British Journal of Radiology (BRIT J RADIOL )

Publisher: British Institute of Radiology


The British Journal of Radiology is the official peer reviewed journal of the British Institute of Radiology covering all clinical and technical aspects of diagnostic imaging, radiotherapy and radiobiology.

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    British Journal of Radiology website
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    British journal of radiology, BJR
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Publications in this journal

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    ABSTRACT: Objectives: The aim of this study was to compare patient-specific radiobiological parameters to population averages in predicting clinical outcome after radiotherapy using a tumor control probability (TCP) model based on BED. Methods: A previously published material of forty-six head and neck carcinomas with individually identified radiobiological parameters; SF2 and Tpot, and known tumor size was investigated. These patients had all been treated with external beam radiotherapy and the majority had also received brachytherapy. TCP for each individual based on BED using patient-specific radiobiological parameters was compared to TCP based on BED using average radiobiological parameters (α = 0.3 Gy-1 and Tpot = 3 days). Results: Forty-three patients remained in the final analysis. There was only a weak trend for increasing local tumor control with increasing BED in both groups. However, when TCP was calculated the use of patient-specific parameters was better to identify local control correctly. Sensitivity and specificity for tumor-specific parameters were 63% and 80%, respectively. The corresponding values for population-based averages were 0% and 91%, respectively. Positive predictive value was 92% when tumor-specific parameters were used compared to 0 % for population-based. A receiver operating characteristic (ROC) curve confirmed the superiority of patient-specific parameters over population averages in predicting local control. Conclusions: Individual radiobiological parameters are better than population derived averages when used in a mathematical model to predict tumor control probability after curative radiotherapy in head and neck carcinomas. Advances in knowledge: TCP based on individual radiobiological parameters are better than TCP based on population based averages.
    British Journal of Radiology 03/2013; 86(1025):20130015.
  • British Journal of Radiology 02/2013;
  • British Journal of Radiology 01/2013;
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    ABSTRACT: We report an unusual case of intracranial extracerebral neuroglial heterotopia (IENH) presenting with parapharyngeal extension. Neuroglial heterotopias are rarely reported pre-natally and, to our knowledge, there are no reported cases presenting pre-natal imaging findings of IENH with parapharyngeal extension. Because pre- and post-natal imaging studies are essential to diagnose IENH and plan surgical treatment, radiologists should be familiar with this rare condition.
    British Journal of Radiology 01/2012; 85(1010):e41-e45.
  • British Journal of Radiology 01/2009; 82(978):114-116.
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    ABSTRACT: The aim of this study is to evaluate the radiation dose to the interventional radiologist in transjugular intrahepatic portosystemic shunt (TIPS) concerning the risk of cancer and deterministic radiation effects and the relation to recommended dose limits. In 18 TIPS interventions radiation doses were measured with thermoluminescence dosemeters (TLD) fixed at the eyebrow, thyroid and hand of the radiologist without special lead shielding of these body parts and at the chest, abdomen and testes under the lead apron. The doses of the eye lens, thyroid gland and hand were assumed to be equal to the corresponding surface doses. The dose at the abdomen under the lead apron was used as an estimation of the ovarian dose. Effective dose equivalent was estimated by Webster's method. The estimated effective dose equivalent was 0.087 mSv and the effective dose 0.110 mSv. The risk of fatal cancer was of 10(-6) and the risk of severe genetic defect of 10(-7) for one single intervention. The maximum permissible number of TIPS interventions was 181, otherwise the dose limit for effective dose would be exceeded. When the radiologist performed more than 372 TIPS procedures per year for many years, the dose to the lens of the eye could exceed the threshold for cataract. If the interventionist performs a large number of TIPS procedures in a year, the risk of fatal cancer and developing cataracts becomes relatively high.
    British Journal of Radiology 07/2006; 79(942):483-6.
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    ABSTRACT: Penile lymphoma is extremely rare and secondary involvement of the penis by lymphoma may be due to retrograde spread or to direct extension from neighbouring organ. The appearance of penile lymphoma varies and can be mistaken for other soft tissue tumours. We report on a case with malignant lymphoma of the penis. MRI findings revealed soft-tissue mass of homogeneous isointensity around the middle to distal part of penis on T(1) weighted imaging and T(2) weighted imaging. It was well encapsulated, minimally enhanced and distinct from corpus cavernosum and corpus spongiosum.
