Journal of the American Chemical Society (J AM CHEM SOC)

Publisher: American Chemical Society; American Chemical Society; Marian S. Carson Collection (Library of Congress), American Chemical Society

Journal description

The Journal of the American Chemical Society, founded in 1879, is the flagship journal of the American Chemical Society and a highly esteemed journal in the field. This periodical is devoted to the publication of research papers in all fields of chemistry and publishes approximately 13,000 pages of new chemistry a year. Published weekly, JACS provides research crucial to the field of chemistry. The Journal of the American Chemical Society publishes articles, communications to the Editor, book reviews, and computer software reviews.

Current impact factor: 11.44

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 11.444
2012 Impact Factor 10.677
2011 Impact Factor 9.907
2010 Impact Factor 9.019
2009 Impact Factor 8.58
2008 Impact Factor 8.091
2007 Impact Factor 7.885
2006 Impact Factor 7.696
2005 Impact Factor 7.419
2004 Impact Factor 6.903
2003 Impact Factor 6.516
2002 Impact Factor 6.201
2001 Impact Factor 6.079
2000 Impact Factor 6.025
1999 Impact Factor 5.537
1998 Impact Factor 5.725
1997 Impact Factor 5.65
1996 Impact Factor 5.948
1995 Impact Factor 5.263
1994 Impact Factor 5.039
1993 Impact Factor 5.365
1992 Impact Factor 5.298

Impact factor over time

Impact factor

Additional details

5-year impact 10.24
Cited half-life 7.70
Immediacy index 2.16
Eigenfactor 0.83
Article influence 2.99
Website Journal of the American Chemical Society website
Other titles Journal of the American Chemical Society, Review of American chemical research
ISSN 0002-7863
OCLC 1226990
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

American Chemical Society

  • Pre-print
    • Author cannot archive a pre-print version
  • Restrictions
    • Must obtain written permission from Editor
    • Must not violate ACS ethical Guidelines
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • If mandated by funding agency or employer/ institution
    • If mandated to deposit before 12 months, must obtain waiver from Institution/Funding agency or use AuthorChoice
    • 12 months embargo
  • Conditions
    • On author's personal website, pre-print servers, institutional website, institutional repositories or subject repositories
    • Non-Commercial
    • Must be accompanied by set statement (see policy)
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • If mandated sooner than 12 months, must obtain waiver from Editors or use AuthorChoice
    • Reviewed on 07/08/2014
  • Classification
    ​ white

