Orvosi Hetilap (Orv Hetil)

Publisher: Akadémiai Kiadó

Journal description

The journal publishes original and review papers in the fields of experimental and clinical medicine. It covers epidemiology, diagnostics, therapy and the prevention of human diseases as well as papers of medical history. This is the oldest, still in-prin

Current impact factor: 0.00

Impact Factor Rankings

Additional details

5-year impact 0.00
Cited half-life 0.00
Immediacy index 0.00
Eigenfactor 0.00
Article influence 0.00
Website Orvosi Hetilap / Hungarian Medical Journal website
Other titles Hungarian medical journal
ISSN 0030-6002
OCLC 183307148
Material type Periodical
Document type Journal / Magazine / Newspaper

Publisher details

Akadémiai Kiadó

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Authors own final version only can be archived
    • Publisher's version/PDF cannot be used
    • On author's personal website or institutional repository or any repository mandated by Author's funding body
    • Published source must be acknowledged
    • Must state that the file is not the final published version of the paper
    • Must link to publisher version(http://dx.doi.org/[DOI of the Article without brackets])
    • Articles in some journals can be made Open Access on payment of additional charge
  • Classification
    ​ green

Publications in this journal

  • Orvosi Hetilap 10/2015; 156(41):1653-1660. DOI:10.1556/650.2015.30273
  • Orvosi Hetilap 10/2015; 156(40):1614-1617. DOI:10.1556/650.2015.30263
  • Orvosi Hetilap 10/2015; 156(41):1643-1652. DOI:10.1556/650.2015.30267
  • Orvosi Hetilap 10/2015; 156(41):1661-1666. DOI:10.1556/650.2015.30268
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    ABSTRACT: Myositis is an autoimmune disease characterised by proximal muscle weakness. The aim of the authors was to determine the frequency of dermatomyositis-specific autoantibodies (anti-Mi-2, anti-transcriptional intermediary factor 1 gamma, anti-nuclear matrix protein 2, anti-small ubiquitin-like modifier activating enzyme, anti-melanoma differentiation-associated gene) in a Hungarian myositis population and to compare the clinical features with the characteristics of patients without myositis-specific antibodies. Antibodies were detected using immunoblot and immunoprecipitation. Of the 330 patients with nyositis, 48 patients showed dermatomyositis-specific antibody positivity. The frequency of antibodies in these patients was lower than those published in literature Retrospective analysis of clinical findings and medical history revealed that patients with dermatomyositis-specific autoantibody had more severe muscle weakness and severe skin lesions at the beginning of the disease. Antibodies seem to be useful markers for distinct clinical subsets, for predicting the prognosis of myositis and the effectiveness of the therapy. Orv. Hetil., 2015, 156(36), 1451-1459.
    Orvosi Hetilap 09/2015; 156(36):1451-9. DOI:10.1556/650.2015.30221
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    ABSTRACT: Insulin therapy is the most effective treatment of diabetes. It is proven to prevent microvascular disease and likely to decrease the risk of cardiovascular complications. However, these benefits are associated with a 2-3 times increased risk of hypoglycaemia and a faster weight gain compared to other antidiabetic medications. In addition, one study found elevated all-cause mortality among patients on intensive therapy (requiring more frequent insulinisation). Insulin has growth factor properties that may translate to increased mitogenicity. These factors could prevent the medical team or the patient from initiation or intensification of insulin therapy. The authors describe evidence on long-term remission related to transient intensified insulin therapy at diabetes diagnosis. The currently recommended method of insulin initiation is once daily basal insulin treatment that offers different schedules for intensification. The authors review the pharmacokinetics of analogue insulins that translate to similar efficacy to human insulins with a 20-30% lower risk of hypoglycaemia. Orv. Hetil., 2015, 156(36), 1443-1450.
    Orvosi Hetilap 09/2015; 156(36):1443-50. DOI:10.1556/650.2015.30239
  • Orvosi Hetilap 09/2015; 156(38):1540-1546. DOI:10.1556/650.2015.30258
  • Orvosi Hetilap 09/2015; 156(36):1472-1474. DOI:10.1556/650.2015.30226
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    ABSTRACT: Besides clinicopathological parameters, molecular markers can be very important, and further characterize colorectal carcinomas into chromosomally unstable, microsatellite instable and "CqG-island methylator phenotype" groups. To study the frequency of microsatellite instability using immunohistochemical evaluation of MLH1, MSH2, MSH6 and PMS2 proteins in colorectal carcinoma. 122 colorectal carcinomas as well as in 69 paired liver metastases were evaluated. Additionally, prognostic and predictive potential of mismatch repair status was tested. Microsatellite instable phenotype was identified in 11.5% (14/122) of the tumours. There were no differences regarding staining intensity of tumour regions. Mismatch repair status was discordant in primaries vs. metastases in 20.2%. There was no difference in progression free- and overall survival according to mismatch repair status. The mismatch repair status was not predictive for survival within systemic therapy regimen groups. The subgroups of colorectal carcinomas could be evaluated in a larger and homogenised patient cohort to predict prognosis and response to therapy. Orv. Hetil., 2015, 156(36), 1460-1471.
