# Chromatographia (CHROMATOGRAPHIA )

Publisher: Springer Verlag

## Description

The ever increasing demands on the analyst make the rapid communication of new techniques and developments in the field of analytical chemistry of prime importance. CHROMATOGRAPHIA has been fulfilling this function for chromatography since it was first founded in 1968. During the intervening years, however, the journal has itself evolved to meet the challenges of changing times and demands. Thus, the composition of the Editorial Board is reviewed at regular intervals so as to reflect shifts in interest and the establishment of centres of excellence in countries that have not previously been active in the field. Publishing policy, including the number of papers and the format, are subject to continuous appraisal.

## Impact factor 1.37

• Hide impact factor history

Impact factor
.
Year
• 5-year impact
1.28
• Cited half-life
7.00
• Immediacy index
0.15
• Eigenfactor
0.01
• Article influence
0.30
• Website
Chromatographia website
• Other titles
Chromatographia (Online)
• ISSN
0009-5893
• OCLC
38523635
• Material type
Document, Periodical, Internet resource
• Document type
Internet Resource, Computer File, Journal / Magazine / Newspaper

## Publisher details

• Pre-print
• Author can archive a pre-print version
• Post-print
• Author can archive a post-print version
• Conditions
• Author's pre-print on pre-print servers such as arXiv.org
• Author's post-print on author's personal website immediately
• Author's post-print on any open access repository after 12 months after publication
• Publisher's version/PDF cannot be used
• Published source must be acknowledged
• Must link to publisher version
• Set phrase to accompany link to published version (see policy)
• Articles in some journals can be made Open Access on payment of additional charge
• Classification
​ green

## Publications in this journal

• ##### Article: Novel Anion Exchangers with Spatially Distant Trimethylammonium Groups in Linear and Branched Hydrophilic Functional Layers
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ABSTRACT: Novel polystyrene–divinylbenzene (PS-DVB) based anion exchangers having branched structure of ion exchange functional groups are prepared and characterised. Two proposed synthetic methods include acylation of PS-DVB microspherical particles followed by reductive amination with dimethylamine or methylamine, which results in obtaining tertiary or secondary amino groups on the surface, respectively. Further alkylation of amino groups was provided by reaction with either (3-chloro-2-hydroxypropyl)trimethylammonium chloride or glycidyltrimethylammonium chloride, which allowed the simultaneous insertion of trimethylammonium functional group and hydrophilic spacer into the structure. The other considered option is reaction with diglycidyl ethers, which requires further amination of terminal epoxide rings with trimethylamine. The proposed approaches resulted in preparation of the ion exchangers with extended linear or branched anion exchange structure with trimethylammonium groups located at a distance from the surface and connected via hydrophilic linkers. The ion exchange selectivity and separation efficiency of obtained anion exchangers are studied for the model mixture of inorganic anions (F−, HCOO−, Cl−, NO2−, Br−, NO3−, H $${\text{PO}}_{ 4}^{2 - }$$ and $${\text{SO}}_{4}^{ 2- }$$ ) using hydroxide eluents. The adsorbents with branched ion exchange layer having three positively charged sites in the structure of attached groups demonstrate superior column efficiencies and better peak symmetry as compared with anion exchanger having linear structure with two positively charged sites in the chain. In case of branched anion exchangers the calculated values of column efficiencies for polarisable NO3− and Br− are 44,000 and 50,000 N/m, respectively, and significantly higher than 7,000 and 8,000 N/m obtained for anion exchanger with linear structure of the ion exchange layer.
Chromatographia 01/2015;
• ##### Article: Mass Spectrometry in Clinical Microbiology and Infectious Diseases
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ABSTRACT: Mass spectrometry (MS) has a long history in which it has undergone a transformation from an instrument used in elemental analysis to a flexible tool for bio-analysis. Recent years have seen the adoption of the mass spectrometer in the (clinical) microbiology laboratory, as a tool for both research and diagnostic purposes. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS) has been the frontrunner in routine identification, enabling pathogen identification through whole cell extract profiling. However, many more MS-based applications related to clinical microbiology and the study of infectious diseases exist. This review provides an overview of recently published studies using MS for, i.e., pathogen identification, exploration of potential diagnostic makers and dosage studies, exemplifying the versatility of the technique and its potential applications in the study of microbes.
