Ophthalmic Research Journal Impact Factor & Information

Publisher: Karger

Journal description

ëOphthalmic Researchí features original papers, reviews and short communications reporting basic and clinical experimental studies. Authors from throughout the world cover morphologic, physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology and experimental eye research. Articles on methodological problems are included as well. The results of new experimental research are also interpreted in light of their importance to the clinical work of the eye specialist. This journal provides a record of international research for both researchers and clinicians in ophthalmology.

Current impact factor: 1.42

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.422
2013 Impact Factor 1.376
2012 Impact Factor 1.562
2011 Impact Factor 1.561
2010 Impact Factor 0.847
2009 Impact Factor 1.288
2008 Impact Factor 1.317
2007 Impact Factor 1.25
2006 Impact Factor 1.01
2005 Impact Factor 0.874
2004 Impact Factor 1
2003 Impact Factor 0.975
2002 Impact Factor 0.933
2001 Impact Factor 0.934
2000 Impact Factor 0.773
1999 Impact Factor 1.257
1998 Impact Factor 0.799
1997 Impact Factor 0.627

Impact factor over time

Impact factor

Additional details

5-year impact 1.31
Cited half-life 5.90
Immediacy index 0.18
Eigenfactor 0.00
Article influence 0.37
Website Ophthalmic Research website
Other titles Ophthalmic research
ISSN 0030-3747
OCLC 1761331
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • On author's server or institutional server
    • Server must be non-commercial
    • Publisher's version/PDF cannot be used
    • Publisher copyright and source must be acknowledged
    • Must link to publisher version
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: To report the optical coherence tomography angiography (OCT-A) findings in an exudative age-related macular degeneration (AMD) patient presenting mixed type I and II choroidal neovascularization (CNV) during follow-up after intravitreal vascular endothelial growth factor (VEGF) trap treatment. The clinical assessment included both traditional multimodal imaging, based on fluorescein angiography (FA), indocyanine green angiography (ICGA) and B-scan OCT, and OCT-A at baseline and follow-up. OCT-A images were obtained using a Spectralis OCT-A prototype able to acquire 70,000 A-scans per second, with a resolution of 7 µm axially and 14 µm laterally. An amplitude decorrelation algorithm developed by Heidelberg Engineering was applied to a volume scan, on a 15 × 5° area, which was composed of 131 B-scans (35 frames per scan) at a distance of 11 µm each. The borders of type I and type II CNV were manually outlined and then the areas were analyzed using the provided automated software before and after treatment. The qualitative approach revealed a substantial decrease in the visibility of tiny branching vessels and anastomoses both in type I and type II components of the neovascular complex, associated with persistence of a clear hyperintense signal coming from the larger trunks, which remained well-perfused. Quantitative analysis confirmed a reduction of the lesion area after VEGF trap treatment: the type II component decreased from 0.25 to 0.19 mm(2), while the type I component decreased from 2.03 to 1.80 mm(2). Our study qualitatively and quantitatively demonstrated the response of a mixed type I-II CNV to intravitreal VEGF trap therapy. Although FA remains the gold standard for determining the presence of leakage and OCT easily shows fluid accumulation and its variations, OCT-A offers noninvasive monitoring of the retinal and choriocapillaris microvasculature in patients with CNV, aiding in diagnosis and treatment decisions during follow-up. © 2015 S. Karger AG, Basel.
    Ophthalmic Research 07/2015; 54(2):57-63. DOI:10.1159/000433547
