Clinical and experimental obstetrics & gynecology (CLIN EXP OBSTET GYN)

Publisher: Università di Padova. Clinica ostetrica ginecologica

Journal description

Current impact factor: 0.36

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 0.357
2012 Impact Factor 0.379
2011 Impact Factor 0.429
2010 Impact Factor 0.433
2009 Impact Factor 0.45

Impact factor over time

Impact factor

Additional details

5-year impact 0.50
Cited half-life 7.00
Immediacy index 0.01
Eigenfactor 0.00
Article influence 0.13
Website Clinical & Experimental Obstetrics & Gynecology website
Other titles Clinical and experimental obstetrics & gynecology, Clinical and experimental obstetrics and gynecology
ISSN 0390-6663
OCLC 3995609
Material type Periodical
Document type Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: To retrospectively evaluate the effectiveness of intrauterine gauze compress combined B-Lynch uterine compression suture in placenta previa accreta cases. Five patients who experienced postpartum hemorrhage (PPH) due to placenta previa accreta between January 2009 and March 2013 in the present clinics, who were irresponsive to medical therapy, and that had applied intrauterine gauze compress combined B-Lynch uterine compression suture were analyzed retrospectively. Intrauterine gauze compress combined B-Lynch uterine compression sutures were applied in patients in whom medical therapy failed. Intrauterine gauze compresses were removed under sedation. No patients required hysterectomy or any complications. B-Lynch suture in combination with intrauterine gauze compress can be applied easily in placenta previa accreta cases. This is considered to be a highly successful method.
    Clinical and experimental obstetrics & gynecology 02/2015; XLII(1). DOI:10.12891/ceog1781.2015
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    ABSTRACT: Pregnant women with chronic hypertension are at increased risk for complications. This study aims to investigate whether calcium channel blockers plus low dosage aspirin therapy can reduce the incidence of complications during pregnancy with chronic hypertension and improve the prognosis of neonates. From March 2011 to June 2013, 33 patients were selected to join this trial according to the chronic hypertension criteria set by the Preface Bulletin of American College of Obstetricians and Gynecologists, (ACOG). Patients were administrated calcium channel blockers plus low-dosage aspirin and vitamin C. The statistic data of baseline and prognosis from the patients were retrospectively reviewed and compared. Blood pressure of patients was controlled by these medicines with average systolic pressure from 146.3 to 148.7 mmHg and average diastolic pressure from 93.8 to 97.9 mmHg; 39.4% patients complicated mild preeclampsia; however, none of them developed severe preeclampsia or eclampsia, or complicate placental abruption. 30.3% patients delivered at preterm labour; 84.8% patients underwent cesarean section. The neonatal average weight was 3,008 ± 629.6 g, in which seven neonatal weights were less than 2,500 g. All of the neonatal Apgar scores were 9 to 10 at one to five minutes. Small for gestational age (SGA) occurred in five (15%). Calcium channel blockers can improve the outcome of pregnancy women with chronic hypertension to avoid the occurrence of severe pregnancy complication or neonatal morbidity.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):79-81.
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    ABSTRACT: To evaluate the effect of maternal polycystic ovary (PCO) morphology on maternal serum free beta-human chorionic gonadotropin (β-hCG), pregnancy associated plasma protein A (PAPP-A), and nuchal translucency (NT) thickness in the first-trimester. A total of 92 pregnant women in the first-trimester were included in the study. Of them, 57 had PCO morphology, and 35 women constituted the control group, with apparently normal ovaries. Maternal serum free β-hCG, PAPP-A, and NT thickness were measured and compared in all patients. The multiples of median (MoM) levels of serum free β-hCG were significantly higher in the PCO morphology group compared to the normal ovary group (p = 0.024). However, the MoM levels of PAPP-A were similar in both groups (p = 0.947). No difference was found between the groups in terms of fasting glucose levels and NT measurements (p = 0.976 and 0.565, respectively). In pregnancies with maternal PCO morphology, the presence of higher maternal serum free β-hCG levels may require correction in the calculation of risks related to first-trimester screening for chromosomal abnormalities. Larger studies are needed to confirm our preliminary data.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):32-5.
