Der Hautarzt (HAUTARZT )

Publisher: Deutsche Dermatologische Gesellschaft, Springer Verlag

Description

Der Hautarzt ist als Organ der Deutschen Dermatologischen Gesellschaft eine international angesehene Zeitschrift und informiert regelmäßig alle in Klinik und Praxis tätigen Dermatologen über wichtige Entwicklungen in der gesamten Dermatologie einschließlich Allergologie Venerologie und ihrer verwandten Gebiete. In Originalarbeiten werden wichtige klinisch relevante Studien und Forschungsergebnisse veröffentlicht. Kritisch und kompetent widmet sich der Aktuelle Kommentar einer im Brennpunkt stehenden Fragestellung. Die Übersicht führt den Leser in ein zentrales Thema seines klinischen Alltags ein und gibt den Überblick über den state of the art. In den Farbbildkasuistiken zeigen Fallbeispiele Wege der rationalen Diagnostik und Entscheidungsfindung. In der Rubrik Weiterbildung wird dem Assistenzarzt in Weiterbildung zum Facharzt didaktisch aufgearbeiteter Wissensstoff und dem Niedergelassenen ein optimiertes Repetitorium vermittelt. In den Gelben Seiten informiert die DDG regelmäßig über die Aktivitäten der Arbeitsgemeinschaften und des Vorstands Fakten zur Gesundheitspolitik und Kongreßaktivitäten. Die Anfragen aus der Praxis spiegeln den Dialog der Leser mit ihrer Facharztzeitschrift wider. In Gehört - Gelesen - Nachgefragt wird über aktuelle Themen von grundsätzlicher medizinischer bzw. interdisziplinärer Bedeutung berichtet. Zur Publikation eingereichte Manuskripte müssen bei Untersuchungen an Probanden oder Patienten die Erklärung enthalten daß das Versuchsprotokoll von einer Ethikkommission begutachtet wurde und somit den ethischen Standards der Deklaration von Helsinki 1964 in der jeweils gültigen Fassung (Pharm. Ind. Nr. 12/1990 sowie Bundesanzeiger Nr. 243a vom 29. 12. 1989) entspricht. Gleichzeitig ist - gegebenenfalls - die Einwilligung des Patienten nach Aufklärung im Text des Manuskriptes zu fixieren. Hinweise die auf die Identität schließen lassen sind zu vermeiden. Tierversuchsprogramme müssen den Passus enthalten daß die "Principles of laboratory animal care" (NIH publication No. 86-23 revised 1985) eingehalten wurden soweit nicht zusätzlich besondere nationale Regelungen zu beachten sind (für die Bundesrepublik Deutschland ist dies das Tierschutzgesetz in aktueller Fassung). Die Schriftleitung behält sich deshalb das Recht vor Manuskripte abzulehnen die den o.g. Anforderungen nicht entsprechen. Der Autor haftet bei Verstoß gegen die o.g. Anforderungen oder bei falschen Angaben.

Impact factor 0.54

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    Impact factor
  • 5-year impact
    0.40
  • Cited half-life
    0.00
  • Immediacy index
    0.13
  • Eigenfactor
    0.00
  • Article influence
    0.09
  • Website
    Hautarzt, Der website
  • Other titles
    Hautarzt (Online)
  • ISSN
    0017-8470
  • OCLC
    42959962
  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Springer Verlag

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    • Author's pre-print on pre-print servers such as arXiv.org
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    • Articles in some journals can be made Open Access on payment of additional charge
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Infectious diseases of the skin have become rarer in industrialized nations, but they still affect a considerable part of the population in tropical regions. Skin diseases induced by protozoa, worms and ectoparasites are among the 17 "neglected tropical diseases" defined by the WHO (leishmaniasis, dracunculiasis, lymphatic filariasis, onchocerciasis). Skin symptoms in travellers returning from the tropics may challenge dermatologists in Germany regarding differential diagnostic assessment and therapy. Among the 12 most frequent skin diseases in travellers are cutaneous larva migrans, leishmaniasis and myiasis. In this review, diagnosis, treatment and prevention of some the most relevant tropical dermatoses due to protozoa, worms and ectoparasites are discussed.
    Der Hautarzt 09/2014;
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    ABSTRACT: A 14-year-old patient of African ancestry presented with multiple papules in the perioral, perinasal and periocular areas. Histopathology showed sarcoidal granulomas.
    Der Hautarzt 08/2014; 65(10).
