Journal of Endodontics (J ENDODONT )

Publisher: American Association of Endodontists; American Dental Association, Elsevier

Journal description

The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field. The Journal has an impact factor of 1.933, the highest of any journal in the specialty (2005 Journal Citation Index).

Current impact factor: 2.79

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 2.788
2012 Impact Factor 2.929
2011 Impact Factor 2.88
2010 Impact Factor 3.291
2009 Impact Factor 2.953
2008 Impact Factor 2.727
2007 Impact Factor 3.369
2006 Impact Factor 3.077
2005 Impact Factor 1.933
2004 Impact Factor 1.323
2003 Impact Factor 1.056
2002 Impact Factor 0.748
2001 Impact Factor 0.668
2000 Impact Factor 0.668
1999 Impact Factor 0.863
1998 Impact Factor 0.731
1997 Impact Factor 0.906
1996 Impact Factor 0.857
1995 Impact Factor 0.651
1994 Impact Factor 0.632
1993 Impact Factor 0.543
1992 Impact Factor 0.668

Impact factor over time

Impact factor

Additional details

5-year impact 2.87
Cited half-life 6.30
Immediacy index 0.42
Eigenfactor 0.01
Article influence 0.51
Website Journal of Endodontics website
Other titles Journal of endodontics, JOE
ISSN 0099-2399
OCLC 1705956
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Pre-print allowed on any website or open access repository
    • Voluntary deposit by author of authors post-print allowed on authors' personal website, or institutions open scholarly website including Institutional Repository, without embargo, where there is not a policy or mandate
    • Deposit due to Funding Body, Institutional and Governmental policy or mandate only allowed where separate agreement between repository and the publisher exists.
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months .
    • Set statement to accompany deposit
    • Published source must be acknowledged
    • Must link to journal home page or articles' DOI
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • NIH Authors articles will be submitted to PubMed Central after 12 months
    • Publisher last contacted on 18/10/2013
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Four and a half LIM domain protein 2 (FHL2) is 1 member of the LIM-only protein family, which is a transcriptional cofactor, playing important roles in osteoblast differentiation and bone formation. Our previous studies showed that the FHL2 protein was abundantly expressed in odontoblasts both during tooth development and in mature teeth, indicating that FHL2 might play a role in odontoblast differentiation and dentin formation. The aim of this study was to investigate the effects of FHL2 overexpression on odontoblast differentiation and mineralization of human dental pulp cells (hDPCs), exploring the function of FHL2 on dentin formation. FHL2 was steadily transfected into hDPCs. Then, alkaline phosphatase activity assay was shown; the formation of mineralized nodules was assessed by alizarin red staining; and the expression of odontoblast differentiation and mineralization-related molecules including alkaline phosphate (ALP), dentin sialoprotein (DSP), bone sialoprotein (BSP), and osteopontin (OPN) at messenger RNA and protein levels were determined by quantitative real-time polymerase chain reaction and Western blot analysis. It was found that FHL2 overexpression could increase ALP activity and the formation of mineralized nodules of dental pulp cells. Moreover, FHL2 overexpression could up-regulate the expression of ALP, DSP, BSP, and OPN messenger RNA and protein levels significantly. FHL2 overexpression could enhance the differentiation and mineralization of hDPCs. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 02/2015;
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    ABSTRACT: Adseverin is an actin-severing and actin-capping protein that is primarily expressed in secretory cells, where it regulates the filamentous actin cytoskeleton during cell differentiation and exocytosis. However, little is known regarding its regulatory role in dental pulp cells (DPCs). This study examined the expression and function of adseverin in the proliferation, migration, and odontoblastic differentiation of DPCs.
    Journal of Endodontics 01/2015;
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    ABSTRACT: Leptin, an inflammation-related adipokine, and its receptor (LEPR) are expressed in human dental pulp. Dentin sialophosphoprotein (DSPP) is involved in dentinogenesis and the dental pulp reparative response. The cell type expressing LEPR in dental human pulp and the resultant effect of the binding of leptin to LEPR remain unknown. This study describes the immmunohistochemical localization of LEPR and the effect of leptin on DSPP expression in human dental pulp.
    Journal of Endodontics 01/2015;
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    ABSTRACT: The purpose of this study was to compare the torsion and bending properties of OneShape (OS; Micro Mega, Besançon, France) and WaveOne (WO; Dentsply Maillefer, Ballaigues, Switzerland) single-file systems. The torsional strength of OS size #25, 0.06 taper and WO primary size #25, 0.08 taper was measured by using a torsiometer after fixing the apical 5 mm of the instrument rigidly. A scanning electron microscope was used to characterize the topographic features of the fracture surfaces of broken files. The files were tested for bending resistance by using the cantilever bending test. Data were statistically analyzed using the independent t test. Statistical significance level was set at P < .05. WO had a significantly higher torsional resistance than OS (P < .001). The average bending resistance as measured by the maximum force (gf) to bend instruments revealed that the WO had a significantly lower resistance to bend than OS (P < .001). Scanning electron microscopic analysis of the fractured cross-sectional surfaces revealed typical features of torsional failure including skewed dimples near the center of the fracture surface and circular abrasion streaks. The WO single-file system showed higher torsional resistance and flexibility than the OS single-file system. Different cross-sectional geometry and the alloy from which the instrument is manufactured could have significant influence on the torsional resistance and flexibility of the instruments. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 12/2014;
