International Journal of Obesity (INT J OBESITY )

Publisher: International Association for the Study of Obesity, Nature Publishing Group

Description

Multi-disciplinary forum for research describing: basic clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders.

  • Impact factor
    5.22
    Hide impact factor history
     
    Impact factor
  • 5-year impact
    5.52
  • Cited half-life
    8.00
  • Immediacy index
    1.17
  • Eigenfactor
    0.04
  • Article influence
    1.85
  • Website
    International Journal of Obesity website
  • Other titles
    International journal of obesity
  • ISSN
    0307-0565
  • OCLC
    26074170
  • Material type
    Periodical, Internet resource
  • Document type
    Journal / Magazine / Newspaper, Internet Resource

Publisher details

Nature Publishing Group

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 6 months embargo
  • Conditions
    • Authors retain copyright
    • Published source must be acknowledged and DOI cited
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • On author's personal website and institutional repository
    • If funding agency rules apply, authors may post authors version to their relevant funding body's archive, 6 months after publication
  • Classification
    ​ yellow

Publications in this journal

  • International Journal of Obesity 04/2015;
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    ABSTRACT: Background:Maternal vitamin D status during fetal development may influence offspring growth and risk of obesity; however, evidence in humans is limited.Objective:To investigate whether maternal circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration in pregnancy is associated with offspring prenatal and postnatal growth and overweight.Methods:Plasma 25(OH)D3 concentration was measured in pregnant women (median weeks of gestation 14.0, range 13.0-15.0) from the INMA cohort (Spain, 2003-2008) (n= 2358). Offspring femur length (FL), biparietal diameter (BPD), abdominal circumference (AC), and estimated fetal weight (EFW) were evaluated at 12, 20, and 34 weeks of gestation by ultrasound examinations. Fetal overweight was defined either as AC or as EFW ≥90th percentile. Child's anthropometry was recorded at ages 1 and 4 years. Rapid growth was defined as a weight gain Z score >0.67 from birth to ages 6 months and 1 year. Age- and sex-specific Z scores for body mass index (BMI) were calculated at ages 1 and 4 years (WHO referent); infant's overweight was defined as a BMI Z score ≥85th percentile.Results:We found no association of maternal 25(OH)D3 concentration with FL and a weak inverse association with BPD at 34 weeks. Maternal deficit of 25(OH)D3 (<20 ng/mL) was associated with increased risk of fetal overweight defined as AC ≥90th percentile (OR=1.50, 95% CI: 1.01-2.21; p=0.041) or either as EFW ≥90th percentile (OR= 1.47, 95% CI: 1.00-2.16; p=0.046). No significant associations were found with rapid growth. Deficit of 25(OH)D3 in pregnancy was associated with increased risk of overweight in offspring at age 1 year (OR=1.42, 95% CI: 1.02-1.97; p=0.039); however, the association was attenuated at age 4 years (OR=1.19, 95% CI: 0.83-1.72; p=0.341).Conclusions:Vitamin D deficiency in pregnancy may increase risk of prenatal and early postnatal overweight in offspring. Clinical trials are warranted to determine the role of vitamin D in the early origins of obesity.International Journal of Obesity accepted article preview online, 05 September 2014. doi:10.1038/ijo.2014.165.
    International Journal of Obesity 09/2014;
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    ABSTRACT: The central nervous melanocortin system maintains body mass and adiposity within a ‘healthy’ range by regulating satiety and metabolic homeostasis. Neural melanocortin-4 receptors (MC4R) modulate satiety signals and regulate autonomic outputs governing glucose and lipid metabolism in the periphery. The functions of melanocortin-3 receptors (MC3R) have been less well defined. We have observed that food anticipatory activity (FAA) is attenuated in Mc3r�/� mice housed in light:dark or constant dark conditions. Mc3r�/� mice subjected to the restricted feeding protocol that was used to induce FAA also developed insulin resistance, dyslipidaemia, impaired glucose tolerance and evidence of a cellular stress response in the liver. MC3Rs may thus function as modulators of oscillator systems that govern circadian rhythms, integrating signals from nutrient sensors to facilitate synchronizing peak foraging behaviour and metabolic efficiency with nutrient availability. To dissect the functions of MC3Rs expressed in hypothalamic and extra-hypothalamic structures, we inserted a ‘lox-stop-lox’ (TB) sequence into the Mc3r gene. Mc3rTB/TB mice recapitulate the phenotype reported for Mc3r�/� mice: increased adiposity, accelerated diet-induced obesity and attenuated FAA. The ventromedial hypothalamus exhibits high levels of Mc3r expression; however, restoring the expression of the LoxTB Mc3r allele in this nucleus did not restore FAA. However, a surprising outcome came from studies using Nestin-Cre to restore the expression of the LoxTB Mc3r allele in the nervous system. These data suggest that ‘non-neural’ MC3Rs have a role in the defence of body weight. Future studies examining the homeostatic functions of MC3Rs should therefore consider actions outside the central nervous system.
