Acta Oto-Laryngologica (ACTA OTO-LARYNGOL )

Publisher: Taylor & Francis


Acta Oto-Laryngologica presents original articles of basic research interest regarding clinical questions at hand, as well as clinical studies in the field of otorhinolaryngology and related subdisciplines. Acta Oto-Laryngologica is published by a non-profit society of Swedish otolaryngologists. The journal publishes original papers on basic research as well as clinical studies in the field of otolaryngology and head and neck surgery and related subdisciplines. The aim is not only to present clinical and research data but also to bridge the gap between clinical and basic science research, being an international journal for translational research in otolaryngology and head and neck surgery. Review articles presenting state of the art for a selected topic, and containing an internationally representative bibliography are also published. Letters to the editor, Short communications, recent advances in Commercial technology and their clinical applicability, and well documented Clinical trials are also within the scope of Acta Oto-Laryngologica . Reviews of current books in the field of otolaryngology and head and neck surgery are also published.

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    Acta Oto-Laryngologica website
  • Other titles
    Acta oto-laryngologica, Acta otolaryngologica
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  • Material type
    Periodical, Internet resource
  • Document type
    Journal / Magazine / Newspaper, Internet Resource

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Taylor & Francis

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    • STM: Science, Technology and Medicine
    • SSH: Social Science and Humanities
    • 'Taylor & Francis (Psychology Press)' is an imprint of 'Taylor & Francis'
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Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: With the growing acceptance of nonsurgical therapies for laryngeal squamous cell carcinomas (LSCC), it has become important to delineate surgical salvage strategies for disease recurrences. Total laryngectomy (TL) is often recommended but appropriately selected laryngeal recurrences may be treated successfully with partial laryngectomy. Using proper selection criteria for conservative salvage laryngeal surgery, laryngeal function can be preserved with oncological efficacy. The most appealing feature of salvage transoral laser surgery (TLS) is the opportunity to make tumor-tailored excisions without any reconstructive limitations and retaining the option to switch to open partial laryngectomy. A recent detailed review of 11 series found a pooled local control rate of 57% after a first TLS procedure, and 64% after repeated TLS procedures. Supracricoid laryngectomy (SCL) seems to achieve good local control rates in selected cases of recurrent supraglottic-glottic carcinoma: one review considering 7 series calculated that 85% of the patients treated with salvage SCL after radiotherapy experienced no local recurrence; and TL after salvage SCL afforded an overall local control rate of approximately 65%. Neck dissection is mandatory in all cases of local LSCC recurrence with evidence of neck metastases, and routine elective neck dissection is recommended for recurrent supraglottic and transglottic cancers.
    Acta Oto-Laryngologica 09/2014;
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    ABSTRACT: In recent years, it has become clear that HPV affects the development of head and neck cancer, particularly oropharyngeal squamous cell carcinoma (OPSCC). HPV-related OPSCCs are reported to be frequently observed among patients with a relatively younger age and those without smoking habits, and also to show a relatively better prognosis compared with OPSCC patients without HPV infection. In the United States, the incidence of HPV-related OPSCC has been increasing in association with the diversification of sexual activity among young individuals. Similarly, the incidence of HPV-related carcinomas has been increasing in Japan. For instance, uterine cervical cancers have been increasing among younger females, and the incidence of OPSCC has also been gradually increasing in spite of a decreasing trend in smoking habits and alcohol consumption. However, there have been only a few Japanese studies that have examined the incidence and prognostic significance of HPV infection in terms of its impact on the outcomes of OPSCC. Therefore, further analyses are needed to establish an appropriate treatment strategy for Japanese OPSCC patients. The aim of this study was to elucidate the frequency and clinical implications of the HPV infection status in Japanese OPSCC, using both a sequencing analysis and IHC.
    Acta Oto-Laryngologica 07/2014;
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    ABSTRACT: Conclusions: Reconstruction of the ossicular chain differentially affects the motion of the tympanic membrane (TM) and the stapes. Objectives: To determine the effect of different ossicular replacement procedures on the sound-induced motion of the TM and stapes. Methods: A combination of digital stroboscopic holography and laser Doppler vibrometry was used to determine the sound-induced motion of the TM and stapes in cadaveric temporal bones in which the ossicular chain was reconstructed using 12 varied standard techniques. The variations included the use of total or partial ossicular prosthesis, size of cartilage interposed between the TM and the prosthesis, and the length or fit of the prosthesis between the TM and stapes. The measurements were carried out in repeated measures format, so that each manipulation was performed in each temporal bone. Results: The volume displacement of the TM was in general reduced by reconstruction, with the largest reductions occurring with high-frequency stimulation in the reconstructions with a ‘large’ cartilage oval interposed between the TM and the prosthesis. Larger stapes motions in response to low-frequency sound were observed with either ‘loose’ or ‘best’ fit TORP with a ‘small’ cartilage plate between the TM and the prosthesis.
