Journal of Endodontics Impact Factor & Information

Publisher: American Association of Endodontists; American Dental Association, Elsevier

Journal description

The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field. The Journal has an impact factor of 1.933, the highest of any journal in the specialty (2005 Journal Citation Index).

Current impact factor: 2.79

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 2.788
2012 Impact Factor 2.929
2011 Impact Factor 2.88
2010 Impact Factor 3.291
2009 Impact Factor 2.953
2008 Impact Factor 2.727
2007 Impact Factor 3.369
2006 Impact Factor 3.077
2005 Impact Factor 1.933
2004 Impact Factor 1.323
2003 Impact Factor 1.056
2002 Impact Factor 0.748
2001 Impact Factor 0.668
2000 Impact Factor 0.668
1999 Impact Factor 0.863
1998 Impact Factor 0.731
1997 Impact Factor 0.906
1996 Impact Factor 0.857
1995 Impact Factor 0.651
1994 Impact Factor 0.632
1993 Impact Factor 0.543
1992 Impact Factor 0.668

Impact factor over time

Impact factor

Additional details

5-year impact 2.87
Cited half-life 6.30
Immediacy index 0.42
Eigenfactor 0.01
Article influence 0.51
Website Journal of Endodontics website
Other titles Journal of endodontics, JOE
ISSN 0099-2399
OCLC 1705956
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Pre-print allowed on any website or open access repository
    • Voluntary deposit by author of authors post-print allowed on authors' personal website, or institutions open scholarly website including Institutional Repository, without embargo, where there is not a policy or mandate
    • Deposit due to Funding Body, Institutional and Governmental policy or mandate only allowed where separate agreement between repository and the publisher exists.
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months .
    • Set statement to accompany deposit
    • Published source must be acknowledged
    • Must link to journal home page or articles' DOI
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • NIH Authors articles will be submitted to PubMed Central after 12 months
    • Publisher last contacted on 18/10/2013
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Endogenous cannabinoid compounds are involved in many physiological processes, including bone metabolism. Cannabinoid receptor 2 (CB2) plays a role in modulating bone density, but published research results are conflicting. Furthermore, the specific role of CB2 in inflammation-induced bone resorption and craniofacial bone density has not been reported. The objective of this study was to assess the role of CB2 in dental pulp exposure-induced periapical bone loss and mandibular bone density. Adult female wild-type (WT) and CB2 homozygous knockout (KO) mice were used. Pulp exposures were created unilaterally in the mandibular first molars, and the pulp was left exposed to the oral cavity to induce periapical lesion formation. Mandibles were harvested 26 days after pulp exposure. Mandibular bone mineral density and periapical lesion volume were assessed using micro-computed tomographic imaging. Periapical lesion volume measured on the mesial root of the pulp-exposed first molar was significantly less in CB2 KO than WT mice (P < .05). No significant difference was detected between KO and WT mice in the size of the PDL space measured on the mesial root of the contralateral intact first molar. CB2 KO mice exhibited greater mandibular bone density than WT mice (P < .05). CB2 plays a role in mandibular bone metabolism. Increased bone density in CB2 KO mice may contribute to the smaller periapical lesion size observed after pulp exposure in KO compared with WT mice. Additional experiments are needed to further elucidate the function of CB2 and clinical implications of cannabinoids on bone and periapical pathosis. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 03/2015; DOI:10.1016/j.joen.2015.01.030
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    ABSTRACT: L-type calcium channel (LTCC) is a unique and important factor in several cell lineages, whereas its role in the differentiation of dental pulp stem cells (DPSCs) is not well-known. In this study, we examined the function of LTCC α1C subunit (Cav1.2) and its distal C-terminus (DCT) during the in vitro differentiation of rat DPSCs (rDPSCs). After fluorescence-activated cell sorting, rDPSCs were differentiated toward dentin sialophosphoprotein-positive odontoblasts and neural cells expressing specific neuronal markers. The inhibition of rDPSC differentiation via LTCC blocker nimodipine and Cav1.2 knockdown through short hairpin RNA was evaluated by using quantitative real-time polymerase chain reaction, Western blot, and immunofluorescence staining. Nimodipine treatment and Cav1.2 knockdown generated similar results. The number of positive calcium nodules and the protein and mRNA levels of dentin sialophosphoprotein were significantly reduced during odontogenic differentiation. The levels of microtubule-associated protein-2 and β-III-tubulin were reduced in neural differentiation. The expression of DCT decreased after odontogenic differentiation but significantly increased after neural differentiation (P < .05, n = 9). Our data showed that LTCC blocker nimodipine inhibits the odontogenic and neural differentiation of rDPSCs, and Cav1.2 is responsible for the activity of LTCC. The expression of DCT of Cav1.2 significantly changes during both odontogenic and neural differentiation. Thus, Cav1.2 of LTCC plays an essential role in differentiation of DPSCs, which might be mediated through the regulation of DCT levels in DPSCs. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 02/2015; DOI:10.1016/j.joen.2015.01.009
