Indian Journal of Medical Sciences (Indian J Med Sci )

Publisher: Medknow Publications


Indian Journal of Medical Sciences is a monthly journal published as a medium for the advancement of scientific knowledge in all the branches of Medicine and allied Sciences and publication of scientific investigation in these fields. It is also indented to present this as a form suitable to the general practitioner and primary care physician. The journal is owned by the Indian Journal of Medical Sciences Trust, a registered charitable organisation and published by Medknow Publications, Mumbai, India.

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  • Website
    Indian Journal of Medical Sciences website
  • Other titles
    Indian journal of medical sciences (Online)
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  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Medknow Publications

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    • Author can archive a pre-print version
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    • Author can archive a post-print version
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    • Non-commercial
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    • Creative Commons Attribution Non-Commercial Share Alike License
    • Published source must be acknowledged
    • All titles are open access journals
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Triclisia dictyophylla have been used traditionally for the treatment of different ailments. The root was therefore subjected to phytochemical analysis and antimicrobial/antifungal activity against some hospital-strain disease causing microorganisms. Standard methods were used for the phytochemical screening. The extract was subjected to antimicrobial/antifungal activity using Staphylococcus aureus, Escherichia coli, Klebsiella spp, Pseudomonas aeruginosa and Candida albicans. The sensitivity pattern was compared to that of ciprofloxacin, cotrimoxazole and ofloxacin. Phytochemical analysis revealed mostly alkaloids and protein while tannins, glycoside and saponin were revealed in trace (+) amounts. The extract showed a good antimicrobial activity on Staphylococcus aureus isolated from sputum and on E. coli from both urine and sputum with no antifungal activity. The extract contains active components which could be harnessed for formulation of antibiotics.
    Indian Journal of Medical Sciences 04/2013; 4(1):15-20.
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    ABSTRACT: Some mumbo and jumbo.
    Indian Journal of Medical Sciences 04/2013; 1(2):233-234. DOI:12345.67890.
  • Indian Journal of Medical Sciences 06/2012;
  • Article: Asst. Prof
    Indian Journal of Medical Sciences 03/2012;
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    ABSTRACT: Abstract Introduction Agents that induce apoptosis in breast cancer cells have great potential to facilitate chemotherapeutic intervention and improve patient outcomes. Apoptotic execution requires activation of members of the caspase family. The present study was aimed at assessing the tumor response to anthracycline-based chemotherapy at molecular level and correlating the same with clinical response. Materials and Methods: Caspase-3 activity was chosen as an index to indicate apoptotic activity by inducing chemotherapeutic agents in eighty female patients with advanced breast cancer. Biopsy was performed and activity was assessed prior to chemotherapy, before 2nd cycle and at surgery/before 4th cycle. Caspase-3 activity was measured by Caspase-3/CPP32 Fluorometric Assay Kit and Clinical response by standard RECIST guidelines. Results and Discussion: Clinical progressive disease with less than 1-fold increase in Caspase-3 levels; and Clinical complete response with more than 3 folds increase in Caspase-3 levels has the highest probability to predict chemoresistance/sensitivity before 2nd cycle respectively. Probability of occurrence of the same response at surgery/before 4th cycle for both Clinical Progressive Disease and Clinical Complete Response is 100%. Before 2nd cycle itself, patients presenting with clinical progressive disease with <1 fold increase in Caspase-3 can be recommended for a change in chemotherapy regimen and patients with clinical complete response with more than 3 folds increase in Caspase-3 can be suggested to continue the same chemotherapy regimen. There is a strong correlation between caspase-3 fold increase and clinical response. Therefore, the study suggests that Caspase-3 is useful to serve as a good surrogate marker for chemoresistance/sensitivity.
    Indian Journal of Medical Sciences 01/2012; 1(2):1-10.
  • Indian Journal of Medical Sciences 01/2012; 66(3):49.