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    ABSTRACT: Purpose: The aim of this study was to investigate the effects of quercetin on vascular endothelial growth factor (VEGF)-induced choroidal and retinal angiogenesis in vitro using a rhesus macaque choroid-retinal endothelial (RF/6A) cell line. Methods: RF/6A cells were cultured in Dulbecco's modified Eagle's medium containing 10% fetal bovine serum. Then the cells were treated with different concentrations (from 0 to 100 μM) of quercetin and 100 ng/ml VEGF. The cell proliferation was assessed using cholecystokinin octapeptide dye. The cell migration was investigated by a Transwell assay. The tube formation was measured on Matrigel. Furthermore, the impact of quercetin's effects on VEGF-induced activation of VEGF receptor 2 (VEGFR-2) downstream signal pathways was tested by Western blot analysis. Results: Quercetin inhibits RF/6A cell proliferation in a dose-dependent fashion: 22.7, 31.5 and 36.7% inhibition on treatment with 10, 50 and 100 μM quercetin, respectively. VEGF-induced migration and tube formation of RF/6A cells were also significantly inhibited by quercetin in a dose-dependent manner. Quercetin inhibits VEGF-induced VEGFR-2 downstream signal pathways of RF/6A. Conclusions: The results show that quercetin inhibits VEGF-induced cell proliferation, migration and tube formation of RF/6A. We suggest that quercetin inhibits VEGF-induced choroidal and retinal angiogenesis in vitro. Collectively, the findings in the present study suggest that quercetin inhibits VEGF-induced choroidal and retinal angiogenesis by targeting the VEGFR-2 pathway. This suggests that quercetin is a choroidal and retinal angiogenesis inhibitor.
    Ophthalmic Research 04/2015; 53(3):109-116. DOI:10.1159/000369824
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    ABSTRACT: Purpose: To evaluate the rotational stability of two intraocular lenses (IOLs) of similar design and material but with a difference of 1 mm in overall length. Methods: In this prospective study patients with age-related cataract were included. An IOL with an overall diameter of 12 mm (ACR6 = small-diameter IOL) was compared to an IOL with an overall diameter of 13 mm (IDEA 613 XC = large-diameter IOL). Results: In total, 60 patients were included in this study. Absolute rotation in the small- and large-diameter groups was 4.4° (SD: 4.0; range: 0.3-17.8) and 3.0° (SD: 2.4; range: 0.1-7.8), respectively. The differences between the two IOLs were not found to be statistically significant. Conclusion: The effect of the overall length of an IOL appears to have little impact on early rotation after cataract surgery.
    Ophthalmic Research 04/2015; 53(3):117-121. DOI:10.1159/000368658
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    ABSTRACT: Micro-RNAs (miRNAs) are members of the family of noncoding RNA molecules that regulate gene expression by translational repression and mRNA degradation. Initial identification of miRNAs revealed them only as developmental regulators; later, their radiated roles in various cellular processes have been established. They regulate several pathways, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation and proliferation. Their roles in eye disorders are being explored by biologists around the world. Eye physiology requires the perfect orchestration of all the regulatory networks; any defect in any of the networks leads to eye disorders. The dysregulation of miRNA expression has been reported in many eye disorders, which paves the way for new therapeutics. This review summarizes the biogenesis of miRNAs and their role in eye disorders. miRNA studies also have implications for the understanding of various complex metabolic pathways leading to disorders of the eye. The ultimate understanding leads to potential opportunities in evaluating miRNAs as molecular biomarkers, prognostic tools, diagnostic tools and therapeutic agents for eye disorders.
    Ophthalmic Research 03/2015; 53(4):169-186. DOI:10.1159/000371853
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    ABSTRACT: SIRT2 and SIRT6 are members of the sirtuin family and are associated with cancer development and progression in certain tumours, but their expression in retinoblastoma has not been studied. The primary objective of our study was to determine the expression of SIRT2 and SIRT6 in human retinoblastoma cases. Eighteen formalin-fixed paraffin-embedded blocks of retinoblastoma cases from the Ocular Pathology Registry at the Henry C. Witelson Ocular Pathology Laboratory were obtained, classified and immunostained for SIRT2 and SIRT6 using mouse monoclonal antibodies. Sixteen cases were poorly differentiated retinoblastoma cases. SIRT2 and SIRT6 were expressed in all cases of retinoblastoma although differences in the staining intensity were found between cases. SIRT2 and SIRT6 expression was also observed in various normal structures of the remaining ocular tissue. SIRT2 and SIRT6 are expressed in retinoblastoma, as well as in some normal ocular structures. While precise roles of these proteins must still be determined in retinoblastoma, their expression profiles suggest that further functional studies of both SIRT2 and SIRT6 should be pursued in this cancer. © 2015 S. Karger AG, Basel.