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Methyl anion abstraction from Cp*2Zr(CH3)OCH2CH2NiPr2 (13) with trityl cation generates [Cp*2Zr(OCH2CH2NiPr2)]+ (14). Complex 14 behaves as a reactive Zr+/amine frustrated Lewis pair (FLP). It reacts with dichloromethane to give the [Zr]Cl[OCH2CH2N(CH2Cl)iPr2]+ cation (15), it slowly looses H2 upon standing at 60°C to give a metallacyclic iminium cation product 18, and it reacts with terminal alkynes to give the [Zr]-alkynyl/ammonium systems 19. The organometallic FLP 14 cleaves dihydrogen heterolytically at near to ambient conditions to give the [Zr]H[OCH2CH2NHiPr2]+ complex 20, which reduces benzaldehyde to the respective [Zr]OCH2Ph product 21 and is able to transfer the H+/H- pair to styrene to give ethylbenzene. Consequently, the Zr+/amine FLP 14 was used as an active hydrogenation catalyst for a series of alkenes and internal alkynes. The catalytic hydrogenation reactions were carried out under mild conditions (r.t., 1.5 bar H2) using between 1 to 4 mol% of the FLP catalyst 14.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b01623
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    ABSTRACT: Molecules in crystals often suffer from severe limitations on their dynamic processes, especially on those involving large structural changes. Crystalline compounds, therefore, usually fail to realize their potential as dielectric materials even when they have large dipole moments. In order to enable polar molecules to undergo dynamic processes and to provide their crystals with dielectric properties, weakly bound charge-transfer (CT) complex crystals have been exploited as molecular architecture where the constituent polar molecules have some freedom of dynamic processes, which contribute to dielectric properties of the crystals. Several CT crystals of polar tetrabromophthalic anhydride (TBPA) molecules were prepared using TBPA as an electron acceptor and aromatic hydrocarbons, such as coronene and perylene, as electron donors. Crystal structures and dielectric properties of the CT crystals as well as the single-component crystal of TBPA were investigated at various temperatures. Molecular reorientation of TBPA molecules did not occur in the single-component crystal, and the crystal did not show dielectric response due to orientational polarization. We have found that the CT crystal formation provides a simple and versatile method to develop molecular dielectrics, revealing that molecular dynamics of the TBPA molecules and the dielectric property of their crystals were greatly changed in CT crystals. The TBPA molecules underwent rapid in-plane reorientations in their CT crystals, which exhibited marked dielectric responses arising from the molecular motion. An order-disorder phase transition was observed for one of the CT crystals, which resulted in an abrupt change in the dielectric constant at the transition temperature.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b00412
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    ABSTRACT: Chalcogen bonding is the noncovalent interaction between an electron-deficient, covalently bonded chalcogen (Te, Se, S) and a Lewis base. Although substantial evidence supports the existence of chalcogen bonding in the solid state, quantitative data regarding the strengths of the interactions in the solution phase are lacking. Herein, determinations of the association constants of benzotelluradiazoles with a variety of Lewis bases (Cl(-), Br(-), I(-), NO3(-) and quinuclidine, in organic solvent) are described. The participation of the benzotelluradiazoles in chalcogen bonding interactions was probed by UV-vis, (1)H and (19)F NMR spectroscopy as well as nano-ESI mass spectrometry. Trends in the free energy of chalcogen bonds upon variation of the donor, acceptor and solvent are evident from these data, including a linear free energy relationship between chalcogen bond donor ability and calculated electrostatic potential at the tellurium center. Calculations using the dispersion-corrected B97-D3 functional were found to give good agreement with the experimental free energies of chalcogen bonding.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/ja512183e
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    ABSTRACT: Coenzyme F420 is a redox cofactor found in methanogens and in various actinobacteria. Despite the major biological importance of this cofactor, the biosynthesis of its deazaflavin core (F0) is still poorly understood. F0-synthase, the enzyme involved, is an unusual multi-domain radical SAM enzyme that uses two separate 5'-deoxyadenosyl radicals to catalyze F0 formation. In this paper, we report a detailed mechanistic study on this complex enzyme that led us to identify (A) the hydrogen atoms abstracted from the substrate by the two radical SAM domains, (B) the second tyrosine-derived product, (C) the reaction product of the CofH catalyzed reaction, (D) the demonstration that this product is a substrate for CofG, and (E) a stereochemical study that is consistent with the formation of a p-hydroxybenzyl radical at the CofH active site. These results enable us to propose a mechanism for F0 synthase and uncover a new catalytic motif in radical SAM enzymology involving the use of two 5'-deoxyadenosyl radicals to mediate the formation of a complex heterocycle.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/ja513287k
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    ABSTRACT: Well-defined iron bis(diphosphine) complexes are active catalysts for the dehydrogenative C-H borylation of aromatic and heteroaromatic derivatives with pinacolborane. The corresponding borylated compounds were isolated in moderate to good yields (25-73%) with a 5 mol% catalyst loading under UV irradiation (350 nm) at room temperature. Stoichiometric reactivity studies and isolation of an original trans-hydrido(boryl)iron complex, Fe(H)(Bpin)(dmpe)2, allowed us to propose a mechanism showing the role of some key catalytic species.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b00895
