Pathology (Pathology )

Publisher: Royal College of Pathologists of Australasia, Taylor & Francis

Journal description

Pathology is committed to publishing peer-reviewed, original articles related to the science of pathology in its broadest sense, including chemical pathology, experimental pathology, genetics, haematology, histopathology, immunology, microbiology, molecuar pathology and morbid anatomy. Call for Papers Manuscripts to be considered for publication should be submitted to the Editor: Professor C. S. Lee, Editorial Office, Royal College of Pathologists of Australasia, Durham Hall, 207 Albion Street, Surry Hills, NSW 2010, Australia. Tel: +61 2 8356 5858; Fax: +61 2 8356 5828. All submissions will be independently judged by at least two referees. Authors should consult the ' Notes for Contributors ' before sending a manuscript.

Current impact factor: 2.62

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 2.62
2012 Impact Factor 2.657
2011 Impact Factor 2.378
2010 Impact Factor 2.168
2009 Impact Factor 2.673
2008 Impact Factor 2.324
2007 Impact Factor 1.772
2006 Impact Factor 1.643
2005 Impact Factor 1.471
2004 Impact Factor 1.26
2003 Impact Factor 1.112
2002 Impact Factor 0.88
2001 Impact Factor 0.851
2000 Impact Factor 0.994
1999 Impact Factor 0.943
1998 Impact Factor 0.494
1997 Impact Factor 0.395

Impact factor over time

Impact factor

Additional details

5-year impact 2.65
Cited half-life 5.80
Immediacy index 0.78
Eigenfactor 0.01
Article influence 0.77
Website Pathology website
Other titles Pathology (Online)
ISSN 0031-3025
OCLC 41386267
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Taylor & Francis