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this study was to compare the cutting efficiency of 3 reciprocating single-file systems used with a brushing motion in oval-shaped canals. Sixty premolars with single oval canals were selected and randomly assigned to 3 groups according to the file used in canal instrumentation: R25 Reciproc (VDW, Munich, Germany), Primary WaveOne ((Dentsply Maillefer, Ballaigues, Switzerland), and a novel prototype instrument (UFile; MicoMega, Besancon, France). Instrumentation was performed in 4 consecutive steps; according to manufacturers' instructions, 5 brushing strokes against the buccal wall with a nonworking instrument followed by another 5 and 15 brushing strokes with a working file. Cone-beam computed tomographic scans were taken after each step of preparation. Pre- and postinstrumentation images were superimposed at the apical and midroot levels and then evaluated in terms of changes in the maximum buccolingual (ΔBL) and mesiodistal dimensions (ΔMD). Instrumentation with a brushing motion resulted in the following findings. At the apical levels, no significant difference was found in ΔBL for the 3 groups (P > .05). However, ΔMD was significantly less for the Reciproc (P = .006) and UFile (P = .03) groups. At the midroot levels, the UFile group showed the highest significance in terms of ΔBL (P < .0001) but the lowest in terms of ΔMD (P = .003). ΔMD was significantly the highest for the WaveOne group at the midroot levels (P = .05). The prototype file was more efficient than the other files at the midroot levels, whereas all systems acted the same at the apical levels. The increase in the number of brushing strokes resulted in more dentinal cutting in the direction of those strokes. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 02/2015; DOI:10.1016/j.joen.2014.12.016
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this retrospective study was to determine the clinical and radiographic outcome of root-end surgery when EndoSequence BC Root Repair (ES-BCRR) was used as the root-end filling material and to identify any possible prognostic factors that may have affected the healing outcome. Clinical records and periapical radiographs were collected from patients who had undergone endodontic microsurgery between 2009 and 2013 in a private endodontic office and had a minimum 1-year follow-up. All surgical procedures were performed by a single endodontist. ES-BCRR was used as the root-end filling material in all cases. Outcome was categorized into healed, healing, and non-healing on the basis of clinical and radiographic findings. The healed and healing cases were pooled and considered as success, and non-healing cases were considered failure. For statistical analysis of the prognostic factors, the dependent variable was the dichotomous outcome (ie, success versus failure). Ninety-four patients with 113 teeth met the inclusion criteria and were included in the study. The overall success rate was 92.0%. None of the prognostic factors, including age, sex, tooth position, size of periapical radiolucency, presence of a sinus tract, preoperative symptoms, and retreatment previous to surgery, appeared to have any significant effects on the outcome (P > .05). This current study suggests that ES-BCRR is a suitable root-end filling material to be used in endodontic surgery. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 02/2015; DOI:10.1016/j.joen.2014.12.028
  • [Show abstract] [Hide abstract]
    ABSTRACT: Like other tissues in the body, the human dental pulp is equipped with a network of immune cells that can be mobilized against pathogens when they invade the tooth. Very little data, mostly obtained with classic histologic methods, have reported their quantities and relative percentages. The objective of this study was to characterize and precisely quantify immunocompetent cells in healthy human dental pulp by using fluorescence-activated cell sorting, together with identifying specific cell subsets in the leukocyte (CD45(+)) cells. Healthy human third molars were collected from 42 young patients. Dental pulps were separated from the hard tissues and prepared for flow cytometry or immunostaining analyses. CD45(+) cells represented 0.94% ± 0.65% of cells obtained from the enzymatic digestion of whole dental pulps (n = 34). CD16(+)CD14(+) granulocytes/neutrophils (50.01% ± 9.08%, n = 7) were found to represent the major subpopulation in CD45(+) cells followed by CD3(+) T lymphocytes (32.58% ± 11%, n = 17), CD14(+) monocytes (8.93% ± 5.8%, n = 7), and HLA-DR(high) Lin1(-) dendritic cells (4.51% ± 1.12%, n = 7). Minor subpopulations included CD3(-)CD56(+) natural killer cells (2.63% ± 1.15%, n = 7) and CD19(+) B lymphocytes (1.65% ± 0.89%, n = 17). We further identified cells harboring a phenotype compatible with Foxp3/CD25-expressing regulatory T lymphocytes (CD45(+)CD3(+)CD4(+)CD127(low)). Fluorescence-activated cell sorting analysis and confocal microscopy also revealed expression of HO-1 in HLA-DR(+) cells. For the first time, this study identifies and precisely quantifies the relative proportion of immunocompetent cells potentially involved in tissue homeostasis of healthy human dental pulp. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 02/2015; DOI:10.1016/j.joen.2015.01.005
