Journal of Microencapsulation (J MICROENCAPSUL )

Publisher: Taylor & Francis


The Journal of Microencapsulation is a well-established journal devoted to the preparation, properties and uses of individually encapsulated small particles. Its scope extends beyond microcapsules to all other small particulate systems which involve preparative manipulation. These forms find a wide variety of medical, biological, industrial and research applications. The journal covers the chemistry of encapsulation materials; the physics of release through the capsule wall; the techniques of preparation; content and storage; and the many uses to which microcapsules are put. Also found in every issue of the journal is an extensive information and reference section comprising patent briefing and literature alerts listings.

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  • Website
    Journal of Microencapsulation website
  • Other titles
    Journal of microencapsulation (Online)
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  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

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Taylor & Francis

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    • Author can archive a pre-print version
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    • Author cannot archive a post-print version
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    • 12 month embargo for STM, Behavioural Science and Public Health Journals
    • 18 month embargo for SSH journals
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    • Post-print on authors own website, Institutional or Subject Repository
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    • Published source must be acknowledged
    • Must link to publisher version
    • Set statements to accompany deposits (see policy)
    • Publisher will deposit to PMC on behalf of NIH authors.
    • STM: Science, Technology and Medicine
    • SSH: Social Science and Humanities
    • 'Taylor & Francis (Psychology Press)' is an imprint of 'Taylor & Francis'
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    ​ yellow