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    ABSTRACT: To evaluate the effectiveness and reliability of microinsert hysteroscopic sterilization method at short- and long-term. In the period between January 2004 and December 2005, 34 patients who submitted to the present gynecology outpatient clinic seeking for permanent contraception and accepted tubal sterilization with microinsert method were included in this prospective, interventional study. Bilateral microinsert placement was successful in 28 (87.5%) of 32 patients that underwent the procedure. In all of the 30 patients (100%) in whom the placement procedure was attempted, bilateral tubal occlusion was documented by hysterosalpingogram (HSG) including the two patients in whom unilateral placement was carried out. First three procedures were performed under general anesthesia. Local or general anesthesia was not administered in any other cases (97.5%). The mean visual analogue scale score for pain felt during the procedure was 3.1. The mean procedure time was 11.5 ± 4.88 (5-22) minutes, the average time from beginning the procedure to discharge of the patients was 41.7 ± 18.5 (15-94) minutes. One intrauterine pregnancy was detected in one of the patients nine months after cessation of the alternative contraceptive period. This patient was excluded from the follow-up. At short-term all patients rated their microinsert-wearing tolerance as good or excellent. At eighth year, three patients were lost to follow-up. Mean follow-up time was 83.4 ± 15.0 (36-103) months. During 2,420 woman-months of follow-up, no other pregnancies were detected. Almost all of the patients were happy with the procedure and recommended it to a friend. Essure microinsert is a safe, effective, minimally invasive sterilization method which can be performed in outpatient settings without any anesthesia requirement. It appears to be a good alternative to laparoscopic tubal sterilization. The procedure time and the time to discharge are brief. Patient tolerance during the procedure and at long-term is very good.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):72-8.
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    ABSTRACT: The aim of this study was to evaluate serum cardiac troponin I and D-Dimer (D-Di) levels in preeclampsia (PE), eclampsia (E), and normotensive healthy pregnant women in third trimester in order to define their diagnostic value. The study group consisted of 42 preeclamptic patients and 16 eclamptic patient; 108 healthy normotensive pregnant women in third trimester who were chosen from outpatients clinic and examined regularly used as a control group. Serum cardiac troponin I and D-Di levels were measured using an immunoassay. The average levels of troponin I were 0.0134 ± 0.0091, 0.017 ± 0.0085, 0.180 ± 0.136 in control group, preeclamptic, and eclamptic patients, respectively. The levels of troponin in eclamptic patients were statistically higher than the normotensive and preeclamptic group (p = 0.016, p = 0.014). There were no differences in terms of troponin I level between preeclamptic group and normotensive pregnant women in third trimester (p = 0.089). The average D-Di levels were 634 ± 228 ng/ml, 1426 ± 430 ng/ml, 2067 ± 580 ng/ml in control group, preeclamptic, and eclamptic patients, respectively. The levels of D-Di in preeclamptic and eclamptic patients were found significantly higher than the control groups (p = 0.034, p = 0.020). Serum troponin I levels increased in eclamptic patient because of myocardial damage. An increased level of troponin was not detected in preeclamptic patients. However; D-Di level increased in preeclamptic and eclamptic patients.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):26-31.
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    ABSTRACT: The failure of labor induction often requires following cesarean section and suffering of patients. Cervical ripening is therefore critical in clinical care of pregnant mothers. The present study demonstrated the use of dinoprostone in cervical ripening for delivery induction in 685 cases of pregnancy mothers. The authors conclude that dinoprostone is a very useful and safe drug for delivery induction. The combined use of oxytocin and careful monitoring of all body symptoms are important for the clinical safety.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):69-71.
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    ABSTRACT: To investigate the cause and preventative measures of late postpartum hemorrhage resulted from placental and fetal membrane residuals. Retrospective analysis on 161 cases of late postpartum hemorrhage resulting from residuals of placenta and fetal membrane from 2002 to 2012. Among the 161 cases, there were 148 cases of vaginal delivery and 13 cases of cesarean section delivery. One hundred twenty-one cases (4.77%) of placental and fetal membrane residuals were present in 2,535 cases of pregnant women with history of abortion; 40 cases (2.01%) of placental and fetal membrane residuals were found in 1,989 cases of pregnant women without history of abortion. Placental and fetal membrane residuals are the major cause of late postpartum hemorrhage. Repeated abortion will increase the incidence of late postpartum hemorrhage resulting from placental and fetal membrane residuals.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):104-5.