    Ophthalmic Research 02/2015; 53(2):100-8. DOI:10.1159/000368718
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    ABSTRACT: Erythropoietin (Epo) was once considered to be a regulator of erythropoiesis by controlling the apoptosis, proliferation and differentiation of erythroid precursor cells over an extended period of time. However, the expression of Epo and Epo receptor (Epo-R) occurs in the brain and retina in addition to the kidney. These expression behaviors lead to physiological effects in addition to hematocrit elevation. In this review we discuss the protective effect of Epo on retinal cells. © 2015 S. Karger AG, Basel.
    Ophthalmic Research 01/2015; 53(2):74-81. DOI:10.1159/000369885
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    ABSTRACT: Background: Peripheral anterior synechiae (PAS) is a common problem after penetrating keratoplasty (PK) and leads to intraocular pressure (IOP) elevation. This study examines the risk factors for IOP elevation and post-keratoplasty glaucoma. Methods: A retrospective analysis was performed of 47 eyes following PK and of 65 eyes following Descemet's stripping endothelial keratoplasty (DSEK) between 2009 and 2011. The assessment included preoperative history of corneal disease and glaucoma, response to treatment, IOP, and visual acuity. Irido-trabecular contacts (ITC), the angle opening distance (AOD 500) and the anterior chamber angle (ACA 500) were calculated. Results: The incidences of IOP elevation and post-keratoplasty glaucoma were 27-36% and 10-29%, respectively. The incidence did not differ significantly between both procedures. Pre-existing glaucoma increased the risk for developing IOP elevation and post-DSEK glaucoma. Eyes with bullous keratopathy (BK) developed significantly more IOP elevation (p = 0.01, d.f. = 1, χ(2) = 6.11) and post-keratoplasty glaucoma (p = 0.01, d.f. = 1, χ(2) = 6.22) than eyes with Fuchs' endothelial dystrophy. Eyes with ITC developed post-keratoplasty glaucoma significantly more often than eyes without ITC (p = 0.01, d.f. = 1, χ(2) = 6.63). Conclusion: IOP elevation and post-keratoplasty glaucoma showed a high incidence. Risk factors like pre-existing glaucoma, BK and PAS elevated the rate of IOP elevation and post-keratoplasty glaucoma for both procedures.
    Ophthalmic Research 12/2014; 53(1):36-47. DOI:10.1159/000365252
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    ABSTRACT: Background/aims: To identify the underlying molecular genetic cause of disease in a patient with Harboyan syndrome and to perform a detailed assessment of her renal function. We also assessed the influence of the SLC4A11 mutation identified on the corneal endothelium in the heterozygous state. Methods: A 55-year-old female was examined ophthalmologically, audiologically and nephrologically including 24-hour urine collection. The coding region of SLC4A11 was directly sequenced. Specular microscopy was performed in the proband's 21-year-old daughter. Results: The proband had bilateral iridectomy at the age of 3 months because of an initial diagnosis of congenital glaucoma and since the age of 12 years she underwent several keratoplasties in each eye. Nephrological examination did not reveal any abnormalities. Moderate bilateral sensorineural hearing loss was confirmed by audiometry. A novel homozygous mutation predicted to lead to a premature stop codon at the protein level, c.2188C>T; p.(Arg730*), was identified in SLC4A11. No changes in corneal endothelial cell morphology or density were observed in the heterozygous daughter. Conclusion: In contrast to the Slc4a11(-/-) mouse, no abnormalities in daily renal ion excretion or polyuria were observed in the Harboyan syndrome patient. The mutation identified does not affect corneal endothelial cell morphology or density in the heterozygous state.
    Ophthalmic Research 12/2014; 53(1):30-35. DOI:10.1159/000365109
