Acta physiologica Polonica (Acta Physiol Pol )

Publisher: Polskie Towarzystwo Fizjologiczne; Polska Akademia Nauk. Wydział VI--Nauk Medycznych


Impact factor 0.00

  • 5-year impact
  • Cited half-life
  • Immediacy index
  • Eigenfactor
  • Article influence
  • Website
    Acta Physiologica Polonica website
  • Other titles
    Acta physiologica polonica
  • ISSN
  • OCLC
  • Material type
  • Document type
    Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: The effects of reserpine (Serpasil) and chlorpromazine (Largactil) on preoptic area (POA), supraoptic nucleus (SON) and paraventricular nucleus (PVN) of hypothalamus were studied in female rats having 4-day normal oestrus cycle. 30 rats were treated with reserpine in three doses i.e. 0.5 mg, 1.0 mg and 1.5 mg/kg body weight, whereas 20 other rats were treated with chlorpromazine in two doses i.e. 5.0 mg and 10.0 mg/Kg body weight. Gomori positive neurosecretory neurons of the hypothalamus were studied by measuring the diameters of nuclei and cells of POA, SON and PVN. When compared to controls both drugs caused a significant (p less than 0.001 to p less than 0.05) decrease in the nuclear and cell size of the neurons.
    Acta physiologica Polonica 10/2013; 32(3):239-45.
  • [Show abstract] [Hide abstract]
    ABSTRACT: No abstract prepared.
    Acta physiologica Polonica 12/1998; B30.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The central effects of pancreatic glucagon and insulin given intracerebroventriculary (i.c.v.) upon sympathetic activity in the cervical trunk and adrenal nerve were examined in Wistar Kyoto rats. Glucagon i.c.v. administration led to an increase in sympathetic nerve activity in both nerves. Insulin injected into lateral ventricle caused opposite to glucagon inhibitory influence on sympathetic discharge in the cervical trunk and adrenal nerve. This two different central effects of glucagon and insulin on sympatho-adrenal system may contribute to glycemia homesthasis.
    Acta physiologica Polonica 02/1990; 41(4-6):115-21.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The presence of hypothalamic hormones in the pituitary portal blood is regarded as the principal factor by which the hypothalamus controls pituitary secretion. In contrast to numerous investigations on hypothalamic hormone release, the regulation of the hypophysial-portal blood flow (HPBF) has been scarcely studied. Hypophysial-portal vessels were exposed according to the Worthington's method [1966]. The 10-min blood samples were collected before and during unilateral or alternative bilateral electrical stimulation of the preganglionic fibers of the superior cervical ganglia (SCG). During blood samples collection the stable systemic arterial blood pressure was maintained by a barostat. The HPBF was estimated according to the determination of the hemoglobin in samples of washed and collected blood from the cut pituitary portal vessels. The mean HPBF was 3.5 microliters/min. Electrical stimulation of SCG. did not change HPBF. This indicates that sympathetic efferents do not participate in the regulation of HPBF under conditions of stabilization of the systemic arterial blood pressure.
    Acta physiologica Polonica 02/1990; 41(1-3):53-62.
  • Acta physiologica Polonica 02/1990; 41(1-3):9-17.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Thermal responses to prazosin (0.75 mg/kg, i.v. as a bolus injection or 3 h infusion) were investigated in febrile rabbits (treated with E. coli lipopolysaccharide, PLPS) at 3 ambient temperatures (Ta) of 5, 19, 28 degrees C. The drug produced antipyresis which increased with the simultaneous drop of Ta. This antipyretic activity was accompanied by an inhibition of heat production or enhanced elimination of heat, depending on Ta. It is suggested that antipyresis produced by prazosin is mainly due to the effector part of the thermoregulatory system.
    Acta physiologica Polonica 02/1990; 41(1-3):45-52.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The effects of ketamine on the activities of the mylohyoid nerve (a branch of the Vth nerve) and of both phrenic nerves were investigated in rabbits anaesthetized with halothane, paralyzed and artificially ventilated. Intravenous administration of ketamine elicited a marked prolongation of the phrenic inspiratory discharge (without significantly affecting its amplitude) and a depression of the mylohyoid expiratory activity. An elimination of the volume-related input from the lungs ("no-inflation manoeuvre") or deflation elicited under these conditions typical apneustic pattern of breathing. The response to tracheal occlusion at peak-inspiration was "classical". We conclude that ketamine inhibits the Vth nerve motor nucleus which is not only an important component of the central inspiratory-inhibitory neurones but also a "relay station" between the vagal and the central inspiratory "off-switch" mechanisms.
