Journal of Microencapsulation (J MICROENCAPSUL)

Publisher: Informa Healthcare

Journal description

The Journal of Microencapsulation is a well-established journal devoted to the preparation, properties and uses of individually encapsulated small particles. Its scope extends beyond microcapsules to all other small particulate systems which involve preparative manipulation. These forms find a wide variety of medical, biological, industrial and research applications. The journal covers the chemistry of encapsulation materials; the physics of release through the capsule wall; the techniques of preparation; content and storage; and the many uses to which microcapsules are put. Also found in every issue of the journal is an extensive information and reference section comprising patent briefing and literature alerts listings.

Current impact factor: 1.88

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 1.878
2012 Impact Factor 1.571
2011 Impact Factor 1.553
2010 Impact Factor 1.515
2009 Impact Factor 1.89
2008 Impact Factor 1.314
2007 Impact Factor 1.168
2006 Impact Factor 0.805
2005 Impact Factor 1.37
2004 Impact Factor 1.492
2003 Impact Factor 0.915
2002 Impact Factor 1.024
2001 Impact Factor 0.966
2000 Impact Factor 1.076
1999 Impact Factor 0.991
1998 Impact Factor 0.841
1997 Impact Factor 0.775
1996 Impact Factor 0.514
1995 Impact Factor 0.783
1994 Impact Factor 0.442
1992 Impact Factor 0.43

Impact factor over time

Impact factor
Year

Additional details

5-year impact 1.77
Cited half-life 9.40
Immediacy index 0.19
Eigenfactor 0.00
Article influence 0.36
Website Journal of Microencapsulation website
Other titles Journal of microencapsulation (Online)
ISSN 0265-2048
OCLC 41407365
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Informa Healthcare

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • On author's personal website or institution website
    • Publisher copyright and source must be acknowledged
    • On a non-profit server
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • NIH funded authors may post articles to PubMed Central for release 12 months after publication
    • Wellcome Trust authors may deposit in Europe PMC after 6 months
  • Classification
    ​ yellow

