The Antiseptic (Antiseptic)
Current impact factor: 0.00
Impact Factor Rankings
|Document type||Journal / Magazine / Newspaper|
Publications in this journal
- The Antiseptic 03/2012; 109(3):142-144.
- The Antiseptic 01/2012; 109(1):30-32.
- The Antiseptic 12/2011; 108(12):607-610.
- The Antiseptic 12/2011; 108(2):595-597.
- The Antiseptic 07/2011; 108(7):326-328.
- The Antiseptic 06/2011; 108(6):285-287.
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ABSTRACT: Acne Vulgaris is the most common dermatological disorder and Propionibacterium acnes is the commonest causative organism in pathogenesis of acne inflammation. The Propionibacterium acnes release neutrophil chemotactic factors, which attracts polymorph nuclear leukocytes at the site of infection. A polymorph nuclear leukocyte induces the reactive oxygen species to create an oxidative stress, which is responsible for acne inflammation. Conventional medical treatment has its own side effects besides the high cost. Ethno botanical search reveals use of many traditional herbs in treatment of acne, which are usually free from side effects, are economical and also accessible to humans. The present in-vitro study was conducted to evaluate the antibacterial activity of Clarina cream and compare with Tetracycline against Propionibacterium acnes by agar well diffusion method using Reinforced clostridial agar media (RCA) Hi-media. The antibacterial activity of Clarina cream at concentrations of 50 and 100 mg was compared with Standard antibiotic Tetracycline (0.5µg). The results showed the zone of inhibition with Clarina cream at 50mg against Propionibacterium acne was 12.00 ± 0.00 mm when the concentration of Clarina Cream increased to 100 mg showed a further inhibition of 15.25 ± 0.25 mm. In comparison with that of standard antibiotic Tetracycline at 0.5µg concentration using agar well diffusion method showed 19.75 ± 0.25 mm inhibition. This comparative in-vitro evaluation of Clarina cream clearly shows that Clarina cream inhibits the growth of the acne causing organism Propionibacterium acnes, which is comparable to the standard antibiotic Tetracycline which is the most effective and commonly used treatment for acne. The efficacy of Clarina cream can be attributed to the synergistic effects of its potent herbs. Key words: Clarina cream, Propionibacterium acnes, Antibacterial activityThe Antiseptic 05/2011; 108.
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ABSTRACT: Paracetamol, also known as acetaminophen, is a non-steroidal analgesic and antipyretic agent with very little anti-inflammatory action. The study was designed to evaluate the comparative efficacy and safety of test product Paracetamol 1000 mg SR Tables compare to reference product Crocin 500mg Tablets in patients with fever and pain. To meet the objectives of the study, sufficient number of patients was screened under pre-defined inclusion and exclusion criteria. The study was an open labeled, randomized, multicentre, parallel and comparative clinical trial. Duration of treatment was three days; while dosage regimen for Paracetamol 1000 mg SR was one tablet twice daily for three days and that for Crocin 500 mg tablets was one tablet four times a day for three days. The aim was to include 400 patients with the span of 2 months. Antipyretic activity was measured by monitoring body temperature as the primary efficacy parameter and analgesic activity was measured using VAS (Visual Analogue Scale) as secondary efficacy parameter, as per schedule. Incidences of any adverse drug reactions were monitored throughout the course of treatment for safety assessment. Temperature reduction in case of test product was from 102.9°F mean temperature before treatment to 99.06°F temperature after treatment after treatment with Paracetamol 1000 mg SR; while those in case of reference product was from 102.76°F mean temperature before treatment to 99.93°F temperature after treatment with Crocin 500mg. For pain reduction, VAS mean rank reduced from 590.6 to 588.59 after treatment with test product, while those reduced from 597.69 to 598.41 after treatment with Crocin 500mg. There were no significant adverse reactions observed with either product. Antipyretic and analgesic efficacy of test and reference product was similar. Both the products were found to be safe with similar extent.The Antiseptic 05/2011; 108(5 May 2011):8.
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