Rheumatology International (RHEUMATOL INT )

Publisher: Springer Verlag


Rheumatology International is an independent journal reflecting world-wide progress in the research diagnosis and treatment of the various rheumatic diseases. It is designed to serve the international and interdisciplinary group of workers involved in problems of rheumatic diseases. Rheumatology International will cover all modern trends in clinical and experimental research as well as in the management of rheumatic diseases. Special emphasis will be given to immuno-pathogenetic mechanisms inflammatory reactions collagen metabolism genetics epidemiology therapeutic modulation of immunological and inflammatory mechanisms and development and evaluation of diagnostic procedures connected with rheumatic diseases. Contributions to these topics will appear in the form of original publications informative case reports short communications editorials and reviews. "Letters to the editor" will be welcome as an enhancement to discussion. Every effort will be made to ensure speed of publication while maintaining a high standard of contents and production.

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    Rheumatology International website
  • Other titles
    Rheumatology international (Online)
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  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

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Springer Verlag

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    • Articles in some journals can be made Open Access on payment of additional charge
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Publications in this journal

  • [show abstract] [hide abstract]
    ABSTRACT: Performance of rheumatoid arthritis (RA) classification by the 2010 American College of Rheumatology (ACR)/European League against Rheumatism (EULAR) criteria, compared to the 1987 ACR criteria, has not been assessed in population-based cohorts in which disease identification is by mailed questionnaire. Women followed in the Nurses’ Health Study and Nurses’ Health Study II cohorts self-reported new doctor-diagnosed RA on biennial questionnaires. Two RA experts reviewed medical records of 128 new RA self-reports to obtain individual 1987 and 2010 criteria and arrived at a consensus opinion. We compared agreement in classification by the two criteria sets (kappa), and calculated sensitivity and specificity, with reviewers’ opinion as gold standard. Ninety-eight (77 %) participants were classified as RA by reviewers’ consensus opinion; 98 (77 %) fulfilled 1987 criteria, while 79 (63 %) fulfilled 2010 criteria. Seventy-two (56 %) were classified as RA by both sets, 21 (16 %) by neither, 26 (20 %) by only 1987 criteria, and 9 (7 %) by only 2010 criteria. Kappa for concordance was 0.36 (95 % CI 0.20–0.53). Compared to reviewer’s opinion, sensitivity and specificity were 0.93 and 0.77 for 1987 criteria, and 0.79 and 0.87 for 2010 criteria. Participants fulfilling 1987 criteria only were more likely to be seronegative. In these prospective population-based cohorts, significant discordance between 1987 ACR and 2010 ACR/EULAR criteria for classifying RA exists. Using the 2010 ACR/EULAR criteria alone had decreased sensitivity, and seronegative RA cases would be excluded in particular. Combined use of both will be necessary to maximize inclusion and allow sensitivity analyses.
    Rheumatology International 03/2014; 34(3).
  • [show abstract] [hide abstract]
    ABSTRACT: We described the recent spatial distribution of Rheumatoid arthritis in Turkey, and assessed the role of environmental variables in this distribution. We developed an observed RA incidence grid map by using geo-referenced Rheumatoid arthritis case data (2011) from the centres of 81 provinces and the kriging method with a spherical variogram model in geographic information systems (GIS). We also modelled Rheumatoid arthritis incidence in GIS by using complementary spatial database including the grid map layers of 14 environmental variables of Turkey. We conducted principle component analysis (PCA) and multiple regression to investigate relationships among variables and develop a model, respectively. The produced model was run in GIS to obtain a predicted (model) RA map. We tested the reliability of the model map by residual statistics, and found the model map dependable. Observed and model incidence maps revealed the geographic distribution of Rheumatoid arthritis cases in Turkey. The mean temperature, minimum temperature, maximum temperature, water vapour pressure, elevation, potential evapotranspiration, latitude, distance to seas, sunshine fraction, precipitation, longitude and aspect variables were found to have significant impacts on Rheumatoid arthritis. Consequently, the model incidence map established a good background to predict Rheumatoid arthritis cases following environmental changes.
    Rheumatology International 07/2013;
  • Rheumatology International 01/2012;
  • Source
    [show abstract] [hide abstract]
