Biomédica: revista del Instituto Nacional de Salud (BIOMEDICA)

Publisher: Instituto Nacional de Salud (Colombia)

Journal description

Current impact factor: 0.62

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 0.617
2012 Impact Factor 0.315
2011 Impact Factor 0.545
2010 Impact Factor 0.442
2009 Impact Factor 0.573

Impact factor over time

Impact factor

Additional details

5-year impact 0.56
Cited half-life 5.80
Immediacy index 0.29
Eigenfactor 0.00
Article influence 0.15
Website Biomedica website
Other titles Biomédica (Online)
ISSN 0120-4157
OCLC 61313430
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Introducción. La exposición a contaminantes como plaguicidas y metales pesados se asocia a problemas de salud. Estudios revelan la presencia de estos contaminantes en Cali, sin embargo, no existe información sobre las rutas principales de esa exposición y el riesgo que aporta cada una. Objetivo. Estimar los riesgos asociados a la ingesta de Cd, Pb, Hg, y los plaguicidas 2,4-D y Diurón por el consumo de agua potable y alimentos en un grupo poblacional de Cali. Materiales y métodos. Se obtuvieron datos poblacionales y ambientales, y se valoró el riesgo empleando los modelos de la Agencia de Protección Ambiental. Resultados. Las concentraciones de los contaminantes evaluados estuvieron debajo de los niveles permisibles por el Ministerio de Ambiente, Vivienda y Desarrollo Territorial (3 μg.L-1 Cd; 10 μg.L-1 Pb; 1 μg.L-1 Hg; 1 μg.L-12,4 D; 1 μg.L-1 Diuron). En las muestras de pescado manteco (Peprilus Snyderi), se reportó presencia de Cd, con niveles entre 20 μg.Kg-1 y 80 μg.Kg-1, por debajo del límite permisible por la Organización Mundial de la Salud (100 μg.Kg-1). Los resultados de la valoración del riesgo en salud, mostraron que el riesgo cancerígeno y no cancerígeno atribuible a la salud de la población por ingesta de alimentos y agua potable, para los contaminantes evaluados, está por debajo de los valores máximos admisibles por la Agencia de Protección Ambiental. Conclusiones. Se cree que los hallazgos de contaminantes en estudios anteriores pueden deberse a eventos puntuales de contaminación y se recomiendan monitoreos y alertas tempranas en la bocatoma de agua. El reporte de Cd en pescado sugiere un mejor control en la calidad de los alimentos por parte de las entidades reguladoras.
    Biomédica: revista del Instituto Nacional de Salud 04/2015; 35(1). DOI:10.7705/biomedica.v35i0.2464
  • Biomédica: revista del Instituto Nacional de Salud 12/2014; 34(2). DOI:10.7705/biomedica.v34i2.2384
  • Biomédica: revista del Instituto Nacional de Salud 12/2014; 34(2). DOI:10.7705/biomedica.v34i2.1851
  • [Show abstract] [Hide abstract]
    ABSTRACT: Histoplasmosis is a multifaceted condition caused by the dimorphic fungi Histoplasma capsulatum whose infective spores are inhaled and reach the lungs, the primary organ of infection. The meningeal form, considered one of the most serious manifestations of this mycosis, is usually seen in individuals with impaired cellular immunity such as patients with acquired immunodeficiency syndrome, systemic lupus erythematous or solid organ transplantation, and infants given their immunological immaturity. The most common presentation is self-limited and occurs in immunocompetent individuals who have been exposed to high concentrations of conidia and mycelia fragments of the fungi. In those people, the condition is manifested by pulmonary disorders and late dissemination to other organs and systems. We report a case of central nervous system histoplasmosis in an immunocompetent child.
    Biomédica: revista del Instituto Nacional de Salud 12/2014; 34(4):506-13. DOI:10.1590/S0120-41572014000400002
