Archives of Medical Research (ARCH MED RES )

Publisher: Elsevier


Archives of Medical Research publishes original peer-reviewed medical research in an attempt to bridge the gaps created by medical specialization. Contributions are grouped into three main categories - biomedical, clinical, and epidemiological. Review articles, outstanding case reports, and preliminary communications will also be considered. As an international publication, the study of diseases is presented from various perspectives to provide the medical community with original investigation from molecular biology to clinical epidemiology within a single publication.

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    Archives of medical research (Online)
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    Document, Periodical, Internet resource
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    Internet Resource, Computer File, Journal / Magazine / Newspaper

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    • Publisher last contacted on 18/10/2013
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Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Quercitrin (QR; quercetin-3-O-rhamnoside) has been used previously as an antibacterial agent and has been shown to inhibit the oxidation of low-density lipoproteins and prevent an allergic reaction. Furthermore, it was demonstrated that quercitrin exerts protective effects against H2O2-induced dysfunction in lung fibroblast cells. However, the mechanisms of quercitrin effects on cancer cell proliferation and apoptosis is not well understood. The aim of this study is to investigate the cytotoxic and apoptotic effects of quercitrin and the molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer (NSCLC) cell lines.
    Archives of Medical Research 09/2014;
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    ABSTRACT: Awareness about biomedical research among postgraduate students at a tertiary care hospital, central India: Pretest- posttest study design Thakre SB,1,Thakre SS2, Golawar SH3, Ughade SN4, Thakre AD5 11Associate Professor, Department of Community Medicine, Government Medical College, Nagpur, 2Associate Professor, Department of Community Medicine, Indira Gandhi Government Medical College, Nagpur, 3Assistant Professor, Department of Community Medicine, Government Medical College, Nagpur, 4Senior Assistant Professor, Department of Community Medicine, Government Medical College, Nagpur, 5Assistant Professor, Department of Pathology, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha. Corresponding Author: Dr. Subhash B Thakre, Associate Professor , Department of Community Medicine, Government Medical College, Nagpur Email: Abstract Introduction: :Promotion of biomedical research among postgraduate medical students is of immense importance and there is an urgent need of sensitization and incorporation of research skills among them for the generation of new knowledge and evidences in the field of medical sciences. The present study was undertaken with the objective of evaluation of knowledge, attitude and practices related to medical research among postgraduate medical students before and after a three days workshop. Materials and Methods:Present study was carried out during basic research methodology workshop held at Government Medical College, Nagpur, India during the period between September and October 2013. Pre and post-test study design was used. Study participants include 109 postgraduates admitted to the Doctor of Medicine (MD) / Master of Surgery (MS) course, from all the specialties of which 107 were included for final analysis. A pretested, semi-structured questionnaire was developed based on the study objectives, by reviewing the existing literature. The questionnaire consisted of evaluation of baseline characteristics, knowledge and attitude of the postgraduate students about biomedical research. Statistical measures obtained were numbers, percentages and mean values. The paired sample t test was used to compare the mean knowledge and attitude scores before and after the workshop. Results: Mean age of study participants was 27.45 ±1.74 years. The average monthly income of resident doctor was Rs.33615. Presentations at various conferences were done by 42.05% and 9.34% had publication record. Training about research and ethics was not received by 90.82% study subjects. Significant improvement was observed in the mean knowledge score after the workshop (36.07% vs. 77.38%; p-value 0.000). Significant improvement was observed in the mean attitude score after the workshop (36.07% vs. 75.83%; p-value 0.000). Conclusion: This study investigated the impact of a workshop on research skills, as a short-term intervention on the knowledge and attitudes of medical students regarding health research. Significant improvement was observed in the level of knowledge and attitude of medical students at the end of the workshop. Keywords :Biomedical research, Postgraduate students, Knowledge, Attitude, Workshop.
    Archives of Medical Research 09/2014; Volume : 2(2):8-14.
