Acta Cirurgica Brasileira Journal Impact Factor & Information
Covers current developments relating to all aspects of surgical research.
Current impact factor: 0.57
Impact Factor Rankings
|2015 Impact Factor||Available summer 2015|
|2013 / 2014 Impact Factor||0.57|
|2012 Impact Factor||0.626|
|2011 Impact Factor||0.584|
|2010 Impact Factor||0.5|
|2009 Impact Factor||0.479|
Impact factor over time
|Website||Acta Cirurgica Brasileira website|
|Other titles||Acta cirúrgica brasileira (Online)|
|Material type||Document, Periodical, Internet resource|
|Document type||Internet Resource, Computer File, Journal / Magazine / Newspaper|
Publications in this journal
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ABSTRACT: To evaluate the central nervous system toxicity of cisplatin and neuroprotective effect of selenium. Twenty-one male Wistar albino rats were divided into three groups: control (C), cisplatin (CS), cisplatin and selenium (CSE, n=7 in each group). Cisplatin (12 mg/kg/day, i.p.) was administered to CS and CSE groups for three days. Furthermore, CSE group received 3mg/kg/day (twice-a-day as 1.5 mg/kg) selenium via oral gavage five days before cisplatin injection and continued for 11 consecutive days. The same volumes of saline were administered to C group intraperitoneally and orally at same time. Heterochromatic and vacuolated neurons and dilated capillary vessels in the brain were observed in the histochemical examinations of cisplatin treated group. Rats that were given a dose of 3mg/kg/day selenium decreased the cisplatin induced histopathological changes in the brain, indicating a protective effect. In addition, cytoplasmic staining of the cell for bcl-2, both cytoplasmic and nuclear staining for bax were determined to be positive in the all groups. Bax positive cells were increased in the CS group compared to C group, in contrast to decreased bcl-2 positivity. Selenium limited apototic activity and histological changes due to the cisplatin related central neurotoxicity.Acta Cirurgica Brasileira 06/2015; 30(6):394-400. DOI:10.1590/S0102-865020150060000004
- Acta Cirurgica Brasileira 05/2015; May-June, 2015)..
- Acta Cirurgica Brasileira 01/2013; 28(1):01-04. DOI:10.1590/S0102-86502013000100001
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.