  • [Show abstract] [Hide abstract]
    ABSTRACT: Beta-2 adrenergic receptor has been found within the osteoblast membrane meditating bone remodeling. Propranolol is a sympatholytic beta antagonist commonly used as long-term medication for the management of many common diseases such as hypertension. This study was performed to verify the presence of this receptor on odontoblasts in rats and, if present, to investigate its possible association with tertiary dentinogenesis. Twenty male Sprague-Dawley rats (9 weeks old) were randomly assigned to 4 groups: CP0.8 group, cavity preparation + propranolol treatment (0.8 mg/day, n = 5); CP4 group, cavity preparation + propranolol treatment (4.0 mg/day, n = 7); CON group, cavity preparation + saline treatment (0.2 mL/day, n = 5); and NT group, no treatment (n = 3). Cavity preparation was performed on the mesial aspect of the maxillary first molars bilaterally. After 2 weeks, the tertiary dentinogenesis (CP0.8, CP4, and CON) was examined by hematoxylin-eosin staining, and the localization of beta-2 adrenergic receptor (NT) was examined by immunohistochemistry. The beta-2 adrenergic receptor immunoreactivity was observed in the odontoblastic layer in normal rat molar dental pulp. The tertiary dentinogenesis beneath the prepared cavity was significantly higher in the rats receiving 2-week systemic administration of propranolol than in those without the propranolol treatment. The higher-dose treatment of propranolol (P < .001) presented more effective up-regulation of tertiary dentinogenesis than the lower-dose treatment (P < .01). These results indicate that the sympathetic nervous system decreases tertiary dentin formation via beta-2 adrenergic receptors located on rat odontoblasts. It suggests that adrenergic beta antagonist is expected to use in the treatment of inducing tertiary dentin formation to protect dental pulp. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 02/2015; DOI:10.1016/j.joen.2015.01.010
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    ABSTRACT: This controlled, single-center historic cohort study project evaluates treatment outcomes of a nonsurgical treatment approach after failed apicoectomy. The treatment outcomes of nonsurgical retreatment after a failed apicoectomy were evaluated clinically and radiographically. The study cohort consisted of teeth that had received primary root canal treatment and subsequent apicoectomy elsewhere before the patients presented with post-treatment disease. Orthograde retreatment and obturation using an apical mineral trioxide aggregate plug was performed by postgraduate students and endodontic specialists in 25 cases between 2004 and 2012. Pre-, intra-, and postoperative information and the potential effect on the retreatment outcome were evaluated and statistically analyzed using the chi-square test. Twenty-two patients with 23 teeth attended the follow-up examinations (recall rate = 92%). The follow-up periods ranged from 12 to 102 months (median = 35 months). Twenty teeth (87%) were classified as "success," and 3 teeth were considered (17%) "failure." The chi-square test confirmed that the preoperative factor "number of roots" had a statistically significant effect on treatment outcome (odds ratio = 0.08; 95% confidence interval, 0-1.76; P = .03). The factor "tooth location" was of borderline significance (odds ratio = 0.1; 95% confidence interval, 0-2.14; P = .05). The results of the present study suggest that orthograde retreatment combined with orthograde placement of an apical mineral trioxide aggregate plug is a promising long-term treatment option for teeth with postsurgical pathosis. The success rates were higher for single-rooted teeth. The use of cone-beam computed tomographic imaging in cases of inconclusive periapical radiographs is recommended to minimize the risk of misinterpretation when assessing treatment outcome. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 02/2015; DOI:10.1016/j.joen.2015.01.002
  • [Show abstract] [Hide abstract]