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Context: Scaffold if suitably modified could be used as a drug delivery system. Objective: To develop chitosan scaffold as a delivery system for delivering curcumin in wound-healing application. Materials and methods: Chitosan–curcumin microcomplex particles were prepared, and the effect of drug–polymer ratio (DPR) and homogenisation speed (HS) was studied using a two-level full-factorial design. Chitosan scaffold was prepared and incorporated with curcumin microcomplexes to obtain a chitosan scaffold-containing chitosan–curcumin microcomplex (CS-CCM). Antimicrobial property of the CS-CCM against Escherichia coli was studied. The cytotoxicity of CS-CCM was studied by assessing the cell viability by MTT assay. Results and discussion: DPR had a significant effect (p ≤ 0.05) on the drug content. CS-CCM was able to inhibit the growth of E. coli considerably. The MTT results showed that CS-CCM is non-cytotoxic and supports cell proliferation. Conclusion: CS-CCM due to its biocompatibility and antimicrobial property could be further evaluated for potential application in wound healing.
    Journal of Microencapsulation 04/2015;
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    ABSTRACT: Abstract Hydrophobic materials, in particular hydrogenated vegetable oils, HVO, are extensively used as coating materials in food and pharmaceutical systems. Correct application of these coatings requires an evaluation of their behaviour as a function of various parameters such as melting temperature, solubility, concentration and/or pH. The purpose of this study was to assess the physico-chemical properties of an HVO in terms of composition, crystallisation, phase transition and polymorphism using a variety of analytical techniques, such as electrospray mass spectrometry (ESI-MS), differential scanning calorimetry (DSC) and X-ray diffraction (XRD). High-resolution ESI-MS allowed establishment of the HVO main composition of long-chain triglycerides (average molecular weight 1183 Da). DSC results showed that thermal history determines the formation of at least two polymorphs of HVO, namely two different crystal forms, assigned as form α, melting point (m.p.) 48 °C, and form β', m.p. 60 °C. A third polymorph, the more thermodynamically stable β-form, having a melting point at 62 °C, is obtained by solution-mediated re-crystallisation. Phase transformation paths were investigated by isothermal DSC experiments, which evidenced that the α-form is kinetically stable at temperatures lower than 25 °C. These data are of particular interest in practical applications such as spray freezing or pan coating where significant heat transfer phenomena are involved.
    Journal of Microencapsulation 12/2014; DOI:10.3109/02652048.2014.995732
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    ABSTRACT: Abstract This study evaluated the feasibility of mizolastine-loaded microparticles as therapy for atopic dermatitis. Microparticles have been researched for decades as a controlled-release drug delivery system, but seldom been used as treatment for skin disease. In this research, we induced dermatitis in BALB/c mice model by repeated topical application of dinitrofluorobenzene and compared the mizolastine microparticles injection and daily mizolastine injection treatment. The results showed that the mizolastine microparticles treatments significantly inhibited ear thickness and dermatitis index in dermatitis model compared with the dermatitis mice without treatment, showing a similar curative effect compared with daily mizolastine injection treatment, and the improvement continued for several days. Inflammatory cells infiltration into the ears and the plasma level of immunoglobulin E were also suppressed by mizolastine microparticles according to the histopathology analysis. In conclusion, the results suggested that drug-loaded microparticles could be a proper candidate for the treatment of skin diseases.
    Journal of Microencapsulation 12/2014; DOI:10.3109/02652048.2014.995727
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    ABSTRACT: Micronisation of simvastatin dissolved in acetone, dimethyl sulfoxide and ethanol with supercritical carbon dioxide as antisolvent was successfully performed using a supercritical antisolvent technique. The effect of a few process parameters such as precipitation temperature, the pressure and solute concentration in the liquid solution has been studied to evaluate their influence on morphology and size of particles. The micronised simvastatin were evaluated for drug content, particle size analysis and in vitro dissolution profiles. Fourier transform infrared spectroscopy, differential scanning calorimetry and PXRD patterns was used to study the possible changes after micronisation of simvastatin. The dissolution rate was increased after micronised compared with pure simvastatin in distilled water, pH 1.2 buffer and pH 7.0 buffer. In vivo performance of the optimised formulation was evaluated in rats using pharmacodynamic marker parameters like serum total cholesterol (CH) and triglycerides (TG) for 21 days. Pharmacodynamic studies of micronised simvastatin revealed improved reduction in CH and TG values as compared with pure simvastatin indicating improved bioavailability. In vivo pharmacokinetics in rats showed an increase in bioavailability of micronised simvastatin (3.14 times) compared with plain simvastatin.
    Journal of Microencapsulation 12/2014; DOI:10.3109/02652048.2014.995726
