Acta dermato-venereologica. Supplementum (Acta Derm Venereol Suppl)

Publications in this journal

• Article: Personality Vulnerability to Stressful Life Events in Patients with Lichen Simplex Chronicus

  Brufau, Martín-Brufau, Ramirez-Andreo, Limiñana-Gras, Corbalan
  Acta dermato-venereologica. Supplementum 01/2009; 89(5):581-582.
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  Article: Putative mechanisms underlying chronicity in atopic eczema.

  Thomas Bieber
  Acta dermato-venereologica. Supplementum 12/2005;
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  Article: New therapeutic targets in atopic eczema.

  Richard Langley
  Acta dermato-venereologica. Supplementum 12/2005;
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  Article: Allergy workup: when and how for the child with atopic dermatitis?

  Alain Taïeb
  Acta dermato-venereologica. Supplementum 12/2005;
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  Article: Treatment strategies and compliance for the adult patient with atopic eczema.

  Kristian Thestrup-Pedersen
  Acta dermato-venereologica. Supplementum 12/2005;
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  Article: Contact allergic reactions in patients with atopic eczema.

  John McFadden
  Acta dermato-venereologica. Supplementum 12/2005;
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  Article: Superantigens, steroid insensitivity and innate immunity in atopic eczema.

  Donald Leung
  Acta dermato-venereologica. Supplementum 12/2005;
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  Article: Epidemiology and job-related problems for the eczema patient.

  Thomas Diepgen
  Acta dermato-venereologica. Supplementum 12/2005;
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  Article: Probiotics, breastfeeding and atopic eczema.

  Kim Fleischer Michaelsen
  Acta dermato-venereologica. Supplementum 12/2005;
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  Article: Compliance among patients with atopic eczema.

  Tove Agner
  Acta dermato-venereologica. Supplementum 12/2005;
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  Article: Imiquimod 5% cream for the treatment of cutaneous lesions in immunocompromised patients.

  Richard Johnson, Eggert Stockfleth
  Acta dermato-venereologica. Supplementum 10/2003;
• Article: Introduction: immunotherapy for dermatological conditions.

  Darrell Rigel, Brian Berman
  Acta dermato-venereologica. Supplementum 10/2003;
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  Article: Treatment of non-melanoma skin cancer: immunotherapy as a viable option.

  Stephen Shumack, Darrell Rigel
  Acta dermato-venereologica. Supplementum 10/2003;
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  Article: Imiquimod: mode of action and therapeutic potential.

  Olivier Chosidow, Reinhard Dummer
  Acta dermato-venereologica. Supplementum 10/2003;
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  Article: The clinical spectrum of congenital ichthyosis in Sweden: a review of 127 cases.

  Anders Vahlquist, Agneta Gånemo, Maritta Pigg, Marie Virtanen, Per Westermark
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  ABSTRACT: Congenital ichthyosis comprises a rare group of usually monogenetic diseases that present at birth as a collodion phenotype or as variable degrees of ichtHyosiform erythroderma, with or without superficial blisters. Depending on which gene mutation causes the disease, the skin problems later in life may range from a severe lamellar or bullous ichthyosis to mild or only focally expressed hyperkeratotic lesions. It is obviously important, but sometimes painstakingly difficult, to make a correct diagnosis already in infancy. Fortunately, recent advances in our understanding of the molecular genetics of ichthyosis have led to several new diagnostic tools that are continuously being updated. Based on this development, and on our own 5 years of experience in a national genodermatosis centre, we describe 127 cases of congenital ichthyosis examined in childhood or adulthood. Applying a combination of phenotypic and genotypic criteria, the patients were classified into three main groups: 1) Bullous ichthyosis (epidermolytic hyperkeratosis) and related disorders due to keratin mutations (n = 21); 2) Non-bullous ichthyosiform erythroderma and lamellar ichthyosis mainly due to transglutaminase 1 mutations (n = 80); 3) Syndromic ichthyosis, i.e. systemic (multi-organ) diseases due to many different causes (n = 26). Each group could be further stratified into 4-11 entities using mutation analysis, electron microscopy of epidermis and various other techniques. Our findings are discussed in relation to recent data in the literature emphasizing the clinical usefulness of various diagnostic procedures for ichthyosis.
  Acta dermato-venereologica. Supplementum 06/2003;
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  Article: Pruritus: a review.