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aging of the population is a universal epidemiological phenomenon which is not unfamiliar to us and is accompanied by a marked increase of life expectancy. Age-dependent comorbidities, such as hearing disorders, are more prevalent and affect the quality of life in a noticeable manner. To estimate the prevalence of hearing disorders, of the associated factors and their impact on the quality of life of older adults in Bogota. Data was taken from the Bogotá SABE Study, which included 2,000 individuals aged =60 years in a probabilistic cross-sectional study sampled by clusters (with 81.9% coverage). We used the "hearing disorders" variable relating it to socio-demographic variables, as well as to the use of hearing aids, the self-perceived health, the comorbidities, the functionality, the cognition and the quality of life as measured with the Visual Analog Scale of the EuroQol Group (EQ-VAS). We found a prevalence of hearing disorders in 267 individuals (13.5%), of whom 15% used hearing aids. The frequency was higher in individuals aged =75 years (46.1%), in the low socioeconomic level (20.2%) and among illiterate people (19.3%, p<0.05). Regarding comorbidities, we found a higher prevalence in individuals suffering from depression (20.2%, p<0.001), and high blood pressure (15%, p<0.01). The quality of life was worse in individuals with hearing disorders, as measured with the EuroQol EQ-VAS (60.93 ± 1.38 vs. 71.75 ± 0.45, p< 0.0001), but it improved among those who used hearing aids as compared to those who did not use them (59.59 ± 1.52, p<0.01). Hearing disorders are relevant in elderly individuals and they affect their perceived quality of life in a noticeable manner. In addition, they are associated with other clinical, functional and cognitive problems. Nevertheless, the intervention with hearing aids reverses that perception.
    Biomédica: revista del Instituto Nacional de Salud 12/2014; 34(4):574-9. DOI:10.1590/S0120-41572014000400010
  • [Show abstract] [Hide abstract]
    ABSTRACT: The overall prevalence of Helicobacter pylori infection is high in Colombia; however, in the country´s Andean region, gastric cancer rates far surpass those in coastal areas. Helicobacter pylori genotypes cagA positive and vacA s1 and m1 are associated with an increased risk of gastric cancer. To compare the distribution of H. pylori genotypes associated with virulence in two regions in Colombia with opposing risk for gastric cancer. Four hundred and one gastric antral biopsies were obtained and analyzed from 401 individuals diagnosed with non-atrophic gastritis, atrophic gastritis and intestinal metaplasia: 256 came from the high-risk area cities of Tunja and Bogotá, and 145 from the low-risk area cities of Barranquilla, Santa Marta and Cartagena. Genotyping of virulence genes vacA and cagA was performed by PCR. No difference was observed in the frequency of H. pylori infection between the two areas (77.3% vs 77.9 %, p=non significant, ns). The presence of cagA was higher in the low-risk area (77.9% vs. 69.2 %, p=ns). The vacA s1 allele was also more prevalent in the low-risk area (61.8 % vs 72.0 %, p=ns). The vacA m1 allele was more prevalent in the high-risk area (57.2 % vs 42.8 %, p=ns). The cagA positive s1m1 combination was also more frequent in the low-risk area (48.9% vs 38.9%, p=ns). The differences in the risk of gastric cancer in these two geographic areas cannot be explained by differences in the prevalence of infection by H. pylori or by differences in the virulence of circulating strains.
    Biomédica: revista del Instituto Nacional de Salud 12/2014; 34(4):567-73. DOI:10.1590/S0120-41572014000400009
  • Biomédica: revista del Instituto Nacional de Salud 12/2014; 34(4):503-5. DOI:10.1590/S0120-41572014000400001
  • [Show abstract] [Hide abstract]
    ABSTRACT: The epidemiological situation of dengue has worsened over the last decade. The difficulties in preventing its transmission and the absence of a vaccine or specific treatment have made dengue a serious risk to public health, health centers and research systems at different levels. Currently, most studies on the pathogenesis of dengue infection focus on the T-cell immune response almost exclusively in secondary infections and are aimed at identifying the mechanisms involved in the development of vascular permeability and bleeding events that accompany the infection. This report describes the case of a baby girl less than 45 days of age with clinical signs of severe dengue, whose diagnosis was confirmed by reverse transcription polymerase chain reaction in post-mortem tissue samples and by the ancillary diagnostic use of immunohistochemistry, which detected viral antigens in all organs obtained at autopsy. This case highlights the importance of studying primary infections associated with severe dengue, particularly in children, who are more likely to develop the severe form of the disease without previous infection, and it further stresses the importance of a diagnosis that should not be based solely on the examination of liver tissue samples when studying the pathogenesis of the viral infection.
