Progress in Cardiovascular Diseases Journal Impact Factor & Information

Publisher: WB Saunders

Journal description

Each issue of Progress in Cardiovascular Diseases comprehensively covers a single topic in the understanding and treatment of disorders of the heart and circulation. Some issues contain special articles, definitive reviews that capture the state-of-the-art in the management of particular clinical problems in cardiology. Also appearing at least twice per volume is a feature article comparing clinical trials of a single therapeutic problem of interest to cardiologists and internal medicine physicians.

Current impact factor: 2.42

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 2.418
2013 Impact Factor 2.443
2012 Impact Factor 4
2011 Impact Factor 4.931
2010 Impact Factor 4.841
2009 Impact Factor 4.246
2008 Impact Factor 4.714
2006 Impact Factor 2.492
2005 Impact Factor 2.844
2004 Impact Factor 2.676
2003 Impact Factor 2.182
2002 Impact Factor 1.821
2001 Impact Factor 2.075
2000 Impact Factor 2.375
1999 Impact Factor 3.233
1998 Impact Factor 2.13
1997 Impact Factor 3.185
1996 Impact Factor 2.396
1995 Impact Factor 1.596
1994 Impact Factor 1.538
1993 Impact Factor 2.16
1992 Impact Factor 2.4

Impact factor over time

Impact factor

Additional details

5-year impact 3.55
Cited half-life 6.10
Immediacy index 2.20
Eigenfactor 0.01
Article influence 1.30
Website Progress in Cardiovascular Diseases website
Other titles Progress in cardiovascular diseases
ISSN 0033-0620
OCLC 1624043
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