Chromatographia 01/2015;
• ##### Article: Simultaneous Determination of Triterpenoidal Saponins in Rat Urine After Oral Administration of Pulsatilla chinensis Extract Using HPLC–MS
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ABSTRACT: The aim of this study was to develop a liquid chromatography-tandem mass spectrometry (HPLC–MS/MS) method for the simultaneous quantitative determination of the following triterpenoidal saponins: anemoside A3, anemoside B4, 23-hydroxybetulinic acid, pulsatilloside B, pulsatilloside C, and cirenshenoside S in rat urine. The chromatographic separation was performed using a Sapphire C18 column (250 mm × 4.6 mm, 5 μm) and gradient elution was used during the analysis. Anemoside A3, anemoside B4, and 23-hydroxybetulinic acid were detected with the mass spectrometer in negative ion mode monitoring at m/z 749.6/471.2, 1,219.7/749.4, 471.4/471.4 and pulsatilloside B, pulsatilloside C, and cirenshenoside S were in positive ion mode monitoring at m/z 819.4/347.2, 965.5/493.2, and 1,097.9/493.1, respectively. The calibration curves were indicative of good linearity (r 2 ≥ 0.9965) in the range of interest for each analyte. Intra-day and inter-day precision (CV %) was less than 9.1 and 8.7 %, respectively, and accuracy was between −8.4 and 8.3 %. Recovery was 81.02–102.9 %. The method is very rapid, simple, and reliable, and suitable for excretion studies. It can be routinely used for simultaneous determination of six triterpenoidal saponins in rat urine. These results indicated that the newly developed method can also be applied to studies after administration of extraction of saponins from Pulsatilla chinensis to rats.
Chromatographia 01/2015;
• ##### Article: Retention Indices for Identification of Aroma Compounds by GC: Development and Application of a Retention Index Database
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ABSTRACT: In this paper we focus on the development and application of a retention index database for aroma compounds with high structural diversity. Retention indices of over 300 aroma compounds were determined on three capillary columns of different polarity. The capability of the retention index database was evaluated by identification of the components of tobacco flavor. The results showed that the database can be used for qualitative identification. The database also contains a good set of retention index data for study of quantitative structure–retention relationships.
Chromatographia 01/2015; 78(1-2).
• ##### Article: A Fluorescent-Based HPLC Assay Using 4-Chloro-7-nitrobenzo-2-oxa-1, 3-diazole as Derivatization Agent for the Determination of Iron Bioavailability to Red Tide Phytoplankton
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ABSTRACT: A new fluorescent-based high-performance liquid chromatography (HPLC) assay using 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-C1) was employed to determine iron (Fe) bioavailability to red tide phytoplankton in seawater. After growing four red tide species (Prymnesium parvum, Heterosigma akashiwo, Eutreptiella gymnastica, and Oltmannsiellopsis viridis) in f/2 artificial seawater under different Fe conditions, soluble extracts of the phytoplankton were derivatized using different fluorescent reagents (NBD-C1, 4-fluoro-7-nitrobenzo-2-oxa-1,3-diazole; NBD-F, fluorescamine, and ortho-phthalaldehyde; OPA) followed by HPLC assay. Among the four fluorescent reagents, NBD-C1 was most effective for derivatizing the phytoplankton extracts which would consist of proteins and peptides. HPLC chromatograms of the NBD-derivatized extracts showed gradual changes (decrease/increase) of six peaks for different Fe conditions. Four of the peaks decreased, while two peaks increased with the increase of Fe concentrations in the culture medium. Considering the consistency and sensitivity of chromatogram peaks E and A to different Fe, phosphate and nitrate conditions for all phytoplankton studied, the ratio of these two peaks (I E/A ) has been proposed as the indicator of Fe bioavailability to red tide phytoplankton.
Chromatographia 01/2015; 78(1-2).
