Orvosi Hetilap (Orv Hetil)

Publisher: Akadémiai Kiadó

Journal description

The journal publishes original and review papers in the fields of experimental and clinical medicine. It covers epidemiology, diagnostics, therapy and the prevention of human diseases as well as papers of medical history. This is the oldest, still in-prin

Current impact factor: 0.00

Impact Factor Rankings

Additional details

5-year impact 0.00
Cited half-life 0.00
Immediacy index 0.00
Eigenfactor 0.00
Article influence 0.00
Website Orvosi Hetilap / Hungarian Medical Journal website
Other titles Hungarian medical journal
ISSN 0030-6002
OCLC 183307148
Material type Periodical
Document type Journal / Magazine / Newspaper

Publisher details

Akadémiai Kiadó

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Authors own final version only can be archived
    • Publisher's version/PDF cannot be used
    • On author's personal website or institutional repository or any repository mandated by Author's funding body
    • Published source must be acknowledged
    • Must state that the file is not the final published version of the paper
    • Must link to publisher version(http://dx.doi.org/[DOI of the Article without brackets])
    • Articles in some journals can be made Open Access on payment of additional charge
  • Classification
    ​ green

Publications in this journal

  • Orvosi Hetilap 04/2015; 156(16):654-657. DOI:10.1556/OH.2015.HO2517
  • [Show abstract] [Hide abstract]
    ABSTRACT: Malignant melanoma, originating from pigment cells, is a highly aggressive tumour affecting patients of any age group. Its incidence is rapidly growing. The most common form can be easily diagnosed by any physician. There are some well-known genetic (skin-, eye-, hair colour, naevi, melanoma in the personal/family history) and environmental (ultraviolet radiation) predisposing factors. Treatment is based on early diagnosis and excision. When metastasis occurs, the traditional chemo- and radiotherapy gives a low response rate. Recently some newly approved targeted therapies and immunomodulant drugs have become available. This review focuses on the classification and novel therapeutic approaches of malignant melanoma to provide guidance to clinicians. Orv. Hetil., 2015, 156(15), 583-591.
    Orvosi Hetilap 04/2015; 156(15):583-91. DOI:10.1556/OH.2015.30122
  • [Show abstract] [Hide abstract]
    ABSTRACT: As the result of various harmful effects (infectious agents, metabolic diseases, unhealthy diet, obesity, toxic agents, autoimmune processes) hepatic damage may develop, which can progress towards liver steatosis, and fibrosis as well. The most common etiological factors of liver damages are hepatitis B and C infection, alcohol consumption and non-alcoholic fatty liver disease. Liver biopsy is considered as the gold standard for the diagnosis of chronic liver diseases. Due to the dangers and complications of liver biopsy, studies are focused on non-invasive markers and radiological imaging for liver steatosis, progression of fatty liver, activity of the necroinflammation and the severity of the fibrosis. Authors review the possibilities of non-invasive assessment of liver steatosis. The statistical features of the probes (positive, negative predictive values, sensitivity, specificity) are reviewed. The role of radiological imaging is also discussed. Although the non-invasive methods discussed in this article are useful to assess liver steatosis, further studies are needed to validate to follow progression of the diseases and to control therapeutic response. Orv. Hetil., 2015, 156(14), 543-551.
    Orvosi Hetilap 04/2015; 156(14):543-51. DOI:10.1556/OH.2015.30123
  • [Show abstract] [Hide abstract]
    ABSTRACT: Laboratory diagnosis of pheochromocytoma-paraganglioma syndrome has been markedly improved during the past two decades. Retrospective assessment of diagnostic utility of urinary catecholamines and their metabolites as well as serum chromogranin A in 155 patients diagnosed at the 2nd Department of Medicine, Semmelweis University. Urinary catecholamines and metabolites were measured using high-performance liquid chromatography with electrochemical detection in 155 patients with pheochromocytoma-paraganglioma (of whom 28.4% had hereditary background) and in 170 non-pheochromocytoma patients used as controls. Serum chromogranin A was measured by immunoradiometry. Sensitivity (93.2%) and specificity (87.0%) of urinary fractionated metanephrines were higher than those of urinary catecholamines (90.9% vs. 85.7%, respectively) and serum chromogranin A (88.7% and 77.5%, respectively). Urinary normetanephrine and serum chromogranin A correlated positively with tumor size (r = 0.552, p<0.0001 and r = 0.618, p<0.0001, respectively). These data confirm the diagnostic utility of urinary catecholamines and their metabolites. Urinary normetanephrine and serum chromogranin A may help to estimate tumour mass and probably tumour progression. Orv. Hetil., 2015, 156(16), 626-635.
