Clinical and experimental obstetrics & gynecology (CLIN EXP OBSTET GYN)

Publisher: Università di Padova. Clinica ostetrica ginecologica

Journal description

Current impact factor: 0.42

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 0.424
2013 Impact Factor 0.357
2012 Impact Factor 0.379
2011 Impact Factor 0.429
2010 Impact Factor 0.433
2009 Impact Factor 0.45

Impact factor over time

Impact factor

Additional details

5-year impact 0.57
Cited half-life 6.10
Immediacy index 0.07
Eigenfactor 0.00
Article influence 0.13
Website Clinical & Experimental Obstetrics & Gynecology website
Other titles Clinical and experimental obstetrics & gynecology, Clinical and experimental obstetrics and gynecology
ISSN 0390-6663
OCLC 3995609
Material type Periodical
Document type Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective: Obstetric cholestasis is a cholestatic disease usually commencing in the third trimester of pregnancy and characterized by pruritus, elevation of liver enzymes, and increase in bile acids. The objective of this study was to compare the first trimester serum indicators of obstetric cholestasis with normal pregnancies. Materials and Methods: Thirty-five patients diagnosed with obstetric cholestasisin a three-year period with first trimester biochemical assessment available were included in the study. Seventy patients with concordant pregnancy weeks, matched-age normal pregnancies were included as the control group. Pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (beta-hCG) levels were analyzed. Results: No difference was observed between the two groups in terms of age and week of pregnancy. While the mean PAPP-A level was 0.76 ± 0.31 multiples of the medians(MoM) in the obstetric cholestasis group, it was determined to be 1.5 ± 0.84 in the control group (p = 0.0001). Among the two groups, the hCG levels were found to be higher in the obstetric cholestasis group (1.2 ± 0.79 MoM vs. 0.98 ± 0.53, p = 0.041). Conclusion: In this study, the first trimester PAPP-A levels in the obstetric cholestasis cases were found to be significantly lower than the control group. Low PAPP-A levels should be a warning for obstetric cholestasis.
    Clinical and experimental obstetrics & gynecology 09/2015; 42(5):617-18.
  • Clinical and experimental obstetrics & gynecology 08/2015;
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    ABSTRACT: Purpose: To examine the interobserver variability for fetal biometry parameters and to investigate whether this variability affects the second trimester maternal serum screening test results. Methods: A total of 60 singleton pregnancies who were scheduled for second trimester maternal serum screening were investigated. Two experienced sonographers performed all examinations at the same visit. The risk calculations of screening were performed according to the each operator's biometric measurements separately. Interobserver variability in measurements of fetal biometrics and the effect of this interobserver variability on the screening results were assessed. Results: Inter-observer reliability for biparietal diameter and femur lenght were 0.904 and 0.888 (p<0.001), respectively. Inter-observer reliability coefficients for Trisomy 21, Trisomy 13/18 and neural tube defect were 0.887, 0.999 and 0.920 (p<0.0001), respectively. Conclusion: Our results demonstrate that the interobserver reliability and agreement of ultrasound measurements of fetal biometry in cases of routine prenatal screening are highly reliable. Key Words: inter-observer variability, maternal serum screening, triple test, trisomy 21. Content: Fetal biometric measurements for routine prenatal screening by abdominal ultrasound are highly reliable. Interobserver reliability and agreement in BPD and FL measurements are quite high.
    Clinical and experimental obstetrics & gynecology 08/2015;
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    ABSTRACT: To determine if a better response than anticipated to controlled ovarian stimulation in a woman assumed to have diminished oocyte reserve based on an increased day 3 serum follicle stimulating hormone (FSH) level, could be related to a gonadotropinoma. Magnetic resonance imaging (MRI) with and without gadolinium contrast was used in a woman who made 21 mature oocytes despite a history of day 3 serum FSH as high as 20 mIU/mL. A pituitary microgonadotropinoma was detected. The presence of a better response than anticipated to controlled ovarian hyperstimulation (COH) with exogenous gonadotropins despite an increase in day 3 serum FSH should prompt a search for a possible gonadotropinoma.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):279-81.
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    ABSTRACT: Pulmonary hypertension (PH) presents a high risk for maternal mortality. The intravenous administration of treprostinil has demonstrated effectiveness for the treatment of PH, though documentations of its use during pregnancy are few. The authors present a 30-year-old gravid women with symptoms of PH at 23 weeks gestation. Treatment comprised of oxygen therapy, enoxaparin, and intravenous treprostinil from gestational week 25, following a successful elective cesarean section at 33 weeks gestation with favorable outcome. This report demonstrates the effectiveness of an intensive therapeutic protocol, including intravenous treprostinil, for the treatment of PH in pregnancy.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):390-1. DOI:10.12891/ceog1874.2015