    Acta physiologica Polonica 02/1990; 41(4-6):157-63.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Brainstem auditory evoked potentials (BAEPs) were elicited by binaural click stimulation and recorded from the rabbits with chronically implanted electrodes and a cannula for intracerebroventricular injection (i.c.v.). 400 BAEPs were averaged off line. The registration was carried out before and after i.c.v. injection of met-enkephalin (2.5 or 25 nmol), naloxone (20 micrograms), or i.v. injection of morphine (1.0, 2.0, 5.0 mg/kg b.w.). Enkephalin caused shortening of interpeak latency time, naloxone caused its lengthening, while the effect of morphine was not unidirectional. Enkephalin caused increase in the surface area below the negative peaks located in the range of 4.5-7.5 ms from the first positive peak, naloxone caused its decrease while the effect of morphine was also in this respect not unidirectional. It is concluded that opiate receptors are involved in the modulation of the auditory brainstem responses.
    Acta physiologica Polonica 02/1990; 41(1-3):63-70.
  • Acta physiologica Polonica 02/1990; 41(1-3):1-7.
  • Acta physiologica Polonica 02/1990; 41(4-6):105-13.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To determine the role of muscle chemoreflex in the cardiac response to static exercise the effect of the forearm muscle ischemia on systolic time intervals (STI), heart rate (HR) and blood pressure (BP) recovery following static handgrip was studied in 7 healthy men. During handgrip maintained for 4 min at 30% maximal voluntary contraction HR and BP increased significantly while duration of the pre-ejection period (PEP) and isovolumic contraction time (ICT) were shortened with a significant lowering in the ratio of PEP to the left ventricle ejection time (LVET). Occlusion of the circulation to the forearm muscles for 2 min after cessation of exercise did not prevent a rapid decline of HR or increment in PEP, ICT and PEP-to-LVET ratio while BP remained elevated for as long as blood flow to muscles was restricted. The study failed to demonstrate an appreciable effect of muscle chemoreflex on HR or myocardial contractility, suggesting that input from muscle afferents activated by metabolic stimuli induces the pressor response mainly by the peripheral vasoconstriction.
    Acta physiologica Polonica 02/1990; 41(4-6):177-84.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Activities of alanine and aspartate aminotransferase in different muscle types and in the liver of streptozotocin diabetic rats were studied 1,2 and 3 days after administering of streptozotocin. It was shown that the activity of both enzymes was elevated in the "white" layer of the vastus lateralis, in the liver and in the heart, whereas it remained unchanged in the "red" layer of the same muscle, in the soleus and the diaphragm. It is concluded that the effect of acute insulin deficiency on the aminotransferase activity in skeletal muscles depends on the muscle fiber composition and does not appear in muscles with a high oxidative potential. These results indicate that muscle fiber composition should be taken into account when evaluating the role of insulin in amino acid metabolism in the muscle.
    Acta physiologica Polonica 02/1990; 41(4-6):165-9.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the present work was to estimate the dynamics and efficiency (eta sw) of sweating, and thermoregulatory index (TI) defined as a ratio of heat loaded the body to the heat removed to the environment. In the first part of this work 22 men exercised with an intensity of 50% VO2 max. in 22 degrees C, 16 men were exposed to 40 degrees C at rest, and 9 men exercised at the level of 50% VO2 max. at 30 degrees C. In the second part, 8 men and 8 women were exposed to 40 degrees C before and after dehydration (1% of body mass, approximately), 8 men exercised at 23 degrees C before and after hyperhydration (35 ml/kg of body mass) and 22 men exercised before and after 3 months of endurance training. Body heat balance, rectal (Tre), tympanic (Tty) and mean skin (Tsk) temperatures were measured in all subjects. TI was greater during simultaneous (0.84) than during separate endo- (0.76, p less than 0.01) or exogenous (0.67, p less than 0.001) heat loads. The respective values of eta sw were 0.82; 0.57 (p less than 0.001) and 0.78 (p less than 0.001). No difference in TI was found between men and women. Dynamics of sweating was greater in men but efficiency of sweating was greater in women. Dehydration before heat exposure decreased both dynamics of sweating and TI but it increased eta sw in men. As a result Tre was greater in dehydrated (0.45 degrees C) than in normally hydrated men (0.31 degrees C, p less than 0.002). Dehydration did not affect the measured variables in women. Hyperhydration of exercising men caused an increase in TI from 0.72 to 0.82 (p less than 0.05) and in eta sw from 0.57 to 0.81 (p less than 0.01). In men exercising after endurance training the onset of sweating was shortened from 4.0 to 0.9 min (p less than 0.002). TI increased from 0.76 to 0.89 (p less than 0.001), eta sw increased from 0.57 to 0.74 (p less than 0.02) whereas Tty was lower (1.10 and 0.58 degrees C, p less than 0.001, respectively). It is concluded that dynamics and efficiency of sweating, as well as the thermoregulatory index depend on the type of heat load. Men and women tolerate dry heat equally well. Dehydration changes thermoregulatory function in men but not in women. Hyperhydration before exercise and particularly endurance training increase tolerance of endogenous heat.(ABSTRACT TRUNCATED AT 400 WORDS)
    Acta physiologica Polonica 02/1990; 41(4-6):123-45.
