Journal of Medical Microbiology Impact Factor & Information

Publisher: Pathological Society of Great Britain and Ireland, Society for General Microbiology

Journal description

The Journal of Medical Microbiology aims to maintain and enhance its high-quality comprehensive coverage of pathogenic micro-organisms and their diseases from research, clinical, and diagnostic points of view. Each issue contains up-to-the-minute editorials, in-depth review articles, original papers presenting research findings, and brief reports and technical notes.

Current impact factor: 2.25

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 2.248
2013 Impact Factor 2.266
2012 Impact Factor 2.297
2011 Impact Factor 2.502
2010 Impact Factor 2.38
2009 Impact Factor 2.272
2008 Impact Factor 2.19
2007 Impact Factor 2.091
2006 Impact Factor 2.18
2005 Impact Factor 2.318
2004 Impact Factor 2.484
2003 Impact Factor 1.987
2002 Impact Factor 1.779
2001 Impact Factor 1.762
2000 Impact Factor 1.625
1999 Impact Factor 1.735
1998 Impact Factor 1.961
1997 Impact Factor 1.525
1996 Impact Factor 1.935
1995 Impact Factor 1.793
1994 Impact Factor 1.627
1993 Impact Factor 1.522
1992 Impact Factor 1.561

Impact factor over time

Impact factor

Additional details

5-year impact 2.51
Cited half-life 7.40
Immediacy index 0.46
Eigenfactor 0.02
Article influence 0.76
Website Journal of Medical Microbiology website
Other titles Journal of medical microbiology (Online)
ISSN 0022-2615
OCLC 37788051
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Society for General Microbiology

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • Author's pre-print on author's personal website, institutional repository or pre-print archive such as BioRxiv
    • Author's post-print on institutional repository or subject repository
    • Published source must be acknowledged
    • Version deposited must replicate that accepted for publication (authors version)
    • Set phrase to accompany archived copy (see policy)
    • Publisher's version/PDF cannot be used
    • Must link to publisher version with DOI
    • Non-commercial use
    • Publisher last contacted on 06/08/2015
  • Classification
    ​ yellow

