Analytical Chemistry (ANAL CHEM)

Publications in this journal

• Article: Enhancing Secondary Ion Yields in Time of Flight-Secondary Ion Mass Spectrometry Using Water Cluster Primary Beams

  Sadia Sheraz (Rabbani, Andrew Barber, John S. Fletcher, Nicholas P. Lockyer, John C. Vickerman
  Analytical Chemistry 05/2013;
• Article: Identification of ion series using ion mobility mass spectrometry: the example of alkyl-benzothiophene and alkyl-dibenzothiophene ions in Diesel fuels

  Florian Maire, Kieran Neeson, Richard Denny, Michael McCullagh, Catherine Lange, Carlos Afonso, Pierre Giusti
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  ABSTRACT: Ion Mobility - Mass Spectrometry (IMMS) has been presented as a promising method for analysis of highly complex mixtures. This coupling adds, an additional post-ionization separation dimension to MS. The IM separation of ions is obtained in the ms time scale, and can be particularly helpful when chromatographic separation is not possible. For obtaining relevant information about the samples, data processing is usually the bottleneck because of the high amount of data generated with IMMS. In the current work, we present a new workflow using specific comparison software dedicated to IMMS data, which allows by comparing m/z-drift time plots to highlight differences between samples. Two diesel fuels have been compared, i.e. the feed and the product of hydrodesulfurization (HDS) process, and this approach allowed to clearly highlight the variation of intensity of several ions distributed along the plots of both samples. Accurate mass measurements and post IM collision induced dissociation experiments allowed us to identify two series of polycyclic aromatic sulfur heterocycles (PASHs) compounds among the matrix ions.
  Analytical Chemistry 05/2013;
• Article: Rapid and Comprehensive Impurity Profiling of Synthetic Thyroxine by Ultrahigh-Performance Liquid Chromatography−High-Resolution Mass Spectrometry

  Volker Neu, † Chris Bielow, ‡ Iris Gostomski, § Reiner Wintringer, § Ralf Braun, ⊥ Knut Reinert
  Analytical Chemistry 02/2013; 85:3309-3317.
• Article: The degradation process of lead chromate in paintings by Vincent van Gogh studied by means of spectromicroscopic methods. Part III: Synthesis, characterization and detection of different crystal forms of the chrome yellow pigment

  L.Monico, K.Janssens, C.Miliani, B.Brunetti, M.Vagnini, F.Vanmeert, G.Falkenberg, A.Abakumov, Y.Lu, H. Tian, M. Radepont, M. Cotte, E. Hendriks, M. Geldog, L. van der Loeff, J. Salvant, M. Menu
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  ABSTRACT: The painter, Vincent van Gogh, and some of his contemporaries frequently made use of the pigment chrome yellow that is known to show a tendency toward darkening. This pigment may correspond to various chemical compounds such as PbCrO4 and PbCr1‑xSxO4, that may each be present in various crystallographic forms with different tendencies toward degradation. Investigations by X-ray diffraction (XRD), mid-Fourier Transform infrared (FTIR), and Raman instruments (benchtop and portable) and synchrotron radiation-based micro-XRD and X-ray absorption near edge structure spectroscopy performed on oil-paint models, prepared with in-house synthesized PbCrO4 and PbCr1‑xSxO4, permitted us to characterize the spectroscopic features of the various forms. On the basis of these results, an extended study has been carried out on historic paint tubes and on embedded paint microsamples taken from yellow-orange/pale yellow areas of 12 Van Gogh paintings, demonstrating that Van Gogh effectively made use of different chrome yellow types. This conclusion was also confirmed by in situ mid-FTIR investigations on Van Gogh’s Portrait of Gauguin (Van Gogh Museum,Amsterdam).
  Analytical Chemistry 01/2013; 85(2):851-859.
• Article: X.R. Cheng, B.Y.H. Hau, A.J. Veloso, S. Matic, H.-B. Kraatz, K. Kerman, “ Surface Plasmon Resonance Imaging of Amyloid-beta Aggregation Kinetics in the Presence of Epigallocatechin Gallate and Metal”, Anal. Chem. 2013, 85, 2049-2055.

  Heinz-Bernhard Kraatz
  Analytical Chemistry 01/2013; 85:2049-2055.
• Article: Direct Detection of Inorganic Nitrate Salts by Ambient Pressure Helium-Plasma Ionization Mass Spectrometry. Julius Pavlov and Athula B. Attygalle. Analytical Chemistry 85 (2013) 278-282

  Julius Pavlov, Athula B. Attygalle
  Analytical Chemistry 01/2013; 85:278-282.
• Article: Design and development of a field applicable gold nanosensor for the detection of luteinizing hormone.

  Zambre A, Chanda N, Prayaga S, Almudhafar R, Afrasiabi Z, Upendran A, Kannan R
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  ABSTRACT: In this paper, we describe a novel strategy for the fabrication of a nanosensor for detecting luteinizing hormone (LH) of sheep using a gold nanoparticle-peptide conjugate. A new peptide sequence “CDHPPLPDILFL” (leutinizing hormone peptide, LHP) has been identified, using BLAST and Clustal W analysis, to detect antibody of LH (sheep). LHP has been synthesized and characterized, and their affinity toward anti-LH was established using enzyme linked immunosorbant assay (ELISA) technique. The thiol group in LHP directly binds with gold nanoparticles (AuNPs) to yield AuNP-LHP construct. Detailed physicochemical analysis of AuNP-LHP construct was determined using various analytical techniques. Nanosensor using gold nanoparticle peptide conjugate was developed on the basis of competitive binding of AuNP-LHP and LH toward anti-LH. Nitrocellulose membrane, precoated with anti-LH, was soaked in the mixture of AuNP-LHP and sample of analysis (LH). In the absence of LH (sheep), anti-LH coated on the membrane binds with AuNP-LHP, leading to a distinctive red color, while in the presence of LH, no color appeared in the membrane due to the interaction of anti-LH with LH thereby preventing the binding of AuNP-LHP with membrane bound anti-LH. The sensor assay developed in this study can detect LH (sheep) up to a minimal concentration of 50 ppm with a high degree of reproducibility and selectivity. The gold-nanoparticle-peptide based nanosensor would be a simple, portable, effective, and low cost technique for infield applications.
  Analytical Chemistry 11/2012; 84(21):9478.
• Article: Mass Spectrometry Based Acetylcholine Sensor for High Temporal Resolution In Vivo Monitoring

  Peng Song, Neil Hershey, Omar S. Mabrouk, Thomas Slaney, Robert Kennedy
  Analytical Chemistry 05/2012;
• Article: Nanopatterned cadmium selenide langmur-Bloodgel platform for leukemia detection. Sharma A,Pandey CM, Chatterjee T, Malhotra BD,etal. Anal Chem 2012 Apr3,84(7):3082-9

  Sharma A, Pandey CM, Chatterjee T, Malhotra BD
  Analytical Chemistry 04/2012;
• Article: Optimizing the Use of Quality Control Samples for Signal Drift Correction in Large-Scale Urine Metabolic Profiling Studies.

  Kamleh A, Ebbels TM, Spagou K, Masson P, Want EJ
  Analytical Chemistry 02/2012;
• Article: Electrostatic Protein Immobilization Using Charged Polyacrylamide Gels and Cationic Detergent Microfluidic Western Blotting

  Dohyun Kim†, Kelly Karns‡, Samuel Q. Tia‡, Mei He†, Amy E. Herr
  Analytical Chemistry 01/2012;