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    ABSTRACT: Previous studies have shown that crystal planes of heterogeneous catalysts could display enhanced activity, such that higher turnover or chemoselectivity could be achieved. Here we report an example where the reaction stereoselectivity was significantly affected by the catalyst crystal planes. In copper-catalyzed deoxygenation reaction of aromatic epoxides, copper cubes, wires, and plates gave the olefin products with different cis/trans selectivities, whereas homogeneous copper catalysts showed poor selectivity. Scanning tunneling microscope and density functional theory studies revealed that the different adsorption mode and higher adsorption strength of epoxide oxygen on Cu{100} plane were responsible for the observed variation of selectivity. The copper-catalyzed deoxygenation reaction provided new practical access to cis-olefins from readily available aromatic epoxides. Our work also indicated that nanocrystal catalysts may provide useful stereochemical control in organic reactions.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b01391
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    ABSTRACT: Due in part to the common occurrence of five-membered nitrogen heterocycles in bioactive molecules, the discovery of methods for the enantioselective synthesis of such structures is a useful endeavor. Building on a single example by Tong of a phosphine-catalyzed [4 + 1] annulation of an amine with an allene that furnished an achiral dihydropyrrole in 22% yield, we have developed, with the aid of a new chiral spirophosphine catalyst, a method with increased utility, specifically, improved yield, enhanced scope (the use of γ-substituted allenes), and good ee. The enantioenriched dihydropyrrole products can be transformed into other interesting families of compounds with very good stereoselectivity.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b01944
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    ABSTRACT: The precursor of the solution processed perovskite thin films is one of the most central components for high efficiency perovskite solar cells. We first present the crucial colloidal chemistry visualization of perovskite precursor solution based on analytical spectra and reveal that perovskite precursor solutions for solar cells are generally colloidal disper-sion in mother solution, with colloidal size up to mesoscale, hence rather than real solution. The colloid is made of soft coordination complex in the form of lead poly-halide framework between organic and inorganic components and can be structurally tuned by the coordination degree, thereby primarily determining the basic film coverage and morphology of deposited thin films. By utilizing the coordination engineering, particularly through employing additional methylammonium halide over the stoichiometric ratio for tuning coordination degree and mode in initial colloidal solution, along with a thermal leaching for the selective release of excess methylammonium halides, we achieved full and even coverage, preferential orientation and high purity of planar perovskite thin films. We have also identified that excess organic component can reduce the colloidal size of and tune the morphology of coordination framework in relation to final perovskite grains and partial-chlorine-substitution can accelerate the crystalline nucleation process of perovskite. This work demonstrates the important fundamental chemistry of perovskite precursors and provides genuine guideline for accurately controlling high quality of hybrid perovskite thin films without any impurity, thereby delivering efficient planar perovskite solar cells with a PCE as high as 17% without distinct hysteresis owing to the high quality of perovskite thin films.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b00321
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    ABSTRACT: Low levels of γ-aminobutyric acid (GABA), one of two major neurotransmitters that regulate brain neuronal activity, are associated with many neurological disorders, such as epilepsy, Parkinson's disease, Alzheimer's disease, Huntington's chorea, and cocaine addiction. One of the main methods to raise the GABA level in human brain is to use small molecules that cross the blood-brain barrier and inhibit the activity of γ-aminobutyric acid aminotransferase (GABA-AT), the enzyme that degrades GABA. We have designed a series of conformationally-restricted, tetrahydrothiophene-based GABA analogs with a properly-positioned leaving group that could facilitate a ring-opening mechanism, leading to inactivation of GABA-AT. One compound in the series is eight times more efficient an inactivator of GABA-AT than vigabatrin, the only FDA-approved inactivator of GABA-AT. Our mechanistic studies show that the compound inactivates GABA-AT by a new mechanism. The metabolite resulting from inactivation does not covalently bind to amino acid residues of GABA-AT but stays in the active site via H-bond interactions with Arg-192, a π-π interaction with Phe-189, and a weak nonbonded S···O=C interaction with Glu-270, thereby inactivating the enzyme.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b01155
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    ABSTRACT: We report in this work a strategy of combining Brønsted acid MOF framework with Lewis acid center to afford Lewis acid@Brønsted acid MOF with high catalytic activity, as exemplified in the context of MIL-101-Cr-SO3H·Al(III). Due to the synergy between Brønsted acid framework and Al(III) Lewis acid center, MIL-101-Cr-SO3H·Al(III) demonstrates excellent catalytic performances in a series of fixed bed reactions, out-performing two benchmark zeolite catalysts of H-Beta and HMOR. Our work therefore not only provides a new approach to achieve high cata-lytic activity in MOFs, but also paves a way to develop MOFs as a new type of highly efficient heterogeneous catalysts for fixed bed reactions.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b01352
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    ABSTRACT: Self-assembled monolayer films of a cyclometalated ruthenium complex with a redox-active amine substituent and three carboxylic acid groups have been prepared on ITO electrode surfaces. The obtained thin films show three-state electrochromic switching with low electrochemical potential inputs and high near-infrared absorbance outputs. Thanks to the long retention time of each oxidation states, these films have been used to demonstrate surface-confined flip-flop memory functions with high ON/OFF ratios at the molecular scale.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b00586
