The Medical journal of Cairo University

Publisher: Jāmiʻat al-Qāhirah. Kullīyat al-Ṭibb al-Bayṭarī


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    Majallah al-ṭibbīyah li-Jāmiʻat al-Qāhirah, Majallah al-ṭibbīyah li-Jāmiʻat al-Qāhirah
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Publications in this journal

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    ABSTRACT: Introduction: Multiple myeloma (MM) is a malignant neoplasm of plasma cells accounting for approximately 10% of all hematologic cancers. Aim: To report the experience of the Egyptian National Cancer Institute (ENCI) and Zagazig University Hospital in managing multiple myeloma. Methods: This retrospective study involved 53 patients diagnosed with active multiple myeloma between 2002-2007 in the Medical Oncology department at the National Cancer Institute, Cairo University and Internal Medicine Department, Faculty of Medicine, Zagazig University Hospital. Results: The median age of patients is 57 years. The majority of patients are below 60 yrs (69.8%), and there is male predominance (71.7%). Baseline investigations revealed anemia (Hb ≤10 gm/dl) in 49.1%, impaired renal function (serum Creatinine > 1.4mg/dl) in 17%, hypercalcemia (serum calcium> 11mg) in 28.3%, and ISS stage III (B2-microglobulin ≥5.5mg) in 34%. The induction treatment protocols used were VAD in 73.6%, and melphlan & steroids (MP) in 9.4%. PFS of multiple myeloma patient at 6 months and one year OS of patients of the study and correlation to different prognostic factors revealed significant correlation to age (p=0.003), serum calcium (p=0.009), and serum Creatinine (p 0.006). V.A.D had significantly better outcome MP protocol or best supportive care (p 0.001). Conclusions: Multiple myeloma is a sensitive incurable disease with traditional treatment protocols, with age, baseline creatinine and serum calcium among the major prognostic variables. Key words: Egyptian Multiple Myeloma, Prognostics, Treatment, Survival.
    The Medical journal of Cairo University 06/2014; 82(2):211-216.
  • The Medical journal of Cairo University 04/2014;
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    ABSTRACT: Aim of the study: To investigate the hazardous of exposure to Incense smoke on health;effect of Date palm pollen (DPP) on health and the possible protective or therapeutic role of DPP against the Incense smoke hazard effects after 14 days. Results: Incense smoke can cause a variety of health effects. The exposure of mice to Incense smoke (15 min/day) for 14 consecutive days led to significant reduction in spleen relative wt., splenocytes count and Glutathione (GSH) while the percentage of DNA fragmentation and Malonaldhyde (MDA) of mice splenocytes showed s significant increase. Additionally , the histopathological examination of liver and lung of mice showed clear granuloma in liver and acute inflammation in lung. The treatment of mice exposed to Incense smoke with DPP (i mg/kg/b.w.) for 14 consecutive days led to a significant decrease in the percentage of DNA fragmentation and MDA while it revealed a significant increase in GSH of mice splenocytes . Additionally , the histopathological examinations of DPP pre-treated mice showed marked protection in the hepatic and pulmonary tissues of mice as compared to that of incense group. The results of the present study clearly demonstrated that DPP treatment was effective in amelioration the hazard effects of Incense smoke exposure.
    The Medical journal of Cairo University 01/2014; 82(1):495-504.