    Orvosi Hetilap 04/2015; 156(16):626-635. DOI:10.1556/OH.2015.30127
  • [Show abstract] [Hide abstract]
    ABSTRACT: Of the world-wide used Cotrel-Dubousset instrumentation and surgical technique providing breakthrough for the three-dimensional correction and multi-segmental fixation of spinal deformity surgery in Hungary is linked to the author's name, who carried out 1655 spine deformity surgeries in the last 21 years. The aim of the author was to discuss his own results in the field of spine surgery and compare his own data to those published in the international literature. At the beginning hooks, followed by hybrid instrumentation with hooks in thoracic area and transpedicular screws in lumbar spine have been used for the segmental fixation. During the correction process, initially the classic derotation maneuver was used, followed by the translation and then the in situ bending techniques and, finally, a combination of the above three techniques have been applied. In addition to the restoration of normal sagittal balance, an average of 40.8° (SD, 25.9), a 65.5% correction was achieved in the frontal plane, which partly exceeds and partly consistent with the published international results. The incidence of inflammation (3.9%), and mechanical complications (1.7%) was similar to the international average, while the incidence of neurological complications (0.48%) was slightly lower than the average of international data. The author believes that the better correction results as compared to the international average could be due to the always consistent application of the Cotrel-Dubousset instrumentation correction philosophy based on the meticulous segmental analysis of spine deformities. Orv. Hetil., 2015, 156(15), 598-607.
    Orvosi Hetilap 04/2015; 156(15):598-607. DOI:10.1556/OH.2015.30108
  • [Show abstract] [Hide abstract]
    ABSTRACT: The authors review the history and risk factors of thrombophlebitis of the lower limb, and describe the main points of surgical and conservative treatment of varicophlebitis. They present the case of a 71-year-old woman who had ascending varicophlebitis and bilateral pulmonary embolism. The authors draw attention to important points: patients must be followed after phlebitis of the lower limb, and their thrombotic factors must be examined to prevent the new thromboembolic events. Orv. Hetil., 2015, 156(16), 644-649.
    Orvosi Hetilap 04/2015; 156(16):644-649. DOI:10.1556/OH.2015.30130
  • [Show abstract] [Hide abstract]
    ABSTRACT: Due to significant technical evolution complex surgeries can be performed laparoscopically nowadays. However, laparotomy is needed frequently for the extraction of the specimen, which decreases the advantages of laparoscopy. The aim of the authors was to analyse and present their experience on the use of natural orifices and abdominal wall defects for extraction of the surgical specimen. From 2009 the authors used natural orifices (stomach, vagina, rectum) when viscerotomy was an obligate part of laparoscopic surgery and, in a special gastrointestinal laparoscopic operation, the gate of the inguinal hernia for specimen extraction. In 3 patients benign lesions of the stomach were extracted using gastroscope. In 6 patients with bowel endometriosis, in whom the wall of the vagina was completely infiltrated, the resected bowel was extracted transvaginally, and in 5 patients transrectal extraction of the specimen was performed. In 2 patients the inguinal hernia was used for the surgical specimen extraction after laparoscopic sigmoid resection, and in one patient a single-port was inserted into the gate of the hernia during laparoscopic cholecystectomy. Complications occurred only after transvaginal specimen extraction (rectovaginal fistula in 2 patients). Use of natural orifices and abdominal wall defects for surgical specimen extraction further decreases the invasiveness of laparoscopic surgery, if indications made appropriately. Orv. Hetil., 2015, 156(14), 552-557.
    Orvosi Hetilap 04/2015; 156(14):552-7. DOI:10.1556/OH.2015.30116
  • [Show abstract] [Hide abstract]
