Arquivos de Gastroenterologia (Arq Gastroenterol)

Publisher: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia; Colégio Brasileiro de Cirurgia Digestiva; Sociedade Brasileira de Motilidade Digestiva

Journal description

Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE, Colégio Brasileiro de Cirurgia Digestiva - CBCD, Sociedade Brasileira de Motilidade Digestiva - SBMD. Mission: To publish scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.

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Website Arquivos de Gastroenterologia website
Other titles Arquivos de gastroenterologia (Online), Archives of gastroenterology
ISSN 0004-2803
OCLC 53922577
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publications in this journal

  • Arquivos de Gastroenterologia 01/2016;
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    ABSTRACT: ABSTRACT – Background –Colonoscopy is an important diagnostic and therapeutic procedure. Adequate bowel preparation is mandatory. Several regimens were discussed in the literature. Among the drugs which has recently used, polyethylene glycol is one of the most popular agents …Objectives – The aim of this study was to compare efficacy of three different methods for one day preparation before colonoscopy. Methods – This study included children with the range of ages (2-21) who had an indication of colonoscopy. Exclusion criteria were based on the history of previous surgery, parental disagreement, and patients who did not use preparation protocol. Three methods for bowel preparation were studied: 1- Polyethylene glycol only; 2- Polyethylene glycol and bisacodyl suppositories; 3- Polyethylene glycol plus normal saline enema. Boston Bowel Preparation Score was used for evaluation of preparation. SPSSversion 16.0 (Chicago, IL, USA) were used for data analysis. Results – In this study 83 cases completed the bowel preparation completely. Acceptable bowel preparation in 24 (85.71%), 36 (94.73%), and 14 (82.35%) of cases in PEG, PEG+ bisacodyl, and PEG+ normal saline enema groups respectively. PEG+ bisacodyl suppositories was more effective than PEG+ Normal saline for the preparation of the first segment (P=0.05). For 2nd and 3rd segment of colon, BPPS score was higher in PEG + bisacodyl suppositories compared to other regimens, but this difference was not statistically significant. Conclusion – There was no significant difference between one day colonoscopy regimens in terms of bowel preparation score. Lowest score was seen in PEG + Enema group compared to other group.
    Arquivos de Gastroenterologia 12/2015; 52(4).
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    ABSTRACT: Background: Spontaneous bacterial peritonitis (SBP) is defined as an ascetic fluid infection without an evident intra-abdominal surgically treatable source. SBP is one of the severe complications in patients with cirrhosis and ascites. Without early antibiotic treatment, this complication is associated with high mortality rate; therefore, early diagnosis and treatment of SBP is necessary for survival. Leukocyte esterase dipstick test (LER) can rapidly diagnose the SBP. This study aimed to find out the diagnostic accuracy of leukocyte esterase dipstick test for the diagnosis of spontaneous bacterial peritonitis. Methods: A single centered hospital-based cross-sectional study was conducted during July 2013 to August 2014 on children with cirrhotic liver disease and ascites who were admitted in the Department of Pediatric Gastroenterology in Nemazee Hospital affiliated to Shiraz University of Medical Sciences (Iran). All patients underwent abdominal paracentesis, and the ascitic fluid was processed for cell count, LER strip test (Combiscreen SL10) and culture. SBP was defined as having a polymorphonuclear count (PMN ≥250/m 3) in ascitic fluid. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of leukocyte esterase test were calculated according to the formula. Result: Totally, 150 ascitic fluid sample of cirrhotic male patients (53.2%) and their mean age (4.33± 1.88 years, p = 0433) were analyzed. Biliary atresia(n=44,29.4%) and idiopathic neonatal hepatitis(n=29,19.3%) were the most frequent etiology of cirrhosis. Also, abdominal pain (68.6%) and distension (64%) were the most common presenting complaint. Of all cases, 41patients (27.35) were diagnosed to have SBP (PMN ≥250/mm3). Sensitivity and specificity of LER test according to PMNs≥ 250mm3 were 87.80% and 91.74%, also on ascitic fluid culture results were 88.23% and 77.44%. PPV and NPV of this test in PMNs≥ 250mm3 were 80% and 95.23% and in cases with positive culture 33.33% and 98.09% were obtained, respectively. Efficiency of LER test in diagnosing SBP, according to PMNs≥ 250mm3 and culture results were 90.66% and 78.66%. Conclusion: The leukocyte esterase strip test may be used as rapid test for diagnosis of SBP due to its high diagnostic validity.
