Trends in Genetics (TRENDS GENET)

Publisher: Elsevier

Journal description

Now the highest-cited journal in Genetics. (ISI/SCI Journal Citation Reports 11.313.1998). Multi-faceted and highly-cited, from developmental biology to genomics. Each monthly issue contains concise, lively and up-to-date Reviews as well as a section for Comment on the latest developments, a journal monitoring feature, Genetwork (a column about Internet resources), Meeting Reports, and Book, Software and CD-ROM reviews, and new in 98 - genetics and society. Most articles are commissioned, and all review articles are peer-reviewed. Trends in Genetics' prestigious Editorial Board attests to the journal's established reputation as essential reading for all those interested in the molecular themes of genetics, differentiation and development. Trends in Genetics' readers use the journal to keep up with the latest developments in both their own and related fields, and as a valuable resource for teaching.

Current impact factor: 9.92

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 9.918
2013 Impact Factor 11.597
2012 Impact Factor 9.772
2011 Impact Factor 10.064
2010 Impact Factor 11.364
2009 Impact Factor 8.689
2008 Impact Factor 8.659
2007 Impact Factor 9.729
2006 Impact Factor 9.95
2005 Impact Factor 12.047
2004 Impact Factor 14.643
2003 Impact Factor 12.016
2002 Impact Factor 13.216
2001 Impact Factor 12.417
2000 Impact Factor 12.912
1999 Impact Factor 16.342
1998 Impact Factor 11.313
1997 Impact Factor 9.978
1996 Impact Factor 10.781
1995 Impact Factor 10.446
1994 Impact Factor 10.11
1993 Impact Factor 9.976
1992 Impact Factor 11.497

Impact factor over time

Impact factor

Additional details

5-year impact 9.86
Cited half-life 8.90
Immediacy index 2.16
Eigenfactor 0.03
Article influence 4.82
Website Trends in Genetics website
Other titles Trends in genetics, Genetics, TIG, Trends in biochemical sciences., Trends in cell biology
ISSN 0168-9525
OCLC 11747206
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details