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    ABSTRACT: Abstract Purpose: To develop a novel preparation approach of solid Self-Emulsifying Drug Delivery System (s-SEDDS) based on spray congealing as potential drug delivery technology for poorly water-soluble drug Glibenclamide (GBD). Methods: Several systems were formulated using suitable excipients, solid at room temperature, with different hydrophilic-lipophilic balance, such as Myverol, Myvatex, Gelucire®50/13 and Gelucire®44/14. Cremophor®EL and Poloxamer 188 were selected as surfactants and PEG 4000 as co-solvent. Results: The screening of the best carrier for s-SEDDS manufacturing revealed that Gelucire®50/13 had greater performance. Then, surfactant-co-solvent systems were developed. Dissolution studies showed that all the formulations promoted the solubilisation performance of the GBD with respect to pure drug; in particular the formulation containing Gelucire®50/13 and PEG 4000 increased the drug solubilisation of five times. These microparticles showed self-dispersibility within 60 min and micelles dimensions around 360 nm. Conclusions: Spray congealing is a promising novel manufacturing technique of solid self-emulsifying systems.
    Journal of Microencapsulation 11/2014; DOI:10.3109/02652048.2014.985341
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    ABSTRACT: Abstract The aim of this study was to improve the oral absorption of loratadine, a pH-sensitive drug, by self-microemulsifying drug delivery systems (SMEDDSs). The optimal SMEDDS was analysed and evaluated after emulsification in distilled water with diameter of 26.57 ± 0.71 nm and zeta potential of -30.5 ± 4.5 mV. Dissolution experiments in vitro were carried out in different released media of pH values and the SMEDDS formulations were able to release loratadine completely in different media while market tablets just performed similarly in the media of pH 1.2. Furthermore, the oral bioavailability and the pharmacokinetic behaviour of loratadine formulations in vivo were studied after a single dose of 1 mg/kg loratadine in beagle dogs. The SMEDDS formulations displayed higher Cmax and AUC, approximately 9 and 5 times increase than those of market tablets (p < 0.01) respectively. These results demonstrated that SMEDDS formulations had significantly increased the oral absorption of loratadine in beagle dogs.
    Journal of Microencapsulation 11/2014; DOI:10.3109/02652048.2014.985340
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    ABSTRACT: Abstract This article describes the physicochemical properties of chitosan-coated liposomes containing skin-protecting agents, coenzyme Q10 and alpha-lipoic acid (CCAL). CCAL had a spherical shell-core structure and liposomes inverted the surface charge from negative to positive after coating with chitosan. Compared with the uncoated liposome, CCAL had higher zeta potential, larger droplet size and long-term stability. Fourier transform infrared spectroscopy (FTIR) study showed that the driving force for chitosan coating the liposomes was enhanced via hydrogen bonding and ionic bond force between the chitosan and the alpha-lipoic acid. While the encapsulation efficiency (EE) of alpha-lipoic acid also increased by interacting with the chitosan shell. In vitro antioxidant activity study showed an excellent hydroxyl radical scavenging activity of CCAL. In vitro release study displayed a sustained drug release, and in vitro penetration studies promoted the accumulation of drugs in rabbit skin.
    Journal of Microencapsulation 10/2014; DOI:10.3109/02652048.2014.973072
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    ABSTRACT: Abstract Poly(sebacic anhydride) (PSA) is a promising polymer for the production of drug delivery vehicles. The aim of this work is to study the effect of preparation parameters on the quality of the nanoparticles. In this study, doxorubicin (DOX)-loaded PSA nanocapsules were prepared by an emulsion method. Effects of factors such as type of organic solvent, co-solute (surfactant) and its concentration on drug-loading efficiency, particle size and size distribution, morphology and release profile were examined to gain insight in the preparation and stability of nanostructures. Particles with sizes in the range of 218-1198 nm were prepared. The smallest particles with a narrow size distribution were prepared by using polyvinyl alcohol as a co-solute and dichloromethane as a solvent. Efficiency and intracellular release of doxorubicin from the formulated particles were studied on MDA-MB-231 cells. It was observed that DOX-loaded PSA particles can diffuse into the cells and intracellular antitumour activity is directly related to the released amount of drug from the PSA nanocapsules.
    Journal of Microencapsulation 10/2014; DOI:10.3109/02652048.2014.973073
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    ABSTRACT: Liposomes are known to be a potent adjuvant for a wide range of antigens, as well as appropriate antigen carriers for antibody generation response in vivo. In addition, liposomes are effective vehicles for peptides and proteins, thus enhancing their immunogenicity. Considering these properties of liposomes and the antigenicity of the Leishmania membrane proteins, we evaluated if liposomes carrying glycosylphosphatidylinositol (GPI)-anchored proteins of Leishmania amazonensis promastigotes could induce protective immunity in BALB/c mice. To assay protective immunity, BALB/c mice were intraperitoneally injected with liposomes, GPI-protein extract (EPSGPI) as well as with the proteoliposomes carrying GPI-proteins. Mice inoculated with EPSGPI and total protein present in constitutive proteoliposomes displayed a post-infection protection of about 70% and 90%, respectively. The liposomes are able to work as adjuvant in the EPSGPI protection. These systems seem to be a promising vaccine prototype for immunisation against leishmaniasis.