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Some individual journals may have policies prohibiting pre-print archiving
    • On author's personal website or departmental website immediately
    • On institutional repository or subject-based repository after either 12 months embargo for STM, Behavioural Science and Public Health Journals or 18 months embargo for SSH journals
    • Publisher's version/PDF cannot be used
    • On a non-profit server
    • Published source must be acknowledged
    • Must link to publisher version
    • Set statements to accompany deposits (see policy)
    • The publisher will deposit in on behalf of authors to a designated institutional repository including PubMed Central, where a deposit agreement exists with the repository
    • STM: Science, Technology and Medicine
    • SSH: Social Science and Humanities
    • Publisher last contacted on 25/03/2014
    • 'Taylor & Francis (Psychology Press)' is an imprint of 'Taylor & Francis'
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Summary: Since the early 2000s, Clostridium difficile has emerged as a major international pathogen. Recently, strains of C. difficile in circulation appear to be changing, with greater diversity, leading to challenges for diagnostics and surveillance. Currently molecular diagnostic methods are favoured for their high sensitivity and rapid processing times; however, a number of issues still exist with molecular tests, in particular high cost, low clinical specificity and failure to detect some variant C. difficile strains. Molecular typing methods are used to determine the continually evolving epidemiology of C. difficile infection. Typing methods including PCR ribotyping and pulsed field gel electrophoresis are currently popular in Europe and North America, respectively, while high-throughput next-generation sequencing is likely to become more widely used in years to come. This review discusses current molecular detection and typing techniques for C. difficile.
    Pathology 01/2015;
  • Pathology 12/2014; 46(7):579-80.
  • Pathology 12/2014; 46(7):655-7.
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    ABSTRACT: Large cell transformation of mycosis fungoides (MF-LCT) occurs in 20-50% of advanced MF, and is generally associated with poor prognosis, although some patients have indolent disease. We sought to identify clinicopathological prognostic factors in a large number of patients with MF-LCT.We identified patients with MF-LCT treated between 1991 and 2012 at a referral centre for cutaneous lymphoma. Clinical and pathological records, and histopathological slides were reviewed. Associations of clinicopathological variables with disease-specific survival were analysed.In 51 patients with MF-LCT, factors significantly associated with shorter survival were: age >60 years (25 versus 61 months, p = 0.01), stage III/IV (25 versus 44 months, p = 0.049), high serum lactate dehydrogenase (LDH; 24 versus 53 months, p = 0.007), absent papillary dermal involvement (8 versus 30 months, p = 0.008); follicular mucin at transformation (24 versus 42 months, p = 0.007); and the absence of fibrosis at transformation (21 versus 42 months, p = 0.03). Patients presenting with transformation at diagnosis had better survival than those who started with a small cell phenotype (p = 0.02). Age >60 years was independently associated with poorer survival (HR 5.61, 95%CI 1.17-26.8, p = 0.03), and the presence of fibrosis at transformation was independently associated with improved survival (HR 0.30, 95%CI 0.09-0.97, p = 0.045).In patients with MF-LCT, clinical features (age, stage, serum LDH) are important in assessing prognosis. Additional clinical and pathological features identified in this study may also assist in prognostic stratification. Studies of larger cohorts should be performed to validate the prognostic significance of these features.
    Pathology 12/2014; 46(7):610-6.
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    ABSTRACT: We report two compound heterozygous mutants that caused severe type I protein C (PC) deficiency in two independent Chinese families.PC antigen was determined by enzyme-linked immunosorbent assay (ELISA), and PC activity was measured by chromogenic assay. Genetic mutations were screened with polymerase chain reaction (PCR) followed by direct sequencing. PC mutants were transiently expressed in COS-7 cells for the evaluation of PC secretory activity and function. The subcellular location was visualised by immunofluorescence assay. The structural analysis of mutation was performed as well.Compound heterozygous mutations of Arg178Trp and Asp255His with reduced PC activity and antigen levels were identified in Proband 1, a 28-year-old male with deep vein thrombosis (DVT) and pulmonary embolism. The other mutations of Leu-34Pro and Thr295Ile with reduced PC activity and antigen levels were identified in Proband 2, a 19-year-old male with DVT. The PC activities with Arg178Trp, Asp255His, Leu-34Pro and Thr295Ile mutations decreased significantly. Immunofluorescence assay demonstrated that only trace amount of PC with novel Thr295Ile mutation was transported to the Golgi apparatus. Subsequent structural analysis indicated severe impairments of intracellular folding and secretion.The two rare compound heterozygous mutations could cause type I PC deficiency via impairment of secretory activity of PC.
    Pathology 12/2014; 46(7):630-5.