  • Pre-print
    • Author cannot archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • On non-commercial hosting platforms including institutional repository
    • Published source must be acknowledged
    • Must link to journal homepage with DOI
    • Publisher's version/PDF cannot be used
    • Publisher last reviewed on 05/08/2015
    • 'Elsevier (Cell Press)' is an imprint of 'Elsevier'
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.
    Trends in Genetics 11/2015; DOI:10.1016/j.tig.2015.10.004
  • [Show abstract] [Hide abstract]
    ABSTRACT: Microbial communities are complex and constitute important parts of our environment. Genomic analysis of these populations is a dynamic research area but remains limited by the difficulty in assembling full genomes of individual species. Recently, a new method for metagenome assembly/analysis based on chromosome conformation capture has emerged (meta3C). This approach quantifies the collisions experienced by DNA molecules to identify those sharing the same cellular compartments, allowing the characterization of genomes present within complex mixes of species. The exploitation of these chromosome 3D signatures holds promising perspectives for genome sequencing of discrete species in complex populations. It also has the potential to assign correctly extra-chromosomal elements, such as plasmids, mobile elements and phages, to their host cells.
    Trends in Genetics 11/2015; DOI:10.1016/j.tig.2015.10.003
  • [Show abstract] [Hide abstract]
    ABSTRACT: Eukaryotic genomes are pervasively transcribed but until recently this noncoding transcription was considered to be simply noise. Noncoding transcription units overlap with genes and genes overlap other genes, meaning genomes are extensively interleaved. Experimental interventions reveal high degrees of interdependency between these transcription units, which have been co-opted as gene regulatory mechanisms. The precise outcome depends on the relative orientation of the transcription units and whether two overlapping transcription events are contemporaneous or not, but generally involves chromatin-based changes. Thus transcription itself regulates transcription initiation or repression at many regions of the genome.
    Trends in Genetics 11/2015; DOI:10.1016/j.tig.2015.10.006
  • [Show abstract] [Hide abstract]
    ABSTRACT: Plant domestication modifies a wild species genetically for human use. Among thousands of domesticated plants, a major distinction is the difference between annual and perennial life cycles. The domestication of perennials is expected to follow different processes than annuals, with distinct genetic outcomes. Here we examine domestication from a population genetics perspective, with a focus on three issues: genetic bottlenecks during domestication, introgression as a source of local adaptation, and genetic load. These three issues have been studied nominally in major annual crops but even less extensively in perennials. Here we highlight lessons from annual plants, motivations to study these issues in perennial plants, and new approaches that may lead to further progress.
    Trends in Genetics 11/2015; DOI:10.1016/j.tig.2015.10.002
  • [Show abstract] [Hide abstract]
    ABSTRACT: Information warfare is not limited to the cyber world because it is waged within our cells as well. The unique AID (activation-induced cytidine deaminase)/APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide) family comprises proteins that alter DNA sequences by converting deoxycytidines to deoxyuridines through deamination. This C-to-U DNA editing enables them to inhibit parasitic viruses and retrotransposons by disrupting their genomic content. In addition to attacking genomic invaders, APOBECs can target their host genome, which can be beneficial by initiating processes that create antibody diversity needed for the immune system or by accelerating the rate of evolution. AID can also alter gene regulation by removing epigenetic modifications from genomic DNA. However, when uncontrolled, these powerful agents of change can threaten genome stability and eventually lead to cancer.
    Trends in Genetics 11/2015; DOI:10.1016/j.tig.2015.10.005
  • [Show abstract] [Hide abstract]
    ABSTRACT: Chemoreception is essential for survival. Feeding, mating, and avoidance of predators depend on detection of sensory cues. Drosophila contains diverse families of chemoreceptors that detect odors, tastants, pheromones, and noxious stimuli, including receptors of the odor receptor (Or), gustatory receptor (Gr), ionotropic receptor (IR), Pickpocket (Ppk), and Trp families. We consider recent progress in understanding chemoreception in the fly, including the identification of new receptors, the discovery of novel biological functions for receptors, and the localization of receptors in unexpected places. We discuss major unsolved problems and suggest areas that may be particularly ripe for future discoveries, including the roles of these receptors in driving the circuits and behaviors that are essential to the survival and reproduction of the animal.
    Trends in Genetics 10/2015; DOI:10.1016/j.tig.2015.09.005
  • [Show abstract] [Hide abstract]
    ABSTRACT: Pericentromeric DNA represents a large fraction of the mammalian genome that is usually assembled into heterochromatin. Recent advances have revealed that the composition of pericentromeric heterochromatin is surprisingly dynamic. Indeed, high levels of histone H3 trimethylation on lysine 9 (H3K9me3) and DNA methylation normally characterize the repressive environment of this region. However, in specific tissues and in cancer cells, Polycomb proteins can occupy pericentromeric heterochromatin and act as a molecular sink for transcriptional regulators. Restoring heterochromatin methylation marks could, thus, be an important way to bring back normal gene expression programs in disease. Here, I discuss the potential mechanisms by which Polycomb complexes are recruited to pericentromeric DNA.