• ##### Article: Search for Potential Biomarkers by UPLC/Q-TOF–MS Analysis of Dynamic Changes of Glycerophospholipid Constituents of RAW264.7 Cells Treated With NSAID
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ABSTRACT: It is well-known that alteration of the glycerophospholipid (GPL) constituents of tissues can lead to disease. We report dynamic changes of GPL constituents of RAW264.7 cells with different status, revealed by use of modern analytical techniques and chemometrics to find potential biomarkers. An inflammation model of Kdo2-lipid A (KLA)-stimulated RAW264.7 cells was developed. Effects on the model of treatment with three non-steroidal anti-inflammatory drugs (NSAID), aspirin, indomethacin, and brufen, were determined by use of UPLC-Q/TOF–MS analysis. Total-ion-current profiles representative of GPL metabolism under different conditions were acquired and the data were processed by principal-components analysis (PCA) and partial least-squares discriminant analysis (PLSDA). The results revealed changes of GPL metabolites related to the anti-inflammatory effects of the NSAID. Seventeen potential biomarkers were selected by use of t tests, Shrinkt, Principal Component Linear Discriminant (PCLDA), Variable importance in projection (VIP), and PLSDA. Among these biomarkers, amounts of phosphatidylcholine (PC, 16:0/18:1) and phosphatidylethanolamine (PE, 18:0/18:1) changed significantly in the three NSAID treatment groups and may be the important GPL biomarkers of the occurrence and resolution of inflammation. UPLC/Q-TOF–MS-based metabolomics provide novel insight into the mechanism of action of anti-inflammatory drugs distinct from that afforded by traditional biological investigations.
Chromatographia 12/2014;
• ##### Article: Simultaneous Analysis of Inorganic Monovalent Anions/Cations Using Mixed-Bed Single-Column Ion Chromatography
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ABSTRACT: The ion-exchange properties of a new mixed-bed ion-exchange column Scherzo SSC18 (Imtakt, USA) were investigated. This mixed-mode column is packed with two types of 3 µm spherical silica particles having either octadecyl- and strong cation-exchange functional groups or octadecyl- and strong anion-exchange functional groups. The regularities of the retention of alkali metal cations and inorganic anions were studied with diluted acids (sulfuric, perchloric to phosphoric, nitric, oxalic and citric acids) as eluents and direct conductivity for the detection. Eluent concentration, column temperature and organic solvent addition effects were investigated. The separations were achieved on the basis of ion-exchange interactions introduced by the strong anion and strong cation-exchange functionalities of the stationary phase; meanwhile, contribution of hydrophobic interactions was also evident for the hydrophobic iodide and thiocyanate. The simultaneous separation of 12 inorganic anions and cations in 20 min was obtained under isocratic conditions with 1 mM oxalic acid as eluent. The applicability of developed method to the determination of chloride, sodium, potassium as well as nitrite, nitrate and ammonium in soil extracts was demonstrated with good potential for nitrogen speciation studies.
Chromatographia 12/2014;
• ##### Article: Microchip-Grafted P(NIPAAm-co-VPBA) with Thermoresponsive Boronate Affinity for Capture–Release of cis-Diol Biomolecules
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ABSTRACT: Based on the successful graft of P(N-isopropylacrylamide-4-vinylphenylboronic acid) [P(NIPAAm-co-VPBA)] on glass substrates by surface-initiated atom transfer radical polymerization, a microfludic chip with the performance of thermoresponsive boronate affinity was fabricated and was used for capture–release of the cis-diol biomolecule adenosine. The copolymers modified successfully on the surface of glass substrate were characterized by Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy. The results demonstrated that, by simply adjusting the temperature from 4 to 55 °C, the microchip grafted with P(NIPAAm-co-VPBA) was specific to the cis-diol-containing molecules, and can selectively and quickly realize the capture and release of the cis-diol biomolecule adenosine from the mixture of adenosine and deoxyadenosine, which was validated by high performance liquid chromatography/electronic spray ion–ion trap mass spectrometry (HPLC/ESI–ion trap MS). Moreover, less than 10 min was taken from injection to the collection of the sample at the end of the channel. With further development, the P(NIPAAm-co-VPBA)-grafted microchip with high selectivity and repeatability may be chosen as a promising tool for the enrichment of the cis-diol-containing biomolecules, such as glycoproteins, carbohydrates, glycosylated peptides, nucleosides, etc.
Chromatographia 12/2014;
• ##### Article: Simultaneous HPLC–DAD Analysis of Tocopherols, Phytosterols, and Squalene in Vegetable Oil Deodorizer Distillates
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ABSTRACT: A simple and accurate HPLC–DAD method has been developed for simultaneous determination of tocopherols (α, (β + γ), and δ-tocopherols), phytosterols (campesterol, β-sitosterol, and stigmasterol), and squalene in vegetable oil deodorizer distillates (VODD). Chromatographic separation was performed on a C18 column with a mobile phase gradient prepared from 98:2 (v/v) methanol–water and isopropanol, at a flow rate of 1.0 mL min−1, in 33 min, at 30 °C. Tocopherols, phytosterols, and squalene were detected at 296, 210, and 210 nm, respectively. Recoveries ranged from 92.4 to 103.8 %. Limits of quantification were in the range 0.50–2.50 μg mL−1. The proposed method was successfully used for simultaneous analysis of tocopherols, phytosterols, and squalene in VODD.