    ABSTRACT: Review articles comprehensively covering a specific topic are crucial for successful research and academic projects. Most editors consider review articles for special and regular issues of journals. Writing a review requires deep knowledge and understanding of a field. The aim of this review is to analyze the main steps in writing a narrative biomedical review and to consider points that may increase the chances of success. We performed a comprehensive search through MEDLINE, EMBASE, Scopus, and Web of Science using the following keywords: review of the literature, narrative review, title, abstract, authorship, ethics, peer review, research methods, medical writing, scientific writing, and writing standards. Opinions expressed in the review are also based on personal experience as authors, peer reviewers, and editors.
    Rheumatology International 01/2011;
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    ABSTRACT: Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study
    Rheumatology International 01/2011;
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    ABSTRACT: We proposed to assess antioxidant status and nitric oxide in fibromyalgia (FM) patients in comparison to healthy controls. Additionally, the association between the serum antioxidant levels and clinical findings in FM patients was also investigated. Thirty-seven FM patients and 37 healthy controls were enrolled in this study. Severity of fatigue and pain were determined by Visual Analogue Scale. Functional capacity in daily living activities was evaluated by fibromyalgia impact questionnaire. Serum NO, catalase and glutathione were measured. Serum glutathione and catalase levels were significantly lower in FM patients than controls. However, no significant difference was seen in serum NO levels between the two groups. A significant correlation was evident between serum NO level and pain. Additionally, the correlation between glutathione level and morning stiffness was found to be significant. These findings support other studies, we assume that these two antioxidants might have impact on the pathogenesis of FM disease.
    Rheumatology International 03/2009; 29(6):629-633.
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    ABSTRACT: We described a pilot study using Video capsule endoscopy (VCE) aiming the assessment of small bowel in Behçet’s disease (BD). Ten patients with BD and abdominal complaints underwent VCE with Given Pillcam SB (Given Imaging Ltd., Yoqneam). VCE revealed small bowel lesions in all ten subjects. Five patients had active symptoms of BD while five others had clinically inactive disease. Jejune was the most frequently affected GI segment being involved in eight cases, four from each group. We suggest that small bowel involvement may be frequent in BD patients, even in the absence of oral ulcerations.
    Rheumatology International 02/2009; 29(5):601-603.
  • [show abstract] [hide abstract]
    ABSTRACT: Uveitis is reported in vanishingly small numbers in gout. This case with bilateral uveitis, increased intraocular pressure and blurred disc margins may unravel strange ocular complications of the disease and arise awareness of gout while prescribing diuretics and cyclosporine in patients with uveitis and increased intraocular pressure.
    Rheumatology International 01/2009; 29(5):557-559.
  • [show abstract] [hide abstract]
    ABSTRACT: Shared epitope (SE) and anti-cyclic citrullinated peptide (CCP) antibody are known to be associated with rheumatoid arthritis (RA). The authors investigated their adjusted effects on RA from Korean population. Clinical features were evaluated in 226 RA patients; 164 healthy controls were enrolled. HLA-DRB1 typing for SE was done by polymerase chain reaction. Anti-CCP antibody levels were determined by enzyme linked immunosorbent assay. Logistic regression analysis method was used for adjusted effects. SE and anti-CCP antibody were associated with RA susceptibility. Anti-CCP antibody was associated with RA susceptibility independent of SE [odds ratio, OR 179.9 (95% confidence interval, CI 40.8–792.2), P<0.001]. Anti-CCP antibody was associated with radiographic erosive changes independent of SE or rheumatoid factor [OR 3.9 (95% CI 1.1–13.3), P=0.032]. Anti-CCP antibody was strongly associated with RA susceptibility and radiographic erosion of RA patients, independent of SE in Korean.
    Rheumatology International 12/2008; 29(3):251-256.
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    ABSTRACT: Osteoporosis associated with pregnancy and lactation is a rare condition. The prevalence, etiology and its pathogenesis is unknown. It causes one or more vertebral fractures with severe, prolonged back pain and height loss in affected women. Majority of the cases are seen in the third trimester or just after delivery in primagravid women. In this case report, a 30-year-old woman who had severe pregnancy-induced osteoporosis with 8 vertebral fractures was presented. During last month of her first pregnancy she had moderate back pain. After delivery, the back pain has gotten worse. The radiological examinations have shown that there was 50% in T6, T8 and T10; 30% in L2; 20% in L1 height loss and biconcave vertebral images in L3-5. In the bone mineral density, L2-4 T score was -4.7 and total femoral T score was -3.1. There was no abnormality in the laboratory findings except mild elevation in alkaline phosphates. Although pregnancy-associated osteoporosis is a rare condition, when pain occurs in the last trimester or early postpartum period, it should be considered in differential diagnosis.
    Rheumatology International 12/2008; 29(2):197-201.