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    ABSTRACT: Objective: To report the clinical outcome of autologous cultured limbal epithelial cell transplantation (CLECT) followed by deep anterior lamellar keratoplasty (DALK) in paediatric eyes and to correlate the clinical outcome with the phenotype of rejuvenated corneal epithelium. Methods: Four patients with total limbal stem cell deficiency (LSCD) underwent autologous CLECT. Cultivated cell sheets were transplanted onto the damaged ocular surface followed by DALK surgery. Excised corneal buttons were subjected to histopathological analysis. Data recorded included age, sex, laterality, nature of injury, follow-up period, severity of stem cell deficiency, visual acuity, Schirmer's test and impression cytology. Results: At a mean follow-up period of 19.5 ± 7.4 (range 9-26) months after CLECT, all 4 eyes showed epithelialized and clinically stabilized ocular surface. Manual DALK was performed in all 4 eyes, with a mean follow-up of 9.75 ± 4.5 (range 5-15) months. All eyes exhibited smooth and clear corneal epithelium with improved visual acuity. Excised corneal buttons demonstrated organized corneal epithelial morphology and showed expression of cornea-specific CK3/12 marker. Conclusion: Restoration of severely damaged ocular surface following chemical injury by using 2-stage meticulous approaches offers a new modality for the treatment of severe LSCD. Transplantation of cultivated autologous limbal epithelial cell sheet followed by DALK surgery can efficiently restore the corneal phenotype with improved vision.
    Ophthalmic Research 06/2013; 50(1):59-64.
  • Ophthalmic Research 01/2013; 50(1):27-53.
  • Ophthalmic Research 01/2013; 50(2):99-107.
  • Ophthalmic Research 01/2011; 46(2):91-91. DOI:10.1159/000323134
  • Source
    Ophthalmic Research 01/2008; 40(1):1-1. DOI:10.1159/000112134
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    ABSTRACT: To investigate the role of poly(ADP-ribose)-polymerase (PARP) in protecting against oxidative (H(2)O(2)) and alkylation (MMS) damage to the nDNA and mtDNA genomes of the retinal pigment epithelium (RPE). We further hypothesized that PARP ribosylation enzymatic activity is required to facilitate efficient nDNA and mtDNA repair to enable the RPE to survive chronic oxidative stress exposure. Cellular sensitivity to H(2)O(2) and MMS was determined by the MTT and LDH assays. PARP ribosyl(ation) activity was inhibited by supplementation of 3-aminobenzamide (competitive PARP inhibitor). The susceptibility and repair capacities of nuclear and mitochondrial genomes were assessed by quantitative PCR and PARP activity assessed using an enzyme assay. This study demonstrated that cells lacking ribosyl(ation) activity had a significantly lower lesion repair capacity in both nDNA and mtDNA (p < 0.05), which culminated in reduced cell viability after H(2)O(2) exposure only (p < 0.05). Furthermore, the mtDNA demonstrated a significantly greater sensitivity compared to nDNA to both oxidative and alkylation damage (p < 0.05). PARP activity has an important role in providing the RPE with the high oxidative tolerance required for this cell type to survive the constant reactive oxygen species attack in vivo for several decades.
    Ophthalmic Research 06/2007; 39(4):213-23. DOI:10.1159/000104683
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    ABSTRACT: Osteopontin (OPN) has diverse functions such as cell adhesion, chemoattraction, immunomodulation, and angiogenesis. The aim of this study is to analyze the OPN levels in vitreous fluid obtained from diabetic retinopathy (DR) and non-DR patients. Nineteen patients out of 11 with DR and 8 without DR underwent pars plana vitrectomy and vitreous fluid was obtained simultaneously. Two distinct sandwich enzyme-linked immunosorbent assay systems (systems 1 and 2) were applied, which have been developed in our laboratories to quantify the OPN concentrations in vitreous fluid. The non-thrombin-cleaved full-length OPN levels in the vitreous fluid were 921.63 +/- 45.38 ng/ml in DR and 632.80 +/- 83.43 ng/ml in non-DR using system 1. Also, vitreous thrombin-cleaved and noncleaved OPN levels were increased to 2,109.22 +/- 151.651 and 1,651.13 +/- 229.82 ng/ml in patients with DR and non-DR using system 2. The vitreous OPN levels were significantly higher in DR than those in non-DR (p < 0.01 by system 1 and p < 0.05 by system 2). Thrombin-cleaved and noncleaved vitreous OPN levels in patients with DR were increased compared with control subjects, suggesting that OPN plays a potential role in the pathogenesis of diabetic retinal ischemia.
    Ophthalmic Research 05/2007; 39(3):143-7. DOI:10.1159/000102936