Medical Hypotheses (MED HYPOTHESES)

Publications in this journal

• Article: Are psychobiological markers strongly correlated with allostatic load in population with autism spectrum disorders (ASD)? Minniti G, Lorini R, Veneselli E, Vergani L, Voci A, Calevo MG, Battaglia FM. Med Hypotheses. 2013 Jan 16. doi:pii: S0306-9877(12)00560-9. 10.1016/j.mehy.2012.12.011. [Epub ahead of print] No abstract available. PMID:23332179[PubMed - as supplied by publisher]

  Minniti G, Lorini R, Veneselli E, Vergani L, Voci A, Calevo MG, Battaglia FM
  Medical Hypotheses 01/2013;
• Article: Sport-related Brain Injury : a Terminological Update.

  Ivan Sosa, Alan Bosnar
  Medical Hypotheses 01/2013; 80(2).
• Article: Intelligent bioengineering in vitiligo treatment: transdermal protein transduction of melanocyte-lineage-specific genes

  Mou Y, Jiang X, Du Y, Xue L
  Medical Hypotheses 09/2012;
• Article: The defense architecture of the superficial cells of the oral mucosa

  Pekka Asikainen, Timo Ruotsalainen, Jopi Mikkonen, Arto Koistinen, Chris ten Bruggenkate, Arja Kullaa
  Medical Hypotheses 06/2012; 78(6):790-792.
• Article: Tumor malignancy is engaged to prokaryotic homolog toolbox

  Fernandes J, Guedes PG, Lage CL, Rodrigues JC, Lage CD
  Medical Hypotheses 01/2012;
• Article: Kraepelin-fraud syndrome.

  Emil Kraepelin, Sigmund Freud, David Healy
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  ABSTRACT: Emil Kraepelin (1856-1926) and Sigmund Freud (1856-1936) here (via mysterious mediumistic mechanisms) describe a syndrome, which probably emerged in the 1950s, and can now readily be observed at medical conferences. At its core, the syndrome is comprised of extreme abilities to compartmentalise information of the type found in scientific conferences, an episodic preoccupation with the surface of a science but inability to appreciate its substance (episodic logosagnosia) and a mood state that is heavily dependent on gratification from the range of outlets available at modern conferences. Current estimates of the frequency of the condition are that there are approximately 20 full-blown psychopharmacological carriers of the syndrome per 100 million populations. This should yield a figure of 200 in Europe and North America. If a similar phenomenon applies in other branches of medicine this would yield a further 1200 affected individuals in Western medical circles. It is of pressing interest to establish whether the Kraepelin-Fraud Syndrome exists to any degree in non-medical science, and whether there are differences between those sciences with and without significant commercial applications.
  Medical Hypotheses 03/2009; 72(4):378-80.
• Article: Is cancer a genetic program with an unknown function?

  Abel Garcia-Garcia
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  ABSTRACT: Cancer is a tissue that requires a genetic program, possibly involving hundreds of genes, as indicated by studies of differential gene expression performed with microarrays in various types of cancer. Cancer is thus a biological process of considerable precision as described by Schrödinger's equation, and it is not simply the random expression of hundreds of genes, but rather a program that gives neoplastic tissue characteristics that are independent of the originating tissue: invasion capacity and destruction of neighbouring tissues, metastasis, and capacity to progressively disengage from the genetic program of the original tissue. This program is common to all types of cancer, and does not appear to be related to the genetic program of any known differentiated tissue. In other words, cancer's genetic program appears to be universal in all tissues, since cancer behaves similarly in all tissues; though depending on the tissue in which it originates it will show certain specific characteristics, reflecting the extent to which the neoplastic cells are able to escape from the characteristics of the original tissue.
  Medical Hypotheses 02/2009; 72(4):407-8.
• Article: Hurtle cell change: the precursor of the immunologic phase of thyroiditis.

  Angus Stuart
  Medical Hypotheses 02/2009; 72(3):359-60.
• Source

  Available from: uhms.org

  Article: Gas bubbles may not be the underlying cause of decompression illness - The at-depth endothelial dysfunction hypothesis.

  Leigh A Madden, Gerard Laden
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  ABSTRACT: Gas formed in tissues and the circulating blood due to decompression is thought to be a significant factor in the progression of decompression illness (DCI). DCI is a potential problem for a growing population of professional and recreational divers. We hypothesise that these gas bubbles are not the causative agent in progression of DCI, rather an exacerbating factor. Endothelial dysfunction caused by a temporary loss of haemostasis due to increased total oxidant status is postulated to be the cause in this at-depth endothelial dysfunction hypothesis. Breathing oxygen at any pressure increases the oxidant status in the circulation causing vasoconstriction; this increase can be prevented by antioxidants, such as Vitamin C, maintaining haemostasis and preventing activation of endothelium, leukocyte recruitment and subsequent localised inflammation. Bubbles have the potential to exacerbate the situation on decompression by damaging the vascular endothelium either through ischemia/reperfusion, physical contact with the endothelium or by an increase in shear stress. Furthermore, this damage may manifest itself in the release of endothelial membrane fragments (microparticles).
  Medical Hypotheses 02/2009; 72(4):389-92.
• Article: Low-magnitude mechanical vibration may be applied clinically to promote dental implant osseointegration.

