Molecular Biology and Evolution (MOL BIOL EVOL)

Publisher: Molecular Biology and Evolution Society; American Society of Naturalists; Society for the Study of Evolution, Oxford University Press (OUP)

Journal description

Molecular Biology and Evolution (MBE) is devoted to the interdisciplinary science between molecular biology and evolutionary biology. MBE emphasizes experimental papers, but theoretical papers are also published if they have a solid biological basis. Although this journal is primarily for original papers, review articles and book reviews are also published. MBE is an appropriate outlet for the examination of molecular evolutionary processes and patterns, and the testing of evolutionary hypotheses with molecular data. MBE is not an appropriate outlet for purely taxonomic treatments and the detailing of systematic issues. Published by the Society for Molecular Biology and Evolution.

Current impact factor: 9.11

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 9.105
2013 Impact Factor 14.308
2012 Impact Factor 10.353
2011 Impact Factor 5.55
2010 Impact Factor 5.51
2009 Impact Factor 9.872
2008 Impact Factor 7.28
2007 Impact Factor 6.438
2006 Impact Factor 6.726
2005 Impact Factor 6.233
2004 Impact Factor 6.355
2003 Impact Factor 6.05
2002 Impact Factor 5.271
2001 Impact Factor 5.357
2000 Impact Factor 5.298
1999 Impact Factor 4.983
1998 Impact Factor 5.291
1997 Impact Factor 5.249
1996 Impact Factor 5.969
1995 Impact Factor 5.399
1994 Impact Factor 5.024
1993 Impact Factor 3.902
1992 Impact Factor 3.737

Impact factor over time

Impact factor

Additional details

5-year impact 11.67
Cited half-life 7.10
Immediacy index 1.75
Eigenfactor 0.09
Article influence 4.44
Website Molecular Biology and Evolution website
Other titles Molecular biology and evolution, MBE
ISSN 0737-4038
OCLC 9364605
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

Oxford University Press (OUP)

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • Pre-print can only be posted prior to acceptance
    • Pre-print on pre-print servers
    • Pre-prints that are accepted will be required to select Oxford Open when accepted
    • Pre-print must be accompanied by set statement (see link) and state of article review
    • Pre-print must match current version under consideration
    • Pre-print must be ammended with a a link to published version
    • Post-print in Institutional repositories or Central repositories
    • Publisher's version/PDF cannot be used
    • Published source must be acknowledged
    • Must link to publisher version
    • Set phrase to accompany archived copy (see policy)
    • Eligible authors may deposit in OpenDepot
    • The publisher will deposit in PubMed Central on behalf of NIH authors
    • This policy is an exception to the default policies of 'Oxford University Press (OUP)'
  • Classification

Publications in this journal

  • Molecular Biology and Evolution 11/2015; DOI:10.1093/molbev/msv232

  • Molecular Biology and Evolution 11/2015; DOI:10.1093/molbev/msv231
  • [Show abstract] [Hide abstract]
    ABSTRACT: By definition, pseudogenes are relics of former genes that no longer possess biological functions. Operationally, they are identified based on disruptions of open reading frames (ORFs) or presumed losses of promoter activities. Intriguingly, a recent human proteomic study reported peptides encoded by 107 pseudogenes. These peptides may play currently unrecognized physiological roles. Alternatively, they may have resulted from accidental translations of pseudogene transcripts and possess no function. Comparing between human and macaque orthologs, we show that the nonsynonymous to synonymous substitution rate ratio (ω) is significantly smaller for translated pseudogenes than other pseudogenes. In particular, five of 34 translated pseudogenes amenable to evolutionary analysis have ω values significantly lower than 1, indicative of the action of purifying selection. This and other findings demonstrate that some but not all translated pseudogenes have selected functions at the protein level. Hence, neither ORF disruption nor presence of protein product disproves or proves gene functionality at the protein level.
    Molecular Biology and Evolution 11/2015; DOI:10.1093/molbev/msv268
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    ABSTRACT: Changes in gene expression are an important mode of evolution, however the proximate mechanism of these changes is poorly understood. In particular, little is known about effects of mutations within cis binding sites for transcription factors, or the nature of epistatic interactions between these mutations. Here, we tested the effects of single and double mutants in two cis binding sites involved in the transcriptional regulation of the Escherichia coli araBAD operon, a component of arabinose metabolism, using a synthetic system. This system decouples transcriptional control from any post-translational effects on fitness, allowing a precise estimate of the effect of single and double mutations, and hence epistasis, on gene expression. We found that epistatic interactions between mutations in the araBAD cis regulatory element are common, and that the predominant form of epistasis is negative. The magnitude of the interactions depended on whether the mutations are located in the same or in different operator sites. Importantly, these epistatic interactions were dependent on the presence of arabinose, a native inducer of the araBAD operon in vivo, with some interactions changing in sign (e.g., from negative to positive) in its presence. This study thus reveals that mutations in even relatively simple cis regulatory elements interact in complex ways such that selection on the level of gene expression in one environment might perturb regulation in the other environment in an unpredictable and uncorrelated manner.
    Molecular Biology and Evolution 11/2015; DOI:10.1093/molbev/msv269