WB Saunders

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Pre-print allowed on any website or open access repository
    • Voluntary deposit by author of authors post-print allowed on institutions open scholarly website including Institutional Repository, without embargo, where there is not a policy or mandate
    • Deposit due to Funding Body, Institutional and Governmental policy or mandate only allowed where separate agreement between repository and the publisher exists.
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months
    • Set statement to accompany deposit
    • Published source must be acknowledged
    • Must link to journal home page or articles' DOI
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • NIH Authors articles will be submitted to PubMed Central after 12 months
    • Authors who are required to deposit in subject-based repositories may also use Sponsorship Option
    • Publisher last reviewed on 03/07/2015
    • 'WB Saunders' is an imprint of 'Elsevier'
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Coronary artery disease (CAD) is the leading cause of death in patients with diabetes mellitus (DM). Patients with DM and CAD undergoing revascularization with either a surgical or a percutaneous approach are at higher risk of adverse outcomes and mortality compared with non-DM patients. It is within this background that the optimal choice of revascularization is of critical importance in this high-risk population. The large FREEDOM trial randomized 1900 patients with DM and multivessel CAD to either revascularization with coronary artery by-pass graft (CABG) surgery or percutaneous coronary intervention (PCI). Compared with PCI, CABG significantly reduced the rates of death and myocardial infarction but was associated with a higher risk of stroke. In a real-world setting the decision-making process for the optimal revascularization strategy in these patients is challenging as many clinical factors may influence the decision to either pursue a surgical or a percutaneous revascularization. However, the current consensus is that CABG should be the preferred revascularization strategy in diabetic patients with extensive multivessel CAD. Copyright © 2015. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 08/2015; DOI:10.1016/j.pcad.2015.08.005
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    ABSTRACT: Atrial fibrillation (AF) is the most prevalent arrhythmia worldwide and the most common arrhythmia leading to hospitalization. Due to a substantial increase in incidence and prevalence of AF over the past few decades, it attributes to an extensive economic and public health burden. The increasing number of hospitalizations, aging population, anticoagulation management, and increasing trend for disposition to a skilled facility are drivers of the increasing cost associated with AF. There has been significant progress in AF management with the release of new oral anticoagulants, use of left atrial catheter ablation, and novel techniques for left atrial appendage closure. In this article, we aim to review the trends in epidemiology, hospitalization, and cost of AF along with its future implications on public health. Copyright © 2015. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 07/2015; DOI:10.1016/j.pcad.2015.07.002
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    ABSTRACT: Over the last several decades, radionuclide myocardial perfusion imaging (MPI) with single photon emission tomography and positron emission tomography has been a mainstay for the evaluation of patients with known or suspected coronary artery disease (CAD). More recently, technical advances in separate and complementary imaging modalities including coronary computed tomography angiography , computed tomography perfusion , cardiac magnetic resonance imaging , and contrast stress echocardiography have expanded the toolbox of diagnostic testing for cardiac patients. While the growth of available technologies has heralded an exciting era of multimodality cardiovascular imaging, coordinated and dispassionate utilization of these techniques is needed to implement the right test for the right patient at the right time, a promise of "precision medicine." In this article, we review the maturing role of MPI in the current era of multimodality cardiovascular imaging, particularly in the context of recent advances in myocardial blood flow quantitation, and as applied to the evaluation of patients with known or suspected CAD. Copyright © 2015. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 03/2015; 57(6). DOI:10.1016/j.pcad.2015.03.004
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    ABSTRACT: Until recently, our understanding of coronary artery disease (CAD) has been largely based on a purely anatomical approach as derived from the invasive angiogram. The confirmation of the diagnosis of "significant" CAD, the assessment of its extent, the risk stratification of patients, the therapeutic decisions, the definition of study end-points, and the validation of non-invasive testing, all mainly relied on "eyeballing" the angiogram, i.e. a subjective evaluation of the presence of at least 50% (or 70%) diameter stenosis.With the development of invasive, wire-based, means to quantify coronary pressure and flow with high spatial resolution, one realized that purely angiographic metrics correlated poorly with functional information. Currently, it is admitted that both anatomical and functional information is needed to define CAD and to optimize its management. In the present review, we summarize the main characteristics of invasive functional indices of ischemia and perfusion. Copyright © 2015. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 03/2015; 57(6). DOI:10.1016/j.pcad.2015.03.002
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    ABSTRACT: The worldwide impact of physical activity (PA) on health consequences has received increasing attention . At this point in time, there is little disagreement that increasing levels of PA is an important aspect of public health worldwide. The world literature on PA, exercise and fitness has also grown exponentially since the early 1990's. It is clear that there is a voluminous literature in this area of research and the exponential increase in the number of manuscripts has gained substantial momentum since the year 2000. Given the importance of PA research in regards to health outcomes, and apparent popularity of such research (based on the number of manuscripts published), one could argue that the viability and future of PA is indeed bright. However, one could also assume a different view, that although the field is popular, it is saturated and we already know what we need to know regarding the impact of PA on public health. Much of the future viability of PA research will also be dependent on funding sources available. It is also possible that the impact of PA may vary around the world, thus the "global" impact of PA research may be dependent on location. This review will discuss what we perceive as the current landscape and the future of PA research in three select areas of the world, the United States, South America and Asia.