  Lingzhou Zhao, Zhifen Wu, Yumei Zhang
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  ABSTRACT: Dental implants have been widely used clinically, but there still remain great challenges for a stronger bone-implant bonding and a shorter rehabilitation time. Osseointegration of dental implant is crucial for their long term clinical success. Recently, there are abundant evidences showing that low mechanical stimuli can strengthen bones, inhibit osteopenia and enhance bone healing. It has been showed that low-amplitude mechanical stimuli have favorable influence on osteoblasts and their precursors. Preliminary studies indicated that low-magnitude mechanical stimuli may assist in implant osseointegration. So collectively we hypothesize that low-magnitude mechanical vibration may be applied clinically to strengthen and accelerate osseointegration of dental implants.
  Medical Hypotheses 02/2009; 72(4):451-2.
• Article: Supplementation with insulin and antioxidants could be advantageous in the treatment of vitiligo.

  Yajie Lv, Yanguo Zhang, Qi Luan
  Medical Hypotheses 02/2009; 72(4):480-1.
• Article: Immunohistochemical surfactant protein-A expression: fatal drowning vs. postmortem immersion.

  Valter Stemberga, Sanja Stifter, Drazen Cuculić, Miran Coklo, Alan Bosnar
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  ABSTRACT: The postmortem diagnosis of drowning continues to be one of the most difficult in forensic pathology because of unspecific autopsy findings. It must be always remembered that disposal of a victim body in water is not unknown in homicide. The most important physiological consequence in fatal drowning is hypoxemia. The air-liquid interface of alveoli and distal airways of the mature lung are lined with a thin layer of lung surfactant, composed of phospholipids, proteins and neutral lipids. Surfactant components are synthesized and/or incorporated into lung surfactant in alveolar type II cells, and secreted to form an airspace lining film. The composition and function of lung surfactant is disturbed in cases od acute lung injury (ALI) including drowning. Surfactant protein-A (SP-A) is the most abundant surfactant protein. Surfactant protein-A (SP-A) is secreted by type II alveolar cells and cells. It's immunohistochemical distribution is observed in two different pathways: a linear membranous staining and a granular intra-alveolar staining. We hypothesize the significance of immunohistochemical detection of SP-A and its help in determination of the time of death, and possibly distinguishing of death by immersion vs. postmortem immersion using the morphological analysis applied on SP-A immunohistochemical stained lung tissue samples. We also argue in favor of routine use of SP-A staining in selected forensic cases where pathogenesis includes mechanical asphyxia and lung pathology. Although some studies reached conclusions to define the mechanisms involved in pathogenesis of mechanical asphyxia and aspiration necessity of additional studies arose. The mechanism of the production of massive aggregates remains to be determined. In the mean time the detection of SP-A (immunohistochemical) as well as biochemical is potentially useful tool in the forensic practice with possible application in daily practice.
  Medical Hypotheses 02/2009; 72(4):413-5.
• Article: Tocilizumab as a potential treatment in Schnitzler syndrome.

  Nicolas Kluger, Didier Bessis, Bernard Guillot
  Medical Hypotheses 02/2009; 72(4):479-80.
• Article: Pretreatment with alternate day modified fast will permit higher dose and frequency of cancer chemotherapy and better cure rates.

  J B Johnson, S John, D R Laub
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  ABSTRACT: It is established that calorie restriction (CR) increases the resistance of cells to various stressors such as oxidative damage, excitotoxins, mercury and acetaminophen. Alternate day feeding (ADF) may confer greater stress resistance than daily CR of 30% or 40%. A recent study in three strains of mouse showed that a fast of 48 or 60 h prevented toxic effects due to administration of doses 2-4 times the maximum human dose of etoposide, a chemotherapy agent which acts through increased oxidative stress. In addition, mice inoculated with neuroblastoma survived longer when pretreated with fasting, then given high dose etoposide, as well as not exhibiting toxicity. This increased survival was construed as evidence of differential stress resistance between normal and cancer cells, the cancer cells being only partially protected by the pretreatment fast. In clinical practice, increased differential stress resistance could lead to the use of much higher doses of chemotherapy agents, and in the absence of toxicity, make it possible to repeat the treatment to kill residual cancer cells. Humans are unlikely to comply with a total fast of longer than 24 or 48 h, which may be insufficient to activate the same gene expression process. Based on published data we estimate that an optimal time period for development of stress resistance is 2-3 weeks when alternate day feeding is employed. Our previously published experience suggests that 2-3 weeks of alternate day modified fast in which subjects eat ad libitum one day and <20% of one's estimated caloric requirement the next will confer a similar stress resistance. Compliance with this diet is high and greater maintenance of body weight is feasible. We hypothesize that a pretreatment of 2-3 weeks with the alternate day modified fast will improve outcomes in cancer chemotherapy, decreasing morbidity and raising cure rates.
  Medical Hypotheses 02/2009; 72(4):381-2.