Publications in this journal

  • Journal of Microencapsulation 01/2014;
  • Journal of Microencapsulation 03/2013; 30(3):218-224.
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    Journal of Microencapsulation 01/2013;
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    ABSTRACT: Fenofibrate-loaded microemulsions composed of Labrafil M 1944 CS, Capryol PGMC and fenofibrate as the dispersed phase and Labrasol in demineralised water as the continuous phase were prepared by utilising a Shirasu-porous-glass (SPG) membrane emulsification technique. The process parameters were optimised by adjusting the feed pressure (15-45 kPa), agitator speed (250-800 rpm) and temperature of the continuous phase (25-45°C). As a result, narrowly distributed microemulsions were obtained via SPG membrane emulsification at an agitator speed of 250 rpm, a feed pressure of 30 kPa and a continuous phase temperature of 25°C. Furthermore, TEM images clearly showed that the microemulsion prepared by SPG membrane emulsification had a uniform, spherical morphology with a narrow size distribution. Our results indicated that the SPG membrane emulsification technique is highly efficient for the preparation of narrowly distributed microemulsions with relatively smaller particle sizes compared with the common stirring method.
    Journal of Microencapsulation 01/2013;
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    ABSTRACT: Self-nanoemulsifying drug delivery systems (SNEDDSs) offer potential as suitable carriers for improved oral delivery of poorly soluble and low bioavailable drugs. To derive self-nanoemulsifying powders (SNEPs), the optimized Z-SNEDDS formulation was adsorbed onto different carriers and based on micromeritics the formulation loaded onto neusilin US2 (SNEP-N) was selected for further characterization. The solid-state characterization (scanning electron microscopy, differential scanning calorimetry and powder X-ray diffraction) studies unravel the transformation of native crystalline state to amorphous and/or molecular state. The higher predictive effective permeability coefficient and fraction absorbed in humans extrapolated from in situ single-pass intestinal absorption study data in rats provide an insight on the potential of SNEPs for augment in absorption across gastrointestinal barrier. Overall a 3.5-fold enhancement in the extent of absorption of zaleplon from SNEP-N formulation proves the feasibility of SNEPs formulation for improved oral delivery of zaleplon.
    Journal of Microencapsulation 08/2012;
  • Journal of Microencapsulation 05/2012; in press.
  • Journal of Microencapsulation 01/2012;
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    ABSTRACT: The aim of this study was to develop photostable gastro retentive formulation for nifedipine loading into low-density polypropylene microporous particles (Accurel MP 1000�) by a solvent evaporation technique using the 32 factorial design. Yield, drug loading, surface topography, thermal properties, crystal characteristics, photostability and in vitro drug release were studied. Optimized microparticles formulated into a capsule were evaluated for the dissolution study and compared with marketed formulation. Higher values 15 of T50%, time required for 50% degradation of drug with threefold and 1.5-fold decrease in degradation rate constant (K) under UV and fluorescent lamp were observed for the microparticles, respectively, as compared to pure nifedipine indicated remarkable improved photostability. Microparticles showed good floating ability in 0.1N HCl with initial burst release (16–29%) followed by the zero-order drug release up to 8 h. The capsule formulation followed the ideal modified release pattern.
    Journal of Microencapsulation 01/2012; 29(5):409-416.
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    ABSTRACT: The performance of anatase type titanium dioxide (TiO(2)) encapsulated with styrenic copolymers via the solvent evaporation or suspension polymerization process was investigated as a photocatalyst for the decolourization of methylene blue (MB, 3,4-bis(dimethylamino)-phenothiazine-5-thionium chloride) in the aqueous phase. The TiO(2) microcapsules, loaded with 4-8 wt% TiO(2), were dispersed in a MB aqueous solution containing an adequate amount of hydroperoxide as an oxygen source, and the mixture was exposed to 365 nm UV light. The decolourization of MB proceeded according to the first order of the MB concentration. The apparent rate constant, defined based on the unit weight of loaded TiO(2), depended on the initial concentration of MB. The capsule walls, composed of cross-linked and/or uncross-linked poly(styrene-co-2-ethylhexyl acrylate), favoured the adsorption of MB on the capsule surface and promoted the decomposition. The observations of the cross-section of microcapsules by transmission electron microscopy (TEM) showed similar morphology of microcapsules regardless of preparation method; a thin layer of hydrophilic TiO(2) particles being localized near the particle surface. The sustainability of the microcapsules was also proved by doing experiments successively for 7 days. Smaller size microcapsules were favoured for the decomposition of MB, and the rate constant increased with the surface area of microcapsules in unit volume of the reaction mixture. Although large size microcapsules with uncross-linked polymer wall had a disadvantage of breaking under high shear agitation, those prepared with cross-linked polymer wall by suspension polymerization still remained effective after the sustainability test for 7 days.
    Journal of Microencapsulation 07/2010; 20(1):19-33.
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    ABSTRACT: Chitosan microspheres containing oxytetracycline (OTC), an antibiotic agent, were prepared by spray hardening and interfacial acylation methods. The object of this study was to prepare oxytetracycline-containing microspheres for oral administration and injection using different molecular weight (Mw 70,000 approximately 2,000,000) of chitosan. By the spray hardening method, microspheres with particle sizes between 5 and 30 microns could be obtained and might be suitable for intramuscular injection. On the other hand, chitosan microspheres with the ability to extend the dissolution period of oxytetracycline in low pH medium were also prepared by the interfacial acylation method. The result indicated that the releasing of oxytetracycline from various acylated chitosan microspheres was decreased with increasing the molecular weight of chitosan and would show well sustained-release property. Besides, the morphology of various microspheres and crystalline form transition of oxytetracycline were also studied using electron scanning microscope and X-ray analysis.
    Journal of Microencapsulation 06/2009; 14(5):577-91.
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    ABSTRACT: Drug loaded microspheres were successfully prepared using the dairy protein, sodium caseinate (SC), as the carrier material and containing hydrochlorothiazide, eosin, patent blue violet and sodium salicylate. The morphology of the microspheres varied depending on the incorporated material. Release of the incorporated agents from these systems was rapid with over 90% release in each case within 1 h. Further drug release occurred at a greatly reduced rate with a certain proportion of the drug loading appearing to be indefinitely entrapped within some of the microspheres. The drug release profiles were poorly described using the square root of time and Sinclair and Peppas equations but were well described by a biexponential equation. Analysis of the parameter estimates from the biexponential equation indicated that the initial rapid release phase was essentially completed within 5 min for all but the eosin microsphere systems and this timeframe was of the same order of magnitude as that found for the initial swelling of these microsphere systems as analysed by swelling studies using optical microscopy. Considering both the swelling study and the results from the release experiments, it seems likely that addition of SC microspheres to aqueous media results in immediate hydration and swelling. This process facilitates the rapid diffusional passage of water soluble drugs through the swollen and hydrated microsphere matrix, with drug release occurring almost unhindered unless other factors favour the retention of the incorporated agent with the microsphere.