Publications in this journal

  • Albert Brell · Pere Coll · Daniela de Miniac · Ferran Sánchez-Reus · Miquel Micó · Cristina López · Yésica González · Beatriz Mirelis · Ferran Navarro
    Journal of Medical Microbiology 10/2015; DOI:10.1099/jmm.0.000180
  • Tomoko Yoda · Kenji Yamazaki · Kazuo Takahashi · Ikuko Aoyama · Yasuhiko Suzuki · Shuji Nakata
    Journal of Medical Microbiology 10/2015; DOI:10.1099/jmm.0.000178
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    ABSTRACT: Identification of bacteria causing lower airway infections is important to determine appropriate antimicrobial therapy. Flexible bronchoscopy with bronchoalveolar lavage (BAL) is used to obtain lower airway specimens in young children. The first lavage (lavage-1) is typically used for bacterial culture. However, no studies in children have compared the detection of cultivable bacteria from sequential lavages of the same lobe. BAL fluid was collected from two sequential lavages of the same lobe in 79 children enrolled in our prospective studies of chronic cough. The respiratory bacteria Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and H. parainfluenzae were isolated and identified using standard published methods. H. influenzae was differentiated from H. haemolyticus using PCR assays. Lower airway infection was defined as ≥104 cfu/mL BAL fluid. We compared cultivable bacteria from lavage-1 to the second lavage (lavage-2) using the kappa statistic. Lower airway infections by any pathogen were detected in 46% of first lavages and 39% of second lavages. Detection was similar in both lavages for all pathogens; the kappa statistic was 0.7-0.8 for all bacteria except H. parainfluenzae. Of all infections detected in either lavage, 90% were detected in lavage-1 and 78% in lavage-2. However, culture of lavage-2 identified infections that would have been missed in 8% of children, including infections by additional S. pneumoniae serotypes.Our findings support the continued use of lavage-1 for bacterial culture; however, culture of lavage-2 may yield additional identifications of bacterial pathogens in lower airway infections.
    Journal of Medical Microbiology 09/2015; DOI:10.1099/jmm.0.000173
  • Journal of Medical Microbiology 09/2015; DOI:10.1099/jmm.0.000166
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    ABSTRACT: Some species of the Mycobacterium tuberculosis complex (MTBC), particularly Mycobacterium tuberculosis that causes human tuberculosis (TB), are the first cause of death linked to a single pathogen worldwide. In the last decades, evolutionary studies have much improved our knowledge on MTBC history and have highlighted its long co-evolution with humans. Its ability to remain latent in humans, the extraordinary proportion of asymptomatic carriers (1/3 of the entire human population), the deadly epidemics and the observed increasing level of resistance to antibiotics are proofs of its evolutionary success. Many MTBC molecular signatures show that these bacteria are not only a model of adaptation to humans, but that they have also influenced human evolution. Due to the unbalance between the number of asymptomatic carriers and the number of patients with active TB, some authors suggest that infection by MTBC could have a protective role against active TB disease and also against other pathologies. However, it would be inappropriate to consider these infectious pathogens as commensals or symbionts, given the level of morbidity and mortality caused by TB.
    Journal of Medical Microbiology 09/2015; DOI:10.1099/jmm.0.000171
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    ABSTRACT: Tuberculosis (TB), an infectious disease that is caused by Mycobacterium tuberculosis complex (MTC), remains one of the leading causes of death in the world. In Korea, the current prevalence of multi-drug-resistant TB (MDR-TB) poses a major problem. The most common method for diagnosing TB in developing countries is sputum smear microscopy; however the sensitivity of this test is relatively low, and it usually requires well-trained laboratory staff. Cultures of MTC require up to several weeks in sophisticated facilities, such as Bio Safety Level-3. Effective diagnostic techniques are necessary to control TB. In Korea, we evaluated a loop-mediated isothermal amplification assay (LAMP) targeting the hspX gene (TB-hspX-LAMP) of MTC. For clinical evaluation, culture confirmation, smear microscopy, and TB-hspX-LAMP were performed on 303 sputum specimens obtained from suspected TB patients in Korea. The sensitivity, specificity, positive predictive value, and negative predictive value of TB-hspX-LAMP were 71.1, 98.8, 91.4, and 95.1 %, respectively, compared with TB culture, which is the gold standard for diagnosis of TB. In contrast, the comparable values of the smear microscopy were 24.4, 98.1, 68.8, and 88.2 %, respectively. Therefore, we concluded that the TB-hspX-LAMP was superior to the use of smear microscopy for the detection of MTC in sputum specimens in clinical settings in Korea.
    Journal of Medical Microbiology 09/2015; DOI:10.1099/jmm.0.000164
