European Surgical Research (EUR SURG RES)

Publisher: European Society for Surgical Research, Karger

Journal description

European Surgical Researchí features original clinical and experimental papers and short technical notes serving the information needs of investigators in various fields of operative medicine. Coverage includes surgery, surgical pathophysiology, drug usage, and new surgical techniques. Special consideration is given to information on the use of physiological and biological methods as well as biophysical measuring and recording systems. The journal is of particular value for workers interested in pathophysiologic concepts, new techniques and in how these can be introduced into clinical work or applied when critical decisions are made concerning the use of new procedures or drugs.

Current impact factor: 1.43

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 1.431
2012 Impact Factor 0.75
2011 Impact Factor 0.932
2010 Impact Factor 1.214
2009 Impact Factor 1.5
2008 Impact Factor 1.327
2007 Impact Factor 0.92
2006 Impact Factor 0.684
2005 Impact Factor 0.755
2004 Impact Factor 0.75
2003 Impact Factor 0.706
2002 Impact Factor 0.903
2001 Impact Factor 0.759
2000 Impact Factor 0.754
1999 Impact Factor 0.939
1998 Impact Factor 0.709
1997 Impact Factor 0.602
1996 Impact Factor 0.87
1995 Impact Factor 0.782
1994 Impact Factor 0.795
1993 Impact Factor 0.641
1992 Impact Factor 0.692