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    ABSTRACT: Successful internship programs should be those in which teaching and learning are provided to help the new graduate nurse make the transition from novice to advanced beginner who can demonstrate acceptable performance and cope in real situations. The present study aimed to assess the relationship between nurse interns’ clinical competence and their satisfaction regarding internship program at King Fahd Hospital of the University (KFHU) in Kingdom of Saudi Arabia. Fifty eight respondents participated in the study. The data of the study was collected using two separate instruments developed by the researchers, first one assessed clinical competence contains two parts and the second assess satisfaction levels among nurse interns. After obtaining the subjects’ consents, the researchers distributed the questionnaires on studied tool I on hospital preceptors to assess the interns' clinical competence, they filled the questionnaire while were working in their work settings . and assessed interns' satisfaction regarding internship program by using tool II , once before the end of internship training year. Filling the questionnaire consumed about 10 – 15 minutes for each tool , the data collected during internship training year. This study cancelled the relationship between nurse interns’ clinical competence and their satisfaction regarding internship program. Highest mean score for interpersonal and communication skills dimension, followed by managerial dimension, while knowledge and psychomotor skills dimensions have the lowest mean scores . The study recommended that; Further research focused on nurse internship satisfaction for hospital and College preceptors. Moreover, further research to study the relationship between internship program and new graduates’ retention.
    The Medical journal of Cairo University 03/2013; 81(2).
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    ABSTRACT: Background: A panel of established variant single nude­ otide polymorphisms (SNPs) in patient diagnosed with type 2 diabetes mellitus (T2DM) is being evaluated within many studies compared to a non diabetic control population. These results will be used as a basis of comparison to analyze risk -conferring genotypes in T2DM to demonstrate T2DM risk associated factors. Aim of the work: This study was designed to study the most common SNPs associated with type 2 diabetes to identify genetic markers in type 2 diabetic patients attending in the outpatient clinic of National Institute of Diabetes & Endo­ crinology (NIDE). Subjects and Methods: This study was conducted on a total number of 71 subjects which were subdivided as follows: Group I: Included 49 type 2 diabetic subjects were selected from the outpatient clinic of National Institute of Diabetes and Endocrinology (NIDE), Group II: Included 22 normal healthy subjects (as controls), matching the same age and sex. In addition to the routine investigation the following SNPs genotypes were studied: (rslOOlOl3l, rs7754840, rs4402960/rs1470579, rs13266634 and rs10923931). Results: The IGF2BP2 rs4402960/rs1470579 polymor­ phism showed the highest odds ratio (OR) for type 2 diabetes group (4.714). Odds ratio of other polymorphisms ranged from 1.131 to 4.270. The logistic regression used to assess the contribution of individual SNPs to risk of type 2 diabetes showed that the IGF2BP2 rs4402960/rs 1470579 polymor­ phism showed significant risk of type 2 diabetes, p-value is less than 0.05 and this mean that we have evidence against HO (HO: coefficients=O). The other polymorphisms (WFS 1 rslOOlOl3 1, CDKAL1 rs7754840, SLC3OA8 rs13266634, NOTCH2 rs1092393 1) present withp-value which is greater than 0.05 and this mean that we have little evidence against HO, i.e. we accept HO, thus (WFS1 rslOOlOl3l, CDKAL1 rs7754840, SLC3OA8 rs 13266634, NOTCH2 rs 10923931) are showed insignificant risk of type 2 diabetes. Within positive cases to SNPs IGF2BP2 rs4402960/rs1470579, there are significant difference in triglycerides between two allele positive cases and one allele positive cases. Conclusion: It can be concluded that SNPs (IGF2BP2 rs4402960/rs1470579) one of the evaluated 5 SNPs was found to be associated with an enhanced risk of future diabetes and prediction of future disease in diabetic Egyptian patients. This finding can be used in the prediction, prevention and early detection of the disease especially if the study applied to large scale.
    The Medical journal of Cairo University 03/2013; 81(2):35-38.