    ABSTRACT: An enhanced revision of the revitalization endodontic technique for immature teeth with apical periodontitis has been described. It includes the addition of collagen-hydroxyapatite scaffold to the currently practiced revascularization technique. Four cases treated in series are presented in this report, 1 case involving 2 teeth. Periapical diagnoses of immature teeth included "asymptomatic apical periodontitis," "symptomatic apical periodontitis," and "acute apical abscess." Additionally, 1 fully developed tooth that had undergone root canal treatment that failed had a periapical diagnosis of acute apical abscess. An established revascularization protocol was used for all teeth. In addition to stimulating blood clots, all teeth were filled with collagen-hydroxyapatite scaffolds. Periapical radiolucencies healed in all teeth, and diffuse radiopacity developed within the coronal portions of canal spaces. Root development with root lengthening occurred in the immature nonvital maxillary premolar that had not undergone prior treatment. The technique of adding a collagen-hydroxyapatite scaffold to the existing revitalization protocol has been described in which substantial hard tissue repair has occurred. This may leave teeth more fully developed and less likely to fracture. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 02/2015; DOI:10.1016/j.joen.2014.12.010
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    ABSTRACT: Four and a half LIM domain protein 2 (FHL2) is 1 member of the LIM-only protein family, which is a transcriptional cofactor, playing important roles in osteoblast differentiation and bone formation. Our previous studies showed that the FHL2 protein was abundantly expressed in odontoblasts both during tooth development and in mature teeth, indicating that FHL2 might play a role in odontoblast differentiation and dentin formation. The aim of this study was to investigate the effects of FHL2 overexpression on odontoblast differentiation and mineralization of human dental pulp cells (hDPCs), exploring the function of FHL2 on dentin formation. FHL2 was steadily transfected into hDPCs. Then, alkaline phosphatase activity assay was shown; the formation of mineralized nodules was assessed by alizarin red staining; and the expression of odontoblast differentiation and mineralization-related molecules including alkaline phosphate (ALP), dentin sialoprotein (DSP), bone sialoprotein (BSP), and osteopontin (OPN) at messenger RNA and protein levels were determined by quantitative real-time polymerase chain reaction and Western blot analysis. It was found that FHL2 overexpression could increase ALP activity and the formation of mineralized nodules of dental pulp cells. Moreover, FHL2 overexpression could up-regulate the expression of ALP, DSP, BSP, and OPN messenger RNA and protein levels significantly. FHL2 overexpression could enhance the differentiation and mineralization of hDPCs. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 02/2015; DOI:10.1016/j.joen.2014.12.005
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to compare the efficacy of the Nd:YAG laser, ultrasound, the ProTaper Universal system (Dentsply Maillefer, Ballaigues, Switzerland), and the CanalBrush (Coltene Whaledent, Langenau, Germany) methods for the removal of the smear layer from the apical third of root canals.
    Journal of Endodontics 01/2015; 41(3). DOI:10.1016/j.joen.2014.11.004
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to evaluate in vitro a new protocol for removing intraradicular retainers from multirooted teeth applying ultrasonic vibration.
    Journal of Endodontics 01/2015; 41(3). DOI:10.1016/j.joen.2014.11.014
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    ABSTRACT: Pulpal reactions after acute dental injury have been puzzling for many clinicians. The management of dental trauma and an understanding of clinical and treatment factors in outcomes arose from multivariate statistical analyses of archive material from Copenhagen. The aim of this article was to review the works of this period with respect to pulpal reaction after acute mechanical trauma. These traumas include luxation, avulsion, root fracture, and crown fracture. A PubMed search identified other literature where multivariate analysis was used, and these results were compared with earlier pioneering studies. This article will describe pulpal responses after the said acute injuries and outline the competition that takes place between ingrowth of a new neurovascular system into the traumatized tissue versus bacterial invasion. If there is an intact neurovascular supply to the pulp, then the same immunologic defenses that are found in the rest of the body can function and defend against infection. If this is disturbed in any way, alterations in the pulp (eg, pulp canal obliteration, resorption processes) or pulp death (pulp necrosis) will occur. Intermediary stations in pulpal response (ie, transient apical breakdown) mimicked the cardinal signs of pulp necrosis, which could be reversible and lead to pulpal healing. These processes will also be addressed with respect to a more conservative treatment approach. In young patients, it is of the utmost importance that pulp vitality be maintained to ensure continued root growth and development and an intact dentition. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 01/2015; 41(3). DOI:10.1016/j.joen.2014.11.015