Impact factor over time

Impact factor

Additional details

5-year impact 1.24
Cited half-life 7.80
Immediacy index 0.16
Eigenfactor 0.00
Article influence 0.35
Website European Surgical Research website
Other titles European surgical research, ESR
ISSN 0014-312X
OCLC 55890244
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • On author's server or institutional server
    • Server must be non-commercial
    • Publisher's version/PDF cannot be used
    • Publisher copyright and source must be acknowledged
    • Must link to publisher version
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Introduction: Tantalum is used in orthopaedic surgery because it readily osseointegrates with host bone and allows immediate weight bearing. It also has the potential to provide a scaffold for fibrous ingrowth and soft tissue re-attachment. It is therefore commonly used in revision arthroplasty and tumour surgery, to augment bone loss and to facilitate re-attachment of tendons and ligaments. However, clinical results are variable and the aim of this study was to review the literature in order to gain an overall understanding of the basic science of soft tissue attachment to tantalum Methods: A systematic review of the literature was performed and eligible studies were critically appraised and relevant data extracted. Results: Tantalum has beneficial cellular effects; it stimulates human osteoblasts and upregulates leukocyte activity. However, it is shown to have an inhibitory effect on fibroblasts, which may be one explanation for variable levels of soft tissue integration in clinical series. Conclusion: Tantalum has previously been considered to be biologically inert. However recent evidence demonstrates that it does influence cellular activity but exactly how is not well studied nor clearly understood. Given that clinical results are mixed this is clearly an area that warrants further study as manipulation of the biomaterial properties may offer a potential avenue for improving clinical outcomes
    European Surgical Research 06/2015; 55(1):167. DOI:10. 1159/381839
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    ABSTRACT: Introduction: Porous metal is used in orthopaedic surgery because it is considered to readily osseointegrate with host bone and also to provide a scaffold for fibrous ingrowth and soft tissue attachment. The most popular applications are in revision arthroplasty and tumour surgery where tantalum is used to augment bone loss and to facilitate soft tissue re-attachment potentially restoring function and stability. However, the role of tantalum for tendon re-attachment is not clearly understood. The aim of this study was to systematically review the literature reporting clinical outcomes of soft tissue re-attachment using tantalum in order to determine key areas for further research. Methods: A systematic review of the literature was performed. Eligible studies were critically appraised and data extracted for analysis. Fifteen human studies using tantalum for soft tissue attachment were included. Results: No controlled studies were identified. Reporting of results from clinical series was of variable quality. Outcomes were also mixed and did not reflect excellent results seen in animal studies. Conclusion: The effectiveness of porous metal as a platform for soft tissue reattachment is not fully understood but it appears that the presence of bone stock is one of the most important factors for long term success. The disparity between animal studies and clinical outcomes highlights the importance of understanding the weaknesses of the animal models used when designing future studies.
    European Surgical Research 06/2015; 55(1):107.
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    ABSTRACT: Peritoneal lavage after cancer surgery is performed to reduce microscopic residual tumors in the peritoneum. This study evaluated the effects and mechanism of dialysate lavage in reducing the peritoneal implantation of gastric cancer cells. Gastric cancer cells (MKN45 or AGS) were cultured with 1.5% peritoneal dialysate (PD) or normal saline (NS) for 30 min. The in vitro cell susceptibility to dialysate, including cell proliferation, cell death, cleaved PARP expression, and mitochondrial membrane potential, was evaluated. A murine model for gastric cancer cell peritoneal seeding was established to test the effects of PD and NS lavage on animal survival and tumor growth. A significant decrease in cell proliferation in PD and NS (75.2 ± 0.1 vs. 12.4 ± 0.2% in MKN45, p = 0.009; 58.2 ± 0.01 vs. 28.0 ± 0.01% in AGS, p = 0.008), an increase in mitochondrial permeability transition (93.0 ± 2.6 vs. 18.0 ± 2.9% in MKN45, p = 0.021; 86.8 ± 4.6 vs. 47.7 ± 10.2% in AGS, p < 0.001), and an increase in the expression of cleaved PARP and increased death (25.6 ± 9.4 vs. 16.9 ± 5.3% in MKN45, p = 0.031; 39.5 ± 5.1 vs. 20.9 ± 3.9% in AGS, p = 0.008) were recorded for gastric cancer cells separately exposed to PD and NS. Twenty-four days after inoculating MKN45 cells (5 × 10(6)/0.1 ml) in the peritoneal cavity, the average number of seeded tumors was 67.3 ± 10.8, 92.3 ± 6.0, and 29.2 ± 16.7 (p = 0.032), and the total weight of tumors was 0.98 ± 0.21, 0.58 ± 0.12, and 0.31 ± 0.17 g (p = 0.008), respectively, for mice receiving sham operation, NS lavage, and PD lavage. The 45-day survival rate for the PD lavage group was 22% compared to 0% for the sham injection and NS lavage groups (p = 0.034). PD induced significant cytotoxicity in gastric cancer cells that was related to mitochondrial perturbation. The use of PD lavage was effective in reducing the peritoneal implantation of gastric cancers in a murine model. © 2015 S. Karger AG, Basel.
    European Surgical Research 03/2015; 55(1-2):24-34. DOI:10.1159/000371345