    Arquivos de Gastroenterologia 09/2015; 52(3).
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    ABSTRACT: Context Intestinal inflammation can induce a local reduction in oxygen levels that triggers an adaptive response centered on the expression of hypoxia-inducible factors (HIFs). Nitric oxide, a well-described inflammatory mediator, may interfere with hypoxia signaling. Objectives We aimed to evaluate the role of nitric oxide in hypoxia signaling during colonic inflammation. Methods Colitis was induced by single (acute) or repeated (reactivated colitis) trinitrobenzenosulfonic acid administration in rats. In addition, one group of rats with reactivated colitis was also treated with Nw-Nitro-L-arginine methyl ester hydrochloride to block nitric oxide synthase. Colitis was assessed by macroscopic score and myeloperoxidase activity in the colon samples. Hypoxia was determined using the oxygen-dependent probe, pimonidazole. The expression of HIF-1α and HIF-induced factors (vascular endothelial growth factor - VEGF and apelin) was assessed using Western blotting. Results The single or repeated administration of trinitrobenzenosulfonic acid to rats induced colitis which was characterized by a high macroscopic score and myeloperoxidase activity. Hypoxia was observed with both protocols. During acute colitis, HIF-1α expression was not increased, but VEGF and apelin were increased. HIF-1α expression was inhibited during reactivated colitis, and VEGF and apelin were not increased. Nw-Nitro-L-arginine methyl ester hydrochloride blockade during reactivated colitis restored HIF-1α, VEGF and apelin expression. Conclusions Nitric oxide could interfere with hypoxia signaling during reactivated colitis inflammation modifying the expression of proteins regulated by HIF-1α.
    Arquivos de Gastroenterologia 12/2014; 51(4):302-8. DOI:10.1590/S0004-28032014000400007
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    ABSTRACT: Context Tissue sampling of renal masses is traditionally performed via the percutaneous approach or laparoscopicaly. The utility of endoscopic ultrasound to biopsy renal lesions it remains unclear and few cases have been reported. Objectives To evaluate the feasibility and outcome of endoscopic ultrasound fine needle aspiration of renal tumors. Methods Consecutive subjects undergoing attempted endoscopic ultrasound fine needle aspiration of a kidney mass after evaluation with computerized tomography or magnetic resonance. Results Ten procedures were performed in nine male patients (median age 54.7 years) on the right (n = 4) and left kidney (n = 4) and bilaterally (n = 1). Kidney masses (median diameter 55 mm ; range 13-160 mm) were located in the upper pole (n = 3), the lower pole (n = 2) and the mesorenal region (n = 3). In two cases, the mass involved more than one kidney region. Surgical resection confirmed renal cell carcinoma in six patients in whom pre-operative endoscopic ultrasound fine needle aspiration demonstrated renal cell carcinoma. No complications were reported. Conclusions Endoscopic ultrasound fine needle aspiration appears as a safe and feasible procedure with good results and minimal morbidity.
    Arquivos de Gastroenterologia 12/2014; 51(4):337-40. DOI:10.1590/S0004-28032014000400013
