Fitoterapia (FITOTERAPIA)

Publisher: Indena (Firm), Elsevier

Journal description

Fitoterapia is an international journal publishing original research in chemistry, pharmacology and use of medicinal plants and their derivatives. The journal accepts Reviews, Full Papers, Short Reports, Phytochemical Communications, Safety Data Reviews and Book Reviews. Reviews can be full-length state-of-the-art articles or mini reviews providing a short overview of a particular matter. Short Reports allow preliminary, concise reporting of pharmacological activities. Results of antibacterial and antifungal screenings are published as Short Reports only. Phytochemical Communications are brief contributions on the isolation of known products from new plant sources (original contribution, such as unpublished spectral data or new activity, is required) or new simple products identified on the basis of spectral data. Safety Data Reviews are open to contributions from members of official international committees. Table of Contents for the 1996 - 1998 issues of Fitoterapia can be found at the Indena SpA site.

Current impact factor: 2.35

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 2.345
2013 Impact Factor 2.216
2012 Impact Factor 2.231
2011 Impact Factor 1.848
2010 Impact Factor 1.899
2009 Impact Factor 1.363
2008 Impact Factor 1.2
2007 Impact Factor 1.106
2006 Impact Factor 0.908
2005 Impact Factor 0.845
2004 Impact Factor 1.042
2003 Impact Factor 0.848
2002 Impact Factor 0.584
2001 Impact Factor 0.486
2000 Impact Factor 0.278

