American Journal of Obstetrics and Gynecology (AM J OBSTET GYNECOL)

Publications in this journal

• Article: Cardiovascular Risk Factors in Women Who Had Hypertensive Disorders Late in Pregnancy: A Cohort Study. Hermes W, Franx A, van Pampus MG, Bloemenkamp KW, Bots ML, van der Post JA, Porath M, Ponjee GA, Tamsma JT, Mol BW, de Groot CJ. Am J Obstet Gynecol. 2013 Feb 8. doi:pii: S0002-9378(13)00157-9. 10.1016/j.ajog.2013.02.016. [Epub ahead of print] PMID:23399350[PubMed - as supplied by publisher]

  Hermes W, Franx A, van Pampus MG, Bloemenkamp KW, Bots ML, van der Post JA, Porath M, Ponjee GA, Tamsma JT, Mol BW, de Groot CJ
  [show abstract] [hide abstract]
  ABSTRACT: Abstract OBJECTIVE: The purpose of this study was to determine cardiovascular risk factors in women with a history of hypertensive pregnancy disorders at term, 2.5 years after pregnancy. STUDY DESIGN: In a multicenter cohort study in the Netherlands between June 2008 and November 2010, cardiovascular risk factors were compared between women with a history of hypertensive pregnancy disorders at term (HTP cohort, n=306) and women with a history of normotensive pregnancies at term (NTP cohort, n=99). HTP women had participated in a randomized, longitudinal trial assessing the effectiveness of induction of labor in women with hypertensive pregnancy disorders at term. All women were assessed 2.5 years after pregnancy for blood pressure, anthropometrics, glucose, HbA1C, insulin, HOMA score, total cholesterol, HDL cholesterol, triglycerides, high sensitive CRP and micro-albumin and metabolic syndrome. RESULTS: After a mean follow-up period of 2.5 years, hypertension (HTP, 34%; NTP, 1%; P<.001) and metabolic syndrome (HTP, 25%; NTP, 5%; P<.001) were more prevalent in HTP women compared with NTP women. HTP women had significantly higher systolic and diastolic blood pressure, higher BMI and waist circumference. Glucose, HbA1C, insulin, HOMA score, total cholesterol, triglycerides and high sensitive CRP-levels were significantly higher and HDL cholesterol was significantly lower in HTP women. CONCLUSIONS: In women with a history of hypertensive pregnancy disorders at term hypertension and metabolic syndrome are more common, and they have higher levels of biochemical cardiovascular risk factors 2.5 years after pregnancy.
  American Journal of Obstetrics and Gynecology 02/2013;
• Article: Perinatal death of triplet pregnancies by chorionicity

  Haruna Kawaguchi, Keisuke Ishii
  American Journal of Obstetrics and Gynecology 01/2013;
• Article: Perinatal death of triplet pregnancies by chorionicity

  Kawaguchi H
  American Journal of Obstetrics and Gynecology 01/2013;
• Article: Phenotyping Clinical Disorders: Lessons Learned From Pelvic Organ Prolapse.

  Wu JM, Ward RM, Allen-Brady KL, Edwards TL, Norton PA, Hartmann KE, Hauser ER, Velez Edwards DR
  [show abstract] [hide abstract]
  ABSTRACT: Genetic epidemiology, the study of genetic contributions to risk for disease, is an innovative area in medicine. Although research in this arena has advanced in other disciplines, few genetic epidemiological studies have been conducted in obstetrics and gynecology. It is crucial that we study the genetic susceptibility for issues in women's health because this information will shape the new frontier of personalized medicine. To date, preterm birth may be one of the best examples of genetic susceptibility in obstetrics and gynecology, but many areas are being evaluated including endometriosis, fibroids, polycystic ovarian syndrome, and pelvic floor disorders. An essential component to genetic epidemiological studies is to characterize, or phenotype, the disorder to identify genetic effects. Given the growing importance of genomics and genetic epidemiology, we discuss the importance of accurate phenotyping of clinical disorders and highlight critical considerations and opportunities in phenotyping, using pelvic organ prolapse as a clinical example.
  American Journal of Obstetrics and Gynecology 11/2012;
• Article: Haptoglobin Phenotype, Angiogenic Factors and Preeclampsia Risk

