue with Thiel fluid can affect PRF Thermometry. The chemical composition of the Thiel fluid and the electrical conductivity might be some possible reasons for that.
    Magnetic Resonance in Medicine 01/2014;
  • Magnetic Resonance in Medicine 12/2013;
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    ABSTRACT: Contrast-enhanced magnetic resonance angiography is challenging due to the need for both high spatial and temporal resolution. A multishot trajectory composed of pseudo-random rotations of a single multiecho radial readout was developed. The trajectory is designed to give incoherent aliasing artifacts and a relatively uniform distribution of projections over all time scales. A field map (computed from the same data set) is used to avoid signal dropout in regions of substantial field inhomogeneity. A compressed sensing reconstruction using the GraDeS algorithm was used. Whole brain angiograms were reconstructed at 1-mm isotropic resolution and a 1.1-s frame rate (corresponding to an acceleration factor > 100). The only parameter which must be chosen is the number of iterations of the GraDeS algorithm. A larger number of iterations improves the temporal behavior at cost of decreased image signal-to-noise ratio. The resulting images provide a good depiction of the cerebral vasculature and have excellent arterial/venous separation.
    Magnetic Resonance in Medicine 01/2012;
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    ABSTRACT: The aim of this study was to investigate T2* in the Achilles tendon (AT), in vivo, using a three-dimensional ultrashort time echo (3D-UTE) sequence, to compare field strength differences (3 and 7 T) and to evaluate a regional variation of T2* in healthy and pathologic tendon. Ten volunteers with no history of pain in the AT and five patients with chronic Achilles tendinopathy were recruited. 3D-UTE images were measured with the following echo times, at echo time = [0.07, 0.2, 0.33, 0.46, 0.59, 0.74, 1.0, 1.5, 2.0, 4.0, 6.0, and 9.0 ms]. T2* values in the AT were calculated by fitting the signal decay to biexponential function. Comparing volunteers between 3 and 7 T, short component T2s* was 0.71 ± 0.17 ms and 0.34 ± 0.09 ms (P < 0.05); bulk long component T2l* was 12.85 ± 1.87 ms and 10.28 ± 2.28 ms (P < 0.05). In patients at 7 T, bulk T2s* was 0.53 ± 0.17 ms (P = 0.045, compared to volunteers), T2l* was 11.49 ± 4.28 ms (P = 0.99, compared to volunteers). The results of this study suggest that the regional variability of AT can be quantified by T2* in in vivo conditions. Advanced quantitative imaging of the human AT using a 3D-UTE sequence may provide additional information to standard clinical imaging. Finally, as the preliminary patient data suggest, T2s* may be a promising marker for the diagnosis of pathological changes in the AT. Magn Reson Med, 2011. © 2011 Wiley Periodicals, Inc.
    Magnetic Resonance in Medicine 12/2011;
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    ABSTRACT: In this study we utilized manganese-enhanced MRI (MEMRI) to evaluate the in vivo transneuronal efficiency of manganese ion (Mn(2+)) movement as a means to assess overall changes in neuronal function. We designated this extension the manganese transfer index (MTI) value. To evaluate the MTI value as an index of transneuronal physiology we examined both pharmacological agents and different mouse models of neuronal dysfunction. We found that treatment with isoflurane, which attenuates synaptic vesicle release, or memantine, which attenuates postsynaptic uptake of Ca(2+) as well as Mn(2+), resulted in a decrease in the MTI value. Furthermore, we evaluated if changes in the MTI value can be detected in three knockout mice with altered brain function accompanied either with or without neurodegeneration. Our data demonstrate that the MTI values either decreased or increased in response to different functional as well as anatomical changes. These results demonstrate the potential utility of the MTI value as an in vivo index for the detection of changes in neuronal function in animal models of human disease.
    Magnetic Resonance in Medicine 08/2008; 60(1):169-75.
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    ABSTRACT: Many diagnostic MRI sequences demand reliable and uniform fat suppression. Multipoint water-fat separation methods, which are based on chemical-shift induced phase differences, have shown great success in the presence of field inhomogeneities. This work presents a computationally efficient and robust field map estimation method. The method begins with subsampling image data into a multiresolution image pyramidal structure, and then utilizes a golden section search to directly locate possible field map values at the coarsest level of the pyramidal structure. The field map estimate is refined and propagated to increasingly finer resolutions in an efficient manner until the full-resolution field map is obtained for final water-fat separation. The proposed method is validated with multiecho sequences where long echo-spacings normally impose great challenges on reliable field map estimation.
    Magnetic Resonance in Medicine 08/2008; 60(1):236-44.
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    ABSTRACT: As a consequence of the Maxwell equations, linear field gradients are accompanied by additional spatially dependent field components. A description of the Maxwell field terms is presented which explicitly takes into account the asymmetry of the gradient coil. It is shown both theoretically and experimentally that, in contrast to symmetric coils, an asymmetric coil generates concomitant field terms of zeroth and first order in space. Artifacts induced by concomitant fields can be much more pronounced for asymmetric coil designs than for symmetric ones. For the strong gradient amplitudes available on modern MR systems the effect of these concomitant magnetic fields on the evolution of magnetization has to be taken into consideration in a variety of NMR acquisition techniques. The formalism is used experimentally to compensate for artifacts observed in three different imaging methods: an image shift in standard echo planar imaging (EPI), an echo shift in diffusion-weighted EPI, and a phase shift in a flow quantification technique based on phase contrast images.
    Magnetic Resonance in Medicine 08/2008; 60(1):128-34.
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    ABSTRACT: Functional mapping of the lateral lemniscus and the superior olivary complex as part of the auditory pathway was accomplished for the first time in mice in vivo using manganese-enhanced MRI (2.35T, 3D FLASH, 117 microm isotropic resolution). These and other auditory centers in the brainstem presented with pronounced signal enhancements after systemic administration of manganese chloride when animals were exposed to acoustic stimuli for 48 hr, but not when kept in a quiet environment. The results indicate an activation-dependent accumulation of manganese in the neural circuit composed of the cochlear nucleus, the superior olivary complex, the lateral lemniscus, and the inferior colliculus. The marked enhancement of the lateral lemniscus suggests that the stimulus-related accumulation of manganese reflects not only a regional uptake from extracellular fluid but also a concurrent delivery by axonal transport within the auditory system.
    Magnetic Resonance in Medicine 08/2008; 60(1):210-2.
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    ABSTRACT: The purpose of this study was to develop a (1)H-nuclear magnetic resonance metabolomic approach capable of predicting the occurrence of exercise-induced ischemia in patients with suspected coronary artery disease and to identify the metabolite patterns that contribute most importantly to the prediction. In 31 patients with suspected effort angina and without previous myocardial infarction, serum was obtained just prior to a stress single-photon emission computed tomography. Serum NMR spectra were acquired with pulse-and-acquire and T(2)-edited sequences. The region between 0.50 and 4.25 ppm was used for analysis. Twenty-two patients had reversible myocardial perfusion defects and nine did not. Both groups had similar age and clinical profile, except for more smokers and diabetics in the ischemia group, and attained a similar peak heart rate. The best separation was achieved with long T(2)-edited spectra, 84% of patients being correctly classified based on the partial least square discriminant analysis. The main contributors to discrimination were lactate, glucose, as well as methyl and methylene moieties of lipids and long-chain amino acids. Metabolomic analysis of serum can predict exercise-inducible ischemia in patients with suspected coronary artery disease. This capability could be useful in screening and risk stratification of patients with coronary risk factors.
    Magnetic Resonance in Medicine 08/2008; 60(1):27-32.

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