    International Journal of Obesity 07/2014; Supplements(4):S37-S44.
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    ABSTRACT: Background Elevated levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive sleep apnea (OSA) and obesity. The relationship between OSA and obesity in determining ICAM-1 and VCAM-1 levels, and the effect of treatment, is unclear.Objective Our aim was to study whether positive airway pressure (PAP) usage resulted in changes in ICAM-1 and VCAM-1 after 2 years within 309 OSA patients from the Icelandic Sleep Apnea Cohort, and determine how obesity affected such changes.Subjects/Methods The mean body mass index (BMI) was 32.4±5.1 kg/m(2); subjects had moderate-to-severe OSA (apnea-hypopnea index=45.0±20.2) and 79% were male. There were 177 full PAP users (⩾4 hours/night and ⩾20 of last 28 nights), 44 partial (<4 hours/night or <20 nights), and 88 non-users.ResultsICAM-1 (P<0.001) and VCAM-1 (P=0.012) change was significantly different among the PAP groups. The largest ICAM-1 differences were among the most obese subjects (P<0.001). At follow-up, non-users had increased ICAM-1 compared to decreased levels in full users. All groups had increased VCAM-1, but non-users had a significantly larger increase than full users.Conclusion Within moderate-to-severe OSA patients, PAP usage prevents increases in adhesion molecules observed in non-users after two years. For ICAM-1, the largest effect is in the most obese subjects. As OSA and obesity commonly coexist, the usage of PAP to limit increases in adhesion molecules may decrease the rate of progression of OSA-related cardiovascular disease.International Journal of Obesity accepted article preview online, 21 July 2014; doi:10.1038/ijo.2014.123.
    International Journal of Obesity 01/2014;
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    ABSTRACT: Depression has been associated with increased risk of cardiovascular disease. The inflammatory marker C-reactive protein (CRP) has also been identified as an independent predictor of short- and long-term cardiovascular disease events. Inflammation may influence the relationship between depression and cardiovascular disease.
    International Journal of Obesity 08/2013;
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    ABSTRACT: This study investigated changes in the quality of life of men and women who participated in a primary care-based weight loss intervention program.
    International Journal of Obesity 08/2013;
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    ABSTRACT: To examine changes in eating behaviors and physical activity, as well as predictors of weight loss success, in obese adults who participated in a 2-year behavioral weight loss intervention conducted in a primary care setting.
    International Journal of Obesity 08/2013;
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    ABSTRACT: Although there is growing consensus that population-level improvements in cardiovascular health depend upon environments that promote healthy lifestyles, evidence to support large-scale investments in neighborhood greenery to tackle obesity is inconsistent and has not focused on adults in middle-to-old age who experience the greatest burden of chronic health problems. Multilevel linear and multinomial logit regression models were fitted to investigate association between body mass index and an objective measure of green space in a sample of 246 920 Australian adults aged 45 years and older (The 45 and Up Study). Proximity to green space was constructed using catchment areas of 1 km radius around each participant. Women with over 80% proximity to green space had relative risk ratios of 0.90 (95% confidence interval: 0.83, 0.97) for overweight and 0.83 (0.74, 0.94) for obese. No similarly protective association was found for men. These results were consistent after controlling for moderate-to-vigorous physical activity (MVPA) and sitting time, each of which was favorably associated with green space proximity in men and women. Large-scale investments to enhance green spaces may promote MVPA and reduce sedentary behavior in middle-to-older-aged adults, but the impact on obesity may not benefit everyone to the same extent.
    International Journal of Obesity 06/2013;
  • International Journal of Obesity 05/2013;