Chromatographia 12/2014;
• ##### Article: Development of an Analytical Method for Strong Mutagens/Carcinogens, 3,9-Dinitrofluoranthene and Dinitropyrene Isomers, in the Environment and Their Particle-Size Distribution in Airborne Particles
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ABSTRACT: 3,9-Dinitrofluoranthene (DNF) and 1,3-, 1,6-, and 1,8-dinitropyrene (DNP) isomers are classified as “possible human carcinogens (Group 2B)” by the International Agency for Research on Cancer (IARC). In the present study, we developed an analytical method for DNF and DNP isomers, which is composed of efficient purification of nitroarenes from impurities and separation of nitroarenes from each other using high-performance liquid chromatography (HPLC) and two-dimensional HPLC analysis. These nitroarenes are reduced to corresponding aminoarenes online and sensitively quantified by their fluorescence. We adopted this analytical method for surface soil and airborne particle samples. In the chromatograms of HPLC analysis, DNF and DNP isomers were sufficiently separated from each other and no interfering peaks were observed around DNF and DNP isomers. DNF and 1,3-, 1,6-, and 1,8-DNP isomers were detected in the ranges of 47–579, 27–165, 30–238, and 34–228 pg g−1 of soil, respectively, from all analyzed samples (n = 6). The contribution ratios of DNF to the mutagenicity toward Salmonella typhimurium TA98 without a metabolic system (S9) were high in the range of 11.6–36.6 %. When classified airborne particles, namely, 7.0 µm in size, were analyzed, amounts of DNF were 64, 14, 13, 6, and 5 fg m−3, respectively, and DNF tended to be detected in smaller airborne particles. This is the first report on an analytical method for DNF in the environment and the particle-size distribution of DNF in airborne particles.
Chromatographia 12/2014;
• ##### Article: Toshihiko Hanai: Quantitative In Silico Chromatography
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ABSTRACT: It is encouraging to find a book written by one author as it is more usual nowadays for one person to edit a book with chapters written by other authors. Toshihiko Hanai must be congratulated on what must have been a mammoth task of processing, collecting the data, processing it and finally writing this book.The book consists of 11 chapters including the introduction. They cover the basic concepts of molecular energies to model phases, then the range of separation techniques to the final chapters where protein affinity chromatography and high sensitivity detection are discussed. It is unfortunate that they are written as scientific papers rather than a style suitable for a book format. The chapters are full of data but lack information on how the data were obtained. In the early chapters details are given on the simple energy equations used, but there was no information on how this was done.In Chapter 3 “The design of model phases for chromatography” this point is highlighted. The chap ...
Chromatographia 12/2014;
• ##### Article: Chiral Separation of the Enantiomers of Omeprazole and Pantoprazole by Capillary Electrophoresis
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ABSTRACT: We report systematic screening of different native and derivatized, charged and uncharged cyclodextrin (CD) derivatives for chiral separation, by capillary electrophoresis, of the enantiomers of omeprazole and pantoprazole, the two most frequently used proton-pump inhibitors. To optimize the analytical and electrophoretic conditions the effect of buffer composition, concentration, and pH, chiral selector type and concentration, potential, temperature, and injection volume were investigated. Baseline chiral separation was achieved by use of phosphate buffer at pH 2.5 and randomly methylated β-CD as chiral selector for omeprazole, and phosphate buffer at pH 7.0 and sulfobutyl ether-β-CD as chiral selector for pantoprazole. Of all the CD tested, sulfobutyl ether-β-CD was the only CD that interacted stereoselectively with both analytes at pH 7.0, but resolution of the enantiomers of omeprazole was only partial. The analytical performance of the optimized methods, in terms of repeatability, linearity, and limits of detection and quantification, was evaluated, and the methods were used for analysis of the enantiomers of these proton-pump inhibitors in pharmaceutical formulations.