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    ABSTRACT: INTRODUCTION: A growing body of evidence supports the regeneration potential of dental tissues after regenerative endodontic treatment (RET). Nevertheless, a standard method for the evaluation of RET outcome is lacking. The aim of this study was to develop a standardized quantitative method for RET outcome analysis based on cone-beam computed tomographic (CBCT) volumetric measurements. METHODS: Five human teeth embedded in mandibular bone samples were scanned using both an Accuitomo 170 CBCT machine (Morita, Kyoto, Japan) and a SkyScan 1174 micro-computed tomographic (μCT) system (SkyScan, Antwerp, Belgium). For subsequent clinical application, clinical data and low-dose CBCT scans (preoperatively and follow-up) from 5 immature permanent teeth treated with RET were retrieved. In vitro and clinical 3-dimensional image data sets were imported into a dedicated software tool. Two segmentation steps were applied to extract the teeth of interest from the surrounding tissue (livewire) and to separate tooth hard tissue and root canal space (level set methods). In vitro and clinical volumetric measurements were assessed separately for differences using Wilcoxon matched pairs test. Pearson correlation analysis and Bland-Altman plots were used to evaluate the relation and agreement between the segmented CBCT and μCT volumes. RESULTS: The results showed no statistical differences and strong agreement between CBCT and μCT volumetric measurements. Volumetric comparison of the root hard tissue showed significant hard tissue formation. (The mean volume of newly formed hard tissue was 27.9 [±10.5] mm3 [P < .05]). CONCLUSIONS: Analysis of 3-dimensional data for teeth treated with RET offers valuable insights into the treatment outcome and patterns of hard tissue formation.
    Journal of Endodontics 12/2014;
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    ABSTRACT: A supernumerary tooth is an additional entity to the normal series of teeth that may occur in isolation or may be fused to a normal counterpart. Diagnosis and delineation of an accurate treatment plan in cases involving supernumerary teeth are often a challenge. This report describes a case of unilateral fusion of a supernumerary tooth to a maxillary permanent lateral incisor in which a conservative approach was used to reach a favorable outcome. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 12/2014;
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    ABSTRACT: Dental tissue-derived mesenchymal stem cells (MSCs) are a reliable cell source for dental tissue regeneration. However, the molecular mechanisms underlying their directed differentiation remain unclear, thus limiting their use. Trimethylation of lysine 4 of histone H3 (H3K4Me3) correlates with gene activation and osteogenic differentiation. We used stem cells from apical papilla (SCAPs) to investigate the effects of genomic changes in H3K4Me3 modification at gene promoter regions on MSC osteogenic differentiation. ChIP-on-chip assays were applied to compare the H3K4Me3 profiles at gene promoter regions of undifferentiated and differentiated SCAPs. Alkaline phosphatase activity assay, alizarin red staining, quantitative analysis of calcium, the expressions of osteogenesis-related genes, and transplantation in nude mice were used to investigate the osteogenic differentiation potentials of SCAPs. In differentiated SCAPs, 119 gene promoters exhibited >2-fold increases of H3K4Me3; in contrast, the promoter regions of 21 genes exhibited >2-fold decreases of H3K4Me3. On the basis of enriched H3K4Me3 and up-regulated gene expression on the osteogenic differentiation of SCAPs, WDR63 may be a potential regulator for mediating SCAP osteogenic differentiation. Through gain-of-function and loss-of-function studies, we discovered that WDR63 enhances alkaline phosphatase activity, mineralization, and the expression of BSP, OSX, and RUNX2 in vitro. In addition, transplant experiments in nude mice confirmed that SCAP osteogenesis is triggered by activated WDR63. These results indicate that WDR63 is a positive enhancer for SCAP osteogenic differentiation and suggest that activation of WDR63 signaling might improve tissue regeneration mediated by MSCs of dental origin. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 12/2014;
