Fitoterapia (FITOTERAPIA)

Publisher: Indena (Firm), Elsevier

Journal description

Fitoterapia is an international journal publishing original research in chemistry, pharmacology and use of medicinal plants and their derivatives. The journal accepts Reviews, Full Papers, Short Reports, Phytochemical Communications, Safety Data Reviews and Book Reviews. Reviews can be full-length state-of-the-art articles or mini reviews providing a short overview of a particular matter. Short Reports allow preliminary, concise reporting of pharmacological activities. Results of antibacterial and antifungal screenings are published as Short Reports only. Phytochemical Communications are brief contributions on the isolation of known products from new plant sources (original contribution, such as unpublished spectral data or new activity, is required) or new simple products identified on the basis of spectral data. Safety Data Reviews are open to contributions from members of official international committees. Table of Contents for the 1996 - 1998 issues of Fitoterapia can be found at the Indena SpA site.

Current impact factor: 2.22

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 2.216
2012 Impact Factor 2.231
2011 Impact Factor 1.848
2010 Impact Factor 1.899
2009 Impact Factor 1.363
2008 Impact Factor 1.2
2007 Impact Factor 1.106
2006 Impact Factor 0.908
2005 Impact Factor 0.845
2004 Impact Factor 1.042
2003 Impact Factor 0.848
2002 Impact Factor 0.584
2001 Impact Factor 0.486
2000 Impact Factor 0.278

Impact factor over time

Impact factor

Additional details

5-year impact 2.14
Cited half-life 8.00
Immediacy index 0.35
Eigenfactor 0.01
Article influence 0.46
Website Fitoterapia website
Other titles Fitoterapia (Online)
ISSN 0367-326X
OCLC 41377497
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Pre-print allowed on any website or open access repository
    • Voluntary deposit by author of authors post-print allowed on authors' personal website, or institutions open scholarly website including Institutional Repository, without embargo, where there is not a policy or mandate
    • Deposit due to Funding Body, Institutional and Governmental policy or mandate only allowed where separate agreement between repository and the publisher exists.
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months .
    • Set statement to accompany deposit
    • Published source must be acknowledged
    • Must link to journal home page or articles' DOI
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • NIH Authors articles will be submitted to PubMed Central after 12 months
    • Publisher last contacted on 18/10/2013
  • Classification
    ​ green