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    ABSTRACT: Despite intensive research we remain ignorant of the cause of both Crohn's disease and ulcerative colitis. The dramatic rise in incidence, particularly of Crohn's disease, points towards environmental factors as playing a significant role. A major purpose of this review is to stimulate a co-ordinated international effort to establish an on-going data base in Central and South America in which new cases are registered and through which investigations into aetiology can be conducted. In both Brazil and Mexico there is evidence that the incidence of ulcerative colitis is increasing, as also is the case for Crohn's disease in Brazil. The pattern of disease is, therefore, directly comparable to that reported from Europe and the USA during the 1970s and 1980s, but much lower than contemporary data from Spain. Although the incidence is similar to that reported from Portugal, the studies from Almada and Braga were conducted a decade before that from Sao Paulo. The situation in Brazil compares dramatically with Uruguay and Argentina where the reported incidence of inflammatory bowel disease is significantly less. However, with growing industrialisation it is likely that there will be an explosion of inflammatory bowel disease in some areas of Central and South America over the next 20 years. The creation of a network of researchers across South and Central America is a real possibility and through a Concerted Action there is the possibility that major strides could be made towards understanding the cause of inflammatory bowel disease and so develop preventive strategies.
    Arquivos de Gastroenterologia 12/2014; 51(4):271-5. DOI:10.1590/S0004-28032014000400002
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    ABSTRACT: Context Clinical presentation of celiac disease is extremely variable and the diagnosis relies on serologic tests, mucosal intestinal biopsy and clinic and serologic response to a gluten-free diet. Objectives To correlate the endoscopic and histological aspects of adult patients with suspicion of celiac disease and to evaluate the interobserver histological agreement. Methods Endoscopic aspects of 80 adult patients were evaluated and correlated with the histological features according the Marsh-Oberhuber classification system. The interobserver histological agreement was based on kappa values. Results The symptoms of the patients varied largely, with prominence for chronic diarrhea, present in 48 (60%) patients. The endoscopic aspects related with the duodenal villous atrophy had been observed in 32 (40%) patients. There were confirmed 46 cases of celiac disease, with prevalence of 57.5%. The sensitivity, specificity, positive predictive value and negative predictive value of the endoscopic markers for celiac disease diagnosis were of 60.9%, 88.2%, 87.5% and 62.5%. There was moderate interobserver histological agreement (kappa = 0.46). Conclusions The endoscopic markers of villous atrophy, although not diagnostic, had assisted in the suspicion and indication of the duodenal biopsies for diagnosis proposal. Histology is sometimes contradictory and new biopsies or opinion of another professional can provide greater diagnostic agreement.
    Arquivos de Gastroenterologia 12/2014; 51(4):290-6. DOI:10.1590/S0004-28032014000400005
  • Arquivos de Gastroenterologia 10/2014; 51(4).
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    ABSTRACT: Context Sour acidic liquid has a slower distal esophageal transit than a neutral liquid. Our hypothesis was that an acidic sour bolus has a different ingestion dynamic than a neutral bolus. Method In 50 healthy volunteers and 29 patients with gastroesophageal reflux disease (GERD), we evaluated the ingestion dynamics of 100 mL of acidic sour liquid (concentrated lemon juice, pH: 3.0) and 100 mL of water (pH: 6.8). The time to ingest the total volume, the number of swallows to ingest the volume, the interval between swallows, the flux of ingestion and the volume ingested in each swallow was measured. Results In both groups, healthy volunteers and patients in treatment for GERD, the acidic liquid took longer to be ingested, a higher number of swallows, a slower flux of ingestion and a smaller volume in each swallow than the neutral bolus. There was no difference between healthy volunteers and patients with GERD. The ingestion in women was longer than in men for acidic and neutral liquids. Conclusion Acidic liquid has a different dynamic of ingestion than the neutral liquid, which may be consequence of the slower transit through the distal esophageal body or an anticipation to drink a sour bolus. Patients with GERD have the same prolonged ingestion of the acidic liquid bolus as seen in healthy volunteers.
    Arquivos de Gastroenterologia 09/2014; 51(3):217-220. DOI:10.1590/S0004-28032014000300010