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    ABSTRACT: Gastric gastrointestinal stromal tumors (GISTs) have a highly variable clinical course, and recurrent disease sometimes develops despite curative surgery. This study was undertaken to investigate the surgical role in treating gastric GISTs and evaluate the clinicopathological features of a large series of patients who underwent curative resection for gastric GISTs to clarify which features were independent prognostic factors. The clinicopathological data of 406 patients with gastric GISTs who underwent curative resection at 4 university hospitals in Daegu, South Korea, from March 1998 to March 2012 were reviewed. All cases were confirmed as gastric GISTs by immunohistochemical staining, in which CD117 or CD34 was positive. Clinical follow-up was performed periodically, and disease-free survival rates were retrospectively investigated using the medical records. The mean follow-up period was 42.9 months (range: 2-166). There were 11 recurrent patients (2.7%). Due to the small number of recurrences, age, sex and location were controlled using propensity score matching before performing any statistical analysis. Tumor size, mitotic count, NIH classification, and cellularity were judged to be independent prognostic factors for recurrence by univariate analysis. In a multivariate analysis, tumor size and mitotic count were significantly and independently related to recurrence, and tumor size was determined to be the most important prognostic factor for recurrence after curative resection (hazard ratio: 1.204; p < 0.01). The results of this multicenter study demonstrate that disease-free survival rates are good. Tumor size was disclosed as the most important factor for recurrence in gastric GIST patients who underwent radical resection. © 2015 S. Karger AG, Basel.
    European Surgical Research 02/2015; 55(1-2):12-23. DOI:10.1159/000375234
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    ABSTRACT: Background: The incidence of diabetes has been steadily increasing. The only curative option for diabetes is pancreas transplantation (PTx). Porcine models are valuable because of their anatomical and physiological similarities to human beings. Our aim is to introduce a simplified technique of PTx in a porcine model. Methods: In Landrace pigs (n = 32), after median laparotomy, the pancreas was mobilized, and the portal and splenic veins were divided. The proper hepatic and splenic arteries and the bile duct were also prepared, and the duodenal bulb was prepared and stapled. The third portion of the duodenum was freed up to the ligament of Treitz and stapled, and the renal arteries were ligated. After systemic heparinization, the pancreas was perfused through the abdominal aorta with histidine-tryptophan-ketoglutarate solution. The portal and splenic veins were cut for evaluating the sufficiency of perfusion. Whole pancreaticoduodenal graft was procured along with an aortic jump graft containing mesenteric and celiac trunks. In recipients, after total pancreatectomy, the suprarenal inferior vena cava and infrarenal aorta were prepared for vascular anastomosis in an end-to-side manner. After pancreas reperfusion, duodenoduodenostomy was performed in an end-to-side manner. Results: Median cold and warm ischemia times were 10 h (range, 9-14 h) and 50 min (range, 35-80 min), respectively. The hemodynamic status was stable throughout the operation. The median follow-up period was 7 days (range, 4-10). There were no major intra- and postoperative complications. Conclusion: By using an aortic jump graft, there was no need to perform additional arterial reconstruction resulting in a short warm ischemic and operation time. End-to-side portocaval and duodenoduodenal anastomoses make this model of PTx a very feasible method for experimental evaluations. © 2014 S. Karger AG, Basel.
    European Surgical Research 10/2014; 54(1-2):24-33. DOI:10.1159/000367844
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    ABSTRACT: Background: During the last few years, the gastric cancer nodal staging has been extensively revised. Lately, a new system emerged in this field with the purpose of implementing the prognostic stratification: the lymph-node ratio (LNR). The aim of this study was to investigate the prognostic value of the LNR in relation to cancer survivors undergoing resection for gastric adenocarcinoma. Methods: Off 227 patients undergoing surgical resection for gastric cancer at our Department, 129 curative gastric resections with more than 15 nodes harvested were selected. The LNR was calculated and patients were stratified into 6 subgroups based on the ratio values. The subgroups were compared for data analysis. Survivals were calculated by the Kaplan-Meier method, and the mean follow-up period was 40 months. ROC curves were calculated in order to analyze the performance of the LNR system. Results: LNR stratification correlated with the stage of the disease, with the rate of patients undergoing chemotherapy and patients presenting with a relapse of disease at follow-up. Moreover, an increased ratio correlated with a worse overall, a disease-free and a disease-specific survival of the patients. The ROC curves documented a significant performance of the stratification system with the endpoints of disease-free and disease-specific survivals. Conclusion: LNR stratification correlated with cancer-related survivals in our case series. It is a reliable system that might improve current nodal staging and thereby the identification of patients with a higher risk of recurrence or cancer-related mortality. © 2014 S. Karger AG, Basel.
    European Surgical Research 05/2014; 53(1-4):1-10. DOI:10.1159/000360937
  • European Surgical Research 10/2010;
  • European Surgical Research 09/2009;