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    ABSTRACT: Cutaneous leishmaniasis is one of the most common dermatoses of the tropics. A major focus of this disease is the Syrian city of Aleppo, after which it was named in many textbooks ("Aleppo boil"). The first cases of cutaneous leishmaniasis were reported from Aleppo particularly more than 100 years ago. Syria is one of the most affected countries worldwide. This disease used to be well documented until the onset of the war in Syria in 2012, which is also supported by the numbers of the World Health Organisation (WHO), and Aleppo used to be the most affected Syrian city. Since 2012, the documentation of cutaneous leishmaniasis in Syria is no longer possible. An outbreak of cutaneous leishmaniasis has been detected especially in the besieged regions due to missing prevention measures against the sandflies and a lack of medical care. A short summary of the epidemiologic situation in Syria as well as outstanding and uncommon clinical manifestations of cutaneous leishmaniasis in Aleppo are presented.
    Der Hautarzt 08/2014; 65(10).
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    ABSTRACT: Prurigo nodularis is a chronic reaction pattern associated with severe pruritus that markedly affects the quality of life in patients.
    Der Hautarzt 08/2014; 65(8):691-6.
  • Der Hautarzt 08/2014; 65(8):672-3.
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    ABSTRACT: The term prurigo is still used to designate primary dermatoses and secondary reaction patterns. A clear definition of the term is not available nor a clear clinical classification of diseases categorized under the term. Furthermore, there is no certainty about the entity it was primarily used to refer to, and whether it should always be considered in relation to pruritus. The concept appears already in very early medical treatises. From the very beginning, it was used in dermatology in a non-uniform way, and was alternately accorded and denied the status of an independent disease entity. Moreover, prurigo was subdivided into many different forms, but their descriptions are partly very similar, so that, for instance, it is quite difficult today to draw any conclusions about the clinical entities the frequently used terms prurigo mitis and prurigo formicans referred to. In contrast, the term prurigo nodularis is still commonly used. This article traces exemplarily the use of the term prurigo in the standard medical textbooks up to the definition of prurigo nodularis.
    Der Hautarzt 08/2014; 65(8):674-83.
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    ABSTRACT: Acne vulgaris is worldwide the most common skin disease. Acne is an inflammatory disorder in whose emergence androgens, PPAR ligands, the IGF-1 signaling pathway, regulating neuropeptides and environmental factors are probably involved. These factors interrupt the natural cycling process in the sebaceous gland follicle and support the transition of microcomedones to comedones and inflammatory lesions. Proinflammatory lipids and cytokines are mediators for the development of acne lesions. Bacterial antigens can potentate the inflammatory phenomena. Acne is predominantly treated with combination therapy. Selecting a treatment regimen depends on the exact classification of acne type and severity. The development of scars is the main criterion for the choice of systemic therapy. Retinoids for mild comedonal acne and the combination of retinoids with antibiotics and/or benzoyl peroxide for mild to moderate papulopustular acne are the drugs of first choice for topical treatment. The use of topical antibiotics is not recommended any more because of the development of resistant bacterial strains. Systemic antibiotics, in combination with topical retinoids and/or benzoyl peroxide, for moderate papular/nodular acne and isotretinoin for severe nodular/conglobate acne are the columns of systemic acne treatment. Systemic anti-androgens are used in women against moderate papulopustular acne. Due to advances in the understanding of the underlying inflammatory mechanisms in recent years the development of new therapeutic agents with good efficacy and better side effect profile should be expected in the future.
    Der Hautarzt 08/2014; 65(8):733-50.
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    ABSTRACT: Das Indikationsspektrum Gewebe abtragender Laser in der Dermatologie und Ästhetischen Medizin wurde durch technologische Neuerungen in den letzten Jahren wesentlich erweitert. Im Folgenden werden technische Grundlagen und Laser-Gewebe-Wechselwirkungen beschrieben sowie Indikationen des CO2- und Er:YAG-Lasers mit Behandlungsprinzipien vorgestellt. Nebenwirkungen und Begleitreaktionen der Anwendung dieser Lasersysteme werden aufgeführt und verglichen. In the past few years, the spectrum of indications for ablative lasers in dermatology and aesthetic medicine has been expanded due to technological innovations. In the following, technical basics, laser-tissue interactions, indications for the CO2 and Er:YAG laser and laser treatment management are described. In addition, side effects and reactions associated with the use of these laser systems are listed and compared.
    Der Hautarzt 07/2014; 53(7):447-455.