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    ABSTRACT: This work aims to investigate the application of high definition flow imaging (HD-flow) in fetal hemodynamics, and establish reference range of hemodynamic parameters in fetal with different gestational ages. A thousand of normal pregnant women were divided into five groups: 18-22, 23-27, 28-32, 33-37, and 38-40 gestational weeks. Color Doppler flow imaging (CDFI) and HD-flow were adopted to display the heart structure and measure the blood flow velocity. The pulmonary vein display results were scored. The results of HD-flow and CDFI were compared. The catheter peak velocity of fetal mitral, tricuspid, aortic, pulmonary artery, aortic arch, ductal arch, the inferior vena cava, pulmonary vein, and venous catheter increased continuously with the increase of gestational age, showing a linear correlation. HD-flow was superior to CDFI on the display of pulmonary vein in 18-22, 23-27, and 28-32 weeks (p < 0.05), but was not in 33-37 and 38-40 weeks. HD-flow was an accurate positioning method for the pulmonary veins. HD-flow can make accurate evaluation of fetal hemodynamics and the demonstration of low blood flow, such as pulmonary venous, is better than CDFI. Pulmonary veins can be accurately positioned with HD-flow. HD-flow can demonstrate the main blood vessels of the whole fetal circulation and can display the spatial relationship of the blood vessels. It is of important clinical significance in hemodynamic study.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):11-7.
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    ABSTRACT: This study aims to investigate the number changes and the clinical significance of the peripheral blood T lymphocyte subsets and NK (natural killer) cells in unexplained recurrent spontaneous abortion (URSA) patients before and after abortion, as well as after successful pregnancy. Thirty-nine URSA patients (URSA-abortion group), among who 22 patients were followed up until the final successful parturition (URSA-pregnancy group), 31 normal-pregnancy (NP) cases and 25 normal non-pregnancy (NNP) control cases in which the peripheral blood T lymphocytes and subsets, B cells, and NK cells were assessed flow cytometry. Compared with the URSA-pregnancy group and the NP group, the Th cells and NK cells of the URSA-abortion group increased (p < 0.05); compared with the NNP group, the total number of T cells decreased after the first, second, and third month of the URSA abortion (p < 0.05); Th cells decreased within one to six months of the URSA abortion (p < 0.05); proportion of NK cells was significantly higher in URSA patients (p < 0.05). The abnormal numbers of the peripheral blood T cell subsets and NK cells were related with the occurrence of URSA.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):62-6.
  • Clinical and experimental obstetrics & gynecology 01/2015;
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    ABSTRACT: To investigate the short and long-term effects of ovarian hyperstimulation syndrome (OHSS) on serum levels of vascular endothelial growth factor (VEGF) and endothelin-1 and ovarian follicular reserve (OFR). An experimental case-control study was conducted on a university animal laboratory with 20 immature (22-day-old) virgin female Wistar Albino rats. Firstly, rats were divided into two groups. Group 1 (n = 10): control and Group 2 (n = 10): experimental OHSS induced rats. Secondly, Group 2 was randomly divided into two groups on the day of OHSS development (27th day) as follows: Group 3 (n = 5): 27-day-old OHSS induced rats and Group 4 (n = 5): 27-day-old OHSS induced rats supervised for seven days. Group 1 was divided into two groups to constitute age-matched controls as follows: Group 5 (n = 5): 27-day-old rats, Group 6 (n = 5): 35-day-old rats. The comparisons of Group 3 vs Group 5 and Group 4 vs Group 6 were performed. Main outcome measures were OFR, serum levels of VEGF, and endothelin-1. While the OFR and primordial follicle number (PFN) of Group 3 were significantly lower than those of Group 5 (p < 0.05); VEGF and endothelin-1 levels and atretic follicle number (AFN) were significantly higher in Group 3 compared to Group 5 (p < 0.05). In Group 4, PFN was significantly lower (p < 0.05) and AFN was significantly (p < 0.05) higher than Group 6. However, there were no statistically significant difference between Group 4 and Group 6 regarding the parameters of OFR, serum levels of VEGF, and endothelin-1. This experimental OHSS model revealed increased serum VEGF and endothelin-1 levels and decreased OFR during short-term of OHSS. OHSS showed detrimental effect on PFN of rats during long-term.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):95-100.