  • Pathology 12/2014; 46(7):660-2.
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    ABSTRACT: Although 20 century reforms in medical education and healthcare have led to an impressive doubling of human life-span, there remain many gaps and inequalities in the 21 century, as reflected by the larger disease burden in low income countries, brain drain of workforce to richer countries, the 10/90 gap in research investments, and inequalities in expenditure for laboratory diagnostic services. Compounding these are the demands of more complex health care systems, evolving roles of pathologists, and a rapidly changing environment. Climate change, urbanization and rapid global travel have led to disease emergence which impact on the pathology services. The challenges in under-resourced countries are particularly acute. International pathology organizations, while tending to focus on advances in pathology practices, should do more to address inequalities of health and challenges faced by countries-in-need. Global networks should discuss key global challenges, enhance global cooperation in capacity-building as well as advocate for strategic pathology developments in tandem with other medical disciplines, particularly where the need is greatest. Pathologists play prominent roles in academia, and can be agents of change both as individuals and through academic consortia to bring about reforms in pathology education and training, and in research-capacity strengthening of less developed countries.(Figure is included in full-text article.).
    Pathology 10/2014; 46 Suppl 2:S2-S4.
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    ABSTRACT: As potential precursor lesions of hepatocellular carcinoma (HCC), small cell changes (SCC) and large cell changes (LCC) are frequently noted. Recently, we discovered a progressive decrease in telomere length and a progressive increase in proliferative activity as normal looking cirrhotic hepatocytes transitioned towards LCC, SCC, and HCC. Cell cycle checkpoint markers, p21, p27, and p16, were decreased in SCC and absent in HCC, whereas gamma-H2AX-DNA damage foci were present in both SCC and HCC. These data suggest the precancerous nature of SCC, whereas LCC is rather heterogeneous in nature, depending on the biological setting. Additionally, HBV-related LCC showed significantly high Tp53 labeling index, gamma-H2AX labeling index, and micronuclei index, as well as shorter telomere length, decreased SA-ß-Gal activity, and increased net cellular gain, compared to cholestatic LCC. The characteristics of HBV-related LCC are more consistent with dysplastic lesions than reactive hepatocytes, whereas those of cholestatic LCC more likely highlight a reactive change of more stringent cell cycle checkpoint control. From a practical point of view, identification of SCC and LCC in liver biopsies may be related to an increased risk of HCC over time. Accordingly, the presence of such lesions should be noted in pathology reports.
    Pathology 10/2014; 46 Suppl 2:S23.
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    ABSTRACT: The purpose of this course will be to provide pathologists with an update on breast core needle biopsy procedures using examples of such cases to address areas of recurrent diagnostic difficulty. The educational needs we will be targeting are primarily medical knowledge. We will select cases that constitute recurrent diagnostic problems and discuss challenges presented by such lesions and the entities that may mimic them. We will draw on our experience of core needle biopsy specimens seen in our practices to select cases as well as utilize peer-reviewed publications to support our discussions. The major educational objectives are to ensure competence in diagnosing breast lesions on core needle biopsy specimens; to understand the clinical significance of a variety of breast lesions with particular reference to the implications of these diagnoses in core needle biopsy specimens and to understand the ramifications of these diagnoses with regard to patient management. Additionally, participants will learn to develop differential diagnoses of commonly encountered problems and to appreciate the uses and limitations of immunohistochemistry in solving diagnostic problems in breast core needle biopsy specimens. The importance of radiologic/pathologic correlation in every case will be addressed.
    Pathology 10/2014; 46 Suppl 2:S6.
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    ABSTRACT: The postgraduate education programs in the Arab countries have intra- and intercountry differences in the availability of human resources and adequate training centers. The Arab Board of Pathology was established in 2010 to improve the health services in these countries, to set comprehensive and uniform standards for postgraduate training centers, and to establish uniform assessment of the training programs and the proficiency of the trainees. This presentation covers the foundations and the experience of the Arab Board of Pathology since its inception. It describes the structure of the exams and the performance of the trainees. Despite the noted improvement in the training programs over the past few years, many challenges remain and these relate to the growing populations of the countries of the region and the increasing demand for qualified pathologists, shortage of adequate training facilities and resources, disruptive political instability, differences in the adopted structure of the training programs based on external educational influences by European programs, and lack of national strategies to address these problems.The presentation also includes a brief comparison of the leading certification programs of postgraduate education in pathology in different regions of the world and questions the readiness for a global certification program.
