Retina (RETINA-J RET VIT DIS )

Publisher: Ophthalmic Communications Society (U.S.)

Journal description

RETINAô focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINAô publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards.

Current impact factor: 3.18

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 3.177
2012 Impact Factor 2.825
2011 Impact Factor 2.812
2010 Impact Factor 2.774
2009 Impact Factor 2.932
2008 Impact Factor 3.478
2007 Impact Factor 3.088
2006 Impact Factor 1.403
2005 Impact Factor 1.286
2004 Impact Factor 1.207
2003 Impact Factor 1.391
2002 Impact Factor 1.058
2001 Impact Factor 0.909
2000 Impact Factor 0.74
1999 Impact Factor 0.751
1998 Impact Factor 0.722
1997 Impact Factor 0.836
1996 Impact Factor 1.607
1995 Impact Factor 1.148
1994 Impact Factor 0.621
1993 Impact Factor 0.594
1992 Impact Factor 0.471

Impact factor over time

Impact factor
Year

Additional details

5-year impact 2.76
Cited half-life 5.40
Immediacy index 0.52
Eigenfactor 0.02
Article influence 0.93
Website Retina website
Other titles Retina (Philadelphia, Pa.), Retina
ISSN 0275-004X
OCLC 7066692
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: PURPOSE:: To examine macular retinal thickness and retinal layer thickness with spectral domain optical coherence tomography in a population of children with normal ocular health and minimal refractive errors. METHODS:: High-resolution macular optical coherence tomography scans from 196 children aged 4 years to 12 years (mean age: 8 ± 2 years), were analyzed to determine total retinal thickness and thickness of 6 different retinal layers across the central 5 mm of the posterior pole. Automated segmentation with manual correction was used to derive retinal thickness values. RESULTS:: The mean total retinal thickness in the central 1-mm foveal zone was 255 ± 16 μm, and this increased significantly with age (mean increase of 1.8 μm per year) in childhood (P < 0.001). Age-related increases in thickness of some retinal layers were also observed, with changes of the highest statistical significance found in the outer retinal layers in the central foveal region (P < 0.01). Significant topographical variations in thickness of each of the retinal layers were also observed (P < 0.001). CONCLUSION:: Small magnitude, statistically significant increases in total retinal thickness and retinal layer thickness occur from early childhood to adolescence. The most prominent changes seem to occur in the outer retinal layers of the central fovea.
    Retina 02/2015;
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    ABSTRACT: Purpose: Drug tolerance is the most common cause of treatment failure in neovascular age-related macular degeneration (NAMD). “Low-intensity / high-density” subthreshold diode micropulse laser (SDM) has been reported effective for a number of retinal disorders without adverse effects. It has been proposed that SDM normalizes RPE function. On this basis we postulated SDM might restore responsiveness to anti-vascular endothelial growth factor (VEGF) drugs in drug tolerant eyes. Method: SDM was performed in consecutive eyes unresponsive to all anti-VEGF drugs, including at least 3 consecutive ineffective aflibercept injections. Monthly aflibercept was resumed one month after SDM. Results: 13 eyes of 12 patients were included, aged 73-97 years (average 84), receiving 16-67 (average 34) anti-VEGF injections prior to SDM, followed 3-7 months (average 5 months) post SDM. After SDM and resumption of aflibercept, 92% (12/13) of eyes improved, with complete resolution of macular exudation in 69% (9/13). Visual acuity was unchanged. Central and maximum macular thicknesses significantly improved. Conclusion: SDM restored drug response in drug-tolerant eyes with NAMD. Based on these findings a theory of SDM action is proposed suggesting a wider role for SDM as retinal reparative / protective therapy.
    Retina 02/2015; Publish Ahead of Print | Issue | pp: doi: 10.1097/IAE.0000000000000458.
