Australian Journal of Chemistry (AUST J CHEM )

Publisher: Commonwealth Scientific and Industrial Research Organization (Australia); Institute of Physics (Great Britain). Australian Branch; Australian National Research Council; Australian Academy of Science, CSIRO Publishing

Description

Australian Journal of Chemistry - an International Journal for Chemical Science publishes research papers from all fields of chemical science and technology, including synthesis, structure, new materials, macromolecules, supramolecular chemistry, biological chemistry, nanotechnology, surface chemistry, and analytical techniques.

Impact factor 1.64

  • Hide impact factor history
     
    Impact factor
  • 5-year impact
    1.94
  • Cited half-life
    9.60
  • Immediacy index
    0.74
  • Eigenfactor
    0.01
  • Article influence
    0.49
  • Website
    Australian Journal of Chemistry website
  • Other titles
    Australian journal of chemistry
  • ISSN
    0004-9425
  • OCLC
    1518813
  • Material type
    Periodical, Internet resource
  • Document type
    Journal / Magazine / Newspaper, Internet Resource

Publisher details

CSIRO Publishing

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • On author's personal repository or institutional repository
    • Must link to publisher version
    • Published source must be acknowledged
    • Publisher's version/PDF cannot be used
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Three chiral dinuclear lanthanide compounds, Ln2(m2-L)4(L)2(phen)2 (Ln¼Dy (1), Gd (2), and Er (3); phen¼1,10- phenanthroline), have been synthesized using the (S)-(þ)-2-(6-methoxy-2-naphthyl)propionic acid (HL) ligand. The two lanthanide centres in compound Ln2(m2-L)4(L)2(phen)2 are bridged by four carboxylate groups to give a dinuclear Ln2(m2-L)4 core. The square antiprismatic coordination environment for each lanthanide centre is further completed by a chelating carboxylate group from another L � ligand and two nitrogen atoms from the phen ligand. A weak antiferromagnetic interaction between the two GdIII ions is observed in compound 2. The Dy analogue displays field-induced slow magnetic relaxation behaviour with an effective energy barrier Ueff/k of 17.24(2) K and a pre-exponential factor t0 of 2.7(1)�10 �6 s. However, no slow relaxation phenomenon was observed for the Er derivative even in the presence of 2 kOe applied field.
    Australian Journal of Chemistry 02/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: We describe catalytic asymmetric C–C formation using terminal alkyl-metal nucleophiles generated from internal olefins through a ‘chain-walking’ isomerization mechanism. Hydrometallation of internal olefins with the Schwartz reagent gives the least hindered alkyl-zirconocene after thermal (60°C in THF) isomerization. After switching the solvent from THF to dichloromethane, the alkyl-zirconocenes can be used in copper-catalyzed asymmetric conjugate additions. Addition to a variety of cyclic α,β-unsaturated species were achieved in modest (22–50 %) yield with high (84–92 % ee) enantioselectivity. This work demonstrates that remote C–H functionalization coupled with asymmetric C–C bond formation is possible, but the present procedures are limited in terms of yield and olefin scope.
    Australian Journal of Chemistry 01/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: An improved route to 2-substituted 6-hydroxy-[3H]-pyrimidin-4-ones 4 and to 2-substituted 4,6-dichloropyrimidines 5 is reported. Without using highly toxic reactants, compounds 4 can be prepared conveniently in a one pot synthesis on a onemol scale with average yields up to 80%. 4,6-Dichloropyrimidines 5, which are usually prepared in small quantities, are synthesized with average yields of 80%, using up to 80 g of starting material. The mechanism of the chlorination of 4 is investigated computationally for the first time. The results suggest that the chlorination with phosphoryl chloride occurs in an alternating phosphorylation–chlorination manner (pathway 1) which is preferred over a sequence which starts with two phosphorylations. The investigated 4,6-dichloropyrimidines described herein form strong complexes with dichlorophosphoric acid but weak complexes with hydrochloric acid (generated during workup). These latter complexes explain the necessity of using aqueous sodium carbonate during the working up. In order to prevent possible formation of pyrimidinium salts between intermediates or the final dichloropyrimidines and unreacted hydroxypyrimidone, the latter could be deactivated with a strong acid such as dichlorophosphoric acid, thus allowing chlorination but prohibiting salt formation. Because of its general applicability to all nitrogen heterocycle chlorinations with phosphoryl chloride, the proposed route to dichloropyrimidines without solvent or side products, using less toxic reactants, is of general synthetic interest.
