CHEMICAL & PHARMACEUTICAL BULLETIN Journal Impact Factor & Information

Publisher: Nihon Yakugakkai, Pharmaceutical Society of Japan

Journal description

This journal covers physical and inorganic chemistry, organic chemistry including natural products chemistry, medicinal chemistry, analytical chemistry, pharmacognosy and physical pharmacy.

Current impact factor: 1.16

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.164
2013 Impact Factor 1.375
2012 Impact Factor 1.564
2011 Impact Factor 1.592
2010 Impact Factor 1.507
2009 Impact Factor 1.698
2008 Impact Factor 1.623
2007 Impact Factor 1.223
2006 Impact Factor 1.262
2005 Impact Factor 1.246
2004 Impact Factor 1.184
2003 Impact Factor 1.103
2002 Impact Factor 1.133
2001 Impact Factor 1.113
2000 Impact Factor 1.177
1999 Impact Factor 1.162
1998 Impact Factor 1.135
1997 Impact Factor 1.156
1996 Impact Factor 1.309
1995 Impact Factor 1.026
1994 Impact Factor 1.099
1993 Impact Factor 0.854
1992 Impact Factor 1.098

Impact factor over time

Impact factor

Additional details

5-year impact 1.46
Cited half-life >10.0
Immediacy index 0.22
Eigenfactor 0.01
Article influence 0.34
Website Chemical & Pharmaceutical Bulletin (Tokyo) website
Other titles Chemical and pharmaceutical bulletin, Chemical and pharmaceutical bulletin
ISSN 0009-2363
OCLC 6067231
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

Pharmaceutical Society of Japan

  • Pre-print
    • Archiving status unclear
  • Post-print
    • Author cannot archive a post-print version
  • Conditions
    • Publisher's version/PDF must be used
    • On Institutional Repositories
  • Classification