    Progress in Cardiovascular Diseases 02/2015; 57(4):299-305. DOI:10.1016/j.pcad.2014.09.003
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    ABSTRACT: The recent FAME 2 study highlights the importance of myocardial ischemia assessment, particularly in the post-COURAGE trial era of managing patients with stable coronary artery disease. Qualitative assessment of myocardial ischemia by stress cardiovascular magnetic resonance imaging (CMR) has gained widespread clinical acceptance and utility. Despite the high diagnostic and prognostic performance of qualitative stress CMR, the ability to quantitatively assess myocardial perfusion reserve and absolute myocardial blood flow remains an important and ambitious goal for non-invasive imagers. Quantitative perfusion by stress CMR remains a research technique that has yielded progressively more encouraging results in more recent years. The ability to safely, rapidly, and precisely procure quantitative myocardial perfusion data would provide clinicians with a powerful tool that may substantially alter clinical practice and improve downstream patient outcomes and the cost effectiveness of healthcare delivery. This may also provide a surrogate endpoint for clinical trials, reducing study population sizes and costs through increased power. This review will cover emerging quantitative CMR techniques for myocardial perfusion assessment by CMR, including novel methods, such as 3-dimensional quantitative myocardial perfusion, and some of the challenges that remain before more widespread clinical adoption of these techniques may take place. Copyright © 2015. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 02/2015; 57(6). DOI:10.1016/j.pcad.2015.02.003
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    ABSTRACT: How do we define myocardial ischemia? This is an important question for clinicians and one that, while conceptually straight forward, can be practically difficult to assess. In this article we describe the various imaging methods available in cardiology to quantify myocardial ischemia. Anatomic assessments of ischemia such as angiography, while the "gold standard", have limitations. While some of these limitations can be mitigated with invasively measurements of fractional flow reserve or intravascular ultrasound, these tools have their own weaknesses. Non-invasive metabolic assessment, such as measuring glucose and fatty acid metabolism, are reliable in identifying ischemic, hibernating, or stunned myocardium but can be difficult to use clinically. Non-invasive physiologic assessment with myocardial perfusion agents with single photon emission tomography imaging and positron emission tomography (PET) with measurement of absolute myocardial flow assessment additionally have their own strengths and weaknesses. In this article we review the data behind the various cardiac modalities used in defining myocardial assessments along with their strengths, practical use, and limitations. We conclude by discussing an integrative approach of relative uptake and absolute myocardial flow using cardiac PET imaging that allows for a more accurate assessment of ischemia along with cases demonstrating various scenarios available in cardiac PET imaging. Copyright © 2015. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 02/2015; 57(6). DOI:10.1016/j.pcad.2015.02.001
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    ABSTRACT: There have been significant recent advances in single photon emission computed tomography (SPECT) and positron emission tomography (PET) hardware. Novel collimator designs, such as multi-pinhole and locally focusing collimators arranged in geometries that are optimized for cardiac imaging have been implemented to reduce imaging time and radiation dose. These new collimators have been coupled with solid state photon detectors to further improve image quality and reduce scanner size. The new SPECT scanners demonstrate up to a 7-fold increase in photon sensitivity and up to 2 times improvement in image resolution. Although PET scanners are used primarily for oncological imaging, cardiac imaging can benefit from the improved PET sensitivity of 3D systems without inter-plane septa and implementation of the time-of-flight reconstruction. Additionally, resolution recovery techniques are now implemented by all major PET vendors. These new methods improve image contrast, image resolution, and reduce image noise. Simultaneous PET/ magnetic resonance (MR) hybrid systems have been developed. Solid state detectors with avalanche photodiodes or digital silicon photomultipliers have also been utilized in PET. These new detectors allow improved image resolution, higher count rate, as well as a reduced sensitivity to electromagnetic MR fields. Copyright © 2015. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 02/2015; 57(6). DOI:10.1016/j.pcad.2015.02.002
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    ABSTRACT: In recent years, positron-emitting myocardial flow radiotracers such as (15)O-water, (13)N-ammonia and (82)Rubidium in conjunction with positron-emission-tomography (PET) are increasingly applied in clinical routine for coronary artery disease (CAD) detection, yielding high diagnostic accuracy, while providing valuable information on cardiovascular ( CV) outcome. Owing to a cyclotron dependency of (15)O-water and (13)N-ammonia, their clinical use for PET myocardial perfusion imaging was limited to a few centres. This limitation could be overcome by the increasing use of (82)Rubidium as it can be eluted from a commercially available (82)Strontium generator and, thus, is independent of a nearby cyclotron. Another and novel F-18-labeled myocardial flow radiotracer is Flurpiridaz that has attracted increasing interest due to its excellent radiotracer characteristics for perfusion and flow imaging with PET. In particular, the relatively long half-life of 109minutes of Flurpiridaz may afford a general application of this radiotracer for PET perfusion imaging comparable to technetium-99m-labeled single-photon emission computed tomography (SPECT). The ability of PET in conjunction with several radiotracers to assess myocardial blood flow (MBF) in ml/g/min at rest and during vasomotor stress has contributed to unravel pathophysiological mechanisms underlying coronary artery disease (CAD), to improve the detection and characterization of CAD burden in multivessel disease, and to provide incremental prognostic information in individuals with subclinical and clinically-manifest CAD. The concurrent evaluation of myocardial perfusion and MBF may lead to a new era of a personalized, image-guided therapy approach that may offer potential to further improve clinical outcome in CV disease patients but needing validation in large-scale clinical trials. Copyright © 2015. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 01/2015; 57(6). DOI:10.1016/j.pcad.2015.01.001