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    ABSTRACT: Bei einer Reihe von Antibiotika konnte eine Modifikation von Wirtsfunktionen neben ihrer antimikrobiellen Potenz gezeigt werden. Direkte Wirkungen betreffen phagozytäre Funktionen, Chemotaxis und Lymphozytenaktivitäten. Effekte auf die Produktion und Freisetzung verschiedener Zytokine, die in den Entzündungsprozess einbezogen sind, wurden sowohl in vivo als auch in vitro untersucht. Die molekularen Mechanismen sind jedoch nicht im Detail entschlüsselt. Vermutlich können Antibiotika immunpharmakologische Effekte auf der Grundlage von Struktur-Aktivitäts-Beziehungen unabhängig von ihrer antibakteriellen Aktivität entfalten. Wir präsentieren eine Zusammenstellung klinischer Studien und Fallberichte, die einen Erfolg systemisch applizierter Antibiotika im Krankheitsverlauf ausgewählter Dermatosen beschreiben, die primär als nicht infektiös klassifiziert sind. Therapiestandards, wie beispielsweise Dapson bei Dermatitis herpetiformis und leukozytoklastischer Vaskulitis oder Chloroquin in der Behandlung des Lupus erythematodes, wurden nicht berücksichtigt. Auf der Basis bisheriger klinischer Studien höherer Fallzahl ergeben sich begründete Hinweise für eine Wirksamkeit folgender Antibiotika: Erythromycin beim bullösen Pemphigoid und bei der Pityriasis rosea sowie Tetracycline beim Pemphigus vulgaris, bullösen Pemphigoid und bei der Pustulosis palmaris et plantaris. Die meisten Berichte sind jedoch aufgrund des unkontrollierten Studiendesigns insbesondere bei Dermatosen mit einer Tendenz zur Spontanremission kritisch anzusehen. Trotz dieses Mangels an Evidenzdaten ist für den Kliniker das Wissen um den potenziellen Einsatz von Antibiotika für verschiedene Hauterkrankungen als primäre Behandlungsoption oder steroideinsparende Therapieerweiterung wichtig. In der klinischen Praxis hängt die Antibiotikagabe von mehreren Faktoren ab, insbesondere von der Schwere der Erkrankung, dem Alter des Patienten, Kontraindikationen gegenüber Immunsuppressiva und nicht zuletzt von Kostenaspekten. A range of antibiotics has been shown to modify host functions apart from the antimicrobial potency. They may directly influence phagocyte and lymphocyte function, as well as chemotaxis. Effects on the generation and release of various cytokines involved in the inflammatory process have been studied both in vivo and in vitro. However, the molecular mechanisms have not been elucidated in detail. It is suggested that antibiotics can exert immunopharmacological effects on the basis of structure-activity relationships independent of their antibacterial activity. We present a collection of clinical studies and case reports dealing with the potential benefits of systemic antibiotics in the treatment of selected dermatoses which have primarily been classified as non-infectious. Generally accepted treatments such as dapsone in dermatitis herpetiformis and leukocytoclastic vasculitis or chloroquine in lupus erythematosus have not been considered. Based on existing clinical trials with a higher number of cases the following antibiotics have been shown to be effective: erythromycin in bullous pemphigoid and pityriasis rosea as well as tetracyclines in pemphigus vulgaris, bullous pemphigoid and pustulosis palmaris et plantaris. However, most reports have to be viewed critically due to the uncontrolled study design, particularly in dermatoses with a tendency to spontaneous resolution. Despite this lack of evidence-based data, it is important for the clinician to know about the potential use of antibiotics for various skin disorders as a primary treatment option or steroid-sparing therapeutic adjunct. In clinical practice the use of antibiotics depends on various factors including the severity of the disease, the patient's age, contraindications to conventional therapeutic regiments and economic considerations.
    Der Hautarzt 07/2014; 53(7):456-465.
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    ABSTRACT: A patient presented with Majocchi granuloma caused by T. rubrum. By the use of optical brighteners, fungal elements in the deep dermis could be detected more sensitive than with PAS staining. Healing was achieved by long-term use of oral terbinafine (250 mg per day 12 weeks, followed by 250 mg once per week for another 12 weeks).
    Der Hautarzt 06/2014; 65(8).
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    ABSTRACT: There are about 10,000 monogenic diseases and around 30 % demonstrate alterations in the skin and its appendages. As there are so many genetic different skin diseases, clear diagnosis is often very difficult.
    Der Hautarzt 06/2014; 65(6):513-519.
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    ABSTRACT: Palmoplantar dermatoses are common. They can be both functionally debilitating and markedly stigmatize the patient because they are so visible. Dermatoses on the hands and feet often go along with palmoplantar hyperkeratosis. Such palmoplantar keratoses (PPK) can be classified into acquired (non-hereditary) and hereditary (monogenetic) PPK.