    Australian Journal of Chemistry 12/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: An improved route to 2-substituted 6-hydroxy-[3H]-pyrimidin-4-ones 4 and to 2-substituted 4,6-dichloropyrimidines 5 is reported. Without using highly toxic reactants, compounds 4 can be prepared conveniently in a one pot synthesis on a onemol scale with average yields up to 80%. 4,6-Dichloropyrimidines 5, which are usually prepared in small quantities, are synthesized with average yields of 80%, using up to 80 g of starting material. The mechanism of the chlorination of 4 is investigated computationally for the first time. The results suggest that the chlorination with phosphoryl chloride occurs in an alternating phosphorylation–chlorination manner (pathway 1) which is preferred over a sequence which starts with two phosphorylations. The investigated 4,6-dichloropyrimidines described herein form strong complexes with dichlorophosphoric acid but weak complexes with hydrochloric acid (generated during workup). These latter complexes explain the necessity of using aqueous sodium carbonate during the working up. In order to prevent possible formation of pyrimidinium salts between intermediates or the final dichloropyrimidines and unreacted hydroxypyrimidone, the latter could be deactivated with a strong acid such as dichlorophosphoric acid, thus allowing chlorination but prohibiting salt formation. Because of its general applicability to all nitrogen heterocycle chlorinations with phosphoryl chloride, the proposed route to dichloropyrimidines without solvent or side products, using less toxic reactants, is of general synthetic interest.
    Australian Journal of Chemistry 12/2014;
  • Australian Journal of Chemistry 11/2014; 24(5):1099-1102.
  • [Show abstract] [Hide abstract]
    ABSTRACT: 5-Isopropyl-3-methylbenzene-1,2-diol, obtained by thermal degradation of the diterpenoid 3,10-dihydroxydielmentha-5,11-diene-4,9- has been synthesized.
    Australian Journal of Chemistry 11/2014; 37(12):2607-2610.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The four diepoxides of limonene have been synthesized and separated, and their distinguishing spectral characteristics are described.
    Australian Journal of Chemistry 11/2014; 44(12):1803-1808.
  • Australian Journal of Chemistry 11/2014; 21(7):1923-1925.
  • [Show abstract] [Hide abstract]
    ABSTRACT: A library of novel, highly functionalized spiropyrrolidines has been synthesized stereoselectively for the first time in ionic liquid medium employing [3+2] cycloaddition of a series of 2-arylmethylidene-5,6-dimethoxy-2,3-dihydro-1H-inden-1-ones with an unexplored azomethine ylide derived from acenaphthenequinone or isatin and tryptophan. These compounds were evaluated in vitro for their acetylcholinesterase and butyrylcholinesterase inhibitory activities. Molecular modelling simulation was performed to determine the binding interaction and orientation of these molecules in the active site gorge of the respective receptors.
    Australian Journal of Chemistry 10/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: In this paper we demonstrate that the Turkevich reaction can be used to obtain not only spherical gold nanoparticles of various sizes, but also nanoparticles of different morphologies. The effect of the molar ratios of citrate to HAuCl4 at various temperatures has been studied, and it is found that the reagent ratio plays a significant role in defining the morphology of the gold nanosystems formed at low temperatures. This study shows that by controlling the reagent ratios and the reaction temperature of the Turkevich reaction nanostructured gold systems with various shapes, including spheres, wires, networks and systems comprising only polygonal nanoparticles or only nanochains, the latter two for the first time, can be obtained. The gold nanosystems obtained in this fashion were characterized by transmission electron microscopy and UV-Vis absorption spectroscopy
    Australian Journal of Chemistry 08/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: New interventions against infectious diseases require a detailed knowledge and understanding of pathogen–host interactions and pathogeneses at the molecular level. The combination of the considerable advances in systems biology research with methods to explore the structural biology of molecules is poised to provide new insights into these areas. Importantly, exploring three-dimensional structures of proteins is central to understanding disease processes, and establishing structure–function relationships assists in identification and assessment of new drug and vaccine targets. Frequently, the molecular arsenal deployed by invading pathogens, and in particular parasites, reveals a common theme whereby families of proteins with conserved three-dimensional folds play crucial roles in infectious processes, but individual members of such families show high levels of specialisation, which is often achieved through grafting particular structural features onto the shared overall fold. Accordingly, the applicability of predictive methodologies based on the primary structure of proteins or genome annotations is limited, particularly when thorough knowledge of molecular-level mechanisms is required. Such instances exemplify the need for experimental three-dimensional structures provided by protein crystallography, which remain an essential component of this area of research. In the present article, we review two examples of key protein families recently investigated in our laboratories, which could represent intervention targets in the metabolome or secretome of parasites.
    Australian Journal of Chemistry 08/2014; 67:1732.