  • [Show abstract] [Hide abstract]
    ABSTRACT: In twenty anaesthetized and spontaneously breathing rabbits airway pressures were measured above and below the larynx during tidal respiration through the larynx. Peak inspiratory and expiratory pressures at both sites were recorded in control conditions and then compared to values obtained in the course of progressive denervation of the airways. The two methods of denervation consisted of (1) bilateral section of superior and recurrent laryngeal nerves and of the midcervical vagotomy (horizontal method); (2) right-sided sections of the three nerves followed by left-sided sections (vertical method). Motor denervation of the larynx due to RLNs neurotomy (horizontal method) produced significant increases in intratracheal pressures in both phases of the respiratory cycle. Less prominent increments in pressures were achieved on RLNs neurotomy in the vertical method. SLNs section and vagotomy had little additional effect on airway pressures. Our results indicate that unilateral laryngeal palsy poses far smaller obstruction to breathing than simultaneous bilateral denervation, and that afferent denervation of the larynx has no effect on airway pressures.
    Acta physiologica Polonica 02/1990; 41(4-6):185-93.
  • Acta physiologica Polonica 02/1990; 41(1-3):19-24.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Blood pressure, heart rate, aortic nerve activity and cervical sympathetic discharge were recorded simultaneously in 10 rabbits. Chronic recordings were made with electrodes implanted to the uncut aortic and cervical sympathetic nerves. 1. The alerting acoustic stimulus produced a short lasting decrease in sympathetic activity with a transient bradycardia. 2. In 6 out of 8 rabbits i.v. administration of naloxone chloride (100 mg/kg) diminished or abolished early inhibitory effects evoked by acoustic stimulus. 3. The sympatho-inhibitory system involved in the startling response appears to be independent of the baroreceptor inhibitory reflex and has opposite responsiveness to naloxone. 4. A decrease in efferent sympathetic activity with no accompanying change in the aortic nerve activity suggests some central resetting of the baroreceptor-sympatho-inhibitory reflex. 5. We suggest that the observed autonomic effects following an alerting stimulus are typical for a fear-anxiety drive.
    Acta physiologica Polonica 02/1990; 41(4-6):199-203.
  • Acta physiologica Polonica 02/1990; 41(1-3):33-44.
  • [Show abstract] [Hide abstract]
    ABSTRACT: We prepared insulin-liposomes using one combination of lipids including phosphatidylcholine (cholesterol) stearylamine, 7/2/1 (molar ratio). Non-sonicated liposomes (LMV) and sonicated liposomes (SUV) contained about 20% and 5% of insulin, respectively. Free insulin was removed from liposomes-associated insulin by ultracentrifugation, or ultrafiltration on Sepharose 6B column. Insulin preparations were administered parenterally and non-parenterally into male, Wistar rats with alloxan diabetes to produce the hypoglycaemia. In case of i.v. and s.c. routes of administration all preparations acted in the similar manner giving the clear hypoglycaemia after 2 h. When administered intragastrically only liposome insulin caused hypoglycaemia. In case of buccal and nasal routes of administration only SUV-insulin was effective.
    Acta physiologica Polonica 02/1990; 41(1-3):97-103.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Earlier studies from this department have demonstrated that neurones of the V-th nerve motor nucleus (NVmt) have oligosynaptic, inhibitory output to the inspiratory motoneurone pool being themselves under the influence of a polisynaptic input from vagal afferents. To check the hypothesis that NVmt is a part of the pneumotaxic mechanism, we studied the effects of pharmacological mictroblockade of the NVmt on Breuer-Hering reflexes in halothane-anaesthetized, paralyzed and artificially ventilated rabbits. Activities of NVmt neurones and phrenic nerve firing were recorded. Acid-base balance was controlled and histologic examinations were routinely performed. Expiratory activities were regularly found in NVmt. Its blockade elicited a typical apneustic breathing. During the blockade the Breuer-Hering reflexes gave "paradoxical" effects: an increase in central respiratory frequency following inflation, inspiratory apneusis in response to deflation. We conclude that the NVmt is an important component of the pneumotaxic mechanism or even the anatomical substrate of the pneumotaxic "centre".
    Acta physiologica Polonica 02/1990; 41(4-6):147-55.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The effect of disodium cromoglycate on skin wound healing and collagen formation in the wounds was studied. Disodium cromoglycate (a mast cell stabilizer) administered to the rats in a dose of 2 mg/animal was found to retard wound healing and markedly increased wound surface in all examined days (3rd, 5th, 7th, 10th, 14th day of healing). The mast cell stabilizer injected directly into wounds decreased collagen content, especially on 10th and 14th day of the healing process.
    Acta physiologica Polonica 02/1990; 41(4-6):195-8.