Publications in this journal

  • CHEMICAL & PHARMACEUTICAL BULLETIN 01/2016; DOI:10.1248/cpb.c15-00793
  • [Show abstract] [Hide abstract]
    ABSTRACT: A series of pyridothieno[3,2-d]pyrimidin-4-amines was designed and synthesised as congeners to the classical 4-anilinoquinazolines as ATP-competitive EGFR inhibitors. Compound (5a) exhibited the most potent and selective inhibitory activity against EGFR with IC50 value at 36.7 nM. Moreover, compounds (4b) and (5a) showed a remarkable cell growth inhibition against leukemia, CNS cancer and NSCLC cell lines that overexpress EGFR, with GI50 values around 10 nM in the full NCI 60 cell panel assay. Cell cycle studies indicated that compounds (4b) and (5a) induced significant cell cycle arrest at S-phase and G0/G1 respectively in addition to boosting P27kip expression. Compound (5a) did not alter the viability of placental trophoblasts, which reflects its safety towards normal cells. The standard COMPARE analyses demonstrated considerable correlation levels between compounds (4b), (5a) and erlotinib with PCC values 0.707 and 0.727, respectively.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Photoaffinity labeling has become increasingly important with the development of powerful specific probes that are synthesized by installing a photo-activatable functional group (photophore) on the framework of biological ligands. The present review summarizes the development of diazirine-based photoaffinity labeling by focusing on its application to the structural elucidation of ligand-accepting sites within proteins.
    CHEMICAL & PHARMACEUTICAL BULLETIN 05/2015; 63(1):1-12. DOI:10.1248/cpb.c14-00645
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Four new triterpenoid saponins, Catunaroside I [3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-arjunic acid 28-O-β-D-glucopyranoside] (1), Catunaroside J [3-O-β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D -glucopyranosyl-arjunic acid 28-O-β-D-glucopyranoside] (2), Catunaroside K [3-O-β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl-tormentic acid] (3), and Catunaroside L [3-O-β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl-pomolic acid] (4), and two known triterpenoid saponin Arjunetoside (5) and RandiasaponinVII (6), were isolated from the stem bark of Catunaregam spinosa. Their structures were elucidated on the basis of their spectral data and chemical evidence.
    CHEMICAL & PHARMACEUTICAL BULLETIN 03/2015; 63(5). DOI:10.1248/cpb.c15-00055
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of the present study was to determine the thermodynamic stability orders of co-crystals by co-crystal former (CCF) exchange reactions. Caffeine (CA) was employed as a model drug. The CCF exchange reaction was performed by liquid-assisted grinding using ethanol. When oxalic acid (OX) was added to CA-citric acid co-crystal (CA-CI), CA-CI converted to CA-OX, suggesting that CA-OX is more stable than CA-CI. The stability orders of other co-crystals were determined in the same manner. The stability order of CA co-crystals was determined as CA-OX≈CA-p-hydroxybenzoic acid (HY)>CA-CI>CA-malonic acid>CA-maleic acid. The stability order correlated with the difference in hydrogen bond energy estimated in silico, except for CA-HY. The π-π stacking in CA-HY was suggested as a reason for this discrepancy. The CCF exchange reaction was demonstrated as a useful method to determine the stability order of co-crystals, which can be used for the validation of in silico parameters to predict co-crystal formation.
    CHEMICAL & PHARMACEUTICAL BULLETIN 03/2015; 63(1):18-24. DOI:10.1248/cpb.c14-00480
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: From the EtOAc-soluble fraction of a MeOH extract of the leaves of Glochidion acuminatum, six new compounds along with five known ones were isolated. The structures of the new compounds were elucidated to be two gallates, a p-hydroxybenzoate and an (S)-2-(4-hydroxycyclohex-1-en-1-yl)acetate of a nitrile-containing phenolic glucoside, methyl 2-(2-hydroxyphenyl)acetate β-D-glucopyranoside, and (S)-methyl 2-[4-sulfooxycyclohex-1-en-1-yl]acetate on the basis of spectroscopic evidence.
    CHEMICAL & PHARMACEUTICAL BULLETIN 03/2015; 63(1):49-53. DOI:10.1248/cpb.c14-00638
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: For the determination of seven caffeoylquinic acids [neochlorogenic acid (NcA), cryptochlorogenic acid (CcA), chlorogenic acid (CA), caffeic acid (CfA), isochlorogenic acid A (Ic A), isochlorogenic acid B (Ic B), isochlorogenic acid C (Ic C)] and two flavonoids [luteolin 7-O-glucoside (LtG) and luteolin (Lt)], a three-channel liquid chromatography with electrochemical detection (LC-3ECD) method was established. Chromatographic peak heights were proportional to each concentration, ranging from 2.5 to 100 ng/mL for NcA, CA, CcA, and CfA, and ranging from 2.5 to 250 ng/mL for LtG, Ic B, Ic A, Ic C, and Lt, respectively. The present LC-3ECD method was applied to the quantitative analysis of caffeoylquinic acids and flavonoids in four cultivars of Chrysanthemum morifolium flowers and their sulfur-fumigated products. It was found that 60% of LtG and more than 47% of caffeoylquinic acids were lost during the sulfur fumigation processing. Sulfur fumigation showed a destructive effect on the C. morifolium flowers. In addition, principle component analyses (PCA) were performed using the results of the quantitative analysis of caffeoylquinic acids and flavonoids to compare the "sameness" and "differences" of these analytes in C. morifolium flowers and the sulfur-fumigated products. PCA score plots showed that the four cultivars of C. morifolium flowers were clearly classified into four groups, and that significant differences were also found between the non-fumigated C. morifolium flowers and the sulfur-fumigated products. Therefore, it was demonstrated that the present LC-3ECD method coupled with PCA is applicable to the variation analysis of different C. morifolium flower samples.
    CHEMICAL & PHARMACEUTICAL BULLETIN 03/2015; 63(1):25-32. DOI:10.1248/cpb.c14-00515