  Elke Weisshaar, Michael J Kucenic, Alan B Fleischer
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  ABSTRACT: The history, neurophysiology, clinical aspects and treatment of pruritus are reviewed in this article. The different forms of pruritus in dermatological and systemic diseases are described, and the various aetiologies and pathophysiology of pruritus in systemic diseases are discussed. Lack of understanding of the neurophysiology and pathophysiology of pruritus has hampered the development of adequate therapies. Nevertheless, the discovery of primary afferent neurons and, presumably, second-order neurons with typical histamine responses mediating pruritic sensations can be regarded as a breakthrough in our understanding of the mechanisms behind pruritus. The number of experimental and therapeutic studies has greatly increased during the past few years, reflecting an increased interest in this topic. However, further effort is needed to develop new therapeutic concepts and clarify some confusion arising from promising case reports and uncontrolled clinical studies. A precise work-up for evaluating patients with pruritus is proposed, which may help the physician to identify the underlying causes and thus to treat the patient appropriately.
  Acta dermato-venereologica. Supplementum 06/2003;
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  Article: In vitro permeation of nickel salts through human stratum corneum.

  H Tanojo, J J Hostýnek, H S Mountford, H I Maibach
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  ABSTRACT: Allergic contact dermatitis due to nickel salts is common. It is therefore important to measure the permeation of these salts through the stratum corneum (SC), the primary rate-limiting domain in skin. An advanced diffusion system and analytical techniques now enable better measurement of the flux than was possible in earlier experiments. Human SC was prepared by trypsinization of dermatomed cadaver leg skin. The diffusion system included diffusion cells with a spiral line. Aqueous solutions of nickel salts (Ni(NO3)2, NiSO4, NiCl2 and Ni(-OOCCH3)2 at 1% Ni2+ concentration) were used as the donor solution (400 microL/cell). The receptor fluid, pure water, was collected up to 96 h after application of the donor solutions. Nickel concentrations in the donor and receptor fluid, as well as in the SC, were analysed using inductively coupled plasma mass spectrometry (ICP-MS) with a confidence limit of 0.5 ppb. Based on the total recovery of nickel from the experiments, about 98% of the dose remained in the donor solution, whereas 1% or less was retained in SC and less than 1% was found in the receptor fluid. Following an early surge, nickel permeates slowly across SC. The steady-state permeability coefficients of nickel were calculated from the flux data (approximately 5.2-8.5 x 10(-7) cm/h) with no significant difference among the salts. The results concur in principle with earlier studies conducted using the full-thickness human skin in vitro, and suggest that in vivo nickel ions may permeate simultaneously by routes of diffusion such as the shunt pathway, apart from slow transcellular/intercellular diffusion alone.
  Acta dermato-venereologica. Supplementum 02/2001;
• Article: Human stratum corneum penetration by nickel. In vivo study of depth distribution after occlusive application of the metal as powder.

  J J Hostýnek, F Dreher, A Pelosi, A Anigbogu, H I Maibach
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  ABSTRACT: Sequential tape stripping was implemented on three healthy volunteers to examine the surface distribution of nickel through human stratum corneum in vivo following occlusive application of the metal as powder on the volar forearm. Exposure sites were stripped 20 times at intervals from 5 min to 96 h post-dosing and the strips analyzed for metal content by Inductively Coupled Plasma-Mass Spectroscopy with a detection limit for nickel of 0.5 ppb. The gradients of nickel distribution profiles increased proportionally with occlusion time, but after the 10th strip to the 20th strip continued at constant levels. Total nickel removed with 20 stratum corneum strips to the level of the glistening layer after maximum occlusion of 96 h was 41.6 micrograms/cm2 (+/- 12.2; average n = 3). In order to normalize the nickel depth distribution profiles, stratum corneum removed by stripping of untreated skin after occlusion was determined by weighing. Following application of nickel dust over 24 h, analysis of the 20th strip still indicated nickel present at 1.42 micrograms/cm2 (+/- 0.68; average n = 3). These data indicate that, in contact with skin, nickel metal is oxidized to form soluble, stratum corneum-diffusible compounds which may penetrate the intact stratum corneum, presumably by the intercellular route, and have the potential to elicit allergic reactions.
  Acta dermato-venereologica. Supplementum 02/2001;