    Biomédica: revista del Instituto Nacional de Salud 12/2014; 34(4):514-20. DOI:10.1590/S0120-41572014000400003
  • [Show abstract] [Hide abstract]
    ABSTRACT: Tuberculosis remains a major cause of morbidity and mortality worldwide, and the extrapulmonary presentation represents up to 20% of this disease. The pericardial compromise of this disease has been estimated between 1% and 4% of diagnosed patients. This presentation may have a mortality rate as high as 90% without proper treatment and diagnosis, dropping to 12% with timely diagnosis and treatment. We present the case of a 55 year-old female patient hospitalized for two weeks with constitutional symptoms, intermittent fever, dry cough, pleuritic pain and some symptoms of heart failure. The imaging studies (chest x-rays and ultrasound), revealed bilateral pleural effusion: 300 cc on the right side, 1,000 cc on the left side, and 500 cc of pericardial effusion. Direct bacilloscopy of the pleural fluid, the pericardial fluid and the sputum were negative, as well as the C-reactive protein (CRP); however, the Löwenstein-Jensen culture of the pericardial fluid was positive for Mycobacterium tuberculosis . The result of the purified protein derivative (PPD) test showed a 23 mm swelling, and after quadruple therapy her clinical condition rapidly improved until final discharge. Tuberculous pericarditis can be considered as a rare manifestation of tuberculosis, with high morbidity and significant mortality which decrease with effective early diagnosis and treatment. Although several diagnostic criteria for tuberculous pericarditis have been suggested, a definitive diagnosis may suppose several technical challenges.
    Biomédica: revista del Instituto Nacional de Salud 12/2014; 34(4):528-34. DOI:10.1590/S0120-41572014000400005
  • [Show abstract] [Hide abstract]
    ABSTRACT: Continuous positive airway pressure (CPAP) is useful in low birth weight infants with respiratory distress, but it is not known if it is a better alternative to mechanical ventilation after early pulmonary surfactant administration. To compare the incidence of adverse events in 28 to 32-week newborns with respiratory distress managed with mechanical ventilation or CPAP after early surfactant administration. In total, 176 newborns were treated with CPAP and 147 with mechanical ventilation, all with Apgar scores >3 at five minutes and without apnea. The incidence of CPAP failure was 6.5% (95% CI: 11.3-22.8%); 29 patients died: 7 with CPAP (4.0%) and 22 with mechanical ventilation (15.0%, p<0.001). The relative risk of dying with CPAP versus mechanical ventilation was 0.27 (95% CI: 0.12-0.61), but after adjusting for confounding factors, CPAP use did not imply a higher risk of dying (RR=0.60; 95% CI: 0.29-1.24). Mechanical ventilation fatality rate was 5.70 (95% CI: 3.75-8.66) deaths/1,000 days-patient, while with CPAP it was 1.37 (95% CI: 0.65-2.88, p<0.001). Chronic lung disease incidence was lower with CPAP than with mechanical ventilation (RR=0.71; 95% CI: 0.54-0.96), as were intracranial hemorrhage (RR=0.28, 95% CI: 0.09-0.84) and sepsis (RR=0.67; 95%CI: 0.52-0.86), and it was similar for air leaks (RR=2.51; 95% CI: 0.83-7.61) and necrotizing enterocolitis (RR=1.68, 95% CI: 0.59-4.81). CPAP exposure of premature infants with respiratory distress syndrome is protective against chronic lung disease, intraventricular hemorrhage and sepsis compared to mechanical ventilation. No differences were observed regarding air leak syndrome or death.
    Biomédica: revista del Instituto Nacional de Salud 12/2014; 34(4):612-23. DOI:10.1590/S0120-41572014000400015