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    ABSTRACT: To assess the changes in diabetic retinopathy (DR) in Type 2 diabetes (T2DM) patients after bariatric surgery. Consecutive 20 patients with T2DM who underwent bariatric surgery and were followed for at least 12 months were enrolled. The case history was reviewed retrospectively, and laboratory data were assessed at baseline and every 3 months postoperatively. Two retinal specialists evaluated the severity of DR with dilated fundus examination preoperatively and postoperatively. Factors associated with DR progression were assessed. During the follow-up period, 2 of 12 patients without DR and 2 of 3 patients with mild nonproliferative DR before surgery developed moderate nonproliferative DR. All five patients with moderate nonproliferative DR or worse preoperatively had progression requiring intervention. Preexisting DR (P = 0.005) and albuminuria (P = 0.01) were identified as associated with DR progression. Six patients (30%) entered remission of T2DM, but remission of T2DM could not halt the DR progression. Diabetic retinopathy progression can occur in patients with or without before DR after bariatric surgery, regardless of remission of T2DM. All patients with T2DM should be examined regularly by an ophthalmologist postoperatively, and more carefully patients with previous DR or albuminuria.
    Retina 01/2015;
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    ABSTRACT: Purpose: To evaluate the effect of vitreous floaters on intraocular straylight. Methods: Records of bilaterally phakic patients with unilateral complaint of floaters as the main symptom were identified from an electronic database. Patients who underwent straylight measurements on both affected and unaffected eyes using a C-Quant straylight meter were selected. Data were collected on age, sex, visual acuity, straylight measurements, and optical coherence tomography. The unaffected eye served as a control. Results: Fifteen cases were included (7 women and 8 men; mean age, 54.3 years; age range, 24-71 years). Visual acuity was not correlated with the complaint of floaters. Average straylight value in eyes with floaters was 1.426 log(s) (+/-0.23 SD) with a median value of 1.52 log(s). The mean value for fellow eyes was 1.275 (+/-0.23 SD) with a median of 1.25 log(s). The differences between both groups using a Wilcoxon matched-pair signed-rank test was statistically significant at P = 0.0009. On optical coherence tomography, most patients had a confirmed or probable posterior vitreous detachment. However, in four patients, a posterior vitreous detachment was absent in the affected eyes. Vitreous floaters were inconsistently imaged by optical coherence tomography, with only a few patients presenting appreciable condensations close to the retinal surface. These were present in both affected and unaffected eyes. Conclusion: Intraocular straylight is significantly increased in eyes affected by floaters. No correlation was seen with vision or optical coherence tomography appearance. Straylight is an independent objective measure of visual perception that seems to be closely correlated to complaints expressed by patients experiencing floaters.
    Retina 01/2015;
  • Retina 01/2015;
  • Retina 01/2015;
  • Retina 01/2014;
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    ABSTRACT: Purpose: To evaluate the safety and efficacy of epimacular brachytherapy for the treatment of chronic, active neovascular age-related macular degeneration. Methods: A prospective, multicenter, interventional noncontrolled clinical trial recruited 53 participants with previously treated neovascular age-related macular degeneration. Participants underwent pars plana vitrectomy with a single 24 Gray dose of epimacular brachytherapy, delivered using an intraocular cannula containing a Strontium 90/Yttrium 90 source that was positioned over the active lesion. Participants were retreated with ranibizumab, administered monthly as needed, using predefined retreatment criteria. Coprimary outcomes at 24 months were the proportion of participants losing <15 Early Treatment of Diabetic Retinopathy Study letters and mean number of ranibizumab retreatments. Results: Over 24 months, 68.1% lost <15 letters with a mean of 8.7 ranibizumab retreatments. Mean change in visual acuity was −6.3 (standard deviation, 18.9) letters. There was one case of nonproliferative radiation retinopathy. Conclusion: The apparent reduction in ranibizumab retreatment was less evident in Year 2 than Year 1, with the moderate reduction in visual acuity extending into the second year. Although radiation retinopathy occurred in one case, it was not vision threatening and safety remained acceptable.