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    ABSTRACT: The current study aimed to analyze the short-term and long-term curative effects of nitric oxide (NO) inhalation combined with high-frequency oscillatory ventilation (HFOV) on neonatal severe hypoxemia. A total of 98 neonates meeting the inclusion criteria were retrospectively analyzed. The control group comprised of 48 neonates and the NO inhalation group consisted of 50 neonates. In the control group, conventional mechanical ventilation was replaced by HFOV. In the experimental group, NO inhalation combined with HFOV was performed. The death rates within 28 days, mechanical ventilation and oxygen therapy time, and complications in both groups were observed. The survivors in both groups were followed up for 18 months for neural development evaluation. The treatment group showed a significantly lower death rate and noticeably shorter mechanical ventilation and oxygen therapy time than the control group (8% vs. 22.9% with t = 4.20 andp < 0.05; 5.84 ± 3.36 days vs. 8.05 ± 5.48 days with t = 2.42 and p < 0.05; and 8.02 ± 4.31 days vs. 12.45 ± 5.14 days with t = 4.63 and p < 0.001). They did not show significant differences with regards to the complications and the incidences of cerebral palsy, hearing and visual impairments, and severe nervous damage (p > 0.05). NO inhalation combined with HFOV significantly decreases the death rate of neonates with severe hypoxemia and reduces their mechanical ventilation and oxygen therapy time. It does not increase early adverse effects or affect long-term neurodevelopment.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):22-5.
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    ABSTRACT: To investigate whether leptin acts directly on the anterior hypophysis by influencing gonadotropin secretion in vivo. Cycling female rats were catheterised for frequent blood sampling and were either fasted or allowed free access to food. Stereotactic lesion of the medial preoptic area (MPOA) of the hypothalamus was performed in order to eliminate gonadotropin releasing hormone (GnRH) production. Leptin was administered at a dose of one mg/kg i.v. and blood samples were taken just before leptin administration and then after 30, 60, 90, 120, and 180 minutes. Plasma gonadotropin levels were determined. With completion of sampling, the brains were removed and the localisation of the lesions was verified histologically. Leptin at one mg/kg induced an increase in luteinizing hormone (LH) secretion in fasting rats, both in those with a lesion and those with intact medial preoptic area with a peak occurring 90 minutes after infusion. The augmenting effect was more prominent when the hypothalamus was intact. There was no effect in fed animals with or without lesion. Similarly, no effect was observed on follicle stimulating hormone (FSH) levels in any of the experimental groups. Leptin acts directly on the hypophysis enhancing LH but not FSH secretion. Nutritional state influences leptin's effect on the hypothalamus and the hypophysis.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):18-21.
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    ABSTRACT: To evaluate the complications of urinary incontinence surgery with transobturator tape (TVT-O) system and to describe its diagnosis and management. A total of 156 patients who were diagnosed as having stress incontinence and mixed incontinence with stress predominance underwent a TOT operation under spinal anesthesia by one surgeon or two surgeons (MB, AEY) from the team. TVT-obturator inside out material was used in the operation. Urodynamic tests and pad tests were done on all the patients. This is a prospective and retrospective study of the complications of TVT-O. The operation was performed under regional anesthesia, as described by Deval et al. Patients were excluded from the study if they had been operated under general or local anesthesia, had undergone any vaginal operations except for anterior repair (cystocele), wanted to have a baby, had severe systemic diseases or had been diagnosed as having urge incontinence in urodynamic tests. These situations may affect the rate of complications, the authors also excluded slings that had materials other than monofilament polypropylene, and patients who were suspected of having neurologic bladder conditions. The bladder and urethra were evaluated using cystoscopy. The durations of the TOT procedure, cystoscopy, and if performed, the cystocele operation, were recorded. Perioperative, early, and late postoperative complications were analyzed by follow-up visits (after two months to four years). Of the 156 patients included in the study, 100 (64.1%) had pure stress urinary incontinence and 56 (35.9%) had mixed incontinence, 20 (12.8%) had previous incontinence surgery. The mean duration of follow up was 30.3 ± 7.4 (range 17-42) months. The mean age of the patients was found to be 48.43 ± 6.24 years (range 42-68). The mean parity