  Tracey L. WEISSGERBER, James M. ROBERTS, Arun JEYABALAN, R Powers, MinJae LEE, Robin E. GANDLEY
  [show abstract] [hide abstract]
  ABSTRACT: Objective We sought to determine whether haptoglobin (Hp) phenotype is related to preeclampsia risk, or to plasma concentrations of soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt-1), and placental growth factor (PlGF). Study design Hp phenotype was retrospectively determined in primiparous women with uncomplicated pregnancies (n = 309), gestational hypertension (n = 215), and preeclampsia (n = 249). Phenotype was assessed by peroxidase staining following native polyacrylamide gel electrophoresis of hemoglobin-supplemented serum. Results Compared with Hp 1-1, Hp 2-1 was associated with a significantly increased risk of preeclampsia (odds ratio, 2.11; 95% confidence interval, 1.07–4.18) and term preeclampsia (odds ratio, 2.45; 95% confidence interval, 1.07–5.83) in Caucasian women. Hp phenotype was not associated with preeclampsia risk in African Americans. Preeclamptic women had higher plasma sEng and sFlt-1, and lower PlGF, than control subjects. sEng, sFlt-1, and PlGF did not differ among women of different Hp phenotypes. Conclusion Hp 2-1 is associated with higher preeclampsia risk in primiparous Caucasian women.
  American Journal of Obstetrics and Gynecology 02/2012;
• Article: Haptoglobin Phenotype, Angiogenic Factors and Preeclampsia Risk

  Weissgerber TL, Roberts JM, Jeyabalan A, Powers R, Lee MinJae, Datwyler SA, Gandley RE
  American Journal of Obstetrics and Gynecology 02/2012;
• Article: 183: Maternal obesity and evidence of fetal programming of lipid metabolism

  Beth Plunkett, Gina Morgan, Richard Silver, Susan Crawford
  American Journal of Obstetrics and Gynecology 01/2012;
• Article: Prevention of HIV-1 transmission to the infant through breastfeeding: new developments

  Kourtis AP, Jamieson DJ, de Vincenzi I, Taylor AW, Thigpen MC, Dao H, Farley T, Fowler MG
  American Journal of Obstetrics and Gynecology 01/2007; 197(3):S26.
• Article: Reply (to letter of R.C. Goodlin)

  Little, M.P, Elliott, Steer, P.J
  American Journal of Obstetrics and Gynecology 01/2006; 195:337.
• Article: Characterization of vaginal microflora of healthy, nonpregnant women by chaperonin-60 sequence-based methods.

  Janet E Hill, Swee Han Goh, Deborah M Money, Melissa Doyle, Andra Li, William L Crosby, Matthew Links, Amy Leung, Debbie Chan, Sean M Hemmingsen
  [show abstract] [hide abstract]
  ABSTRACT: The purpose of this study was to use a novel method that was based on the application of chaperonin-60 sequencing to describe the vaginal microflora of 16 healthy women. Asymptomatic women consented for vaginal swabs to be collected at the time of a clinical pelvic examination. Total genomic DNA was isolated from the vaginal swabs. Degenerate, universal polymerase chain reaction primers were used to amplify an approximately 555 base pair region of the universal chaperonin-60 gene, which is found in all eubacteria and eukaryotes, from the total genomic DNA and libraries of cloned polymerase chain reaction products were constructed. Library clones were sequenced, and the resulting sequences were assigned to taxonomic groups on the basis of similarity to reference sequence data. Presence of Chlamydophila psittaci sequences in the samples was confirmed by species-specific polymerase chain reaction. Sixteen of the 23 women who were enrolled had normal flora by Nugent's score of <4 and had adequate polymerase chain reaction product for assessment. Vaginal flora libraries were dominated by a variety of sequences with similarity to Lactobacillus spp L. crispatus, L. iners, L. gasseri, L. jensenii, and L. buchneri. Other sequences that were identified included representatives of Gardnerella spp, sequences with similarity to Porphyromonas spp and Megasphaera spp and sequences identical to C psittaci. Culture-independent, chaperonin-60 sequence-based molecular methods can lead to the identification of greater diversity within defined taxa compared with those that are identified by standard culture-based methods and to the identification of novel organisms that were not previously associated with vaginal flora.
  American Journal of Obstetrics and Gynecology 10/2005; 193(3 Pt 1):682-92.
• Article: The prevalence of Helicobacter pylori in the Hispanic population affected by hyperemesis gravidarum.