    ABSTRACT: Persistent genital arousal disorder is a rare condition among women characterized by unwanted and intrusive sexual arousal that can persist for an extended period of time and unrelated to sexual desire or sexual stimuli. Since its first documentation in 2001, numerous studies have been dedicated to investigate its specifics. The persistent genital arousal occurs in the absence of sexual interest and fantasies and it causes excessive psychological suffering. Masturbation, spontaneous orgasm or sexual intercourse can offer only a temporary relief. Researches provide a limited insight into the characteristics of persistent genital arousal disorder. This paper presents a case and summarizes the scientific findings on prevalence, etiology and treatment perspectives. Orv. Hetil., 2015, 156(15), 614-618.
    Orvosi Hetilap 04/2015; 156(15):614-8. DOI:10.1556/OH.2015.30131
  • Orvosi Hetilap 04/2015; 156(14):571-4. DOI:10.1556/OH.2015.HO2522
  • [Show abstract] [Hide abstract]
    ABSTRACT: Journals published by universities take up a modest part of the scientific literature at the moment, but there are several signs and even more reasons to believe that their significance is rising. Recently, the most significant increase can be detected in social sciences. The top list of university rankings based on journal publishing activity brings into the forefront - beside some obvious favorites (Oxford, Cambridge, Chicago) - some less expected universities, as well. Orv. Hetil., 2015, 156(16), 650-653.
    Orvosi Hetilap 04/2015; 156(16):650-653. DOI:10.1556/OH.2015.30141
  • [Show abstract] [Hide abstract]
    ABSTRACT: Burnout is one of the most challenging questions of the healthcare systems in the 21st century. The aim of this study was to analyze the Hungarian physicians' burnout and its associations with workload factors (work hours, shift work, multiple workplaces). Data of this representative, cross-sectional, online epidemiological study was obtained from online questionnaires completed by 4784 physicians. Medium or high level personal accomplishment was present in 75.9% and emotional exhaustion in 58% among physicians, while medium or high level of depersonalization subscale was 53%. All of the 3 dimensions showed association with young ages (<35 years), work in in-patient care, shift hours and multiple workplaces. The physician partner increased the risk of depersonalization, however, children were protective factors. The work-home interface was associated with higher burnout scores. Physicians' burnout is an important indicator of the functioning and effectiveness of the healthcare system. The results suggest the importance of prevention and intervention. Orv. Hetil., 2015, 156(14), 564-570.
    Orvosi Hetilap 04/2015; 156(14):564-70. DOI:10.1556/OH.2015.30121
  • [Show abstract] [Hide abstract]
    ABSTRACT: The low peripheral absolute lymphocyte and high monocyte count have been reported to correlate with poor clinical outcome in various lymphomas and other cancers. However, a few data known about the prognostic value of absolute monocyte count in chronic lymphocytic leukaemia. The aim of the authors was to investigate the impact of absolute monocyte count measured at the time of diagnosis in patients with chronic lymphocytic leukaemia on the time to treatment and overal survival. Between January 1, 2005 and December 31, 2012, 223 patients with newly-diagnosed chronic lymphocytic leukaemia were included. The rate of patients needing treatment, time to treatment, overal survival and causes of mortality based on Rai stages, CD38, ZAP-70 positivity and absolute monocyte count were analyzed. Therapy was necessary in 21.1%, 57.4%, 88.9%, 88.9% and 100% of patients in Rai stage 0, I, II, III an IV, respectively; in 61.9% and 60.8% of patients exhibiting CD38 and ZAP-70 positivity, respectively; and in 76.9%, 21.2% and 66.2% of patients if the absolute monocyte count was <0.25 G/l, between 0.25-0.75 G/l and >0.75 G/l, respectively. The median time to treatment and the median overal survival were 19.5, 65, and 35.5 months; and 41.5, 65, and 49.5 months according to the three groups of monocyte counts. The relative risk of beginning the therapy was 1.62 (p<0.01) in patients with absolute monocyte count <0.25 G/l or >0.75 G/l, as compared to those with 0.25-0.75 G/l, and the risk of overal survival was 2.41 (p<0.01) in patients with absolute monocyte count lower than 0.25 G/l as compared to those with higher than 0.25 G/l. The relative risks remained significant in Rai 0 patients, too. The leading causes of mortality were infections (41.7%) and the chronic lymphocytic leukaemia (58.3%) in patients with low monocyte count, while tumours (25.9-35.3%) and other events (48.1 and11.8%) occurred in patients with medium or high monocyte counts. Patients with low and high monocyte counts had a shorter time to treatment compared to patients who belonged to the intermediate monocyte count group. The low absolute monocyte count was associated with increased mortality caused by infectious complications and chronic lymphocytic leukaemia. The absolute monocyte count may give additional prognostic information in Rai stage 0, too. Orv. Hetil., 2015, 156(15), 592-597.