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    ABSTRACT: A pair of reversible photochemical reactions correlates their reactant and product specifically, and such a correlation uniquely distinguishes their correlated signal from others that are not linked by this pair of reactions. Here a nanoparticle-shielded fluorophore is photo-driven to undergo structural dynamics, alternating between a green-fluorescence state and a red-fluorescence state. As time elapses, the fluorophore can be in either state but not both at the same time. Thus red-fluorescence maximizes while green-fluorescence minimizes and vice versa. Such an anti-phase dual-color (AD) co-relationship between the red- and green-fluorescence maxima as well as between their minima is exploited to improve the signal-to-noise ratio greatly, thus enhancing the ultimate detection limit. Potential benefits of this correlation include elimination of all interferences origi-nating from single-color dyes and signal amplification of AD photoswitching molecules by orders of magnitude.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b01007
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    ABSTRACT: Layered organic-inorganic hybrid perovskites that consist of metal halides and organic interlayers are a class of low-dimensional materials. Here, we report the fabrication of layered hybrid perovskites using metal halides and silsesquioxane with a cage-like structure. We used a silsesquioxane as an interlayer to produce a rigid structure and improve the functionality of perovskite layers. Propylammonium-functionalized silsesquioxane and metal halide salts (CuCl2, PdCl2, PbCl2 and MnCl2¬) were self-assembled to form rigid layered perovskite structures with high crystallinity. The rigid silsesquioxane structure produces micropores between the perovskite layers that can potentially be filled with different molecules to tune the dielectric constants of the interlayers. The obtained silsesquioxane-metal halide hybrid perovskites exhibit some characteristic properties of layered perovskites including magnetic ordering (CuCl42- and MnCl42-) and excitonic absorption/emission (PbCl42-). Our results indicate that inserting silsesquioxane interlayers into hybrid perovskites retains and enhances the low-dimensional properties of the materials.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b00290
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    ABSTRACT: Materials which induce molecular motion without external input offer unique opportunities for spatial manipulation of molecules. Here, we present the use of polyacrylamide hydrogel films containing built-in chemical gradients (enthalpic gradients) to direct molecular transport. Using a cationic tertiary amine gradient, anionic molecules were directionally transported up to several millimeters. A 40-fold concentration of anionic molecules dosed in aerosol form on a substrate to a small region at the center of a radially symmetric cationic gradient was observed. The separation of mixtures of charged dye molecules was demonstrated using a boronic acid-to-cationic gradient where one molecule was attracted to the boronic acid end of the gradient, and the other to the cationic end of the gradient. Theoretical and computational analysis provides a quantitative description of such anisotropic molecular transport, and reveals that the gradient-imposed drift velocity is in the range of hundreds of nanometers per second, comparable to the transport velocities of biomolecular motors. This general concept of enthalpy gradient-directed molecular transport should enable the autonomous processing of a diversity of chemical species.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b00240
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    ABSTRACT: The bovine antibody (BLV1H12) which has an ultralong CDR3H provides a novel scaffold for engineering new func-tions into the antibody variable region. By modifying the β-strand "stalk" of BLV1H12 with sequences derived from natu-ral or synthetic protease inhibitors, we have generated anti-bodies that inhibit bovine trypsin and human neutrophil elastase (HNE) with low nanomolar affinities. We were also able to generate a humanized variant using a human immu-noglobulin scaffold that shares a high degree of homology with BLV1H12. Further optimization yielded a highly selec-tive humanized anti-HNE antibody with sub-nanomolar affinity. This work demonstrates a novel strategy for gener-ating antibodies with potent and selective inhibitory activi-ties against extracellular proteases involved in human dis-ease.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/ja5130786
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    ABSTRACT: The narrowest armchair graphene nanoribbon (AGNR) with five carbons across the width of the GNR (5-AGNR) was synthesized on Au(111) surfaces via sequential dehalogenation processes in a mild condition by using 1,4,5,8-tetrabromonaphthalene (TBN) as the molecular precursor. Gold-organic hybrids were observed by using high resolution scanning tunneling microscopy (STM) and considered as intermediate states upon AGNR formation. Scanning tunneling spectroscopy (STS) reveals an unexpectedly large band gap of Δ=2.8 ± 0.1 eV on Au(111) surface which can be interpreted by the hybridization of the surface states and the molecular states of the 5-AGNR.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/ja511995r
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    ABSTRACT: Nanoporous zeolitic imidazolate frameworks (ZIFs) form structural topologies equivalent to zeolites. ZIFs containing only one type of imidazole linker show separation capability for limited molecular pairs. We show that the effective pore size, hydrophilicity, and organophilicity of ZIFs can be continuously and drastically tuned using mixed-linker ZIFs containing two types of linkers, allowing their use as a more general molecular separation platform. We illustrate this remarkable behavior by adsorption and diffusion measurements of hydrocarbons, alcohols, and water in mixed-linker ZIF-8x-90100-x materials with a large range of crystal sizes (338 nm to 120 µm), using volumetric, gravimetric, and PFG-NMR methods. NMR, powder FT-Raman, and micro-Raman spectroscopy unambiguously confirm the mixed-linker nature of individual ZIF crystals. Variation of the mixed-linker ratio (x) allows continuous control of n-butane, i-butane, butanol, and isobutanol diffusivities over 2-3 orders of magnitude, and control of water and alcohol adsorption especially at low activities.
    Journal of the American Chemical Society 03/2015; DOI:10.1021/jacs.5b00803