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    ABSTRACT: To establish the serum pattern for glycodelin and to investigate the possible correlations of serum and follicular fluid (FF) glycodelin with clinical pregnancy in gonadotropin-releasing hormone (GnRH)-antagonist controlled cycles. A prospective observational study conducted with 80 infertile couples who received a GnRH-antagonist controlled cycle. Glycodelin levels were measured in FF, day 2-3, and ovarian pick-up (OPU)-day serum samples. There were no significant differences in serum glycodelin concentrations in either the early follicular phase or the preovulatory phase, and in FF glycodelin concentrations between clinically pregnant and non-pregnant patients. OPU-day serum glycodelin was found to be significantly higher than early follicular serum glycodelin level in all patients whether pregnancy occurred or not. Although day 2-3 and OPU-day measurements of serum glycodelin levels were not significant in predicting clinical pregnancy, the pattern of serum glycodelin seems different in GnRH-antagonist controlled cycles than natural and GnRH-agonist controlled cycles.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):367-71. DOI:10.12891/ceog1872.2015
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    ABSTRACT: The objective of this study was to evaluate the impact of luteinizing hormone (LH), estradiol (E2) and progesterone (P) levels on the day of human chorionic gonadotropin (HCG) administration on outcomes of in vitro fertilization (IVF) in controlled ovarian hyperstimulation (COH). In this retrospective study, 129 infertile women undergoing IVF/intracytoplasmic sperm injection (ICSI) treatments were included; these cycles were stratified according to LH levels of ≥ 1.12 IU/L or < 1.12 U/L and according to E2 levels of ≥ 1,005.89 pmol/L or < 1,005.89 pmol/L. The main outcome measure was the clinical pregnancy rate. The clinical pregnancy rate was significantly higher in the group with LH ≥ 1.12 IU/L than in the group with LH < 1.12 U/L (43.28% vs. 30.65%, p < 0.05). The clinical pregnancy rate was also higher in the group with E2 ≥ 1,005.89 pmol/L than in the group with average E2 < 1,005.89 pmol/L (42.86% vs. 30.51%, p < 0.05). Among the LH, E2, and P levels on the day of HCG administration, LH level was the most important predictor of outcomes of IVF in COH. The present data showed an adverse effect of low serum LH level (LH < 1.12 IU/L) on the day of HCG administration on clinical pregnancy rate. E2 level can also predict the outcomes of IVF in COH. Low serum LH level (LH < 1.12 IU/L) and low serum E2 level (average E2 < 1,005.89 pmol/L) on the day of HCG administration led to low clinical pregnancy rates, while the P level on the day of HCG administration may have had little effect on clinical pregnancy.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):361-6. DOI:10.12891/ceog1850.2015
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    ABSTRACT: The aim of this study was to investigate whether performing different fertilization technologies (intracytoplasmic sperm injection [ICSI] and in vitro fertilization [IVF]) may affect the result of fertilization in the normal fertilization cycles. The authors performed a retrospective analysis of 164 cycles using sibling oocytes in combined IVF/ICSI with achieved a normal fertilization ( ≥ 25%) both conventional IVF and ICSI in this infertility centre. It was found that there were no differences in 2PN rate (70.25% vs 70.60%), but higher cleavage rate in ICSI than IVF insemination (98.99% vs 96.81%), higher arrested embryos rate in IVF than ICSI in 2PN group (20.00% vs 13.95%), and higher abnormal fertilization IPN (3.87% vs 1.92%) and 3PN (3.63 vs 0.854%) in IVF than ICSI. There were some differences fertilization outcomes between ICSI and IVF, which may be related to different procedures between two techniques.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):372-5.
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    ABSTRACT: The testing represented a prospective study that was performed at the Gynaecology and Obstetrics Clinic "Narodni Front" in Belgrade during a two-year period. The study encompassed female patients with ovarian endometrioma operated with laparoscopic surgery. The research objective was to determine the percentage of occurrence of relapses in patients operated for endometriosis of the ovary in relation to the stage of the disease and the type of performed operation, and which were receiving suppressive therapy with gonadotropin-releasing hormone (GnRH) analogues after the surgery compared to those who were not receiving suppressive therapy after the operation. The recurrence of endometriosis on the ovary of the test and control groups was monitored during the first year after surgery. In all patients ultrasound checks were done every month during the first six months after surgery, and then every three months for the next six months. In all patients in whom the recurrence, i.e. endometrioma on the ovary larger than three cm was revealed postoperatively by ultrasound, the laparoscopic removal of the endometrioma was performed again as well as the histopathological examination of the material. There was no statistically significant difference in the distribution of recurrence of endometriosis between the groups formed according to the type of surgical technique (cystectomy or cystotomy). The recurrence of endometriosis occurred later in the group of patients in which the treatment GnRH analogues was applied after the surgical treatment. The recurrence of endometriosis in more severe stages (Stage III and IV) occurs later in the group of patients in which the treatment GnRH analogues is applied after the surgical treatment.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):339-43.