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Layered double hydroxides (LDHs) have been used commercially as antacids, to stabilize drugs, to allow the controlled release of incorporated drugs, and to act as drug carriers to reduce drug accumulation within the body. Several types of LDH were investigated: nitrate type (LDH-NO3); chloride type (LDH-Cl); and carbonate type (LDH-CO3). Each type was added to an aqueous or methanol (MeOH) solution containing a drug (pravastatin or nateglinide). With pravastatin sodium, the interlayer distance expanded after reaction with LDH-NO3 and LDH-Cl in aqueous solution. In contrast, the interlayer distance of LDH-CO3 increased in methanol with nateglinide. Each drug was intercalated into the interlayer space of LDH by ion exchange. The hygroscopicity of the drug substances, complexes, and physical mixtures were determined at 70% relative humidity. Increases in weight (%) of the complexes were less than those of the physical mixtures, which demonstrates that hygroscopicity was reduced upon complexation with LDH due to the layer of LDH over the drugs.
    CHEMICAL & PHARMACEUTICAL BULLETIN 03/2015; 63(1):13-7. DOI:10.1248/cpb.c14-00429
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The main purpose of the present study was to evaluate the physicochemical stability of cyclosporine A (CsA)-loaded glycerol monooleate-based dry emulsion (DE). DE formulations containing 5-25% CsA (DE5-25) were stored at 25°C/60% relative humidity for 4 weeks, and freeze-dried solid dispersion formulations containing 5-30% CsA (FD5-30) were also prepared as reference formulations. Even after the storage, no significant changes were observed in the appearance of any formulations. In the dissolution study, both DE and FD exhibited marked enhancement of solubility and there was at least 2.0-fold improvement in the initial dissolution rate of DE formulations compared with that of FD formulations. After storage, DE5, DE15 and FD5 maintained relatively high solubility, with 10% reduction compared with the initial state. However, the solubility of DE25 gradually decreased during storage, as evidenced by 76% reduction of the dissolution amount. No significant changes were seen in DE5-25 using powder X-ray diffraction, although thermal analysis revealed moderate changes in crystallinity in DE25 after storage, possibly leading to the decreased dissolution. Furthermore, particle size distributions of micelles in DE5 and DE15 were almost unchanged after storage for 4 weeks. From these findings, it appears that the physicochemical stability of CsA-loaded DE might vary depending on the manufacturing method and that further optimization could improve physical properties and stability.
    CHEMICAL & PHARMACEUTICAL BULLETIN 03/2015; 63(1):54-8. DOI:10.1248/cpb.c14-00696
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Two new steroidal glycosides (1 and 2), together with 15 known compounds (3-17) were isolated from the fibrous roots of Ophiopogon japonicus, and three new steroidal glycosides (18-20), together with 14 known compounds (21-34) were isolated from the fibrous roots of Liriope spicata var. prolifera. The structures of the new compounds were elucidated on the basis of extensive one-dimensional (1D)- and 2D-NMR spectroscopic analyses and mass spectrometry. The isolated compounds were evaluated for their anti-inflammatory activity in vitro. Most of these steroidal glycosides showed significant inhibitory activity against neutrophil respiratory burst stimulated by phorbol myristate acetate.
    CHEMICAL & PHARMACEUTICAL BULLETIN 03/2015; 63(3):187-94. DOI:10.1248/cpb.c14-00735
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Nine new tirucallane-type triterpenoids, ficutirucins A-I (1-9), were isolated from the fruit of Ficus carica. Their structures were established on the basis of spectroscopic data and chemical methods. All isolates were evaluated for their cytotoxic activities against three human cancer cell lines, MCF-7, HepG-2, and U2OS. Compounds 1-3, 6, 7, and 9 exhibited moderate cytotoxic activities with IC50 values of 11.67-45.61 µM against one or more of the three cancer cell lines.
    CHEMICAL & PHARMACEUTICAL BULLETIN 03/2015; 63(3):237-43. DOI:10.1248/cpb.c14-00779
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Two types of amphoteric calix[n]arene carboxylic acid (CnCA) derivative, i.e., calix[6]arene hexa-carboxylic acid (C6HCA) and calix[8]arene octo-carboxylic acid (C8OCA), were synthesized by introducing acetoxyls into the hydroxyls of calix[n]arene (n=6, 8). C6HCA and C8OCA nanoparticles (NPs) were prepared successfully using the dialysis method. CnCA NPs had regular spherical shapes with an average diameter of 180-220 nm and possessed negative charges of greater than -30 mV. C6HCA and C8OCA NPs were stable in 4.5% bovine serum albumin solutions and buffers (pH 5-9), with a low critical aggregation concentration value of 5.7 mg·L(-1) and 4.0 mg·L(-1), respectively. C6HCA and C8OCA NPs exhibited good paclitaxel (PTX) loading capacity, with drug loading contents of 7.5% and 8.3%, respectively. The overall in vitro release behavior of PTX from the CnCA NPs was sustained, and C8OCA NPs had a slower release rate compared with C6HCA NPs. These favorable properties of CnCA NPs make them promising nanocarriers for tumor-targeted drug delivery.
    CHEMICAL & PHARMACEUTICAL BULLETIN 03/2015; 63(3):180-6. DOI:10.1248/cpb.c14-00699
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The principles of thermal effusivity are applied to an understanding of the detailed mechanisms of the lubrication process in a rotating mixer. The relationships and impact of the lubrication process by the pattern of powder flow, the filling level, and the rotating mixer size were investigated. Thermal effusivity profiles of the lubrication process, as obtained, indicate that lubrication is a two-phase process. The intersection point of the first and second phases (IPFS) is influenced by changing the filling level, thus changing the resulting number of avalanche flows created. The slope of the second phase (SSP) is influenced by the relationship between the number and the length of avalanche flows. Understanding this difference between the first and second phases is important to successfully evaluate the impact of proposed changes in the lubrication process. From this knowledge, a predictive model of the lubrication profile can be generated to allow an evaluation of proposed changes to the lubrication process. This model allows estimation of the lubrication profile at different filling levels and in different rotating mixer sizes. In this study, the actual lubrication profile almost coincides with the model predicted lubrication profile. Based on these findings, it is assumed that lubrication profiles at a commercial scale can be predicted from data generated at the laboratory scale. Further, it is assumed that changes in the filling level can also be estimated from the laboratory or current data.
    CHEMICAL & PHARMACEUTICAL BULLETIN 03/2015; 63(3):164-79. DOI:10.1248/cpb.c14-00634