of the patients was 5.24 ± 2.86 (range 2-13), and mean body mass index was found to be 23.7 ± 4.8. Mean maximum detrusor pressure was 10.30 ± 4.08 and the mean ALP value was 80.80 ± 25.57. Mean operative time was found to be 13.8 ± 5.16 min in patients who underwent only TOT and TOT-anterior repair. Vaginal injury including to the lateral fornix (4.4%), hemorrhaging of more than 200 ml (3.2%), vascular damage (1.9%), hematoma on the leg (1.9%), hemorrhaging of more than 500 ml (0.064%), and bladder perforation (1.2%) were detected as perioperative complications. Urethral injury and perioperative nerve and intestinal injury did not occur. The most common complication in early postoperative period was inguinal pain extending the legs (30.7%), followed by headaches (23.7%), fever (12.8%), urinary tract infection (5.7%), and urinary retention (3.2%), respectively. Late postoperative complications included vaginal erosion (4.4%), de novo urge incontinence (8.9%), de novo dyspareunia (7.1%), perineal pain (4.4%), and worsening urgency (8.9%). Although the TVT-O technique is a minimal invasive surgery method applied to treat the urinary incontinence surgically, it does not imply that it is a complication-free surgical procedure. Despite the low incidence of intraoperative complications, there is a mild risk of early and late postoperative complications. Fortunately these complications can be taken under control by either conservative and simple medical treatments or surgical procedures.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):82-9.
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    ABSTRACT: The objectives of this study were as follows: to present the course and outcome of pregnancies complicated with neural tube defects, determine the association between prenatal ultrasound diagnoses, and definitive diagnoses after autopsy. The survey was designed as a retrospective study and included 24 pregnant women who were attending a regular ultrasound examinations at the Department of Gynecology and Obstetrics, Clinical Center of Serbia, or patients who were referred from other institutions in Serbia. Neural tube defects are divided into five subgroups: spina bifida, meningocele, myelomeningocele, acranius, and anencephaly. The most frequent in the present study was spina bifida with 67%. All pregnancies complicated with neural tube defects were terminated. Their clinical severity and uncertain cause make them priorities for further research, whether to better target primary preventive measures, to improve in-utero surgery for prenatal repair, or to identify the causative genes to provide an objective basis for individual genetic counselling.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):57-61.
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    ABSTRACT: Uterine scar endometriosis is an extremely rare entitiy. As the surgical procedures of the uterus increases through time, scar endometriosis may be diagnosed more often in the future. A case of uterine scar endometriosis is presented with complaints of menstruation lasting one day with associated pelvic pain. When a cystic mass in the site of previous surgery is diagnosed, scar endometriosis must be considered.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):106-7.
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    ABSTRACT: Placenta percreta detected in the first trimester is a very rare condition. It is a known obstetric condition leading to serious maternal morbidity and mortality. High index of clinical suspicion and anticipation of placenta percreta is highly essential in early pregnancy as it is difficult to diagnose. The authors report on a patient who presented with heavy pervaginal bleeding in week 9 of pregnancy. Pelvic examination showed a 12-week sized uterus. Ultrasonography revealed a non-viable fetus. The subsequent emergency curettage performed was complicated by massive haemorrhage which required an abdominal hysterectomy performed as a life-saving procedure.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):101-3.
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    ABSTRACT: Holoprosencephaly (HPE), a complex brain malformation resulting from incomplete cleavage of the prosencephalon into distinct cerebral hemispheres, is rare in newborns. Two preterm male neonates were born at 34 weeks' and five days' gestation in the monochorionic diamniotic twin pregnancy complicated with pre-eclampsia and intrahepatic cholestasis of pregnancy, and one of them was prenatally diagnosed with alobar HPE by ultrasonography with frontal bossing, hydrocephaly, hypotelorism of eyes, flat nasal bridge, macroglossia, and cheilo/palatoschisis at birth. Karyotyping by G-banding of amniocentesis specimens in normal twin and fetal umbilical blood in both fetuses showed 46, XY. This report expands discordant alobar holoprosencephaly in monochorionic diamniotic twins.
    Clinical and experimental obstetrics & gynecology 01/2015; 42(1):114-6.