    Trends in Genetics 10/2015; 31(11). DOI:10.1016/j.tig.2015.09.003
  • [Show abstract] [Hide abstract]
    ABSTRACT: B cell lymphomas (BCLs) are characterized by widespread deregulation of gene expression compared with their normal B cell counterparts. Recent epigenomic studies defined cis-regulatory elements (REs) whose activities are altered in BCL to drive some of these pathogenic expression changes. During transformation, multiple mechanisms are employed to alter RE activities, including perturbations in the function of chromatin modifiers, which can lead to revision of the B cell epigenome. Inherited and somatic variants also alter RE function via disruption of transcription factor (TF) binding. Aberrant expression of noncoding RNAs (ncRNAs) deregulates genes involved in B cell differentiation via direct repression and post-transcriptional targeting. These discoveries have established epigenetic etiologies for B cell transformation that are being exploited in novel therapeutic approaches.
    Trends in Genetics 10/2015; DOI:10.1016/j.tig.2015.09.006
  • [Show abstract] [Hide abstract]
    ABSTRACT: Recent scientific advances in understanding circulating tumor cells, cell-free DNA/RNA, and exosomes in blood have laid a solid foundation for the development of routine molecular 'liquid biopsies'. This approach provides non-invasive access to genetic information - somatic mutations, epigenetic changes, and differential expression - about the physiological conditions of our body and diseases. It opens a valuable avenue for future genetic studies and human disease diagnosis, including prenatal and neurodegenerative disease diagnosis, as well as for cancer screening and monitoring. With the rapid development of highly sensitive and accurate technologies such as next-generation sequencing, molecular 'liquid biopsies' will quickly become a central piece in the future of precision medicine.
    Trends in Genetics 10/2015; 31(10):564-575. DOI:10.1016/j.tig.2015.06.001
  • [Show abstract] [Hide abstract]
    ABSTRACT: Research into chromosome structure and organization is an old field that has seen some fascinating progress in recent years. Modern molecular methods that can describe the shape of chromosomes have begun to revolutionize our understanding of genome organization and the mechanisms that regulate gene activity. A picture is beginning to emerge of chromatin loops representing a widespread organizing principle of the chromatin fiber and the proteins cohesin and CCCTC-binding factor (CTCF) as key players anchoring such chromatin loops. Here we review our current understanding of the features of CTCF- and cohesin-mediated genome organization and how their evolution may have helped to shape genome structure.
    Trends in Genetics 10/2015; 31(11). DOI:10.1016/j.tig.2015.09.004
  • [Show abstract] [Hide abstract]
    ABSTRACT: Rare genetic variants may be responsible for a significant amount of the uncharacterized genetic risk underlying many diseases. An efficient approach to characterizing the disease burden of rare variants may be to impute them into existing large datasets. It is well known that the ability to impute a rare variant is dependent both on the array choice and number of individuals in the reference panel carrying that variant, although it is still unclear exactly how well imputation will work for rare variants. Here, we review the additional challenges that arise when imputing rare variants, looking at studies that have been able to impute rare variants, methods behind merging reference panels, approaches for imputing rare variants, and methods for analyzing rare variants. There have been an increasing number of success stories with regard to imputing rare variants, using different strategies such as merging reference panels.The number of sequenced individuals available for use as reference panels is increasing greatly, allowing us to better impute rarer variation.Tests that combine a group of similar rare variants (e.g., in a gene) initially intended for sequence data are being applied to imputed data, as it also begins to capture rarer variation.
    Trends in Genetics 10/2015; 31(10):556-563. DOI:10.1016/j.tig.2015.07.006
  • [Show abstract] [Hide abstract]
    ABSTRACT: The broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular signals and the DNA is the chromatin, a dynamic nucleoprotein complex that helps to mediate gene regulation. The most basic subunit of chromatin, the nucleosome, consists of DNA wrapped around histones, a set of proteins that play crucial roles as scaffolding molecules and regulators of gene expression. Growing evidence indicates that canonical histones are commonly replaced by protein variants before and during cellular transitions. We highlight exciting new results suggesting that histone variants are essential players in the control of cellular plasticity during development and in the adult nervous system. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Trends in Genetics 08/2015; 31(9). DOI:10.1016/j.tig.2015.07.005
  • [Show abstract] [Hide abstract]
    ABSTRACT: Sixty years ago, the position of a gene on a chromosome was seen to be a major determinant of gene activity; however, position effects are rarely central to current discussions of gene expression. We describe a comprehensive and simplifying view of how position in 1D sequence and 3D nuclear space underlies expression. We suggest that apparently-different regulatory motifs including enhancers, silencers, insulators, barriers, and boundaries act similarly - they are active promoters that tether target genes close to, or distant from, appropriate transcription sites or 'factories'. We also suggest that any active transcription unit regulates the firing of its neighbors - and thus can be categorized as one or other type of motif; this is consistent with expression quantitative trait loci (eQTLs) being widely dispersed. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Trends in Genetics 08/2015; 31(9). DOI:10.1016/j.tig.2015.07.001