Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details. For Instructions to Authors click on "Guide to Authors" in the left-hand column.
- Impact factor3.38Show impact factor historyHide impact factor history
- WebsiteNeuroscience website
Other titlesNeuroscience (Online)
Material typeDocument, Periodical, Internet resource
Document typeJournal / Magazine / Newspaper, Computer File, Internet Resource
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- Pre-print can not be deposited for The Lancet
Publications in this journal
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ABSTRACT: When a consolidated memory is reactivated, it can become labile and prone to enhancement or disruption, a process known as reconsolidation. The reconsolidation hypothesis has challenged the traditional view that memories after consolidation are fixed and unchangeable. Recent studies suggest that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new promise for the understanding of human memory persistence. Although reconsolidation studies typically use amnesic agents, it has also been shown that memory can be enhanced by pharmacological agents and real-life events during reconsolidation. Recently, we demonstrated that a mild stressor, cold pressor stress (CPS), can enhance human declarative memory during reconsolidation in a cued-recall test. Here we evaluate whether the recollection of 7- or 20- day-old long-term memories can be improved by exposure to two different neuromodulators: a mild stressor and glucose during reconsolidation. As expected, poor and very poor memory performance was found at the time of memory reactivation (days 6 and 20 after training). CPS during reconsolidation improved the long-term expression of a declarative memory 6 -but not 20- days after training. However, the administration of an oral source of glucose (juice), but not a diet juice, can enhance memory during reconsolidation even 20 days after training. Interestingly, when a recognition test was applied instead of a cued-recall test, memory performance was still robust at both 1 and 3 weeks after training. Here we show that the period in which this memory can be reactivated and become labile largely exceeds the period in which that memory is recalled, proving evidence that conscious access is not needed for reconsolidation. Present results are consistent with dissociation between the mechanisms mediating memory labilization and the mechanisms that underlie the behavioral expression of memory.Neuroscience 04/2013;
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ABSTRACT: Autism and Asperger’s disorder (AD) are neurodevelopmental disorders primarily characterized by deficits in social interaction and communication, however motor coordination deficits are increasingly recognized as a prevalent feature of these conditions. Although it has been proposed that children with autism and AD may have difficulty utilizing visual feedback during motor learning tasks, this has not been directly examined. Significantly, changes within the cerebellum, which is implicated in motor learning, are known to be more pronounced in autism compared to AD. We used the classic double-step saccade adaptation paradigm, known to depend on cerebellar integrity, to investigate differences in motor learning and the use of visual feedback in children aged 9-14 years with high-functioning autism (HFA; IQ>80; n=10) and AD (n=13). Performance was compared to age and IQ matched typically developing children (n=12). Both HFA and AD groups successfully adapted the gain of their saccades in response to perceived visual error, however the time course for adaptation was prolonged in the HFA group. While a shift in saccade dynamics typically occurs during adaptation, we revealed aberrant changes in both HFA and AD groups. This study contributes to a growing body of evidence centrally implicating the cerebellum in ocular motor dysfunction in autism. Specifically, these findings collectively imply functional impairment of the cerebellar network and its inflow and outflow tracts that underpin saccade adaptation, with greater disturbance in HFA compared to AD.Neuroscience 04/2013;
Article: Region-specific expression of vesicular glutamate and GABA transporters under various ischaemic conditions in mouse forebrain and retina.Neuroscience 02/2013;
Article: Influence of palatability on motivation to operate for caloric and non-caloric food in non food-deprived and food-deprived rats.[show abstract] [hide abstract]
ABSTRACT: Palatability is the hedonic food component that is considered to override the homeostatic mechanisms that control food intake, and we compared how much effort non food-deprived and food-deprived rats were willing to spend in order to earn a palatable caloric (sucrose) or non-caloric (saccharin) snack. We first studied the dopaminergic response, in terms of dopamine levels and dopamine and cAMP-regulated phosphoprotein Mr 32,000 (DARPP-32) phosphorylation pattern, to two consecutive palatable caloric or non-caloric snacks in the nucleus accumbens shell (NAcS) of non food-deprived and fasted rats. We report that non food-deprived rats developed rapid habituation in the NAcS dopaminergic response to the second consumption of both caloric and non-caloric palatable food, while food-deprived rats developed rapid habituation only to saccharin. Next, we show that in self-administration experiments, non food-deprived rats spent a similar effort when operating for sucrose or saccharin. However, the same rats showed an increased response specifically for sucrose after 18-h fasting. After pre-feeding devaluation, rats reduced their response to sucrose but not for saccharin. These results strengthen the hypothesis that food intake is mainly controlled by palatability in non food-deprived rats and by caloric content in food-deprived rats. Moreover, they show that rapid habituation development was associated with a similar, basal working activity aimed at ingesting both caloric and non-caloric food, as observed in non food-deprived rats consuming sucrose or saccharin and in fasted rats consuming saccharin. Conversely, lack of habituation, as present in fasted rats consuming a caloric food, was associated with extra energy expenditure.Neuroscience 01/2013;
Article: The time course of serotonin 2C receptor expression after spinal transection of rats: an immunohistochemical studyNeuroscience 01/2013;
Article: Increased vulnerability of parkin knock down PC12 cells to hydrogen peroxide toxicity: The role of salsolinol and NM-salsolinolNeuroscience 01/2013;
Article: Distinct developmental principles underlie the formation of ipsilateral and contralateral whisker-related axonal patterns of layer 2/3 neurons in the barrel cortexNeuroscience 01/2012; 226:289–304.
Article: Expression pattern of mineralocorticoid and glucocorticoid receptors in Bengalese finch (Lonchura striatta var. domestica) brain suggest the relation between stress hormone and the song system developmentNeuroscience 10/2011; 194:72-83.
Article: Analyzing the effects of a single episode of neonatal maternal deprivation on metabolite profiles in rat brain: a proton nuclear magnetic resonance spectroscopy studyNeuroscience 01/2011; 11(201):12.
Neuroscience 01/2011; 199:515-522.
Article: The role of aqueous extract of crocus sativus (Saffron) and wild honey syrup on aluminium chloride- induced toxicity in different strains of mice.Neuroscience 01/2010;
Article: Protein kinase C deficiency-induced alcohol insensitivity and underlying cellular targets in DrosophilaNeuroscience 12/2009; 166(1):34-39.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.
John Wiley & Sons
ISSN: 1932-7005, Impact factor: 3.28
Public Library of Science, Public...
ISSN: 1932-6203, Impact factor: 4.09
ISSN: 1879-0712, Impact factor: 2.59
ISSN: 1879-0038, Impact factor: 2.34
ISSN: 1875-8908, Impact factor: 3.74