Impact factor over time

Impact factor

Additional details

5-year impact 2.47
Cited half-life 6.70
Immediacy index 0.41
Eigenfactor 0.01
Article influence 0.53
Website Fitoterapia website
Other titles Fitoterapia (Online)
ISSN 0367-326X
OCLC 41377497
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Authors pre-print on any website, including arXiv and RePEC
    • Author's post-print on author's personal website immediately
    • Author's post-print on open access repository after an embargo period of between 12 months and 48 months
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months
    • Author's post-print may be used to update arXiv and RepEC
    • Publisher's version/PDF cannot be used
    • Must link to publisher version with DOI
    • Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License
    • Publisher last reviewed on 03/06/2015
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Ginkgolide B, one of the important components of Ginkgo biloba extracts, has been revealed to exhibit great potential in therapy of cerebrovascular diseases. However the lack of permeability greatly limited it from further clinical application. Based on the prediction model for blood brain barrier (BBB) permeation, herein a potential brain-targeting analog ginkgolide B cinnamate (GBC) was successfully synthesized and characterized. After intravenous administration of GBC or GB, liquid chromatography tandem mass spectrometry (LC-MS/MS) was conducted to determine the analog in rat plasma and brain. The results showed that GBC had a significant increase in BBB permeability. A significant 1.61-times increase in half-life was observed for GBC and the drug targeting index (DTI) value was calculated to be 9.91. The experiment results matched well with the predicted one, which revealed that BBB permeability prediction model combined with in vivo study could be used as a quick, feasible and efficient tool for brain-targeting drug design. Copyright © 2015 Elsevier B.V. All rights reserved.
    Fitoterapia 08/2015; 106. DOI:10.1016/j.fitote.2015.08.012
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    ABSTRACT: Black chokeberry has been known to play a protective role in human health due to its high polyphenolic content including anthocyanins and caffeic acid derivatives. In the present study, we first characterized the polyphenolic content of a commercial chokeberry concentrate and investigated its effect on LPS-induced NF-κB activation and release of pro-inflammatory mediators in macrophages in the presence or the absence of sodium selenite. Examination of the phytochemical profile of the juice concentrate revealed high content of polyphenols (3.3%), including anthocyanins, proanthocyanidins, phenolic acids, and flavonoids. Among them, cyanidin-3-O-galactoside and caffeoylquinic acids were identified as the major compounds. Data indicated that chokeberry concentrate inhibited both the release of TNFα, IL-6 and IL-8 in human peripheral monocytes and the activation of the NF-κB pathway in RAW 264.7 macrophage cells. Furthermore, chokeberry synergizes with sodium selenite to inhibit NF-κB activation, cytokine release and PGE2 synthesis. These findings suggest that selenium added to chokeberry juice enhances significantly its anti-inflammatory activity, thus revealing a sound approach in order to tune the use of traditional herbals by combining them with micronutrients. Copyright © 2015. Published by Elsevier B.V.
    Fitoterapia 06/2015; 105. DOI:10.1016/j.fitote.2015.06.009
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    ABSTRACT: Enterolacaciamine (1), a new potential O-GlcNAcase activator, along with three known triterpenoid saponins, concinnoside B (2), concinnoside D (3), and julibroside A3 (4) were isolated from the leaves of Enterolobium cyclocarpum. Their sturctures were elucidated by chemical and spectroscopic methods (UV, MS, 1D and 2D NMR). Their effects on O-GlcNAcase activity were evaluated using O-GlcNAcase enzymatic assay, the results showed that compound 1 could obviously enhance the activity of O-GlcNAcase. Copyright © 2015. Published by Elsevier B.V.
    Fitoterapia 06/2015; 105. DOI:10.1016/j.fitote.2015.06.008
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    ABSTRACT: Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to be effective in hyperuricemic control. Allopurinol is a commonly used medication to treat hyperuricemia and its complications. In this study, we evaluated whether Pallidifloside D could enhance allopurinol's effects by decreasing the serum uric acid level in a hyperuricemic mouse model induced by potassium oxonate. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level (both P<0.05), leading to the normalized serum and urine uric acid concentrations. Data on serum, urine creatinine and BUN supported these observations. Our results showed that the synergistic effects of allopurinol combined with Pallidifloside D was linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1. Our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions. Copyright © 2015. Published by Elsevier B.V.
    Fitoterapia 06/2015; 105(1). DOI:10.1016/j.fitote.2015.06.002
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    ABSTRACT: The major biological active ingredients of Bulbus Fritillariae cirrhosae (BFC) are steroidal alkaloids, such as peimisine, imperialine-3β-d-glucoside, and peimine. The bulbus of Fritillaria unibracteata var. wabuensis (FUW) was officially recorded in the National Pharmacopoeia of China (2010 edition) as one of the sources of BFC because of its positive therapeutic effects and few side effects. The endophytic fungus strain 6WBY3 was isolated from the fresh bulbus of FUW that had been cultivated for six years. Based on morphological methods and the phylogenetic analysis of internal transcribed spacer (ITS) sequences, this strain was identified as Fusarium redolens. Using color reaction analysis, high performance liquid chromatography with evaporative light scattering detection (HPLC-ELSD), and mass spectrometry (MS), it was demonstrated that F. redolens 6WBY3 could produce peimisine and imperialine-3β-d-glucoside, similar to its host plant. The yields of peimisine and imperialine-3β-d-glucoside were 16.0 μg · l− 1 and 18.8 μg · l− 1, respectively, in one week of culture. These results indicate that F. redolens 6WBY3 is a promising candidate for the large scale production of peimisine and imperialine-3β-d-glucoside. In addition, the results from the strain 6WBY3 lay the foundation for further study into the mechanism of Fritillaria alkaloids biosynthesis in fungi.
    Fitoterapia 06/2015; 103:213-221. DOI:10.1016/j.fitote.2015.04.006
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    ABSTRACT: Obesity is a complex, multifactorial, and chronic disease that increases the risk for type 2 diabetes, coronary heart disease and hypertension, and has become a major worldwide health problem. Developing novel anti-obesity drugs from natural products is a promising solution to the global health problem of obesity. While screening anti-obesity potentials of natural products, the methanol extract of the rhizome of Coptis chinensis (Coptidis Rhizoma) was found to significantly inhibit adipocyte differentiation and lipid contents in 3T3-L1 cells, as assessed by Oil-Red O staining. Five known alkaloids, berberine, epiberberine, coptisine, palmatine, and magnoflorine, were isolated from the n-BuOH fraction of the methanol extract of Coptidis Rhizoma. We determined the chemical structure of these alkaloids through comparisons of published nudear magnetic resonance (NMR) spectral data. Furthermore, we screened these alkaloids for their ability to inhibit adipogenesis over a range of concentrations (12.5-50 mu M). All five Coptidis Rhizoma alkaloids significantly inhibited lipid accumulation in 3T3-L1 cells without affecting cell viability in a concentration dependent manner. In addition, the five alkaloids significantly reduced the expression levels of several adipocyte marker genes including proliferator activated receptor-gamma (PPAR-y) and CCAAT/enhancer-binding protein-alpha (C/EBP-alpha). In the present study, we found that the isolated alkaloids inhibited adipogenesis in a dose-dependent manner in 3T3-L1 cells; this inhibition was attributed to their abilities to downregulate the protein levels of the adipocyte marker proteins PPAR-gamma and C/EBP-alpha. Thus, these results suggest that Coptidis Rhizoma extract and its isolated alkaloids may be of therapeutic interest with respect to the treatment of obesity.
    Fitoterapia 10/2014; 98:199-208. DOI:10.1016/j.fitote2014.08.006
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    ABSTRACT: Three new prenylated chalcones, renifolins A-C (1-3), together with seven known ones (4-10), were isolated from whole Desmodium renifolium plants. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. Compounds 1 and 2 are the first naturally occurring chalcones possessing a 4-methylfuran-2(5H)-one unit. All of the isolates were evaluated for cytotoxicity using five tumor cell lines. Compounds 3-8, and 10 exhibited moderate cytotoxicity against certain cell lines with IC50 values from 4.2 to 8.8 mu M.
    Fitoterapia 09/2014; 9(1). DOI:10.1016/j.phytol.2014.04.003