Acta poloniae pharmaceutica (ACTA POL PHARM)

Publications in this journal

• Article: Healing effect of hydro-alcoholic extract of Ephedra pachyclada Boiss in experimentally gastric ulcer in rat

  Abdollah Ghasemi Pirbalout, Mehdi Amirmohammadi, Shahrzad Azizi
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  ABSTRACT: Ephedra pachyclada Boiss belongs the family Ephedraceae is a medicinal plant very frequently cited as acting against gastrointestinal disorders in ethno-pharmacological inventories of the Kerman region of Iran. This study was done to evaluate the effect of hydro-alcoholic extract from the stems of E. pachyclada for treatment of gastric ulcers induced by ethanol in Wistar rats. Experimental treatments were the hydro-alcoholic extract of E. pachyclada (250, 500, and 1000 mg/kg, orally), omperazole as standard drug (20 mg/kg, orally), and control group. Ulcer index in mm2 and histological examination were evaluated. On 3, 6, 9 and 12 day after treatments, the hydro-alcoholic extract of E. pachyclata (1000 mg/kg) produced 51%, 72%, 98.8%, and 100% and omperazole also produced 53%, 79%, 93%, and 100% curative effect for gastric mucosal damage in ethanol model, respectively. The results of the histopalogical analysis indicated the hydro-alcoholic extract of E. pachyclada at 1000 mg/kg was effective in experimentally healing rat ulcers. E. pachyclada accelerated ulcer healing in rats and, thus supports its folk medicine use by Kerman people.
  Acta poloniae pharmaceutica 11/2013; 6.
• Article: Chemical constitutes and antibacterial activity of essential oil of Satureja bachtiarica (Lamiaceae)

  Abdollah Ghasemi Pirbalouti, Shohreh Dadfar
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  ABSTRACT: The genus Satureja L. (Lamiaceae) consists of more than 200 species of herbaceous perennials worldwide. The Mediterranean region can be described as the center of the genus (1). This genius in flora of Iran is represented fourteen species distributed commonly in rocky mountains (2,3). Nine Satureja species has been reported in “Flora Iranica” (4), two of which, S. kallarica Jamzad and S. bachtiarica Bunge are distributed in Chaharmahal va Bakhtiari province, Southwest Iran (4). The areal parts and volatile constituents of savory are used as a medicinal herb. Satureja species are commonly used for herbal tea, flavoring agents (condiment and spice) and medicinal purposes (5). Infusion and decoction of aerial parts of Satureja species are used to produce a tonic, carminative, digestive and expectorant and for the treatment of colds in Iranian traditional medicine (5,6). The essential oils composition, antimicrobial and antioxidant activities of some Satureja species have been studied (7-17). The pervious study showed that essential oil and extract of S. bachtiarica exhibited antimicrobial activities against E. coli O157:H7, Bacillus cereus and Listeria monocytogenes (18), Bacillus subtilis, Bacillus cereus, Micrococcus luteus, Staphylococcus sp. and Staphylococcus aureus, Klebsiella pneumoniae, Klebsiella oxytoca and Pseudomonas aeruginosa (19), Vibrio parahaemolyticus and Vibrio harveyi isolated from ‎infected fishes (20), Candida albicans (21) and Streptococcus iniae (22). Results a previous (23) showed that the essential oil of S. bachtiarica affected on immune system and growth of rainbow trout (Oncorhynchus mykiss). The essential oil of S. bachtiarica strong aromatic odor is due to the presence of volatile oils especially carvacrol, γ-terpinene and thymol (19). To our knowledge, there are no published reports on the chemical composition, and antibacterial activity of the essential oil of S. bachtiarica against Pseudomonas aeruginosa isolated meat here described. For this reason, the chemical composition of this oil was analyzed by gas chromatography-mass spectroscopy.
  Acta poloniae pharmaceutica 09/2013; 5.
• Article: Investigation into biologically active constituents of Geum rivale L.