    Journal of Microencapsulation 09/2014; DOI:10.3109/02652048.2014.958203
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    ABSTRACT: Abstract Silver sulfadiazine (SSD) is the antibacterial of choice for the treatment of burn. The current marketed formulation of SSD is 1% w/w water soluble cream, which requires frequent applications, which is very painful to patients. Niosomes were prepared by a thin film hydration method. The in vitro antimicrobial efficiency of niosomal SSD (18 ± 0.5 mm) was as good as that of marketed cream (17 ± 0.5 mm) against Staphylococcus aureus even when used in half the concentration (0.5%) of marketed cream (1%). Further SSD (0.5% w/w) niosomal gel was prepared using 1.6% carbopol 934. It was evident through in vitro permeation studies that SSD release was considerably retarded from both niosomes and niosomal gel in comparison with marketed cream thereby decreasing the dosing frequency. In-vivo study demonstrated that a niosomal gel containing 0.5% w/w SSD was more effective in burn wound healing compared to 1% w/w marketed cream even when applied once a day.
    Journal of Microencapsulation 09/2014; DOI:10.3109/02652048.2014.958202
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    ABSTRACT: Abstract Growth factor-loaded fluorescent alginate microspheres, which can realise sustained growth factor release and fluorescence imaging, were synthesised by in situ formation of ZnO quantum dots (QDs) and covalent graft of 4-(1-pyrenyl) butyric acid (PBA). BSA was chosen as a growth factor model protein to study the release kinetic of growth factors from alginate microspheres. The microsphere size and fluorescent properties were also investigated. Investigations of cell culture were used for evaluating biocompatibility of BSA-loaded fluorescent microspheres and fluorescence imaging property of ZnO QDs and PBA-grafted sodium alginate from the microspheres. The results show that they have good fluorescent property either to microspheres or to cells and fluorescent microspheres have good biocompatibility and property in sustained release of growth factors. The obtained microspheres will be expected to realise the imaging of cells and materials and also the release of growth factor in tissue engineering or in cell culture.
    Journal of Microencapsulation 09/2014; DOI:10.3109/02652048.2014.950712
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    ABSTRACT: Abstract Interfacial polymerisation was mainly developed toward the end of the 1960s, leading to applications in microcapsule production by the mid-1970s. The process consists in the dispersion of one phase containing a reactive monomer, into a second immiscible phase to which is added a second monomer. Both monomers react at the droplet surface (interface), forming a polymeric membrane. Over the last 50 years, many studies have been reported, but very few have provided a comprehensive review of this technology. This contribution reviews microcapsule production by interfacial polymerisation from the chemical, physico-chemical and physical perspectives, providing a tool for understanding and mastering this production technology, but also providing guidance toward improvements for future process design.
    Journal of Microencapsulation 09/2014; DOI:10.3109/02652048.2014.950711
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    ABSTRACT: This study was aimed to develop poly(dl-lactide-co-glycolide) (PLGA) nanoparticle of highly water soluble antibiotic drug, netilmicin sulfate (NS) with improved entrapment efficiency (EE) and antibacterial activity. Dextran sulfate was introduced as helper polymer to form electrostatic complex with NS. Nanoparticles were prepared by double emulsification method and optimized using 25-1 fractional factorial design. EE was mainly influenced by dextran sulfate: NS charge ratio and PLGA concentration, whereas particle size (PS) was affected by all factors examined. The optimized NS-loaded-NPs had EE and PS of 93.23 ± 2.7% and 140.83 ± 2.4 nm respectively. NS-loaded-NPs effectively inhibited bacterial growth compared to free NS. Sustained release protected its inactivation and reduced the decline in its killing activity over time even in presence of bronchial cells. A MIC value of 18 μg/mL was observed for NPs on P. aeruginosa. Therefore, NPs with sustained bactericidal efficiency against P. aeruginosa may provide therapeutic benefit in chronic pulmonary infection, like cystic fibrosis.
    Journal of Microencapsulation 09/2014; DOI:10.3109/02652048.2014.944951
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    ABSTRACT: The aim of this work was to develop the method of preparation of magnetically responsive, loaded nanocapsules based on a liquid core encapsulation by polyelectrolyte (PE) multilayer adsorption. Magnetically responsive drug nanodelivery systems were prepared by the sequential adsorption of PEs (layer-by-layer technique) using biocompatible PEs (poly-l-lysine as the polycation and poly-glutamic acid as the polyanion). The model lipophilic drug, β-carotene, was successfully encapsulated in the liquid core while Fe3O4 nanoparticles were embedded into the PE multilayer shell. This magnetically responsive drug nanodelivery system may be a promising platform for future targeted therapies (e.g. cancer) or other biomedical applications (e.g. separation systems and diagnostics).
    Journal of Microencapsulation 09/2014; DOI:10.3109/02652048.2014.950709