Chromatographia 12/2014;
• ##### Article: Chromatographic and Enzymatic Method to Quantify Individual Plasma Free and Triacylglycerol Fatty Acids
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ABSTRACT: Non-esterified and triacylglyceride fatty acid quantification in plasma is important in order to know fatty acid plasma availability and the nutritional status. A reliable method to determine free, triacylglycerol, phospholipid, and cholesterol ester fatty acids in human plasma samples by combining two types of fatty acid isolation and enzymatic and chromatographic methods has been developed and made safer by avoiding diazomethane derivatization. Lipoprotein lipase was used to obtain hydrolyzed fatty acids from triacylglycerides, and chromatography performed with an active carbon column was used to isolate free fatty acids. Posterior safe derivatization to methylated fatty acids by transesterification, with m-trifluoromethylphenyl trimethylammonium hydroxide reagent (Meth-Prep™ II) and gas chromatography enabled us to identify and quantify a wide spectral range of non-esterified and triacylglyceride fatty acids in plasma. Additionally, the method allows the fatty acids of the phospholipid and cholesterol ester fraction to be determined after the determination of total plasma fatty acids. Determining the individual fatty acid recovery with respect to the C17:0 internal standard makes it possible to calculate the individual fatty acid concentration in each fraction of plasma. The method optimizes the derivatization reagent and chromatographic conditions and enables quantification of additional fatty acids such as omega-3 and omega-6 of the C18:3 fatty acid and C20:1n9, C22:0, and C22:6n3 fatty acids. The procedure can be safely used to analyze a large number of samples.
Chromatographia 12/2014;
• ##### Article: A Rapid and Sensitive LC–MS–MS Method for Determination of Hepcidin-25 in Human Serum, and Measurement of its Diurnal Rhythm for Healthy Subjects
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ABSTRACT: Hepcidin is a recently discovered small defensin-like peptide hormone which is a key regulator of systemic iron homeostasis. Serum and urine hepcidin levels may be of diagnostic importance for iron-related disorders. We have developed a sensitive and selective ultra-performance liquid chromatographic–tandem mass spectrometric (UPLC–MS–MS) method for quantitative determination of the concentration of hepcidin in clinical samples. Solid-phase extraction was used to isolate the analyte from biological matrices, and the extracts were injected on to a Waters Acquity UPLC BEH C18 column with gradient elution. Detection was performed by triple-quadrupole tandem mass spectrometry in multiple reaction monitoring mode with positive electrospray ionization. This UPLC–MS–MS method was validated by use of a recently introduced validation strategy based on accuracy profiles. Accuracy, precision, and linearity were good in the concentration range 0.50–500 ng mL−1. The lower limit of quantification was 0.50 ng mL−1 serum. A diurnal rhythm of serum hepcidin-25 levels was found by standardizing the sampling time from 07:30 on one day to 07:30 on the third day for eight healthy volunteers. The results indicated that circulating hepcidin-25 concentrations are different between genders and for different diurnal rhythms.
Chromatographia 12/2014;
• ##### Article: Application of the Solvatic Model for Prediction of Retention in RP-LC for Multi-Step Gradient Profiles
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ABSTRACT: Application of the solvatic retention model of reversed-phase liquid chromatography was studied to predict retention of phenylisothiocyanate derivatives of amino acids from structural formulae and stationary and mobile phase properties. The gradient elution mode with methanol and acetonitrile aqueous mobile phases was used. It was shown that practically acceptable prediction or retention time values can be achieved after the first approximation step when experimental data of one run are used. The zero approximation level predictions—from structural formulae, column and mobile phase properties can be used as a “first guess” method from which further optimization can begin.
Chromatographia 12/2014;
• ##### Article: Support Vector Regression Based QSPR for the Prediction of Retention Time of Peptides in Reversed-Phase Liquid Chromatography
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ABSTRACT: In the present study, Quantitative Structure–Property Relationship (QSPR) models were developed to investigate the retention times (t R ) of various peptides in seven reversed-phase liquid chromatography systems using Partial Least Squares (PLS), Artificial Neural Network (ANN) and Support Vector Machine (SVM) techniques. Different types of molecular descriptors were calculated to represent the molecular structures of the various compounds studied. Important descriptors were selected by a Genetic Algorithm-Partial Least Square (GA-PLS) method. The four descriptors selected using GA-PLS were used as inputs for PLS, ANN and SVM to build models to predict the retention times. Our study reveals that the relation between the chemical properties and retention time is a nonlinear phenomenon and that the PLS method is not capable to properly model it. The results obtained demonstrate that, for all seven data sets, the t R values estimated by SVM were in good agreement with the experimental data, and the performances of the SVM models were comparable or superior to those of PLS and ANN.