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    ABSTRACT: To explore whether sex hormone-binding globulin (SHBG) and free androgen index (FAI) can be seen as therapeutic effect indexes of women with polycystic ovarian syndrome (PCOS). The body mass index (BMI), basal sexual hormones, SHBG, fasting blood glucose (FBG), and fasting insulin (FINS) were collected from 579 women with PCOS, were divided into two groups according to BMI: obese group (n = 145) and non-obese group (n = 434), according to homeostasis model assessment of insulin status (HOMA-IR). Patients were then divided into four groups: A: non-obese without insulin resistance (n = 174), B: non-obese with insulin resistance (n = 260), C: obese without insulin resistance (n = 34), D: obese with insulin resistance (n = 111). A and B groups received Diane-35 alone, C and D groups received Diane-35 plus metformin for three months. Then clomiphene citrate and HMAG were used to induce ovulation then compared ovulation rate and pregnancy outcome. FAI decreased significantly and SHBG increased significantly in all groups. In A group FINS and HOMA-IR increased significantly (p < 0.05), but in B and D groups FINS and HOMA-IR decreased significantly (p < 0.05). After treatment the ovulation rate in non-obese group was higher than obese group (p < 0.01). Compared with non-ovulation patients, SHBG increased significantly and FAI decreased significantly in the patient with ovulation. Regarding the pregnancy outcome, FAI decreased significantly in delivery patients than spontaneous abortion patients. Furthermore, SHBG increased significantly. It was important to check SHBG and FAI during the treatment of PCOS patient. They could be used to assess whether the treatment was effective and as a guidance of clinical medication.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):315-20. DOI:10.12891/ceog1779.2015
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    ABSTRACT: Cantrell's pentalogy (CP) is a rare syndrome characterized by defects in the lower sternum with ectopia cordis, anterior diaphragm defects, midline supraumbilical abdominal wall defects, defects in the diaphragmatic pericardium, and congenital heart disease. The authors report a 12-weeks gestation with multiple fetal anomalies suggesting the diagnosis of CP (a large thoraco-abdominal defect with herniating liver and bowel, heart deviated anteriorly with concomitant ventricular septal defect), and the 'S' shaped fetal spine due to increased lumbar lordosis and scoliosis with accompanying pes equinovarus deformity. Chorionic villus sampling was performed due to increased nuchal translucency (3.7 mm). The fetal karotype was found to be 47, XX,+21 (trisomy 21). In the literature, three scoliosis cases have been reported accompanying the CP along with multiple anomalies and one concomitant pes equinovarus deformity has been reported previously.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):392-4. DOI:10.12891/ceog1879.2015
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    ABSTRACT: The aims of the study were: evaluation of depressive symptoms in climacteric women, comparison of depressive symptoms between peri- and post-menopausal women, and assessment of a possible relationship between the presence of depressive symptoms and the hormonal profile of the studied women. The study included 45 peri-menopausal and 95 post-menopausal women admitted to the Department of Gynecological Endocrinology, Poznafi University of Medical Sciences, because of climacteric symptoms. The following parameters were evaluated in all studied women: intensity of climacteric symptoms (Kupperman Index), intensity of depressive symptoms (Hamilton depression scale), serum concentrations of hypothalamic-pituitary-gonadal axis hormones (FSH, LH, 17β-estradiol), prolactin (PRL) and androgens [total testosterone, dehydroepiandrosterone sulfate (DHEAS)]. FSH, LH, 17β-estradiol, PRL, and total testosterone were evaluated by the immunoenzymatic methods and DHEAS was measured by the radioimmunological method. Psychic and somatic manifestations of anxiety and fear, shallow sleep, and general somatic symptoms were the most frequent depressive symptoms in both studied groups. Both investigated groups differed in relation to the incidence and intensity of symptoms from the genital system (observed more often in post-menopausal women) and hypochondria (noted more frequently in peri-menopausal women). Numerous relationships between the incidence and intensity of certain symptoms and serum concentrations of the investigated hormones were found in both groups. The correlations were different in peri- and post-menopausal subjects.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):285-91. DOI:10.12891/ceog1820.2015