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    ABSTRACT: Background and Aims Cisplatin (CP) is regarded as a major anticancer drug against a wide spectrum of leukemia and other malignancies. The mode of action of CP on cancer cells is attributed to its property of releasing free radicals which, at the same time, has the potential to damage liver and kidney cells. The tissue-specific toxicity of CP to the kidneys is well documented. However, there is a paucity of literature on systemic toxicity and also the amelioration of such effect. The aim of the present study was to evaluate the damage caused by CP and its modulation by using the antioxidant capacity of curcumin (CMN, a natural polyphenolic compound) in Wistar rats. Methods We evaluated the ameliorative effect of CMN (200 mg/kg body weight, b.w.) on the toxicity of CP in rat liver. Oxidative stress biomarkers, enzymatic and nonenzymatic antioxidants were evaluated for assessing the mitigatory potential of CMN against CP-induced toxicity. Results A single dose of CP (7 mg/kg b.w.) caused marked hepatic damage. CP caused a significant increase in lipid peroxidation (LPO) level and protein carbonyl (PC) content. Pretreatment of rat with CMN significantly restored the LPO levels and PC content. It also replenished the CP-induced modulatory effects on altered enzymatic and nonenzymatic antioxidants in liver. Conclusion Our results clearly demonstrated that the role of oxidative stress is detrimental in systemic toxicity induced by CP and suggest a mitigatory effect of CMN on CP-induced hepatotoxicity in rat.
    Archives of Medical Research 08/2014;
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    ABSTRACT: The prevalence and prognostic significance of Epstein-Barr virus (EBV) infection in classical Hodgkin's lymphomas (cHLs) remain elusive. To examine the epidemiological and prognostic differences between EBV-positive and -negative cHLs, we conducted a meta-analysis of 119 published studies including 13,045 cases.
    Archives of Medical Research 06/2014;
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    ABSTRACT: Background and Aims. The motor-evoked potential (MEP) to transcranial magnetic stimulation (TMS), its recruitment and the conditioning effects of weak stimuli in Parkinson’s disease (PD) have shown contradictory results based on limited use and analysis of existing TMS paradigms. We undertook this study to provide definitive data of MEP physiology in PD. Methods. We investigated resting and active motor thresholds (RMT/AMT), resting and active recruitment curves, and short-interval intracortical inhibition (ICI) and facilitation (ICF) in 39 PD patients and 40 healthy individuals. MEP was log transformed prior to analysis. The Unified Parkinson’s Disease Rating Scale (UPDRS) motor scale was used as clinical measure. Results. MEPs to single pulses were slightly, but significantly, larger in the patients at rest, but increased much less with voluntary muscle activation. PD patients also showed clearly and consistently less ICI and ICF by the conditioning pulse. Both facilitation and inhibition correlated with MEP threshold in healthy subjects, but not in patients. No phys- iological measures correlated with the UPDRS score. Conclusions. These findings are compatible with a decreased evoked and spontaneous thalamocortical drive by disturbed signal-noise ratio of pyramidal neuron responses to unbalanced excitatory/inhibitory input. More importantly, they probably represent a complex combination of disturbed presynaptic and surround inhibition, as consequence of aberrant oscillatory neural transmission due to dysfunctional neurotransmitter activity.
    Archives of Medical Research 01/2012; N/A(N/A-N/A):N/A.
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    ABSTRACT: There have been few studies in the literature evaluating the effect of Behçet's disease (BD) on tendons. Thus, we planned to search for the involvement of hand and foot tendons in BD by using ultrasonography and to determine the relation of tendon involvement with clinical measurements. The study consisted of 33 randomly selected BD patients and 36 voluntary healthy controls matched by age and body mass index. Sonographic evaluations were performed from hands (flexor digitorum süperficialis (2-5), flexor digitorum profundus (2-5), flexor carpi radialis) and Achilles tendons of the nondominant extremities using an 8-10 MHz linear array probe. Grip strength and crepitation were also measured on the nondominant side. Mean hand and foot tendon thickness values of BD patients were significantly higher than in control group (p=0.00). Disease duration, age, and presence of crepitation were not correlated with tendon thickness in the BD group (all p values>0.05). Grip strength values were lower in the BD group than in control group but the difference was not statistically significant (p=0.344). Grip strength values were not correlated with hand tendon thicknesses in BD groups (all p values>0.05). Because tendons tears and thicknesses are associated with inflammation, awareness of tendon pathologies is very important in rheumatic diseases. It would be of value to investigate this relationship in future studies in order to determine if this increment in tendon thickness is an indicator of disease activity and affects prognosis. The physician should be on alert about tendon involvement even if the patient has no complaints.