    Der Hautarzt 06/2014; 65(6):499-512.
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    ABSTRACT: The inherited skin fragility encompasses a heterogeneous group of disorders, collectively designated as epidermolysis bullosa, characterized by recurrent mechanically induced blisters, erosions or wounds. The spectrum of clinical manifestations is broad, as well as the molecular background. Besides the skin, mucosal membranes and other organs can be affected. In real-world practice, patients with mild genetic skin fragility usually do not require medical care and often remain underdiagnosed. In contrast, the well-defined severe EB subtypes are recognized based on typical clinical features. The molecular diagnostics is usually performed in order to allow genetic counselling and prenatal diagnosis. Besides wound care and careful management of the disease complications, new experimental targeted therapies are being developed. New very rare forms of inherited skin fragility have been identified with modern sequencing methods.
    Der Hautarzt 06/2014; 65(6):490-498.
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    ABSTRACT: Der Australier Steven Kossard beschrieb erstmals 1994 ein Krankheitsbild, das er “postmenopausal frontal fibrosing alopecia” nannte. Bei 6 Frauen war es zu einem symmetrischen Zurückweichen des frontalen Haaransatzes gekommen. Histologisch lag das Bild eines Lichen planopilaris vor. Die Augenbrauen waren häufig mit betroffen. Das restliche Integument war frei von Hautveränderungen im Sinne eines Lichen ruber. Seit der Erstbeschreibung ist diese spezielle Form einer fibrosierenden Alopezie mehrfach beschrieben worden. Bisher waren fast ausschließlich ältere Frauen betroffen. Wir stellen hier einen männlichen Patienten mit frontaler fibrosierender Alopezie vom Typ Kossard vor. In 1994 Steven Kossard described a new and peculiar type of hair loss that he named postmenopausal frontal fibrosing alopecia. In 6 elderly women he observed a symmetric regression of the frontal hair line. Often the eyebrows were also affected. Histology showed lichen planopilaris. There were no clinical signs of lichen planus on the rest of the body. Since the original description by Kossard, several cases of frontal fibrosing alopecia have been described – almost all of them in elderly women. We report a man with frontal fibrosing alopecia of the Kossard type.
    Der Hautarzt 06/2014; 53(6):409-411.
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    ABSTRACT: The monogenic inherited isolated alopecias comprise a group of clinically and genetically heterogeneous disorders with decreased or absent hair. Clinical classification of the isolated alopecias is based upon the onset of the disorder, the regions affected, and the structure of the hair shaft. Men and women are equally affected, and the mode of inheritance is autosomal dominant or autosomal recessive. Therapy does not exist for these rare forms of alopecia. However, molecular genetic diagnosis is possible for the identification of the genetic causes and for the specification of the recurrence risk. Since the identification of the keratin gene KRT86 as a cause of the so called monilethrix in 1997, mutations in eleven other genes have been identified for various isolated alopecias. These include other keratin genes for monilethrix, the HR gene for atrichia congenita, the genes CDSN, APCDD1 and SNRPE for the autosomal dominant form of hypotrichosis simplex, and the genes DSG4, LIPH and LPAR6 for the autosomal recessive forms of hypotrichosis as well as U2HR for hypotrichosis type Marie Unna. Molecular genetic and pathophysiological studies of these rare disorders of hair development have significantly contributed to our understanding of the basic mechanisms of hair loss as well as the physiological mechanisms of hair growth.
    Der Hautarzt 06/2014; 65(6):520-526.
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    ABSTRACT: Cutaneous malignancies can manifest as isolated and sporadic tumors as well as multiple and disseminated tumors. In the latter case they often point to a genetic disease, which either can be restricted to the skin exclusively or also involve extracutaneous organs in the context of a hereditary tumor syndrome. Such hereditary tumor syndromes are clinically and genetically very heterogeneous. Therefore, the prevailing specific skin tumors play an important diagnostic role in the case of complex symptom constellations. Elucidation of the genetic basis of rare monogenetically inherited disorders and syndromes can contribute to a better understanding of the pathogenesis of frequently occurring cutaneous malignancies because the mutated genes often encode proteins, which have a key position in metabolic signaling pathways that are of high significance for the development of targeted therapies. Here we provide an overview of genodermatoses, which are associated with basal cell carcinomas, sebaceous carcinomas, keratoacanthomas, squamous cell carcinomas and malignant melanomas.
    Der Hautarzt 06/2014; 65(6):527-535.