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    ABSTRACT: Context: Oxidative stress plays a crucial role in the pathogenesis of alcoholic liver disease (ALD). Aim: The present study was undertaken to evaluate the significance of protein carbonyl / glutathione ratio as a biomarker to assess the oxidative stress in alcoholic hepatitis. Settings and Design: The study included 30 patients with alcoholic hepatitis and 30 age-sex- matched controls. Protein carbonyl (PCO) levels was estimated by modified levine's method, malondialdehyde (MDA) by thiobarbituric acid method, reduced glutathione (GSH) by dithiobis-2-nitrobenzoic acid method, total sialic acid (TSA) by modified aminoff's method, plasma transferases (GGT, AST, and ALT), total protein and albumin using commercial kits adapted to autoanalyzer respectively. Statistical Analysis Used: All data were expressed as mean ± SEM. Spearman's correlation analysis and receiver operating characteristic curve were performed using SPSS version 16 for Microsoft. A P value < 0.05 was considered as significant. Results: Alcoholic hepatitis patients showed significantly higher levels of PCO, MDA, GGT, AST, AST/ALT, TSA, and significantly lower GSH, total protein and albumin levels. PCO/GSH ratio in these patients showed a significant positive correlation with GGT (r = 0.594, P = 0.000), AST/ALT (r = 0.443 P = 0.000), MDA (r = 0.727, P = 0.000), TSA (r = 0.729, P = 0.000), and a significant negative correlation with total protein (r = -0.683, P = 0.000) and albumin (r = -0.544, P = 0.000). ROC curve showed a cut off value of 2.735, indicating 100% sensitivity and 90% specificity of PCO/GSH at this value. Conclusions: Alcohol intake regularly for long duration leads to oxidative stress. We suggest that PCO/GSH ratio can be used as a potential biomarker to assess oxidative stress in alcoholic hepatitis.
    Indian Journal of Medical Sciences 10/2010; 64(10):476-83.
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    ABSTRACT: Introduction: A cardiovascular disease, especially the acute myocardial infarction (AMI), is the most important health problem worldwide. Pre-hospital delay in seeking medical treatment is an effective factor on patients' outcomes. The aim of this study was to identify the patients' reactions to the signs and symptoms of AMI and identifying the factors contributing to the pre-hospital delay in a central hospital in Kashan, Iran. Materials and Methods: In this cross-sectional study, a random sample of 248 patients suffering from AMI was recruited. A questionnaire used, which contained demographic data, the time, and place of experiencing the symptoms, and the manner of responding to the initial symptoms. The SPSS software (version, 19was used for data analysis. Result: 248 patients participated in the study, 183 (73.8%) were males and 65 (26.2%) were females. The mean delay time was 127 ± 174 min. Moreover, 162 patients had arrived at the hospital during the first 60 min after the onset of the symptoms. The variables of being female (P = 0.024), low level of education (P = 0.014), living in urban area (P = 0.01) and referring to the hospital by one's own car instead of using ambulance were accompanied by more pre-hospital delay. 63 patients (25.4%) referred to the hospital by ambulance. Conclusion: Despite having only 25% of the patients referring to this center by ambulance, most patients arrived on time to the hospital.
    Indian Journal of Medical Sciences 10/2010; 64(10):448-54.
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    ABSTRACT: Background: Effect of population increase on public water and sanitation facilities in densely populated area, Aboabo, Kumasi, Ghana. Materials and Methods: Town sheet maps, layout and population census data of Aboabo. GPS for observing spatial locations existing water and sanitation facilities and field verification exercise in the study. GIS for building geodatabase, digitization and Cartographic Visualization. Questionnaires were used to collect non-spatial information on the sanitation facilities and all public facilities. Results: GIS and a Statistical Approach have been respectively used to develop cartographic and mathematical models to analyse, predict and visualize the effect of population increase on public water and sewage facilities in densely populated area. The developed mathematical models correlates with the population at each instance to the required number of water accessible points or standing pipes as well as the number of required public toilet (sewage) facilities. The cartographic and mathematical models provides an efficient and effective means of mitigating diseases associated with water and sanitation; and informs planners and assembly members of the effects of increasing population on public facilities for proper future planning and geospatial decision making; and to ensure proper infrastructural management at the community levels. Conclusions: Effective decision support systems for analysing, predicting and visualizing public water and sewage facilities in densely populated area. Draws the awareness of the government, concerned groups and non-Governmental Organizations (NGO's) to the extreme detrimental effect that the increase in population has, especially on public water and sewage facilities and how it can be managed at the community level.
    Indian Journal of Medical Sciences 10/2010; 64(10):455-67.
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    ABSTRACT: Background: Laryngoscopy and endotracheal intubation are known to cause increase in both arterial blood pressure and heart rate. Several strategies have been evolved to blunt the haemodynamic response to tracheal intubation but each method has its own advantages and disadvantages. Esmolol, a cardio selective Beta -1 blocking drug, can alleviate some of these problems. Esmolol, when administered parenterally, exhibits rapid onset and a short duration of action due to its rapid clearance by red blood cell esterases. Hence we conducted the present study to evaluate the efficacy and optimum time of single bolus esmolol administration in attenuating hypertensive- tachycardiac response to laryngoscopy and tracheal intubation. Materials and Methods: The randomized double blind prospective study was conducted in 60 patients, in the age group of 20-40 years, of both sexes, belonging to American Society of Anaesthesiologists (ASA) physical status class I or II and scheduled for elective surgery requiring endotracheal intubation and general anaesthesia. The efficacy and optimum time of single bolus esmolol administration in attenuating hypertensive - tachycardiac response to laryngoscopy and tracheal intubation was evaluated. Patients in group I (n=20) received bolus administration of injection esmolol 1.5 mg/kg intravenously (iv) 90 seconds before intubation; in group II (n=20) three minutes before intubation and in group III (n=20) six minutes before intubation. Results: There was no clinical and statistically significant variation in heart rate in group I and II at different time intervals of the study period but in group III heart rate increased significantly one minute after tracheal intubation. (P<0.05) One minute after intubation, the increase in systolic, diastolic and mean blood pressure and rate pressure product was statistically significant in group I (P<0.01) and group III. (P<0.05) However, in group II increase in systolic blood pressure and rate pressure product was statistically not significant. (P>0.05) Conclusion: To conclude, single intravenous bolus dose of esmolol (1.5 mg/kg) is safe and more effective in attenuating haemodynamic response to laryngoscopy and tracheal intubation when administered three minutes prior to intubation.