    Pathology 10/2014; 46 Suppl 2:S32.
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    ABSTRACT: Primary mesenchymal tumors represent a rare subset of hepatic lesions with overlapping spindle cell morphology. These lesions pose unique diagnostic challenges for pathologists as they are infrequently seen in general practice and can be easily mistaken for their benign counterparts or mimickers. In the current era of personalized medicine, precise pathologic diagnosis of these lesions is critically important to guide targeted therapy. This expectation is difficult to meet when pathologists face uncommon lesions outside their scope of experience. This challenge is further exacerbated when interpreting small biopsy samples.In this lecture, we first present the clinicopathological features of 6 typical cases: inflammatory pseudotumor, angiomyolipoma, epitheleioid hemagioendothelioma, malignant fibrous histiocytoma, leiomyosarcoma, and follicular dendritic cell sarcoma. On each case, the focus of discussion is on the morphology characteristics and how to differentiate them from metastatic tumors, non-neoplastic lesions and other types of primary spindle cell neoplasms. We then outline a practical diagnostic approach based on the unique features of each entity. This lecture provides a comprehensive guidance to general pathologists and pathology trainees on how to navigate through this group of seemingly complex entities and to arrive at a specific diagnosis.
    Pathology 10/2014; 46 Suppl 2:S23.
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    ABSTRACT: Cambodia is one of underserved countries in Southeast Asia and is still suffering from its terrible history in the last 30 years when no pathologist survived from the genocide of Khmer Rouge regime. Today only 8 pathologists, mostly under qualified, are on service for more than 14 million inhabitants. There are 8 laboratories diagnosing 25,000 to 27,000 histological specimens and non-gynecological cytology, and 24,000 to 25,000 Pap smear screening per year. All laboratories are commonly providing routine histology with most on HE, Giemsa, PAP, and PAS staining. Two laboratories have a capability to provide some immunohistochemistry staining, mostly for only some markers to differentiate lymphomas and carcinomas. At present, no frozen section and no autopsy can be done in Cambodia. All these 8 laboratories are concentrated in the capital city and there is no pathology laboratory in provinces. Four laboratories have established a telepathology or personally have connection to outside world via E-mail. We have two intentions to send the cases to experts: one is to confirm our own diagnosis, second is to discuss the difficult and complex cases with senior experts to get a hint of reliable diagnosis. One lab has built up a clinico-pathological teleconference (CPC) in order to get a good connection and discussion for difficult cases. However, we still have challenging to the limits of teleconsultation due to the available experts time even the optimal clinical information, macro-images, X-rays, CT-scans, MRI are together submitted with microscopic images. There is a gap between newly established therapeutic facility, (e.g., hormone therapy in breast cancer, chemotherapy in soft tissue tumor) and the poor histological and immunohistochemistry methods in the country. Another problem is a personal isolation of Cambodian pathologists with low economic situation who cannot frequently attend international meeting outside of the country. Therefore the training level of Cambodian pathologists cannot be adapted to the standard which is demanded worldwide for sufficient tumor therapy.
    Pathology 10/2014; 46 Suppl 2:S8.
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    ABSTRACT: Leptospirosis remains an important infectious dIsease in the tropics. Interest in the disease in recent years has been focused on the pathophysiology and the changing patterns in certain geographical areas. Through direct invasion of leptospires, the outer membrane proteins interact with extracellular matrix causing colonization in the proximal tubules. Activation of TLR2 by LipL32 among outer membrane proteins release NFkB, mitogen-activated kinases and proinflammatory cytokines including TNFα, IL1, IL6 and IL8. Inflammatory reactions are generated. Hemodynamic changes in leptospirosis are essentially similar to those observed in sepsis characterized by decreased systemic vascular resistance, decreased blood pressure, increased cardiac output and increased renal vascular resistance. Kidney, liver and lung injuries are common.
    Pathology 10/2014; 46 Suppl 2:S27.