    Archives of Medical Research 11/2008; 39(7):709-13.
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    ABSTRACT: Increased cardiac sympathetic nerve activity is thought to contribute to ventricular tachyarrhythmias during acute myocardial ischemia (MI). However, the mechanism is not completely understood. This study investigated the effects of sympathetic nerve stimulation (SNS) on ventricular tachyarrhythmias and connexin43 (Cx43) during acute MI in rats. Ninety five male Wistar rats were randomly assigned into four groups receiving the following treatments: myocardial ischemia with sympathetic nerve stimulation (MI-SNS, n=25), sham-operation treated with sham stimulation (SO, n=20), myocardial ischemia with sham stimulation (MI, n=25), myocardial ischemia pretreated with sympathetic nerve stimulation (pSNS-MI, n=25). During the 30-min ischemia, the incidence of ventricular tachyarrhythmias, i.e., ventricular tachycardia or ventricular fibrillation (VT/VF) was increased in the MI-SNS group and decreased in the pSNS-MI group compared to that in the MI group (p<0.05 for both). The total amount of Cx43 protein was significantly decreased in the MI-SNS group but not in the MI group and the pSNS-MI group. The amount of phosphorylated Cx43 in the MI-SNS group was significantly lower compared to that in the SO group and the MI group (p<0.05). However, the amount of phosphorylated Cx43 was significantly increased in the pSNS-MI group compared to that in the MI group and the MI-SNS group (p<0.05). SNS promoted the degradation of Cx43 protein, especially the phosphorylated Cx43 protein, whereas pSNS inhibited the ischemia-induced loss of phosphorylated Cx43 during acute MI. These changes may be related to the pro- or anti-arrhythmic effect of SNS or pSNS during acute MI.
    Archives of Medical Research 11/2008; 39(7):647-54.
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    ABSTRACT: Cardiac resynchronization therapy (CRT) has been shown to improve the clinical status and survival in congestive heart failure (CHF) patients, but little is known about its influence on neurohormonal profile. Heart failure patients treated with CRT for moderate/severe heart failure were studied with echocardiography, cardiopulmonary test, and neurohormonal profile [brain natriuretic peptide (BNP), endothelin (END), big endothelin (big-END), epinephrine (EPI), tumor necrosis factor-alpha (TNF-alpha)] at baseline and after 1 year from the pacemaker implantation. 120 NYHA II-IV patients entered this study, all with an indication to CRT; 100 agreed to be implanted (group A), whereas 20 refused, identifying a control group (group B). In group A NYHA class (from 3.15+/-0.49-1.15+/-0.49, p=0.001), left ventricular ejection fraction (from 19.6+/-4.95-35.6+/-5.95%, p=0.001), severity of mitral regurgitation (from 13.3+/-4.19-6.09+/-4.11 cmq, p=0.001), and peak VO(2) (from 9.68+/-4.61-13.35+/-3.32 mL/kg/min, p=0.001) improved at 1-year follow-up. In the neurohormonal profile only plasma BNP (from 185.1+/-185.9-110.2+/-137.5 pg/mL, p=0.03) and big-END (from 1.8+/-1.5-0.87+/-0.7 fmol/mL, p=0.007) were reduced significantly. None of these parameters significantly changed in the control group at 1-year follow-up. In patients with moderate/severe heart failure, CRT improved clinical status and the functional parameters modifying the neurohormonal profile at 1-year follow-up.
    Archives of Medical Research 11/2008; 39(7):702-8.