    British Journal of Radiology 07/2006; 79(942):526-8.
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    ABSTRACT: Endobronchial brachytherapy was developed as effective treatment of endobronchial cancer and fractionated schedule is applied to decrease late toxicity. However, repeated bronchofiberscopy is onerous to the patient and restricts the treatment schedule itself. We applied mini-tracheostomy for a ready access route, and a torque controlled technique for easy insertion of the endobronchial applicator. Eight patients with tracheobronchial cancer invasion were treated with endobronchial brachytherapy of 18-30 Gy/3-5 fractions/1.5-2.5 weeks (median 24 Gy/4 fractions/2 weeks) at reference points of 5 mm from the bronchial surface. The averaged individual irradiation and single session times were 4 min and 24 min, respectively. There were no procedure-related complications. These technical improvements may facilitate flexible fractionated dose prescriptions.
    British Journal of Radiology 07/2006; 79(942):522-5.
  • British Journal of Radiology 07/2006; 79(942):536; author reply 536.
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    ABSTRACT: Human hepatoma and normal liver cells were irradiated with (12)C(6+) ion beams (linear energy transfer (LET) = 96 keV microm(-1)) and gamma-rays at the Heavy Ion Research Facility in Lanzhou (HIRFL). The numbers and types of chromatid breaks were detected using the premature chromosome condensation technique. Irradiation with (12)C(6+) ions produced a majority of isochromatid break types, while chromatid breaks were dominant for irradiation with gamma-rays. Experimental results showed that the initial level of chromatid breaks is clearly related to the absorbed dose from (12)C(6+) ions and gamma-rays. The (12)C(6+) ions are relatively more effective at inducing initial chromatid breaks when compared with the gamma-rays. A relative biological effectiveness (RBE) of about 2.5 resulted for the induction of initial chromatid breaks by (12)C(6+) ions relative to gamma-rays in both cell lines.
    British Journal of Radiology 07/2006; 79(942):518-21.
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    ABSTRACT: XP14BR is a cell line derived from a xeroderma pigmentosum (XP) patient from complementation group C. The patient was unusual in presenting with an angiosarcoma of the scalp, treated by surgical excision and radiotherapy. Following 38 Gy in 19 fractions with 6 MEV electrons, a severe desquamation and necrosis of the underlying bone ensued, and death followed 4 years later. The cell line was correspondingly hypersensitive to the lethal effects of gamma irradiation. We had previously shown that this sensitivity could be discriminated from that seen in ataxia-telangiectasia (A-T). The cellular response to ultraviolet radiation below 280 nm (UVC) was characteristic of XP cells, indicating the second instance, in our experience, of dual cellular UVC and ionizing radiation hypersensitivity in XP. We then set out to evaluate any defects in repair of ionizing radiation damage and to verify any direct contribution of the XPC gene. The cells were defective in repair of a fraction of double strand breaks, with a pattern reminiscent of A-T. The cell line was immortalized with the vector pSV3neo and the XPC cDNA transfected in to correct the defect. The progeny derived from this transfection showed the presence of the XPC gene product, as measured by immunoblotting. A considerable restoration of normal UVC, but not ionizing radiation, sensitivity was observed amongst the clones. This differential correction of cellular sensitivity is strong evidence for the presence of a defective radiosensitivity gene, distinct from XPC, which is responsible for the clinical hypersensitivity to ionizing radiation. It is important to resolve how widespread ionizing radiation sensitivity is amongst XP patients.
    British Journal of Radiology 07/2006; 79(942):510-7.
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    British Journal of Radiology 07/2006; 79(942):537-9.
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    ABSTRACT: Non-Hodgkin's lymphoma (NHL) is a group of heterogeneous tumours originating in lymphoid tissue. The outcome of patients with lymphoma is, in general, better than non-lymphoid malignancies. Indeed, aggres- sive NHLs, which make about two-thirds of the NHL subtypes, are potentially curable (about 60% of patients are cured) with conventional and high-dose therapy. More than 70% of patients with newly diagnosed lymphoma respond well to chemotherapy alone or to chemoimmunotherapy with or without radiotherapy. In addition to the availability of new treatments, accurate staging and risk stratification with appropriate selection of treatments, as well as improved assessment of response to therapy, have resulted in a higher success rate in the treatment of lymphoma. The increasing number of treatment options available for patients with lymphoma currently being tested in clinical trials clearly requires the availability of standardized guidelines for assessment of response to therapy, which should ensure
    British Journal of Radiology 06/2006; 79(941):365-7.

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