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    ABSTRACT: Introduction: Human umbilical cord blood (HUCB) has been successfully used in clinical allogenic graft transplantation of haematopoietic stem cells (HSCs). However, HUCB has been poorly characterized as a source of Mesenchymal stem cells (MSCs). The aim of this study was to establish HUCB as a source of MSCs using a novel clot spot method. Method:HUCB was collected (n=9) from candidates consenting women, who underwent elective caesarean section. HUCB clot was meticulously explanted in MesenCult basal medium and incubated in 5%CO2 incubator at 37°C. Qualitative and quantitative immunophenotyping of cells was achieved using fluorescein isothiocyanate (FITC) labelled antibodies reactive with CD34, CD45, CD29, CD44, CD73 and CD105 antigen markers. MSCs were plated in neurogenic and adipogenic differentiation media. Immunocytochemistry was used for embryogenic markers SOX2, Olig4 and FABP-4 identification. Results: MSC cultures using the clot spot method showed morphological changes inkeeping with cell lineage differentiation within two weeks of culture with a three fold increase in number, compared with other methods. Cells were negative forHSC markers (CD34, D45), but strongly positive for MSCmarkers CD29 (97%), CD44, CD73 (95%) and CD105 (97%). MSCs expressed the neural SOX2, Olig4 and adipogenic FABP-4 markers. Conclusion: HUCB is a good source of MSCs for transplantation, using this novel technique.
    European Surgical Research 01/2009;
  • European Surgical Research 01/2008;
  • European Surgical Research 01/2008;
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    ABSTRACT: Short-stay thyroid surgery (<24 h hospital stay) is becoming increasingly popular but some potentially lethal complications are considered strong arguments against shortening hospitalization after thyroidectomy. The authors reviewed the data of 1,571 patients undergoing one-day thyroid surgery over a 3-year period to determine safety and patient satisfaction. There were 1,244 females and 327 males. Mean age was 43 years. Patient satisfaction was evaluated by a questionnaire given on discharge, while post-discharge surgical recovery was analyzed by the PSR scale. Total thyroidectomy was performed in 1,119 patients (71%), hemithyroidectomy in 450 (29%), isthmusectomy in 2. Morbidity occurred in 152 patients (9.6%). Surgical complications were transient hypocalcemia in 112 cases and permanent hypoparathyroidism in 3; monolateral transient nerve palsy occurred in 10 cases, bilateral in 3; definitive monolateral recurrent palsy in 4 cases. Bleeding requiring re-intervention occurred in 10 cases, wound complications in 5 cases, and intraoperative tracheal lesion in 1 patient. Among complicated patients, 129 (84.8%) were treated after discharge as outpatients. Conversion to inpatient treatment occurred in 28 patients (1.7%) (25 for surgical reasons). Four patients (0.2%) required hospital readmission. Patients were very satisfied in 84.2%, satisfied in 9.5%, poorly satisfied in 4.3%, completely unsatisfied in 2%. Postoperative recovery mean score by PSR scale resulted in 85.14% (0-100%). Our results confirm that the one-day surgery model is safe, effective, and highly agreeable in patients undergoing surgery for thyroid disease.
    European Surgical Research 02/2007; 39(3):182-8. DOI:10.1159/000100904
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    ABSTRACT: Ascites tumor cells from patients with peritonitis carcinomatosa were tested for cis-diamminedichloroplatinum (CDDP) sensitivity. The patients were divided into CDDP-sensitive and resistant groups. Survival and time to progression (TTP) rates were compared. 18 peritonitis carcinomatosa patients with class V ascites based on cytologic diagnosis were enrolled in this study. Chemosensitivity testing of the ascites tumor cells was done to determine their sensitivity to CDDP using a three-dimensional culture matrix of thermoreversible gelation polymer (TGP). CDDP at a dose calculated to achieve ascitic fluid drug levels equivalent to the IC(50) was given intraperitoneally to 12 CDDP-sensitive patients and 6 CDDP-resistant patients. Both the median survival time and the median TTP were significantly longer in CDDP-sensitive patients than in CDDP-resistant patients (survival time 105 vs. 13 days, p = 0.019; TTP 90 vs. 5 days, p = 0.029). The results indicate the potential feasibility of controlling ascites in cancer patients in whom a maximal dose effect can be achieved with a minimal dose of chemotherapy.
    European Surgical Research 02/2007; 39(1):41-50. DOI:10.1159/000098439
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    ABSTRACT: The aim of this study is to show the effect of simvastatin on intra-abdominal adhesion formation. Adhesion formation was achieved by scratching the cecum and anterior abdominal wall following median laparotomy. Three different groups of 10 rats each were formed. In group I, 0.57 mg/kg/day simvastatin was injected intraperitoneally right after the operation and for 5 days thereafter. In group II, an equal dose of simvastatin to that used in group I was given via gavage. A physiological saline solution was given to group III for the same period of time. On the 6th and 14th day, blood samples were taken and peritoneal lavage was performed to measure the tissue-type plasminogen activator (t-PA) activity. Adhesions were graded via re-laparotomies on the 14th day after the first operation. The adhesion scores were 1.40 +/- 0.22, 1.50 +/- 0.26, and 2.90 +/- 0.34 in groups I, II, and III, respectively (p = 0.007), and the score was higher in group III than in the other groups (p = 0.005, p = 0.011). Intraperitoneal simvastatin application decreases adhesion formation by increasing the t-PA level in abdominal surgery.
    European Surgical Research 02/2007; 39(2):98-102. DOI:10.1159/000099156