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    ABSTRACT: Sphingosine-1-phosphate receptor 1 (S1P1) is crucial for regulation of immunity and bone metabolism. This study aimed to investigate the expression of S1P1 in rat periapical lesions and its relationship with receptor activator of nuclear factor kappa B ligand (RANKL) and regulatory T (Treg) cells. Periapical lesions were induced by pulp exposure in the first lower molars of 55 Wistar rats. Thirty rats were killed on days 0, 7, 14, 21, 28, and 35, and their mandibles were harvested for x-ray imaging, micro-computed tomography scanning, histologic observation, immunohistochemistry, enzyme histochemistry, and double immunofluorescence analysis. The remaining 25 rats were killed on days 0, 14, 21, 28, and 35, and mandibles were harvested for flow cytometry. The volume and area of the periapical lesions increased from day 0 to day 21 and then remained comparably stable after day 28. S1P1-positive cells were observed in the inflammatory periapical regions; the number of S1P1-positive cells peaked at day 14 and then decreased from day 21 to day 35. The distribution of S1P1-positive cells was positively correlated with the dynamics of RANKL-positive cells but was negatively correlated with that of Treg cells. S1P1 expression was differentially correlated with RANKL and Treg cell infiltration in the periapical lesions and is therefore a contributing factor to the pathogenesis of such lesions. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 12/2014;
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    ABSTRACT: Guided tissue regeneration is a valuable technique available to the endodontist because the quality, quantity, or extent of bone loss cannot be visualized by the surgeon until the tissue is reflected and the surgical site is exposed. After repeated attempts at nonsurgical treatment, a patient with a recurring sinus tract over the distobuccal root of an upper molar ultimately had the distobuccal root resected, leaving a 10 × 10 mm bony defect. This dehiscence was filled with freeze-dried bone and covered with a flexible and absorbable bioactive membrane that was new to endodontics. Healing was uneventful, and bone regeneration was rapid and extensive as observed at the time of a second surgery just 5 months later. This can be attributed at least in part to the use of the bioactive membrane that contains an array of growth factors that enhance cell proliferation, inflammation, recruitment of progenitor cells, and metalloproteinase activity. The use of the bioactive membrane in endodontic surgery should be considered to best restore the attachment apparatus to the tooth and prevent the downgrowth of a long junctional epithelium. The endodontist's attention must not be limited to the apical region alone. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 12/2014;
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    ABSTRACT: We compared the apical extrusion of sodium hypochlorite delivered with a 27-G needle, self-adjusting file (SAF), passive ultrasonic irrigation, or the EndoVac system (SybronEndo, Orange, CA) during the instrumentation and final irrigation of root canals. Matched paired single-canal teeth were divided into 8 groups. The experimental groups were needle irrigation size #30 (NI30) and #50 (NI50), SAF size #30 (SAF30) and #50 (SAF50), passive ultrasonic irrigation size #30 (PUI30) and #50 (PUI50), and EndoVac size #30 (EV30) and #50 (EV50). Teeth were embedded in 0.2% agarose gel (pH = 7.4) containing 1 mL 0.1% m-Cresol purple (Sigma-Aldrich, St Louis, MO), which changes color at a pH level of 9.0. Root canals were irrigated with sodium hypochlorite and EDTA using 4 different techniques, and the amount of irrigant was controlled. Standardized digital photographs were taken 20 minutes after the first irrigant was used and were analyzed to determine the amount of extrusion (expressed as a percentage of total pixels). The amounts of apical extrusion obtained in the NI30, NI50, SAF30, SAF50, PUI30, PUI50, EV30, and EV50 groups were 30% (3/10), 50% (5/10), 20% (2/10), 70% (7/10), 40% (4/10), 40% (4/10), 10% (1/10), and 10% (1/10), respectively. The overall extrusion frequency, regardless of the apical preparation size, was 40% (8/20) for needle, 45% (9/20) for SAF, 40% (8/20) for ultrasonic irrigation, and 10% (2/20) for EndoVac. Although the SAF group showed more extrusion, the percentage of pixels was significantly higher in the needle irrigation group (P < .01). The EndoVac group showed significantly lower extrusion values than the other techniques in terms of the number of teeth and pixels (P < .05 and P < .01, respectively). The risk of apical extrusion is significantly lower with the EndoVac in comparison with the 3 other techniques. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 12/2014;
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    ABSTRACT: The aim of this study was to compare the incidence of root cracks after root canal instrumentation with the TF Adaptive, WaveOne, ProTaper Next, and ProTaper Universal systems. Seventy-five extracted mandibular central incisors with mature apices and straight root canals (<5°) were selected and kept in distilled water. The root canals were instrumented by using the ProTaper Universal, ProTaper Next, WaveOne, and TF Adaptive systems. All the roots were horizontally sectioned 3, 6, and 9 mm from the apex with a low-speed saw under water cooling. The slices were then viewed through a stereomicroscope at ×25 magnification. The samples were photographed with a camera to determine the presence of dentinal cracks. The control group had no cracks, and the difference between the control group and the experimental groups was statistically significant (P < .001). The ProTaper Next and TF Adaptive systems produced significantly less cracks than the ProTaper Universal and WaveOne systems in the apical section (3 mm) (P < .05). Under the study conditions and within the limitations of this study, it can be concluded that the ProTaper Universal, ProTaper Next, WaveOne, and TF Adaptive instruments can result in dentinal cracks. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
    Journal of Endodontics 12/2014;