    Retina 01/2014; 34(5):874-879.
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    ABSTRACT: Purpose: To evaluate the outcome of vitrectomy with internal limiting membrane peeling and no gas tamponade in the treatment of eyes with myopic foveoschisis. Methods: Medical records of 10 eyes of 9 consecutive patients with myopic foveoschisis without macular hole treated by vitrectomy were reviewed. Results: The patients' refractive error was −4.00 diopters to −34.00 diopters, and axial length was 28.38 mm to 35.90 mm. Six eyes had foveal retinal detachment with retinoschisis. All cases were treated by vitrectomy with internal limiting membrane removal without gas tamponade. The mean preoperative best-corrected visual acuity was 0.61 ± 0.42 in logarithm of the minimum angle of resolution units (Snellen equivalent of 20/82). Myopic foveoschisis was reduced in 8 eyes (80%) with a single surgery. Two eyes without improvement developed a postoperative macular hole and were treated by additional vitreoretinal surgery. All 10 eyes showed anatomical repair, and 5 eyes showed improvement in best-corrected visual acuity to 0.47 ± 0.48 (Snellen equivalent of 20/60), by 17 months after the initial surgery. Conclusion: Vitrectomy with internal limiting membrane peeling and no gas tamponade can effectively treat some cases of myopic foveoschisis, suggesting that tractional forces at the vitreoretinal interface may contribute to the pathogenesis of myopic foveoschisis, thereby avoiding gas tamponade.
    Retina 01/2014; 34(3):455-460.
  • Retina 01/2014; 34(2):414-417.
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    ABSTRACT: Purpose: To compare evaluation by clinical examination with image grading at a reading center for the classification of diabetic retinopathy and diabetic macular edema. Methods: Action to Control Cardiovascular Risk in Diabetes (ACCORD) and Family Investigations of Nephropathy in Diabetes (FIND) had similar methods of clinical and fundus photograph evaluation. For analysis purposes, the photographic grading scales were condensed to correspond to the clinical scales, and agreement between clinicians and reading center classification were compared. Results: Six thousand nine hundred and two eyes of ACCORD participants and 3,638 eyes of FIND participants were analyzed for agreement (percent, kappa) on diabetic retinopathy on a 5-level scale. Exact agreement between clinicians and reading center on diabetic retinopathy severity category was 69% in ACCORD and 74% in FIND (kappa 0.42 and 0.65). Sensitivities of the clinical grading to identify the presence of mild nonproliferative retinopathy or worse were 0.53 in ACCORD and 0.84 in FIND. Specificities were 0.97 and 0.96, respectively. Diabetic macular edema agreement in 6,649 eyes of ACCORD participants and 3,366 eyes of FIND participants was similar (kappa 0.35 and 0.41). Sensitivities of the clinical grading to identify diabetic macular edema were 0.44 and 0.53 and specificities were 0.99 and 0.94, respectively. Conclusion: The results support the use of clinical information for defining broad severity categories but not for documenting small-to-moderate changes in diabetic retinopathy over time.
    Retina 01/2013; 33(7):1393-1399.
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    ABSTRACT: Purpose: To describe clinical and imaging features of eyes with and without vitreomacular interface disease (VMID) treated with intravitreal anti–vascular endothelial growth factor injections for exudative age-related macular degeneration, followed over an average of 2.5 years. Methods: Retrospective interventional case series involving 32 eyes with VMID and 146 eyes without traction. Best-corrected visual acuity (BCVA), manually measured central foveal thickness from optical coherence tomography imaging, and the number and timing of intravitreal anti–vascular endothelial growth factor injections were reviewed. Results: Eyes with VMID and exudative age-related macular degeneration received more intravitreal injections (mean 14.7) for 4 years than eyes without traction (mean 9.5) (P = 0.0224). Eyes with VMID had similar BCVA to eyes without traction at baseline (P = 0.8013) and Year 1 through Year 4 (P = 0.5417, 0.6275, 0.4574, 0.0570, respectively). Best BCVA showed significant improvement over baseline BCVA in eyes with (logarithm of the minimum angle of resolution 0.67–0.47, P = 0.0182) and without (logarithm of the minimum angle of resolution 0.61–0.44, P = 0.0001) VMID. Central foveal thickness was similar to eyes without traction at baseline and Year 1 through Year 3 and declined over time in eyes with VMID. Conclusion: In eyes with VMID, anti–vascular endothelial growth factor therapy resulted in improved BCVA and decreased central foveal thickness despite continued vitreomacular traction. Eyes with VMID required more intravitreal anti–vascular endothelial growth factor agents than eyes without VMID.
    Retina 01/2013; 33(7):1359-1364.
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    ABSTRACT: Purpose: To discuss the potential role of microplasmin (ocriplasmin) as a surgical adjunct to vitrectomy in pediatric vitreoretinopathies. Methods: Literature review of the laboratory and clinical evidence to date for the use of both autologous plasmin enzyme as an adjunct to vitrectomy and more recently recombinant microplasmin (ocriplasmin) as monotherapy for focal vitreomacular traction in adults. Results: Autologous plasmin enzyme is currently being used as a surgical adjunct to vitrectomy, with supporting Levels 2 and 3 published evidence in a range of pediatric vitreoretinopathies including Stage 5 retinopathy of prematurity and congenital X-linked retinoschisis. The availability of autologous plasmin enzyme is limited. In recent Phase 3 clinical trials, intravitreal ocriplasmin versus sham injection resulted in resolution of focal vitreomacular traction in 27% versus 10% (P < 0.001, n = 652). Conclusion: Ocriplasmin may potentially be used as a surgical adjunct to vitrectomy in place of autologous plasmin enzyme. A Phase 2, randomized, placebo-controlled surgical trial is under way to assess this.
    Retina 01/2013; 33(2):339-348.
  • Retina 07/2012;
  • Retina 03/2012;
  • Retina 01/2012;
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    ABSTRACT: Purpose: To examine volume-rendered spectral-domain optical coherence tomography images in patients who had undergone vitrectomy, many of whom had internal limiting membrane removal to investigate a condition termed “dissociated optic nerve fiber layer appearance.” Methods: Patients who had undergone vitrectomy for either macular hole or epiretinal membrane were evaluated. Spectral-domain optical coherence tomography B-scan images were acquired with the use of eye tracking at an interval of either 30 μm or 60 μm. These were registered and exported to a volume-rendering program, and the resultant volume-rendered images were evaluated. The images were graded for the presence of inner retinal abnormalities, and correlates were made to corresponding alterations seen in fundus photographs and B-scan spectral-domain optical coherence tomography images. Results: There were 25 eyes of 24 patients with a mean age of 72.4 (±7.3) years, 15 of whom were women. The primary preoperative diagnosis was macular hole in 10 eyes (40%) and epiretinal membrane in 15 eyes (60%). As part of the surgery, 18 eyes (72%) had planned peeling of the internal limiting membrane. Volume rendering showed that 13 eyes had pitting or dimples of the inner retinal surface that seemed to follow the course of the nerve fiber layer in the region of the macula. The inner retinal dimples occurred only in eyes that had internal limiting membrane peeling. Correlation of the volume-rendered images with B-scan spectral-domain optical coherence tomography showed focal areas of thinning of the ganglion cell layer with decreased reflectivity from the nerve fiber layer in the areas of the dimples. Conclusion: A high proportion of eyes with internal limiting membrane peeling develop inner retinal dimples that course along the path of the nerve fiber layer. The dimples seem to be the result of an interplay between trauma and healing processes constrained by nerve fiber layer and do not appear to be because of dissociation of optic nerve fibers. The true nature of the abnormalities induced should be investigated to evaluate the long-term risks and benefits of routine internal limiting membrane peeling.
    Retina 01/2012; 32(9):1719-1726.