  Richard H Lee, Vivien L Pan, Deborah A Wing
  [show abstract] [hide abstract]
  ABSTRACT: The purpose of this study was to determine the prevalence of Helicobacter pylori seropositivity in pregnant Hispanics affected by hyperemesis gravidarum. This was a prospective cross-sectional study conducted over a 22-month period. Serum from pregnant Hispanics affected by hyperemesis gravidarum and unaffected Hispanics matched for age, gravidity, parity, and country of origin were tested for H pylori immunoglobulin G (IgG). IgG levels specific for H pylori were determined by enzyme-linked immunosorbent assay (ELISA). Assuming the background prevalence of H pylori serum positivity in the Hispanic population is approximately 60%, 38 patients in each group were needed to detect a 30% difference in affected patients versus controls with a power of 80% and P = .05. Statistical analysis was performed using Yate's chi-square, Student t test, Mann-Whitney U, and binary logistic regression. A total of 82 patients between the ages of 18 to 39 years were enrolled. Of 40 patients diagnosed with hyperemesis gravidarum, 26 (65%) were seropositive for H pylori compared with 28 of 42 (67%) unaffected controls (P = 1.0). There were no statistical differences in maternal age or countries of origin between the 2 groups. The overall prevalence of H pylori seropositivity in this patient population is 66%. In pregnant Hispanics affected by hyperemesis gravidarum, H pylori seropositivity is not increased compared with unaffected controls.
  American Journal of Obstetrics and Gynecology 10/2005; 193(3 Pt 2):1024-7.
• Article: Issues in clinical trial design: stopping a trial early and the large and simple trial.

  Elizabeth A Thom, Mark A Klebanoff
  [show abstract] [hide abstract]
  ABSTRACT: During the conduct of a clinical trial, a primary function of the Data Safety and Monitoring Committee is to select the trial conduct and the accumulating data to determine whether the trial should continue or be discontinued earlier than planned. Reasons for early discontinuation of a trial include: evidence of benefit, evidence of harm, and evidence of futility. More than 1 of these elements will often be present. These principles will be illustrated with examples from National Institute of Child Health and Human Development-Maternal-Fetal Medicine Units clinical trials. The "large and simple clinical trial" is a study design rarely undertaken in the United States but commonly used elsewhere. The principles of this type of trial will be introduced and contrasted with those of the "conventional clinical trial."
  American Journal of Obstetrics and Gynecology 10/2005; 193(3 Pt 1):619-25.
• Source

  Available from: usdoc.co.il

  Article: Isolated fetal pyelectasis and chromosomal abnormalities.

  Claudio Coco, Philippe Jeanty
  [show abstract] [hide abstract]
  ABSTRACT: The primary objective of this study was to determine if isolated pyelectasis is a risk factor for trisomy 21. Twelve thousand, six hundred and seventy-two unselected singleton fetuses were examined by prenatal ultrasound during the second trimester at a single institution. The sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio of pyelectasis (either isolated or in association with other soft markers/structural anomalies) to detect trisomy 21 were calculated. Pyelectasis (anteroposterior pelvic diameter >/=4 mm) was detected in 2.9% (366/12,672) of the fetuses. Among these, 83.3% (305/366) were isolated, and 16.7% (61/366) were associated with other markers/structural anomalies. The prevalence of trisomy 21 was 0.087% (11/12,672) and, among these fetuses, 2 (18.1%) had pyelectasis, 1 isolated, and 1 associated with other markers/structural anomalies. The presence of isolated pyelectasis had 9.09% sensitivity, 97.6% specificity, 0.33% positive predictive value, and 99.9% negative predictive value to detect fetuses with trisomy 21. The likelihood ratio of trisomy 21 in this group of fetuses was 3.79 (95% CI 0.582-24.616). Among fetuses with pyelectasis and other associated markers/structural anomalies, the sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio for trisomy 21 were 9.09%, 99.5%, 1.64%, 99.9%, and 19.2 (95% CI 2.91-126.44). In the absence of other findings, isolated pyelectasis is not a justification for the performance of an amniocentesis.
  American Journal of Obstetrics and Gynecology 10/2005; 193(3 Pt 1):732-8.
• Source

  Available from: neonataler-drogenentzug.de

  Article: High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes.