  • Molecular Biology and Evolution 11/2015; DOI:10.1093/molbev/msv233

  • Molecular Biology and Evolution 11/2015; DOI:10.1093/molbev/msv245

  • Molecular Biology and Evolution 11/2015; DOI:10.1093/molbev/msv238
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    ABSTRACT: Wild populations of the model organism Drosophila melanogaster experience highly heterogeneous environments over broad geographical ranges as well as over seasonal and annual timescales. Diapause is a primary adaptation to environmental heterogeneity, and in D. melanogaster the propensity to enter diapause varies predictably with latitude and season. Here we performed global transcriptomic profiling of naturally occurring variation in diapause expression elicited by short day photoperiod and moderately low temperature in two tissue types associated with neuroendocrine and endocrine signaling, heads and ovaries. We show that diapause in D. melanogaster is an actively regulated phenotype at the transcriptional level, suggesting that diapause is not a simple physiological or reproductive quiescence. Differentially expressed genes and pathways are highly distinct in heads and ovaries, demonstrating that the diapause response is not uniform throughout the soma and suggesting that it may be comprised of functional modules associated with specific tissues. Genes down-regulated in heads of diapausing flies are significantly enriched for clinally varying SNPs and seasonally oscillating SNPs, consistent with the hypothesis that diapause is a driving phenotype of climatic adaptation. We also show that chromosome location-based co-regulation of gene expression is present in the transcriptional regulation of diapause. Taken together, these results demonstrate that diapause is a complex phenotype actively regulated in multiple tissues, and support the hypothesis that natural variation in diapause propensity underlies adaptation to spatially and temporally varying selective pressures.
    Molecular Biology and Evolution 11/2015; DOI:10.1093/molbev/msv263
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    ABSTRACT: North American populations of Drosophila melanogaster derive from both European and African source populations, but despite their importance for genetic research, patterns of ancestry along their genomes are largely undocumented. Here, I infer geographic ancestry along genomes of the Drosophila Genetic Reference Panel (DGRP) and the D. melanogaster reference genome, which may have implications for reference alignment, association mapping, and population genomic studies in Drosophila. Overall, the proportion of African ancestry was estimated to be 20% for the DGRP and 9% for the reference genome. Combining my estimate of admixture timing with historical records, I provide the first estimate of natural generation time for this species (~15 generations per year). Ancestry levels were found to vary strikingly across the genome, with less African introgression on the X chromosome, in regions of high recombination, and at genes involved in specific processes (e.g. circadian rhythm). An important role for natural selection during the admixture process was further supported by evidence that many unlinked pairs of loci showed a deficiency of Africa-Europe allele combinations between them. Numerous epistatic fitness interactions may therefore exist between African and European genotypes, leading to ongoing selection against incompatible variants. By focusing on hubs in this network of fitness interactions, I identified a set of interacting loci that includes genes with roles in sensation and neuropeptide/hormone reception. These findings suggest that admixed D. melanogaster samples could become an important study system for the genetics of early-stage isolation between populations.
    Molecular Biology and Evolution 09/2015; 32(12):msv194. DOI:10.1093/molbev/msv194