Publications in this journal

  • Fitoterapia 06/2015; 103:213-221. DOI:10.1016/j.fitote.2015.04.006
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    ABSTRACT: Four new tetramic acid analogues neopestalotins A-D (1-4), one new furanone derivative neopestalotin E (6), and the known compound hymenosetin have been isolated from the solid cultures of the plant endophytic fungus Neopestalotiopsis sp. The structures of the new compounds were determined mainly by nuclear magnetic resonance (NMR) experiments. The absolute configurations of 1 and 2 were assigned by circular dichroism (CD) data, whereas those of 3 and 4 were deduced by a combination of CD and heteronuclear long range coupling (HETLOC) data. Compound 2 showed modest antimicrobial activity against the Gram-positive bacteria, Bacillus subtilis, Staphylococcus aureus col, and Streptococcus pneumoniae. Copyright © 2015. Published by Elsevier B.V.
    Fitoterapia 03/2015; 103. DOI:10.1016/j.fitote.2015.03.023
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    ABSTRACT: Three new prenylated chalcones, renifolins A-C (1-3), together with seven known ones (4-10), were isolated from whole Desmodium renifolium plants. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. Compounds 1 and 2 are the first naturally occurring chalcones possessing a 4-methylfuran-2(5H)-one unit. All of the isolates were evaluated for cytotoxicity using five tumor cell lines. Compounds 3-8, and 10 exhibited moderate cytotoxicity against certain cell lines with IC50 values from 4.2 to 8.8 mu M.
    Fitoterapia 09/2014; 9. DOI:10.1016/j.phytol.2014.04.003
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    ABSTRACT: Two new steroidal esters with an unusual framework, Sinkiangenorin A and B, a new organic acid glycoside, Sinkiangenorin C, and four known lignin compounds were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds were established by spectroscopic analysis and single-crystal X-ray diffraction. All of the isolated compounds were tested against Hela, K562 and AGS human cancer cell lines. Sinkiangenorin C showed cytotoxic activity against AGS cells with an IC50 of 36.9μM.
    Fitoterapia 06/2014; 97. DOI:10.1016/j.fitote.2014.06.016
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    ABSTRACT: The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivatives that are relatively selective ligands for the alpha7 nAChR. Flavonoids are not known for this activity, so we screened a small library of pure flavonoids to confirm our findings. Some flavonoids, e.g. rhamnetin, displaced a selective alpha7 nAChR radioligand from rat brain membranes whereas similar structures e.g. sakuranetin, did not. To evaluate the contribution of this putative nAChR activity to the known anti-inflammatory properties of these flavonoids, we compared their effects on lipopolysaccharide induced release of inflammatory mediators from BV2 microglia. Both rhamnetin and sakuranetin reduced mediator release, but differed in potency (rhamnetin>sakuranetin) and the Hill slope of their concentration response curves. For rhamnetin the Hill coefficient was >3.0 whereas for sakuranetin the coefficient was 1.0, suggesting that effects of rhamnetin are mediated through more than one mechanism, whereas sakuranetin has a single mechanism. nACHR antagonists decreased the Hill coefficient for rhamnetin toward unity, which suggests that a nAChR-mediated mechanism contributes cooperatively to its overall anti-inflammatory effect. In contrast nAChR antagonists had no effect on the potency or Hill coefficient for sakuranetin, but a concentration of nicotine (1μM) that had no effect alone, significantly increased the Hill coefficient of this flavonoid. In conclusion, the anti-inflammatory effects of rhamnetin benefit cooperatively from a nAChR-mediated mechanism. This action, together with potent free radical scavenging activity, suggests that flavonoids with alpha7 nAChR activity have therapeutic potential in neuroinflammatory conditions.
    Fitoterapia 06/2014; 98. DOI:10.1016/j.fitote.2014.06.012
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    ABSTRACT: A series of previously unreported compounds including seven new apotirucallane protolimonoids, xylogranatumines A-G (1-7), were isolated together with three known analogues (8-10) from the twigs and leaves of the Chinese mangrove, Xylocarpus granatum. The structures of these new compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry (HRESIMS) and by comparison with those of related known compounds in the literature. Xylogranatumine F (6) exhibited cytotoxic activity against A549 tumor cell in vitro.
    Fitoterapia 06/2014; 97. DOI:10.1016/j.fitote.2014.06.009
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    ABSTRACT: A hairy root line of Edelweiss (Leontopodium nivale ssp. alpinum (Cass.) Greuter) was obtained upon transformation with Agrobacterium rhizogenes strain ATCC15834. Elicitation of this line with silver nitrate, sucrose, methyl jasmonate and yeast extract at various concentrations in most cases resulted in a stimulation of lignan biosynthesis. Through elicitation with 6% sucrose the roots accumulated the pharmacologically active lignans leoligin and 5-methoxy-leoligin at levels of 0.0678% and 0.0372%, respectively, without significant growth inhibition. These lignan levels were comparable to those found in intact roots of cultivated Edelweiss. The biotechnological production of leoligin could be an attractive option for the continuous, field culture-independent production of the valuable secondary metabolites leoligin and 5-methoxy-leoligin.