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    ABSTRACT: A loop-mediated isothermal amplification (LAMP) assay was developed for the first time to detect Enterocytozoon bieneusi DNA from human faecal specimens. Four primers specific for E. bieneusi were designed corresponding to SSU rRNA gene sequences and tested on 100 human faecal specimens. Thirty-nine out of 100 faecal specimens (39%) were confirmed positive for E.bieneusi by LAMP as compared to polymerase chain reaction (PCR) (33/100; 33%) and light microscopy (32/100; 32%). LAMP yielded 94% sensitivity and 88% specificity compared to microscopy (sensitivity = 48%, specificity = 76%). No significant differences in positive detection of E. bieneusi were found among the three methods (p-value > 0.05). However, LAMP has showed a substantial agreement with PCR (κ = 0.78) and fair agreement was demonstrated between microscopy and PCR (κ = 0.25). In conclusion, the LAMP assay showed to be useful as a simplified, rapid, sensitive and specific alternative molecular screening tool in the diagnosis of E. bieneusi in faecal specimens.
    Journal of Medical Microbiology 08/2015; DOI:10.1099/jmm.0.000156
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    ABSTRACT: Listeria monocytogenes is a dangerous bacterium that causes the food-borne disease listeriosis and accounts for nearly 20% of food-borne deaths. This organism can survive the body's natural defenses within the digestive tract, including acidic conditions and bile. Though the bile response has been analyzed, limited information is available concerning the ability of L. monocytogenes to resist bile under anaerobic conditions, especially at acidic pH, which mimics conditions within the duodenum. Additionally, it is not known how the bile response varies between serotypes. In this study the survival of strains representing six serotypes were analyzed under aerobic and anaerobic conditions following exposure to bile. Exposure to bile salts at acidic pH increased toxicity of bile, resulting in a significant reduction in survival for all strains tested. However, following this initial reduction, no significant reduction was observed for an additional two hours except for 10403S (P = 0.002). Anaerobic cultivation increased bile resistance, but a significant increase was only observed in virulent strains when exposed to bile at pH of 5.5. Exposure to pH 3.0 prior to bile decreased viability among avirulent strains in bile at acidic conditions; oxygen availability did not influence viability. Together these data suggest that being able to sense and respond to oxygen availability may influence the expression of stress response mechanisms and that this response may correspond to disease outcome. Further research is needed on additional strains to determine how L. monocytogenes sense and respond to oxygen and how this varies between invasive and non-invasive strains.
    Journal of Medical Microbiology 08/2015; DOI:10.1099/jmm.0.000160
  • Journal of Medical Microbiology 08/2015; DOI:10.1099/jmm.0.000161
  • Journal of Medical Microbiology 08/2015; DOI:10.1099/jmm.0.000157
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    ABSTRACT: Salmonella Typhimurium is one of the leading serovars that causes salmonellosis worldwide. However, few studies have molecularly characterised S. Typhimurium strains in Brazil. In this study, we genotyped 92 S. Typhimurium strains isolated from humans(43) and food(49) between 1983-2013 in Brazil using PFGE, MLVA and ERIC-PCR. Moreover, we assessed the frequency of 12 virulence markers by PCR and the resistance profile against 12 antimicrobials. More than 85.8% of the strains studied carried 11 of the virulence markers or more. Thirty-three (25%) strains were multi-drug resistant (MDR). The 92 S. Typhimurium studied were grouped by PFGE in PFGE-A, PFGE-B1 and PFGE-B2; by MLVA in MLVA-A, MLVA-B1 and MLVA-B2 and, finally, were grouped by ERIC-PCR in ERIC-A and ERIC-B. The strains isolated from humans before the mid-1990s were allocated in all clusters. The strains isolated from humans after the mid-1990s were distributed in the PFGE-B1, MLVA-B1, MLVA-B2 and ERIC-A clusters. The strains isolated from food were distributed in all clusters, except in the PFGE-B2. All typing results suggest that the S. Typhimurium strains of human clinical origin isolated before the mid-1990s were genetically more diverse, which might indicate the selection of a more adapted S. Typhimurium subtype after S. Enteritidis became the most prevalent serovar in Brazil. Regarding strains isolated from food, the results suggest the current circulation of more than one subtype. Furthermore, the high frequency of virulence genes and the presence of MDR strains reinforces their potential hazard for humans and the risk of their presence in foods in Brazil.
    Journal of Medical Microbiology 08/2015; DOI:10.1099/jmm.0.000158