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    ABSTRACT: Background: gastric cancer is the 4th most common malignancy worldwide representing 7.8 % of the total malignancies. In Egypt, it represents 1.8% of all types of cancers. Aim: to study gastric carcinoma (GC) among patients presenting to Tanta Cancer Center (TCC), Gharbiah, Egypt. Methods: A total number of 118 patients with gastric cancer registered at TCC between 2003 and 2006 were investigated. Results: The incidence of GC at Gharbiah, Egypt increased with time. The mean age was 54.9 years and there was a male predominance. Most of the cases (~55%) presented with advanced stages. The commonest site of metastasis was liver (35%). Surgery was used in 59% of cases. It was curative in 67% & palliative in 33%. Chemotherapy was used in 56% of cases. Cislatin- 5-flurouracial was the most commonly used regimen (57.5%). The median OS was 6 months. The 1-2-&-5 years OS rates were 38, 25 and 17% respectively. For patients who underwent curative surgery the 1-, 2-and 5- year DFS were 58, 38 and 13% respectively. The median DFS was 27 months for patients who received adjuvant chemotherapy. DFS was significantly better in patients who underwent curative surgery followed by adjuvant chemotherapy compared to those who did not receive it. The median PFS for patients who received palliative chemotherapy was 4 months. Conclusions: Most of patients with GC presents with advanced stage disease with a very poor survival. Measures that focus on early detection and prompt curative therapies are eagerly needed. Key Words: gastric carcinoma outcomes, Egypt
    The Medical journal of Cairo University 03/2013; 82(2):251-257.
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    ABSTRACT: The goal of the present study aimed to evaluate the prophylactic effect of Hypericum perforatum extract on amino acids neurotransmitters contents in cortex and hippocampus in memory dysfunction induced by scopalamine in adult male albino rats .The study used Memantine Hcl as a reference drug FDA approved for Alzheimer's disease treatment .Adult male albino rats werwe daily orally administered of Hypericum perforatum (350mg/ kg) and Memantine Hcl (20mg/kg) for two,four eight weeks and at the end of each interval each ra i.p. administered single dose of scopalamine (0.4mg/kg) . Scopalamine caused significant in the level of aspartic acid, glutamic acid,serine , glycine and taurine. Also scopalamine caused significant decrease in asparagine and GABA levels in cortex and hippocampus .Administration of both Hypericum perforatum and memantine caused decrease in aspartic acid, glutamic acid, taurine,glycine and serine and significant increase in cortical and hippocampal asparagine and GABA .The study demonstrate a significant neuroprotective effect of Hypericum perforatum extract mimics that of memantine against scopalamine- induced neuronal excitotoxic and cognitive impairment.
    The Medical journal of Cairo University 01/2013; 81(1):375-384..
  • The Medical journal of Cairo University 12/2012; 80(2):121-126.
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    ABSTRACT: Introduction: The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that have been damaged by oxygen radicals, thus preventing lung cancer. Objective: This work is aiming to study the relationship between the variation in the blood levels of the 8-oxoguanine DNA glycosylase (OGG1), smoking and risk of lung cancer. Material and Methods: This study included 36 patients diagnosed as bronchogenic carcinoma, divided pathologically into 30 non small cell lung cancer (NSCLC) patients and 6 small cell lung cancer (SCLC) patients, 40 non-smoker and 40 smokers’ healthy subjects, taken as control. They were subjected to medical history taking, clinical examination, chest radiography and Quantitative RT- PCR of mRNA levels of OGG1 in blood. Results: There was a non significant increase in the mean level of the OGG1 in the non smoker group compared to the cancer and smokers’ groups (p>0.5). There was a non statistical significant decrease in the mean value of the OGG1 in the NSCLC compared to that of SCLC (p>0.5). There was statis-tical highly significant decrease in the mean value of the OGG1 in cases of adenocarcinoma compared to that in cases of squamous cell carcinoma and SCLC (p<0.0001). Conclusion: The decreased in the levels of OGG1 in blood could be a risk factor for lung cancer and was associated with adenocarcinoma. A substantial fraction of lung cancer cases might result from a combination of smoking and reduced OGG1 level.
    The Medical journal of Cairo University 09/2012; 80(1):495-499.
  • The Medical journal of Cairo University 03/2012; 80(2):85-93.
  • The Medical journal of Cairo University 01/2012; 80:1-10.