  John J McCarthy, Martin H Leamon, Michael S Parr, Barbara Anania
  [show abstract] [hide abstract]
  ABSTRACT: This study assesses the effect of higher doses of methadone during pregnancy on maternal and fetal outcomes. We retrospectively reviewed clinical data for 81 mothers who received methadone and their 81 offspring. The cohort was divided into high-dose (>/=100 mg) and low-dose (<100 mg) groups. There were no differences in the rate of medication treatment for neonatal abstinence symptoms or days of infant hospitalization between the high-dose (mean, 132 mg) and low-dose (mean, 62 mg) groups. Despite longer histories of opiate abuse, the high-dose group had less illicit drug use at delivery. The whole cohort, which received an average of 101 mg/d, had an 81% rate of negative toxicology screens at delivery. High doses of methadone were not associated with increased risks of neonatal abstinence symptoms but had a positive effect on maternal drug abuse. Arbitrarily limiting methadone dose as a way of minimizing the risks of neonatal abstinence symptoms may be unwarranted.
  American Journal of Obstetrics and Gynecology 10/2005; 193(3 Pt 1):606-10.
• Article: Early discharge from obstetrics-pediatrics at the Hospital de Valme, with domiciliary follow-up.

  José Antonio Sainz Bueno, María Ruiz Romano, Rogelio Garrido Teruel, Antonio Gutiérrez Benjumea, Ana Fernández Palacín, Carmen Almeida González, Manuel Caballero Manzano
  [show abstract] [hide abstract]
  ABSTRACT: This study was undertaken to evaluate the advantages and disadvantages of a program of early obstetric-pediatric discharge (24 hours postpartum) with domiciliary follow-up, compared with the traditional postpartum hospital stay (more than 48 hours), according to the criteria described by reviewers of the subject. A randomized controlled trial of early obstetric discharge for healthy mothers and term infants, with postpartum randomization, with no prenatal preparation and with observational and clinical follow-up was performed. The participants were mothers with healthy, term neonates (37-42 weeks) weighing more than 2500 g and produced via vaginal delivery and with a verified normal evolution before discharge. The sample consisted of 430 cases (213 cases with early discharge, and 217 control cases) in which the following variables were evaluated: existence of complications in the mother and/or child that required rehospitalization or a medical consultation, existence of maternal problems of fatigue or anxiety/depression after the birth, continuity of lactation and its problems, satisfaction of the mother and family, and relative costs. After demonstrating the homogeneity of the groups, no significant differences were found in the rates of maternal rehospitalization (1.9% in the early discharge group vs 2.3% in the control group, relative risk 0.81, 95% CI 0.21-3.03) or in the rates of rehospitalization of the neonates (1.4% in the early discharge group vs 2.3% in the control group, relative risk 0.16, 95% CI 0.15-2.56). No increases were observed in maternal or neonatal disease, puerperal fatigue, or maternal anxiety/depression. A prolongation of maternal lactation to 3 months was observed in the early discharge group (P=.016 <.05 Fisher exact test). When the cost of early discharge is compared with that of traditional discharge with a minimum of 48 hours hospital stay, we find a saving of 18% to 20%. The level of maternal satisfaction with early discharge is better than 90%.
  American Journal of Obstetrics and Gynecology 10/2005; 193(3 Pt 1):714-26.
• Article: Impact of maternal-fetal surgery for myelomeningocele on the progression of ventriculomegaly in utero.

  Amy Adelberg, Angela Blotzer, Gary Koch, Rachael Moise, Nancy Chescheir, Kenneth J Moise, Honor Wolfe
  [show abstract] [hide abstract]
  ABSTRACT: Intrauterine myelomeningocele (MMC) repair decreases hindbrain herniation and the need for postnatal ventriculoperitoneal shunting. We examined the impact of intrauterine repair on the progression of ventriculomegaly in utero. Fetuses with MMC were identified through computerized databases from June 1988 to April 2003. A retrospective cohort design was used to evaluate the impact of intrauterine repair on ventricular progression with a multivariate linear regression model that included baseline ventricle measurement, gestational age, level of lesion, and gender. Fourteen fetuses with intrauterine repair and 39 fetuses with postnatal repair were identified. The natural history of progression of ventricular diameter increased in a linear fashion throughout gestation (0.57 mm/week). After adjusting for confounding variables, no transient or sustained difference was observed in the rate progression of ventriculomegaly between intrauterine and postnatal repair (0.27 +/- 0.35 mm/week; P=.45). Intrauterine MMC repair does not impact the progression of ventriculomegaly.
  American Journal of Obstetrics and Gynecology 10/2005; 193(3 Pt 1):727-31.