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    ABSTRACT: The quantitative assessment of myocardial blood flow (MBF) and coronary flow reserve (CFR) may be useful for the functional evaluation of coronary artery disease, allowing judgment of its severity, tracking of disease progression, and evaluation of the anti-ischemic efficacy of therapeutic strategies. Quantitative estimates of myocardial perfusion and CFR can be derived from single-photon emission computed tomography (SPECT) myocardial perfusion images by use of equipment, tracers, and techniques that are available in most nuclear cardiology laboratories. However, this method underestimates CFR, particularly at high flow rates. The recent introduction of cardiac-dedicated gamma cameras with solid-state detectors provides very fast perfusion imaging with improved resolution, allowing fast acquisition of serial dynamic images during the first pass of a flow agent. This new technology holds great promise for MBF and CFR quantification with dynamic SPECT. Future studies will clarify the effectiveness of dynamic SPECT flow imaging.
    Progress in Cardiovascular Diseases 01/2015; 57(6). DOI:10.1016/j.pcad.2014.12.007
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    ABSTRACT: The American Society of Nuclear Cardiology has recently published documents that encourage laboratories to take all the appropriate steps to greatly decrease patient radiation dose and has set the goal of 50% of all myocardial perfusion studies performed with an associated radiation exposure of 9 mSv by 2014. In the present work, a description of the major software techniques readily available to shorten procedure time and decrease injected activity are presented. Particularly new reconstruction methods and their ability to include means for resolution recovery and noise regularization are described. The use of these improved reconstruction algorithms result in a consistent reduction in acquisition time, injected activity and consequently in the radiation dose absorbed by the patient. The clinical implications to the use of these techniques are also described in terms of maintained and even improved study quality, accuracy and sensitivity for the detection of heart disease.
    Progress in Cardiovascular Diseases 12/2014; 57(6). DOI:10.1016/j.pcad.2014.12.006
  • Progress in Cardiovascular Diseases 12/2014; 57(5). DOI:10.1016/j.pcad.2014.12.004
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    ABSTRACT: The major factors determining myocardial perfusion and oxygen delivery have been elucidated over the past several decades, and this knowledge has been incorporated into the management of patients with ischemic heart disease (IHD). The basic understanding of the fluid mechanical behavior of coronary stenoses has also been translated to the cardiac catheterization laboratory where measurements of coronary pressure distal to a stenosis and coronary flow are routinely obtained. However, the role of perturbations in coronary microvascular structure and function, due to myocardial hypertrophy or coronary microvascular dysfunction, in IHD is becoming increasingly recognized. Future studies should therefore be aimed at further improving our understanding of the integrated coronary microvascular mechanisms that control coronary blood flow, and of the underlying causes and mechanisms of coronary microvascular dysfunction. This knowledge will be essential to further improve the treatment of patients with IHD. Copyright © 2014. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 12/2014; 57(5). DOI:10.1016/j.pcad.2014.12.002
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    ABSTRACT: Pharmacologic interventions are an integral component of peripheral artery disease (PAD) management, supported by high-quality clinical studies. Those affected by this potentially debilitating and life-threatening disease process often have multiple contributing conditions, such as tobacco abuse, diabetes, hypertension, and hyperlipidemia. In addition to medications aimed at improving claudication symptoms, risk factor modification and appropriate use of antiplatelet agents is essential to decreasing rates of major adverse clinical events and improving vessel patency following intervention. While lower extremity PAD is increasingly recognized as a prevalent condition, affected individuals remain undertreated with optimal pharmacotherapy. Novel approaches to treatment of PAD include stem cell therapy, which may play a beneficial role in those with minimal revascularization options but disease placing them at high risk for limb amputation. Additionally, timely initiation of optimal pharmacotherapy represents a cost-effective approach to management of this chronic condition. Copyright © 2014. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 12/2014; 57(5). DOI:10.1016/j.pcad.2014.12.001
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    ABSTRACT: Coronary blood flow closely matches to metabolic demands of heart and myocardial oxygen consumption and is conditioned by function of coronary resistance vessels. The microvascular endothelium of coronary resistance vessels is exposed to a spatially and temporally regulated input from cardiomyocytes and the haemodynamic forces of the cardiac cycle. Functional measurements of coronary pressure and flow are important approaches that provide complementary information on the function of coronary vessel function that could not be assessed by the methods utilized for the anatomic characterization of coronary disease, such as coronary angiography. The goal of this paper is to review the methodologies for assessment of coronary vascular function and haemodynamics which are utilized in research and to discuss their potential applicability in the clinical settings. Copyright © 2014. Published by Elsevier Inc.
    Progress in Cardiovascular Diseases 11/2014; 57(5). DOI:10.1016/j.pcad.2014.11.006
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    ABSTRACT: The endothelium plays a crucial role in the regulation of vascular homeostasis. Our understanding of its role in health and disease has increased dramatically since the pivotal discovery of nitric oxide more than 30 years ago. Clinical researchers utilized emerging technologies to study the vasodilator properties of the endothelium in both the coronary and peripheral circulation. Early studies established the methodologies and were able to demonstrate attenuated endothelium-dependent vasodilation in response to atherosclerosis and its risk factors. A variety of interventions can modulate endothelial function. More recent studies have established that some of these measures are independent predictors of cardiovascular outcomes. As such, peripheral measures of endothelial function are now established surrogate markers of vascular risk and have become important markers for clinical research. In this review, we will discuss a variety of measures of peripheral artery function to assess both conduit and resistance vessel function in humans.
    Progress in Cardiovascular Diseases 11/2014; 57(5). DOI:10.1016/j.pcad.2014.11.005