    Indian Journal of Medical Sciences 10/2010; 64(10):468-75.
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    ABSTRACT: Context: Insertion pain or fear of it may make women hesitate to use the intrauterine device (IUD); a long-term, reversible, highly-effective contraception method. Further study has been recommended on the effects of lidocaine (xylocaine) gel on IUD insertion pain in the recent Cochran review. Aims: To determine the effect of lidocaine gel on pain from TCu-380AIUD insertion. Materials and Methods: At a health center in Tabriz, Iran, 96 women were allocated into 3 groups using block randomization with 6 and 9 block sizes considering allocation concealment. In 1 st group, lidocaine 2% gel and in the 2 nd , lubricant gel was placed in the cervical canal 1 minute before an IUD insertion, and the 3 rd group got no intervention. Immediately after IUD insertion, pain during the insertion was measured using 0-10 cm visual analogue scale. Statistical Analysis Used: Kruskal-Wallis and linear regression in SPSS-13 were used to identify effect of lidocaine gel on the pain. Results: Overall, the mean pain score was 3.5 ± 1.8. In univariate analysis, there was no significant difference in pain scores between the 3 groups. Also, results of linear regression model by controlling effect of the possible confounding showed no significant effect of lidocaine gel on the insertion pain. The mean pain score in the lidocaine group was 0.39 less than the no intervention group, but it was not significant (CI 95% of the difference: -1.3, 0.57). Conclusions: Use of 2% lidocaine gel into the cervical canal has no effect on reducing overall pain during IUD insertion.
    Indian Journal of Medical Sciences 08/2010; 64(8):349-55.
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    ABSTRACT: Background: Misoprostol is effective for cervical priming before manual vacuum aspiration (MVA). Aim of study was to determine whether sublingual misoprostol with a shorter interval of 2 hours before MVA would be as effective as its standard vaginal administration. Study Design: This randomized control trial included 82 women randomly assigned to receive 400 mcg of misoprostol, either sublingually or vaginally. MVA was performed 2 hours and 3 hours after in sublingual and vaginal group, respectively. Results: Cervical dilatation of 8 mm was achieved within 2 hours in sublingual group. Mean time taken for procedure (14.4 ± 5.3: sublingual group and 16.2 ± 5.7: vaginal group), and blood loss was comparable (12.2 ± 9.7 ml in sublingual group and 13.7 ± 8.5 ml in vaginal group). Conclusion: 2 hour of cervical priming with 400 mcg of sublingual misoprostol before MVA was as good as 3 hours with vaginal administration of the same dose.
    Indian Journal of Medical Sciences 08/2010; 64(8):356-62.
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    ABSTRACT: Background: Diphtheria is a fatal disease and may cause serious complications if not recognized early and treated properly. Objectives:To study the epidemiology, clinical features, complications, and outcomes in respiratory diphtheria. Materials and Methods:Diphtheria cases admitted in the infectious disease hospital, Beliaghata, Kolkata, India between January 2009 to January 2011 were evaluated in respect to demographic profile, immunization status, clinical features, complications, and outcomes. Results: 200 diphtheria cases were studied. 150 (75%) patients had history of an adequate immunization, and 100 (50%) patients were from lower socio-economic groups. Common clinical features observed were throat pain in 148 (74%) cases and fever in 112 (56%) cases. Complications observed were myocarditis in 136 (68%) cases, neuropathy in 30 (15%) cases, and respiratory compromise in 14 (7%) cases. Death occurred in 5 (2.5%) patients. Conclusions:diphtheria is still a public health problem in many developing countries. Strict public health measures like an increased immunization coverage, improvement of socio-economic status, easy availability of anti-diphtheritic serum (ADS), early recognition and effective treatment-all may reduce the incidence and mortality.
    Indian Journal of Medical Sciences 08/2010; 64(8):373-7.