Zeitschrift fur Naturforschung. C, Journal of biosciences (Z Naturforsch C Biosci )
Impact factor 0.80
- 5-year impact0.00
- Cited half-life8.50
- Immediacy index0.03
- Article influence0.20
- Other titlesZeitschrift für Naturforschung. Section C, Biosciences, Biosciences
- Material typePeriodical
- Document typeJournal / Magazine / Newspaper
Publications in this journal
- [Show abstract] [Hide abstract]
ABSTRACT: Cucurbita maxima (CM) seed oil is commonly used in Indian folk medicine to treat various ailments. We have investigated the effect of CM seed oil on memory impairment induced by scopolamine in rats. Male adult Wistar rats were administered scopolamine 1 mg/kg body weight, i.p. or 1.25 mg/kg body weight, s.c. to induce memory impairment. The nootropic agent piracetam 100 mg/kg body weight, i.p. and CM seed oil 100 and 200 mg/kg body weight, p.o. were administered daily for five consecutive days. The memory function was evaluated in the Morris water maze (MWM) test, the social recognition test (SRT), the elevated plus maze (EPM) test, and the pole climbing test (PCT). Acetylcholinesterase (AChE) activity and oxidative stress parameters were estimated in the cortex, hippocampus, and cerebellum of the brains after completion of the behavioural studies. The effects of scopolamine on the levels of the tumour necrosis factor alpha (TNF-α) transcript were also investigated. Scopolamine caused memory impairment in all the behavioural paradigms along with a significant increase in the AChE activity and oxidative stress in the brain. Scopolamine also caused a significant increase in the expression of TNF-α in the hippocampus. CM seed oil exhibited antiamnesic activity as indicated by a significant reduction in the latency time in the MWM test and decreased social interaction during trial 2 in the SRT. Further, treatment with CM seed oil significantly decreased the AChE activity and malondialdehyde levels and increased the glutathione level in brain regions. CM seed oil also significantly decreased the expression of TNF-α in the hippocampus. The effect of CM seed oil on behavioural and biochemical parameters was comparable to that observed in rats treated with piracetam. These results indicate that CM seed oil may exert antiamnesic activity which may be attributed to the inhibition of AChE and inflammation as well as its antioxidant activity in the brain. Key words: Cucurbita maxima, Memory Impairment, Tumour Necrosis Factor Alpha http://www.znaturforsch.com/ac/v69c/69c0407.htmZeitschrift fur Naturforschung. C, Journal of biosciences 11/2014; 69c:407-417.
- Zeitschrift fur Naturforschung. C, Journal of biosciences 09/2014;
Article: Stoimenova E., Vasileva-Tonkova E., Sotirova A., Galabova D., Lalchev Z. Evaluation of Different Carbon Sources for Growth and Biosurfactant Production by Pseudomonas fluorescens Isolated from Wastewaters, Zeitschrift fur Naturforschung - Section C Journal of Biosciences 64 (1-2), pp. 96-102, 2009Zeitschrift fur Naturforschung. C, Journal of biosciences 01/2009; 64(1-2).
- Zeitschrift fur Naturforschung. C, Journal of biosciences 01/2004;
- [Show abstract] [Hide abstract]
ABSTRACT: Catalytic activities of catalase (CAT) immobilized on graphite--GMZ, soot--"NORIT" and "PM-100" to mediate decomposition of 3-Cl-C6H4COOOH (3-CPBA) in acetonitrile have been investigated. Under these conditions, the kinetic parameters Km, k, Ea, Vmax, and Z0 were calculated. Conclusions on a probable mechanism of the catalytic process observed were drawn from the calculated values of deltaG*, deltaH*, and deltaS*. A quantitative UV-spectrophotometrical approach was used as the basic analytical tool. The electrochemical reduction of oxygen generated in enzyme catalysed 3-CPBA decomposition was examined with polarization curves method.Zeitschrift fur Naturforschung. C, Journal of biosciences 05/2000; 55(1-2):55-9.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.