  Aleksandra Owczarek, Jan Gudej
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  ABSTRACT: Aerial and underground parts of Geum rivale (Rosaceae) were investigated. Tiliroside, gallic acid, ellagic acid and a sterol fraction were isolated from aerial parts of the plant. The sterol fraction was analyzed using GC-MS. Eleven phenolic acids was identified in aerial parts of the plant, and eight in underground parts, by means of RP-HPLC analysis. The quantitative determination of phenolic acids, tannins and flavonoids was also carried out.
  Acta poloniae pharmaceutica 01/2013; 70(1):111-114.
• Article: GC-MS analysis of essential oils from Salvia officinalis L.: Comparison of extraction methods of the volatile components.

  Tomasz Baj, Agnieszka Ludwiczuk, Elwira Sieniawska, Krystyna Skalicka-Woźniak, Jarosław Widelski, Krzysztof Zięba, Kazimierz Głowniak
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  ABSTRACT: In this paper, comparison of the volatile components composition in the samples obtained by hydrodistillation and solid-phase microextraction of Salvia officinalis was described. Different sample preparation techniques showed considerable differences in volatiles composition, especially with respect to sesqui- and diterpenoids. The comparison of the sage essential oil obtained by hydrodistillation in the Deryng and Clevenger type apparatus, according to the pharmacopoeial methods (FP VI and VII), showed the presence of the same terpenoids in both essential oils, however, the relative percentage composition of the components were different. These differences are caused by the different extraction times used in both methods. Since each essential oil to be admitted to medicinal use should meet requirements regarding the composition of major chemical components, the minimum time for the hydrodistillation of the essential oils from sage should be 1 h.
  Acta poloniae pharmaceutica 01/2013; 70(1):35-40.
• Article: Determination of API content in a pilot-scale blending by near-infrared spectroscopy as a first step method to process line implementation

  Marzena Jamrógiewicz, K. Cal, M. Gruszecka, A. Ciesielski
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  ABSTRACT: Near infrared (NIR) spectroscopy was used for estimation of powder blend homogeneity and manufacturing control of a medicinal product powder mixture containing active pharmaceutical ingredient (API). Aiming at initiating a Process Analytical Technology (PAT) activity, the first step was a stationary mode atline evaluation. In this, the content of pharmaceutical active compound in the powder mixtures intended to the direct tabletting was estimated based on recorded NIR spectra. Five formulations containing different quantities of API were prepared and analyzed also by a reference method ñ UV-Vis spectroscopy. A chemometric model was developed for calculation of the API amount in the mixtures. The Principal Component Regression (PCR) and Partial Least Squares (PLS) algorithms were used to obtain a model useful in further implementation for the PAT recommendations, into in-line blending control.
  Acta poloniae pharmaceutica 01/2013; 70(3):419-429.
• Article: In vitro antimicrobial activity of novel azophenothiazine derivatives. Acta Pol Pfarm 2012, 69(6),1149-1152

  Zieba A, Czuba ZP, Król W
  Acta poloniae pharmaceutica 11/2012; 69(6):1149-1152.
• Article: 3D-QSAR STUDIES OF SOME TETRASUBSTITUTED PYRAZOLESAS COX-II INHIBITORS

  GIRISH KUMAR GUPTA, AJAY KUMAR
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  ABSTRACT: Pharmacophore mapping studies were undertaken for a series of molecules belonging to tetrasubstituted pyrazoles as canine COX-II inhibitors. A six point pharmacophore with 3 hydrogen bond acceptors (A), one hydrophobic group (H) and two aromatic rings (R) as pharmacophoric feature was developed. The pharmacophoric hypothesis yielded a statistically significant 3D-QSAR model, with a correlation coefficient of r2 = 0.958. The developed pharmacophore model was externally validated by predicting the activity of test set molecules. The squared predictive correlation coefficient of 0.852 was observed between experimental and predicted activity values of test set molecules. The geometry and features of pharmacophore model describe the key structure-activity relationship of COX-II inhibitors, can predict their activities, and can thus be used to design novel inhibitors.
  Acta poloniae pharmaceutica 06/2012; 69(4):763-772.
• Article: Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds

  Nabavi S.M, et al
  Acta poloniae pharmaceutica 01/2012;