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    ABSTRACT: Female genital mutilation/cutting (FGM/C) is a cultural practice involving several types of external female genitalia cutting. FGM/C is known to occur in all parts of the world but is most prevalent in 28 countries in Africa and the Middle East and among immigrant communities in Europe, Australia, New Zealand, Canada, and the United States. Studies of FGM/C suffer from many methodological problems including inadequate analysis and an unclear reporting of results. The evidence to link FGM/C to infertility is weak. The management of epidermal clitoral inclusion cysts includes expensive investigations like comprehensive endocrinology tests and MRI resulting in unnecessary anxiety due to delay in surgical treatment. Similarly, unnecessary cesarean sections or rupture of the infibulation scar continue to occur because of the inadequate use of intrapartum defibulation. A significant amount of efforts is required to improve and correct the inadequate care of FGM/C women and girls.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):300-3. DOI:10.12891/ceog1823.2015
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    ABSTRACT: The authors report a case of Kaposi's sarcoma (KS) found in a pregnant woman. On discovery, the condition had spread throughout her body as is characteristic in some cases of individuals with HIV-positive serology. She was unaware of her HIV positive status. Her HIV infection had been diagnosed at the same time as KS at her last prenatal consultation. The newborn was delivered by an uncomplicated cesarean section. Appropriate treatment and multidisciplinary management after childbirth resulted in complete remission.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):378-80. DOI:10.12891/ceog1706.2015
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    ABSTRACT: Uterine perforation, a major complication of dilatation and curettage (D&C), is typically recognized at the time of the procedure. Large defects in the uterine wall or injury to other intraabdominal organs can result in an acute abdomen requiring immediate surgical treatment. On the other hand, small perforations usually resolve on their own without any long-term consequences. Here, the authors report a case of delayed hemoperitoneum, ten days after the D&C evacuation of an early pregnancy. Initially, intramural pregnancy was the suspected etiology. However, histopathology suggested that the inciting event was the rupture of a serosal uterine hematoma, which likely resulted from an incomplete uterine perforation during D&C. The patient did well after undergoing an uneventful laparoscopy.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):388-9. DOI:10.12891/ceog1869.2015
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    ABSTRACT: Perineal ultrasound has not yet been adequately evaluated in relation to the diagnosis of anatomical descensus of pelvic organs. Therefore, the aim of the present study was to assess whether it is possible to carry out a topographical comparison between bladders in normal seat and prolapsed ones and to quantify the extent of descensus. The authors selected 140 women, divided into three groups (two control groups and one case group). All patients underwent urogynaecological examination, according to the Pelvic Organ Prolapse Quantification (POP-Q), and perineal ultrasound to evaluate pubo-bladder distance. Considering the data recorded in the two control groups, the authors established the physiological pubo-bladder distance between 27-33 mm at rest and 25-30 mm under stress. In the group with cystocele, the pubo-bladder distance was significantly lower: 20 mm at rest and three mm under stress (mean value). The authors also performed a classification of ultrasound cystocele in four stages, in accordance with clinical staging. In conclusion, the present data show the excellent potential role of perineal ultrasound in the diagnosis of cystocele, but it is necessary to perform randomized studies to standardize the method.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):321-6. DOI:10.12891/ceog2016.2015
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    ABSTRACT: Myometrial abscess, especially with multiple foci, is quite rare and previous literature prevalently discusses unique locus of intramyometrial abscesses, usually treated with hysterectomy accompanied with or without bilateral salpingo-oophorectomy. The presented case, to the authors' knowledge, is the first multiple myometrial abscess case treated with conservative surgical approach.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):395-7.
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    ABSTRACT: The aim was to investigate the effect of skin contact between mother and child in pain relief of full-term newborns during heel blood collection. The authors randomly divided 40 full-term newborns into two groups. In the experimental group, the newborn received kangaroo care from the mother before, during, and after the 20-minute heel blood collection. In the control group, the heel blood collection was performed under conventional conditions. The authors compared the two groups' heart rate, oxygen saturation, facial expressions of pain, and duration of crying. The two groups had no statistically significant difference in terms of gender, birth weight, mode of delivery, and gestational age (p > 0.05). In the seven time periods during the puncture after ten seconds from the beginning and ten seconds after the end, the neonatal heart rates of the two groups changed and statistically significant differences were observed in the duration of heel blood collection, interaction and group factors, as well as in oxygen saturation (p < 0.01). During heel blood collection, skin contact between the mother and child can relieve pain, reduce changes in heart rate, improve neonatal heel blood oxygen saturation, and enhance the emotional communication between the mother and child.
    Clinical and experimental obstetrics & gynecology 07/2015; 42(3):304-8. DOI:10.12891/ceog1831.2015