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    ABSTRACT: The goal of this study was to compare biofilm synthesis among enterococci recovered from clinical samples (infection or colonization) of patients, as well as, environmental samples in order to determine possible virulence factors and clonal relationship. During a 2-year period, clinical samples (blood, catheter tips, bronchial secretions, wounds, peritoneal fluid, urine) and rectal swabs collected from hospitalized patients, as well as, environmental water samples were tested for the presence of Enterococcus faecalis and E. faecium. Antibiotic susceptibility testing was performed by the disk diffusion method and Etest. Strains were tested for the presence of vanA, vanB, esp, ace and asp genes by PCR. Clones were identified by PFGE (SmaI). From infected patients, 48 strains were identified; 24 E. faecium (10 vanA-positive, 14 vancomycin-susceptible) and 24 E. faecalis (one vanA-positive, 23 vancomycin-susceptible). Among 143 colonizing isolates, 134 were E. faecium (58 vanA-positive, 11 vanB-positive, 65 vancomycin-susceptible) and nine E. faecalis (three vanA-positive, two vanB-positive, four vancomycin-susceptible). Among 167 environmental water samples, 51 E. faecalis and 19 E. faecium, all glycopeptide-susceptible, were recovered. In total, 64 strains produced biofilm, whereas, 34 were esp-positive, 64 asp-positive, and 54 ace-positive. Biofilm production was associated with the presence of esp (P<0.001) and ace genes (P 0.021), being higher in infecting (P <0.001), and water (P 0.005) isolates as compared to colonizing ones. Clones of environmental water-strains were different than the patients' ones. The differences found in the incidence of antibiotic resistance, virulence factors and clones suggest that hospital and water enterococci are of different origin.
    Journal of Medical Microbiology 08/2015; DOI:10.1099/jmm.0.000151
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    ABSTRACT: An alarming increase in the resistance rates of tigecycline and colistin among carbapenemase-producing A. baumannii recovered from a Greek hospital during a three-years' period (2011-2013) was investigated. The antimicrobial resistance profiles and the carbapenemase gene content were determined for a collection of colistin- and/or tigecycline-resistant carbapenemase-producing A. baumannii (42 isolates), which were consecutively recovered during the study period. A gradual increase in the incidence of blaOXA-23 producers was observed from 2011 to 2013. A cluster of 21 isolates was comprised of tigecycline-resistant blaOXA-23 producers and displayed a single antimicrobial resistance pattern. The emergence of two blaOXA-23-producers resistant to both tigecycline and colistin was documented. Furthermore, the determination of mechanisms of colistin and tigecycline resistance and molecular typing by the 3LST scheme for nine isolates recovered from bloodstream infections were performed. Out of nine isolates, five tigecycline- and two colistin-resistant isolates were blaOXA-23 producers of 3LST ST101, corresponding to the international clone II, recovered during 2012-2013. All nine isolates were positive for the presence of the adeB gene of the AdeABC efflux pump. Three colistin-resistant isolates possessed novel substitutions in PmrB, which may be implicated in colistin resistance. According to our knowledge, this is the first report of the acquisition of tigecycline and colistin resistance among blaOXA-23-producing A. baumannii of 3LST ST101 in Greece; thus, continuous surveillance, molecular characterization, prudent use of antibiotics and implementation of infection control measures for A. baumannii are urgent.
    Journal of Medical Microbiology 07/2015; DOI:10.1099/jmm.0.000127.v1
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    ABSTRACT: This study aimed to characterize the relationship between pathogenicity islands (PAIs), single virulence genes and resistance among uropathogenic Escherichia coli, evaluating the resistance plasmid carriage fitness cost related to PAIs. For 65 urinary E. coli, antimicrobial susceptibility and extended-spectrum β-lactamase production were determined with the Vitek 2 Advanced Expert system. Phylogroup determination, detection of PAIs and virulence genes papAH, papC, sfa/foc, afa/dra, iutA, kpsMII, cnf1, eaeA, hlyA, stx1 and stx2, plasmid replicon typing and screening for plasmidic resistance determinants qnr, aac(6')-Ib-cr, qepA and blaCTX-M were carried out by PCR. Conjugation was performed between a donor carrying IncF, IncK and blaCTX-M-15, and receptors carrying one to six PAIs. The relative fitness of transconjugants was estimated by pairwise competition experiments. PAI IV536 (68 %), gene iutA (57 %) and resistance to ampicillin were the most prevalent traits. PAI I536, PAI II536, PAI III536 and PAI IIJ96 were exclusively associated with susceptibility to amoxicillin/clavulanic acid, cefotaxime, ceftazidime, ciprofloxacin, gentamicin and trimethoprim/sulfamethoxazole, and were more prevalent in strains susceptible to ampicillin and cefalotin. PAI IV536, PAI IICFT073 and PAI ICFT073 were more prevalent among isolates showing resistance to amoxicillin/clavulanic acid, cefalotin, cefotaxime, ceftazidime and gentamicin. An inverse relationship was observed between the number of plasmids and the number of PAIs carried. Transconjugants were obtained for receptors carrying three or fewer PAIs. The mean relative fitness rates of these transconjugants were 0.87 (two PAIs), 1.00 (one PAI) and 1.09 (three PAI). The interplay between resistance, PAI carriage and fitness cost of plasmid acquisition could be considered PAI specific, and not necessarily associated with the number of PAIs.
    Journal of Medical Microbiology 06/2015; 64(8). DOI:10.1099/jmm.0.000104