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    ABSTRACT: Digital technology marked the first decade of the 21st century with the advent of whole slide imaging (WSI). Thanks to the invention of digital scanners, WSI technology enables the creation and permanent storage of high resolution images from traditional glass slides. The application of digital pathology has recently been explored within the subspecialty of renal pathology for teaching, pathology-based clinical trials, development of new classification systems, and in support to systems biology-based research in a setting of large consortia. Although an initial investment is required, several general advantages can be listed in support of its application, ultimately resulting in a more neutral budget: 1) enables the anywhere-anytime remote access model; 2) permanent storage of glass slides images, which otherwise with time may fade, get lost or broken; 3) allows annotation of specific structures for teaching, consultation, histology-based research or reproducibility studies; 4) archiving; 5) provide full transparency for regulatory agencies during clinical trials or for research protocols; 6) facilitate training of multiple students looking at the same annotated structures, whether in the classroom, during webinar sections or independent review. This presentation will highlight the current status of digital nephropathology applications in training, clinical and molecular research, and industry-sponsored clinical trials.
    Pathology 10/2014; 46 Suppl 2:S15.
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    ABSTRACT: NGS is a new approach used to identify genetic mutations that may underline kidney disease. The advantages of NGS compared to Sanger sequencing are the ability to run multiple samples simultaneously, shorter turn-around time and lower cost. For example, compared to older methods that took weeks to complete, NGS can shorten the turn-around time for Alport syndrome diagnosis to just 6 days and the cost to 40%. In addition custom NGS can be designed to identify mutations in a selected group of genes associated with proteinuria and FSGS on renal biopsy. FSGS can be a histologic manifestation of a variety of glomerular diseases including specific podocyte gene mutations (NPHS2, PLC1E, CD2AP, TRPC6) but also glomerular basement membrane abnormalities due to COL4A3-5 mutations. Using custom designed NGS on 14 patients and 19 selected genes, we have identified novel and rare mutations in COLA3, COLA4 AND COLA5, but also mutations in LAMA5 in patients phenotyped as FSGS. Other patients with FSGS were found to have a 6p deletion in APOL1 that is known to be associated with the development of FSGS in African Americans. In this cohort, some patients had congenital hydronephrosis and VUR induced proteinuria. There was no history of familial disease. One of these patients unexpectedly was found to have a novel COLA3 mutation in addition to an expected SALL2 mutation known to be associated with urinary tract developmental anomalies. NGS results were verified using Sanger sequencing. The findings in this study suggest that NGS is a powerful method to identify specific structural changes in the genome that could not have been predicted by the histopathological phenotype. A high throughput approach for mutation analysis is more advantageous compared to single gene approaches and promises to become a clinically useful diagnostic tool.
    Pathology 10/2014; 46 Suppl 2:S39-S40.
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    ABSTRACT: Pulmonary hypertension is a disease that is characterized by an increased pulmonary artery pressure and often results in right ventricular failure. Patients of any age might present with exertional dyspnea and fatigue, but clinical signs and symptoms can sometimes be difficult to recognize. Therefore, histopathology might become critical for the diagnosis. Pulmonary hypertension can be idiopathic, familial or associated with drugs/toxins or other diseases. Morphologic changes that lead to pulmonary hypertension can involve pulmonary arteries, veins and/or capillaries. Histopathologic findings might include medial hypertrophy, concentric laminar intimal fibrosis, plexiform lesions, dilatation lesions, fibrinoid necrosis and arteritis and thromboembolic lesions of pulmonary arteries, capillary proliferations and venous changes. Classification of pulmonary hypertension has changed over the years. Heath and Edwards (1958) originally classified pulmonary hypertension based on histopathologic findings in patients with congenital heart disease. The most recent classification, proposed at the 5th World Symposium on Pulmonary Hypertension (2013), groups categories that share similar pathologic and hemodynamic characteristics and management. Progress has been made in our understanding of the pathogenesis of the disease. We will discuss clinical findings, classification, histopathologic features and recent developments in pathology and pathogenesis of pulmonary hypertension.
    Pathology 10/2014; 46 Suppl 2:S37.
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    ABSTRACT: The structure of the nail unit is complex and its knowledge is basic to achieve a correct diagnosis of nail biopsies. Inflammatory or infectious conditions that affect the nail can have a marked impact on a patient\'s quality of life. A wide-ranging variety of tumors can also develop in this region. In this lecture we will briefly review the anatomy and histology of the nail unit as well as the basic histopathologic findings in the most common inflammatory and infectious conditions affecting the nails. Furthermore, we will cover the most important non-melanocytic tumours that may arise in this area.
    Pathology 10/2014; 46 Suppl 2:S12.