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    ABSTRACT: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by a combination of arterial or venous thrombosis and recurrent fetal loss, accompanied by elevated titers of antiphospholipid antibodies (aPL). Catastrophic antiphospholipid syndrome (CAPS) is a small subset of APS characterized by widespread systemic thrombotic disease with multiorgan failure. We herein describe an autopsy case of CAPS who developed severe respiratory failure due to acute respiratory distress syndrome (ARDS) as the initial manifestation. Patients with APS may exhibit a broad spectrum of pulmonary diseases. ARDS is the common pulmonary complication in CAPS, although it rarely occurs in APS. Some mechanisms of ARDS in CAPS have been postulated but the precise mechanism is still not clearly understood. It is important to understand that APS or CAPS could be a cause of ARDS since ARDS might develop as the initial manifestation of APS or CAPS as seen in our case. Our case is interesting in that severe respiratory failure due to ARDS was the initial presentation of CAPS.
    Rheumatology International 12/2008; 29(2):211-6.
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    ABSTRACT: The concept of remission in rheumatology is complicated by the lack of a single gold standard measurement, spontaneous remissions and the usage of several sets of remission criteria. Feasibility is reduced by traditional clinical practice, which does not include remission criteria monitoring. The “window of opportunity” to prevent joint damage with DMARD therapy lasts only a few months. The perspective of the physician and patient differ, as the former gives importance to signs of disease activity, whereas the latter to disability and quality of life. All patients with rheumatoid arthritis are candidates for combination DMARD-based therapy, which should be instituted without delay. Remission is important to prevent joint destruction, preserve adequate quality of life and prevent disability. The introduction of biological agents has made this objective feasible, but the failure rate is still high (about 50%), on account of lack of response, contraindications and intolerance.
    Rheumatology International 11/2008; 29(2):131-139.
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    ABSTRACT: On the 24th of October 2006, the European Medicines Agency (EMEA) stated that "it cannot be excluded that non-selective non-steroidal anti-inflammatory drugs (nsNSAIDs) may be associated with a small increase in the absolute risk for thrombotic events". Reviewing the most recent literature including meta-analyses of randomized clinical studies and pharmacoepidemiological studies show that this statement contrasts with the 2005 EMEA evaluation of cyclooxygenase-2 inhibitors, which contained a number of regulations including several contraindications for coxibs. Recent clinical data indicate that the entire substance group of NSAIDs may have cardiovascular side effects but to different degrees. Results of basic research support these observations showing that the increase for cardiovascular risk not only depends on the ratio of inhibition of thromboxan and prostacyclin but also on other mechanisms including blood pressure elevation and cyclooxygenase independent actions. In clinical practice, many patients require anti-inflammatory therapy with NSAIDs but are at high cardiovascular and gastrointestinal risk. The combination of nsNSAIDs with proton pump inhibitors shows comparable safety to coxibs in averting upper gastrointestinal events, but evidence is increasing coxibs have advantages regarding lower gastrointestinal side effects. Concomitant therapy with aspirin is another issue. There is a negative effect on gastrointestinal safety, as well as the influence of nsNSAIDs on the cardioprotective effect of aspirin. As the contraindications for coxibs announced by the EMEA may prevent some patients from receiving optimal treatment, a warning for the entire substance group, as issued by the American Food and Drug Administration, with no contraindictions, would certainly be more reasonable.
    Rheumatology International 11/2008; 28(12):1187-95.
  • [show abstract] [hide abstract]
    ABSTRACT: We studied causes of death (CoDs) between 1952 and 1991 assessed by a clinician before autopsy and then determined at autopsy by a pathologist in 369 subjects with rheumatoid arthritis (RA) and 370 subjects without RA (non-RA). We analysed clinical data for RA subjects between 1973 and 1991. In RA subjects, leading autopsy-based CoDs were RA, cardiovascular diseases and infections. Between diagnoses of CoDs by the clinician and those determined by the pathologist, RA subjects had lower agreement than did the non-RA regarding coronary deaths (Kappa reliability measure: 0.33 vs. 0.46). In non-RA subjects, autopsy-based coronary deaths showed a decline since the 1970s with no such decline in RA. Between subjects treated at any time during RA with disease-modifying anti-rheumatic drugs and those without, autopsy-based CoDs were similar. Coronary death being less accurately diagnosed in RA subjects may indicate that coronary heart disease in RA patients often remains unrecognized.
    Rheumatology International 11/2008; 28(12):1245-52.

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