    Journal of Microencapsulation 06/2009; 14(1):63-78.
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    ABSTRACT: Lisinopril, an angiotensin converting enzyme (ACE) inhibitor drug, was encapsulated in poly(lactide-co-glicolide) (PLGA) nanoparticles (NP) for site-specific delivery by catheters in prevention of restenosis. NP were prepared by emulsification-diffusion method. The PLGA type, stabilizing agent type and its concentration were studied as process variables. The z-average particle size varied between 265-412 nm. The highest zeta potential was seen in NP prepared with Pluronic F-68. None of the studied variables or their interactions had a significant effect on the particle size while all had main effect on the zeta potential. The highest entrapment efficiency was 93% and all studied variables and their interactions except PLGA type and its interaction with the stabilizer type had significant effects on the loading. Baker-Lonsdale model was the most appropriate model for release of lisinopril from NP. Five per cent PLGA 75:25 and 5% Pluronic F-68 showed promising results for 21 days release of lisinopril as an anti-restenotic agent.
    Journal of Microencapsulation 11/2008; 25(7):478-86.
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    ABSTRACT: Electrospraying is a method of liquid atomization that utilizes electrical forces to overcome the surface tension force. The droplets obtained by electrospraying are charged and for certain modes can be nanometers in size. The charge and size of the droplets can be controlled to some extent by liquid flow rate and the voltage applied to the nozzle. In recent years, electrospraying was tested as a 'bottom-up' technology for building nanostructures from elementary components obtained from fine droplets or submicron jets after solvent evaporation, such as thin films, nanoparticles or nanofibres. It was also tested as a tool for the production of micro- and nanoemulsions and micro- and nanocapsules. Research in this field was aimed at developing new drug delivery systems or medicine production and application of this technique in cosmetic and food industries. Electro-encapsulation was also used as a tool for nanocomposite materials fabrication. The paper reviews various methods based on electrospraying used for electro-emulsification and micro- and nanoencapsulation. Numerous scientific and engineering contributions in this field are presented in this paper.
    Journal of Microencapsulation 11/2008; 25(7):443-68.
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    ABSTRACT: Rhizobacteria Pseudomonas fluorescens-putida were microencapsulated in Eudragit by spray-drying. These microparticles are subsequently included in seed coating or pelleting material. The survival of the bacterial cell in microparticles were studied under different levels of relative humidity (RH): 0, 33, 55 and 100%. The protective effects of silica, present in certain formulations, were demonstrated at the relative humidities of 33 and 55%. The release of the encapsulated bacteria was also studied over time. The release was fast, the bacteria being observed at 15 min immersion of the Eudragit microparticles in an aqueous-buffer medium at 20 degrees C. This result, related to the physicochemical character of the coating polymer, showed that water was the triggering element for the release of rhizobacteria. Compatibility studies between two film-forming agents used for seed coatings and the encapsulated bacteria, as well as wettability measures of tableted microparticles, were carried out. The bacterial survival was good with the seed coating agent, Sepiret 1039G, and the wettability measurements of agglomerated microparticles were in accord with the rapid release of the microencapsulated bacteria. The application of microparticles containing rhizobacteria on seeds can now be considered for preliminary trials.
    Journal of Microencapsulation 09/2008; 16(2):215-29.
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    ABSTRACT: Alginate and chitosan treated alginate beads were prepared and compared as an oral controlled release system for macromolecular drugs. Dextran (M.W. 70,000) was used as a model substance. The beads were prepared by the ionotropic gelation method and the effect of various factors (alginate, chitosan, drug and calcium chloride concentrations, the volume of external and internal phases and drying methods) on bead properties were investigated. The addition of chitosan increased the drug loading capacity of the beads, and larger beads were obtained in the presence of chitosan. On the other hand, addition of chitosan in the gel structure reduced the drug release from beads. The erosion of the beads was suppressed by chitosan treatment. The drying method was important to the properties of the chitosan-alginate beads. It is proposed that chitosan treated alginate beads may be used as a potential controlled release system of such macromolecules.
    Journal of Microencapsulation 09/2008; 16(2):195-203.
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    ABSTRACT: Incorporation of chlorpyrifos into starch matrices was achieved by thermal gelatinization. The level of amylose content in the starch matrices (10 and 52%) and the addition of auxiliary agents, i.e. solvent, emulsifiers or both, were varied and eight different formulations were prepared. According to differential scanning calorimetry (DSC) and X-ray diffraction measurements, chlorpyrifos was partly present in a crystalline form in all the starch formulations. The formulations had controlled release properties, and the release rate into water could be described by a linear model. In a bioassay, the formulations killed all larvae of the cabbage root fly at a dosing of 1.4 kg a.i. per ha. The degradation of chlorpyrifos in soil from the starch formulations could be described in a non-linear logistic model and the half-life was predicted to be 88 days. Differences in the amount of amylose in the starch as well as the addition of solvent and emulsifiers in the preparation procedure had no systematic influence on the release rate, the insecticidal effect and the degradation rate. No correlation between release rate into water and degradation in soil could be established. Two commercial chlorpyrifos formulations Lorsban 15 G (granular) and Cyfos 500 gl(-1) (emulsifiable concentrate), were included in the study for comparison.
    Journal of Microencapsulation 09/2008; 19(3):319-31.
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    ABSTRACT: Ibuprofen-loaded polystyrene microparticles were prepared by the emulsion-solvent evaporation process from an aqueous system. The effects of different parameters on the drug content and on the release of the drug from the microparticles were investigated. The drug content, in all the formulations, was less than the theoretical drug loading. The lower drug content was due to drug partitioning to the external aqueous phase during formulation. Statistical analysis revealed that the variation in the concentrations of the emulsion stabilizer and the organic disperse phase volume did not significantly alter the release of the drug. Although an increase in drug loading increased drug release from the microparticles, a biphasic linear relationship was observed between the time required for 50% drug release and the drug loading. The effect of size of the microparticles on drug release was more important for the low drug-loaded microparticles than that for the high drug-loaded microparticles. Such release behaviour from the microparticles was explained on the basis of the morphological structure of the microparticles.
    Journal of Microencapsulation 09/2008; 17(1):57-67.

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