Chromatographia 12/2014;
• ##### Article: Molecularly Imprinted Mesoporous SBA-15 Synthesized by Surface-Initiated Atom Transfer Radical Polymerization for Bisphenol A Recognition
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ABSTRACT: Ordered mesoporous material has good application potential in solid-phase extractions due to its high surface area and rapid binding kinetics. Molecularly imprinted mesoporous SBA-15 microspheres (MIP-SBA-15) with both advantages of molecularly imprinted polymer (MIP) and mesoporous material have been synthesized in the study. The surface-initiated atom transfer radical polymerization was employed in the imprinting process in order to create more homogeneous polymer layer on the surface of SBA-15. The bisphenol A (BPA) was used as imprinting template to provide selective extraction material with potential application in the BPA determinations. The results demonstrated the spherical MIP-grafted-SBA-15 with ordered mesoporous structure has been synthesized which is good for chromatographic applications. The material has good selectivity, high binding capacity and kinetics. The BPA and its analogs have less peak tailings on the MIP column in HPLC, which is attributed to the thin MIP film and less mass transfer resistance of the material. An online solid-phase extraction/HPLC experiment was established using the MIP-SBA-15 as the extraction material. In the BPA concentration range of 0.04–40 ng mL−1, a linear regression curve with R 2 > 0.9999 has been obtained. The LOD and LOQ are 30.84 and 102.79 pg mL−1, respectively. The recoveries were higher than 97 % determined using spiked tap water samples with different concentrations. It demonstrated the MIP-SBA-15 can be used in the BPA extraction from water samples with good efficiency.
Chromatographia 12/2014;
• ##### Article: Analysis of Stiripentol Enantiomers on Several Chiral Stationary Phases: A Comparative Study
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ABSTRACT: A comparative study was developed for the separation of stiripentol enantiomers on several chiral stationary phases which were CyclobondI 2000®, S,S Whelk O1®, R,R Whelk O1®, Chiralcel OB®, Chiralcel OF®, Chiralcel OB-H® and Chiralpak AD-RH®. The best separation was achieved on Chiralpak AD-RH chiral column where a simple, rapid and validated method for the determination of stiripentol enantiomers was developed. Stiripentol was separated and quantitated on Chiralpak AD-RH chiral column using a mixture of water/acetonitrile (30/70 v/v) as a mobile phase (t 1, t 2 = 5.626, 6.891, α = 1.22, R s = 2.53) at 25 °C and a flow rate of 1 mL min−1. The UV-detector was set at 254 nm. The applied HPLC method allowed the separation and quantification of stiripentol enantiomers with good linearity (r > 0.999) in the studied range. The relative standard deviations (% RSD) were 0.723 and 0.692 for the stiripentol enantiomers with accuracy of 98.40 and 98.53. The limit of detection and limit of quantification of stiripentol were found to be 10 and 30 µg mL−1, respectively. The method was validated through the parameters of linearity, accuracy, precision and robustness. The HPLC method was applied for the quantitative determination of stiripentol in pharmaceutical formulations.
Chromatographia 12/2014;
• ##### Article: Donald G. Barceloux: Medical Toxicology of Drug Abuse. Synthesised Chemicals and Psychoactive Plants
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ABSTRACT: The second in a series of four volumes on medical toxicology, this book is immediately a welcome resource for medics, pharmacists, and toxicologists and will surely be a valued addition to any department of emergency medicine or poisons centre. This volume focuses on those compounds that are used (or abused?) for pleasure or non-medical gain, but in doing so may cause harm; from the ancient and historic use of peyote by the native North Americans, to growth hormone and blood doping, through to designer club drugs like mephedrone.The book is extremely well structured throughout––each section on a drug or group of drugs follows the same format providing invaluable information on the chemistry, pharmacology, clinical response, screening, treatment, and so on, in detail that leaves other reference books wanting. The author has drawn from a large number of reference sources to compile each section, and diagrams, photographs and chemical structures are provided to further supplement the te ...
Chromatographia 12/2014; 77(23-24).