    Orvosi Hetilap 09/2015; 156(36):1460-71. DOI:10.1556/650.2015.30218
  • Orvosi Hetilap 09/2015; 156(37):1514-1518. DOI:10.1556/650.2015.30184
  • Orvosi Hetilap 09/2015; 156(37):1497-1508. DOI:10.1556/650.2015.30242
  • Orvosi Hetilap 09/2015; 156(37):1509-1513. DOI:10.1556/650.2015.30234
  • Orvosi Hetilap 09/2015; 156(37):1491-1496. DOI:10.1556/650.2015.30214
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    ABSTRACT: Despite several therapeutic possibilities the morbidity and mortality of thromboembolic disorders remain high. Improving drug compliance - i. e. keeping up the doctor's prescriptions - may be an effective tool to reach better results. To improve patients' compliance, the risk factors of non-compliance should be recognized. Among these patients' fear of adverse effects of drugs, their lack of knowledge about their illness and medication, forgetfulness, and other social, economic factors may be the most important. Furthermore, adherence may be worsened when the patient feels that the decision has been made over his/her head. Sustained medical adherence is important because anticoagulation may be a life-long treatment. The new oral anticoagulants make the matter of compliance to be current. These new type of drugs do not need regular laboratory monitoring and, therefore, compliance cannot be strictly followed. There are several studies concerning drug compliance to anticoagulant medications. Improvement of adherence is based on regular patient education after reviewing the factors of non-compliance, which needs teamwork with important roles of doctors, pharmacists, dietetics and nurses. Careful and accurate work of the participants of primary care might be complemented by the activity of anticoagulant clinics. Orv. Hetil., 2015, 156(32), 1281-1287.
    Orvosi Hetilap 08/2015; 156(32):1281-7. DOI:10.1556/650.2015.30224
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    ABSTRACT: Introduction: Depression and burnout are frequent comorbidities among nurses. Despite similar symptoms, their management differ. Therefore, their timely diagnosis is essential. Aim: To identify demographic and work-related risk and protective factors of burnout and depression, and facilitate their diagnosis. Method: A cross-sectional study among 1,713 nurses was carried out. Depression and burnout were assessed by the shortened Beck Depression Questionnaire and Maclach Burnout Inventory, respectively. Risk and protective factors were explored using t-tests and analysis of variance. Results: The prevalence of depression and moderate-to-high burnout was 35.1% and 34-74%, respectively. Having a partner/child and longer employment in the outpatient setting protected from burnout. Lack of a partner and male sex emerged as risk factors of depression and depersonalisation, respectively. Conclusions: High prevalence of depression and burnout among nurses poses a significant public health issue. Familiarity with the disease-specific risk and protective factors identified in this research may facilitate timely diagnosis and effective disease management. Orv. Hetil., 2015, 156(32), 1288-1297.
    Orvosi Hetilap 08/2015; 156(32):1288-97. DOI:10.1556/650.2015.30220
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    ABSTRACT: The authors started to use high-fidelity simulators at Semmelweis University, Faculty of Health Sciences in September, 2007. The aim of this study was to evaluate the students' performance in order to determine their knowledge after each simulation course. The Creighton Simulation Evaluation Instrument (C-SEI) was used to evaluate midwifery students' performance during examinations. 67 midwifery students were evaluated after the "Clinical simulation" course and 58 midwifery students after the "Case studies in simulation" course. The average total scores were significantly higher than the desired level of 75 (p<0.01); after the "Clinical simulation" 88.8±9,14, and after the "Case studies in simulation" courses 86.6±14.87. Among subscales the lowest average total score was found in critical thinking in each of the course. Statistically significant correlation was found between the results of "General nursing care" and the results of "Case studies in simulation" courses (r = 0.34; p<0.01). The use of high-fidelity simulators with valid tools simultaneously might be a suitable method for students' evaluation. Orv. Hetil., 2015, 156(33), 1335-1340.
    Orvosi Hetilap 08/2015; 156(33):1335-40. DOI:10.1556/650.2015.30228
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    ABSTRACT: The kynurenine pathway is the main route of tryptophan degradation which gives rise to several neuroactive metabolites. Kynurenic acid is an endogenous antagonist of excitatory receptors, which proved to be neuroprotective in the preclinical settings. Kynurenines have been implicated in the neuroendocrine regulatory processes. Stress induces several alterations in the kynurenine metabolism and this process may contribute to the development of stress-related pathological processes. Irritable bowel disease and gastric ulcer are well-known disorders which are related to psychiatric comorbidity and stress. In experimental conditions kynurenic acid proved to be beneficial by reducing inflammatory processes and normalizing microcirculation in the bowel. Further investigations are needed to better understand the relations of stress and the kynurenines, with the aim of developing novel therapeutic tools for stress-related pathologies. Orv. Hetil., 2015, 156(35), 1402-1405.
    Orvosi Hetilap 08/2015; 156(35):1402-5. DOI:10.1556/650.2015.30246