    Fitoterapia 06/2014; 97(100). DOI:10.1016/j.fitote.2014.06.008
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    ABSTRACT: Three new steroidal saponins, named diospreussinosides A-C (1-3), along with two known ones (4, 5) were isolated from rhizomes of Dioscorea preussii. Their structures were elucidated mainly by 1D and 2D NMR spectrocopic analysis and mass spectrometry as (25S)-17α,25-dihydroxyspirost-5-en-3β-yl-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)- β-D-glucopyranoside (1), (25S)-17α,25-dihydroxyspirost-5-en-3β-yl-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (2), and (24S,25R)-17α,24,25-trihydroxyspirost-5-en-3β-yl-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (3). The spirostane-type skeleton of compound 3 possessing an unusual dihydroxylation pattern on the F-ring is reported for the first time. Cytotoxicity of compounds 2-5 was evaluated against two human colon carcinoma cell lines (HT-29 and HCT 116).
    Fitoterapia 06/2014; 97. DOI:10.1016/j.fitote.2014.06.006
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    ABSTRACT: Geniposide (GE), also called Jasminoidin, is the major active ingredient of Gardenia jasminoides Ellis (GJ) fruit, which has long been used in traditional Chinese medicine (TCM). Growing evidences suggested that GE has a great potentiality for treating rheumatoid arthritis (RA). However, GE is rapidly metabolized, and we know little about its availability or metabolites in tissues. To elucidate the distribution of GE and its metabolites in tissues, three groups of adjuvant arthritis (AA) rats were given GE (33, 66 and 120mg/kg) from days 18 to 24, and the biotransformation of GE in plasma, liver, spleen, synovium, urine and mesenteric lymph node (MLN) of rats was investigated by a novel approach named Information-Dependent Acquisition (IDA) -Mediated LC-MS/MS method. As a result, GE and its four major metabolites were detected as follows: GE, G1, G2 in plasma; GE, G2 in MLNs; only GE in liver and synovium; GE, G2, G3 and G4 in spleen; GE, G1, G2 and G4 in urine. In total four metabolites (G1-G4) involved in the in vivo metabolism processes were identified. The results of this work have demonstrated the IDA-Mediated LC-MS/MS could screen rapidly and reliably the characterization of metabolites from iridoid compounds.
    Fitoterapia 06/2014; 97. DOI:10.1016/j.fitote.2014.05.023
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    ABSTRACT: Phytochemical investigation of ethanolic extract from the fruits of Schisandra chinensis led to the isolation of four new sesquiterpenes (1-4); their structures were determined by a combination of NMR (1D and 2D) and MS spectroscopic techniques. In addition, all these isolates were screened for their cytotoxic activities against MCF-7, Caco-2, Hela, Lncap, Hep G2 and MDA-MB231 cancer cell lines. Results indicated that compounds 2 and 3 displayed potent cytotoxic activity against Caco2 cell lines with IC50 values of 17.10 mu g/mM and 16.46 mu g/mM, respectively.
    Fitoterapia 06/2014; 95. DOI:10.1016/j.fitote.2014.03.003
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    ABSTRACT: Three new polyacetylenes, 8 - (Z) - decene - 4, 6-diyne - 1, 3, 10-triol (1), 1, 3S, 8S - trihydroxydec - 9 - en - 4, 6 - yne (2), 3S, 8S - dihydroxydec - 9 - en - 4, 6 - yne 1 - O - β - D - glucopyranoside (3), and one new glucosyl caffeoate, 1 - O - ethyl - 6 - O - caffeoyl - β - D - glucopyranose (4), together with 34 known compounds were isolated from Artemisia capillaris. The structures of the new compounds were determined by extensive spectroscopic analyses including 1D and 2D NMR, HRESIMS, [α]D and CD experiments. Among them, 19 compounds showed activity inhibiting HBsAg secretion; 20 compounds showed activity inhibiting HBeAg secretion; and 25 compounds possessed inhibitory activity against HBV DNA replication according to our anti-HBV assay on HepG 2.2.15 cell line in vitro. The most active compound 12 could inhibit not only the secretions of HBsAg and HBeAg, but also HBV DNA replication with IC50 values of 15.02μM (SI=111.3), 9.00μM (SI=185.9) and 12.01μM (SI=139.2).
    Fitoterapia 06/2014; 95. DOI:10.1016/j.fitote.2014.03.017
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    ABSTRACT: Illicium lanceolatum is a traditional Chinese medicine (TCM) for treating inflammatory diseases. Anti-inflammatory activities of I. lanceolatum stems and leaves were tested using ear edema models induced by dimethyl benzene in mice. Bioassay-guided fractionation of the ethanol extract of I. lanceolatum leaves and stems revealed that the ethyl acetate fraction exhibited inhibitory potency to dimethyl benzene-induced edema in the mouse ear. Phytochemical investigation on the active fraction led to the isolation of a new phenylpropanoid (1), together with fifteen known compounds. This is the first report of the isolation of 2-16 from I. lanceolatum. Of these compounds, compounds 1, 2 and 3 showed inhibitory activity on LPS-stimulated NO production in RAW 264.7 macrophages with IC50 values of 27.58, 26.59 and 34.35 μg/mL, respectively. I. lanceolatum stems and leaves can be exploited to alleviate inflammatory diseases, which makes the rare medicinal plant resources sustainable.
    Fitoterapia 06/2014; 95. DOI:10.1016/j.fitote.2014.02.015