    Orvosi Hetilap 04/2015; 156(15):592-7. DOI:10.1556/OH.2015.30126
  • [Show abstract] [Hide abstract]
    ABSTRACT: Sulfonylurea compounds have been basic elements of antidiabetic treatment in type 2 diabetes for a long time. However, with the introduction of incretin type insulin secretagogues it is often arises, whether is still there a place for sulfonylureas in the today's therapy. To answer this question the author overviews general pharmaceutical characteristics of the sulfonylurea compounds as well as individual particularities of the second generation derivatives used at present in Hungary. The author details also the most important differences between incretin type drugs - first of all dipeptidyl peptidase-4 inhibitors - and sulfonylureas. On the basis of available data it can be concluded in accordance with the latest international guidelines, that sulfonylureas have still role in the blood glucose lowering therapy of type 2 diabetes, though they became somewhat pushed back among insulin secretagogue type drugs. If a sulfonylurea compound is the drug of choice, it is important to select the appropriate molecule (in case of normal renal function gliclazide or glimepiride). It is also important to re-educate the patient, as well as to apply the minimal dose providing the desired glycaemic effect. Orv. Hetil., 2015, 156(13), 511-515.
    Orvosi Hetilap 03/2015; 156(13):511-515. DOI:10.1556/OH.2015.30114
  • [Show abstract] [Hide abstract]
    ABSTRACT: Early endoscopic diagnosis and endoscopic therapy are very important in cases of acute gastrointestinal bleeding. Hemospray is an inorganic powder with hemostatic properties recently proposed for the treatment of acute gastrointestinal bleeding. The aim of the authors was to report the first Hungarian experience obtained with Hemospray in patients with acute gastrointestinal bleeding. During a 14-month period 10 acute upper gastrointestinal bleeder patients were treated endoscopically with Hemospray in 11 settings. In 5 patients previous endoscopic hemostatic methods failed and in the remaining 5 patients Hemospray was administrated as a first-line therapy. Primary hemostasis was achieved in 9 of the 10 patients treated with Hemospray. Two patients died during hospitalization (uncontrolled arterial bleeding in one patient and hepatic encephalopathy in the other one patient). Primary hemostasis and hemodynamic stability were achieved in each of the 4 patients who had thrombopenia. Hemospray as a rescue therapy may ensure primary hemostasis in severe acute gastrointestinal bleeding even in cases with thrombopenia. Orv. Hetil., 2015, 156(13), 528-531.
    Orvosi Hetilap 03/2015; 156(13):528-531. DOI:10.1556/OH.2015.30112
  • [Show abstract] [Hide abstract]
    ABSTRACT: Since the celebration of the 20th anniversary of the first heart transplantation in Hungary in 2012 the emerging need for modern heart failure management via mechanical circulatory support has evolved. In May 2012 the opening of a new heart failure and transplant unit with 9 beds together with the procurement of necessary devices at Semmelweis University accomplished this need. The aim of the authors was to report their initial experience obtained in this new cardiac assist device program. Since May, 2012, mechanical circulatory support system was applied in 89 cases in 72 patients. Indication for support were end stage heart failure refractory to medical treatment and acute left or right heart failure. Treatment was initiated for acute graft failure after heart transplantation in 27 cases, for end stage heart failure in 24 cases, for acute myocardial infarction in 21 cases, for acute postcardiotomy heart failure in 14 cases, for severe respiratory insufficiency in 2 cases and for drug intoxication in one case. Among the 30 survivor of the whole program 13 patients were successfully transplanted. The available devices can cover all modalities of current bridge therapy from short term support through medium support to heart transplantation or long term support and destination therapy. These conditions made possible the successful start of a new cardiac assist device program. Orv. Hetil., 2015, 156(13), 521-527.
    Orvosi Hetilap 03/2015; 156(13):521-527. DOI:10.1556/OH.2015.30115