Journal of Dental Research (J DENT RES)

Publications in this journal

• Article: Bone implant contact of Zirconia versus Titanium implants

  Allauddin Siddiqi, Jules Kieser, Rohana Kumara De Silva, Warwick Duncan
  Journal of Dental Research 01/2013;
• Article: Gene Regulation in S. mutans: COmplex Control in a Complex Environment

  Smith, E.G, G. A. Spatafora
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  ABSTRACT: Dental Caries is a chronic infectious disease of multifactorial etiology that derives from the interplay among acriogenic bacteria on the dentition, the host diet and other environmental exposures. Streptococcus mutans proliferates as a biofilm on the tooth surface, where it obtains nutrients and metabolizes fermentable dietary carbohydrates. The accumulation of lactic acid as a by-product of fermentation results in acidification of the plaque biofilm and demineralization of tooth enamel, marking the onset of decay. The ability of S. mutans to respond to environmental stresses presented by salivary flow, acid pH, oxidative stress, and changes in carbohydrate source and availability is essential for its survival and predominance in caries lesions. Importantly, S. mutans has evolved a network of regulators to integrate its cellular response to environmental change. Herein we describe the latest insights into global gene regulation in S. mutans, including mechanisms of signal transduction, carbon catabolite repression, and quorunm-sensing. An improved understanding of these regulatory networks can provide a basis for novel therapeutic applications aimed at treating and/or preventing caries.
  Journal of Dental Research 02/2012; 91(2):133-141.
• Article: 1. Moharamzadeh, K., Colley, H., Murdoch, C., Hearnden, V., Chai, W.L., Brook, I.M., Thornhill, M.H., Macneil, S. 2012. Tissue-engineered Oral Mucosa. J Dent Res. 2012 Jan 19. [Epub ahead of print]

  Moharamzadeh, Colley, Murdoch, Hearnden, Chai, W.L, Brook, I.M, Thornhill, M.H, Macneil
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  ABSTRACT: Advances in tissue engineering have permitted the three-dimensional (3D) reconstruction of human oral mucosa for various in vivo and in vitro applications. Tissue-engineered oral mucosa have been further optimized in recent years for clinical applications as a suitable graft material for intra-oral and extra-oral repair and treatment of soft-tissue defects. Novel 3D in vitro models of oral diseases such as cancer, Candida, and bacterial invasion have been developed as alternatives to animal models for investigation of disease phenomena, their progression, and treatment, including evaluation of drug delivery systems. The introduction of 3D oral mucosal reconstructs has had a significant impact on the approaches to biocompatibility evaluation of dental materials and oral healthcare products as well as the study of implant-soft tissue interfaces. This review article discusses the recent advances in tissue engineering and applications of tissue-engineered human oral mucosa.
  Journal of Dental Research 01/2012; 91(7):642-50.
• Article: Triclosan antagonises fluconazole activity against Candida albicans

  Higgins, Pinjon, Oltean, H.N, White, T.C, Kelly, S.L, Hull (nee Martel, C.M, Sullivan, D.J, Coleman, D.C, Moran, G.P
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  ABSTRACT: Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, at subinhibitory concentrations (0.5-2 mg/L), triclosan antagonized the activity of fluconazole. Although triclosan induced CDR1 expression in C. albicans, antagonism was still observed in cdr1Δ and cdr2Δ strains. Triclosan did not affect fluconazole uptake or alter total membrane sterol content, but did induce the expression of FAS1 and FAS2, indicating that its mode of action may involve inhibition of fatty acid synthesis, as it does in prokaryotes. However, FAS2 mutants did not exhibit increased susceptibility to triclosan, and overexpression of both FAS1 and FAS2 alleles did not alter triclosan susceptibility. Unexpectedly, the antagonistic effect was specific for C. albicans under hypha-inducing conditions and was absent in the non-filamentous efg1Δ strain. This antagonism may be due to the membranotropic activity of triclosan and the unique composition of hyphal membranes.
  Journal of Dental Research 01/2012; 91(1):65-70.
• Article: Formation and photocatalytic decomposition of a pellicle on anatase surfaces.

  F Rupp, M Haupt, M Eichler, C Doering, H Klostermann, L Scheideler, S Lachmann, C Oehr, H P Wendel, E Decker, J Geis-Gerstorfer, C von Ohle
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  ABSTRACT: The acquired dental pellicle plays a critical role in the adhesion and detachment of dental plaque bacteria. It has been reported that titanium dioxide biomaterials decompose single-protein films by photocatalysis. However, it is not known whether this can also be achieved with complex structured pellicle films. This in vitro study investigated in real-time the formation and photocatalytic decomposition of human pellicle at anatase-saliva interfaces. Nanostructured polycrystalline anatase layers were deposited on titanium-coated quartz crystals by magnetron-sputtering, serving as a model for titanium implant surfaces. The quartz crystals were used as acoustic sensors in a quartz-crystal microbalance (QCM) system with dissipation. In situ UV irradiation of pellicle-covered anatase caused a statistically significant decrease of the adsorbed salivary mass. In contrast, photocatalytic decomposition of pellicle could not be observed on reference titanium surfaces. Wettability characterization revealed superhydrophilicity of anatase upon UV irradiation, whereas titanium was unaffected. XPS measurements provide further information concerning the decomposition of the salivary films. The results suggest that the photocatalytic activity of polycrystalline anatase-modified biomaterial surfaces is able to decompose complex structured macromolecular pellicle films. Therefore, this study opens the way to surface modifications supporting therapeutic approaches of biofilm removal.
  Journal of Dental Research 01/2012; 91(1):104-9.
• Article: Papadopoulos MA, Papageorgiou SN, Zogakis IP. Clinical effectiveness of orthodontic miniscrew implants: a meta-analysis. J Dent Res. 2011 Aug;90(8):969-76.

  Papadopoulos MA, Papageorgiou SN, Zogakis IP
  Journal of Dental Research 08/2011;
• Article: Can They Be Repaired Using Any Composite System? 2223 Resin-Composite Restorations.

  Turani, Santini A, Holliday R
  Journal of Dental Research 01/2011;
• Article: Curing Composite Materials: Do UK dentists Have Sufficient Evidence-based Knowledge?

  Santini A, S. Turner S, Ladwa R
  Journal of Dental Research 01/2011;
• Article: Dentists' Knowledge of Light Curing of Resin Based Composite Materials.

  A Santini, S. Turner, R. Ladwa
  Journal of Dental Research 01/2010;
• Article: Miletic V, Santini A. Effect of Preparation and Storage on Adhesive Monomer Conversion.

  Miletic V, Santini A
  Journal of Dental Research 01/2010;
• Article: Artificial Aging of Zr-based Dental Materials - A Pilot Study

  PINTO AM, PERDIGAO J, LARANJEIRA P, MONTEIRO RCC, FERNANDES FMB, VEIGA JP
  Journal of Dental Research 01/2010; 89:3994.
• Article: Jinno K, Takahashi T, Tsuchida K, Tanaka E, Moriyama K. Acceleration of palatal wound healing in Smad3-deficient mice.

  Jinno K, Takahashi T, Tsuchida K, Tanaka E, Moriyama K
  Journal of Dental Research 08/2009; 88(8-88):757-761.
• Article: The ratio of carbon – carbon double bonds in different BisGMA/HEMA mixtures.

  Miletic V, Santini A
  Journal of Dental Research 01/2009;