    Acta Oto-Laryngologica 05/2014;
  • Acta Oto-Laryngologica 01/2013; 133(8):874-80.
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    ABSTRACT: Angiogenesis is a hallmark of cancer, fundamental to its growth. The 'angiogenic switch' occurs when pro-angiogenic factors are not balanced by anti-angiogenic factors. A correlation between angiogenic properties and oncological prognosis (for laryngeal squamous cell carcinoma (LSCC) too) was first hypothesized in the 1990s. An exhaustive literature review was performed to investigate available data on angiogenesis markers and their biological role and therapeutic potential in LSCC. The prognostic significance of microvascular density in LSCC was investigated with endothelial targets, e.g. CD105, CD34, and CD31. Epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), VEGF receptor 2, angiogenin, hypoxia-inducible factor 1, and other biological markers were also studied. Only anti-EGFR therapy has been approved by the USFood and Drug Administration (FDA) for head and neck carcinoma in recent years, while several agents interfering with VEGF and its receptors are being studied. Experimental findings indicate that anti-CD105 monoclonal antibodies efficiently inhibit tumor angiogenesis. There are two main ways to approach the vascular profile of solid malignancies: by inhibiting new vessel formation (anti-angiogenic therapy) or selectively damaging neoplastic vessels (vascular targeting therapy). In advanced LSCC, both these strategies seem promising and warrant further preclinical and clinical investigation.
    Acta Oto-Laryngologica 01/2012; 132(6):574-82.
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    ABSTRACT: Conclusion: Sensorineural hearing loss (SNHL) is a neurological situation and celiac disease (CD) may be seen coincidentally. Children with clinical signs of hearing deficiency of unknown etiology should be assessed for CD. Objective: CD is a chronic inflammatory gluten-dependent intestinal disease and has extraintestinal findings. The aim of this study was to determine the incidence of CD and SNHL in our pediatric patients.Methods: A total of 25 pediatric patients (50 ears) with biopsy-proven CD were diagnosed in the pediatric gastroenterology department; 25 healthy control subjects (50 ears) were also included in the study. All subjects underwent pure tone audiometry at frequencies of 250–8000 Hz and tympanometry. Results: In the patients and controls, normal peak compliance, gradient, peak pressure, ear canal volume, and acoustic reflexes were obtained by tympanometry. There was no air–bone gap in any of the participants. There was a statistically significant difference between the audiometric results in the CD and control groups (right ear and left ear) (p < 0.05).
    Acta Oto-Laryngologica 01/2012; 132:146–151.
  • Acta Oto-Laryngologica 01/2012; 132(5):525-32.
  • Acta Oto-Laryngologica 01/2011; 131(11):1220-5..
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    ABSTRACT: Patients with Bell's palsy were investigated with regard to the cellular immune response during the acute and convalescent stages with the purpose of acquiring information concerning the etiology of the condition. In order to ascertain whether there was activation of the immune system, the proportion of activated T cells in the peripheral blood of 14 patients with Bell's palsy was analysed using monoclonal antibodies. A transient increase of these cells occurred in the acute stage, with a return to normal in the convalescent stage. The Leu-7+ cells which play a role in the natural cellular defence against viral infections, were also studied by using monoclonal antibodies in 25 patients. A significant change in the percentage of Leu-7+ cells was not found when the samples from the entire group were analysed. However, 10 patients who were investigated between September and October 1984, when the incidence of Bell's palsy was comparatively high, showed significantly lower percentages of Leu-7+ cells in the acute stage compared with the convalescent stage. The increase in the activated T cells in the acute phase of the palsy suggests a cell-mediated, immuno-regulatory abnormality with primary or secondary immune activation. Similar cellular immune alterations are found also in multiple sclerosis. Further, the differences in the proportions of Leu-7+ cells which occurred in these 10 patients may denote a contribution of various etiological factors to the disease.
    Acta Oto-Laryngologica 07/2010; 105(1-2):108-13.
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    ABSTRACT: Rats were exposed to toluene (1000 ppm, 16 h/d, 5 d/w, 2 w), or noise (100 dB Leq, 10 h/d, 7 d/w, 4 w) or toluene followed by noise. Auditory function was tested by brainstem audiometry using a 1/3 octave filtered sine wave stimulus at the frequencies 1.6, 3.15, 6.3, 12.5 and 20.0 kHz. A high-frequency auditory impairment was observed after exposure to toluene alone and noise alone. A slight recovery was recorded 1 and 6 months after the toluene exposure. Toluene followed by noise resulted in a higher threshold at all frequencies. A slight recovery was recorded 6 months post-exposure. The threshold shift exceeded the summated loss caused by toluene alone and by noise alone, particularly at 3.15 and 6.3 kHz. The latencies varied only slightly. The results indicate that the major cause of the auditory impairment was cochlear damage and that only minor injury was caused to the auditory pathways.
    Acta Oto-Laryngologica 07/2010; 105(1-2):56-63.
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    ABSTRACT: During a one-year period, 82 consecutive patients seeking medical attention for facial palsy primarily of unknown etiology were examined for underlying Ixodes ricinus-borne borreliosis. Evidence of the infection was found in 16 (20%) of the patients, most of whom had cerebrospinal fluid findings indicating meningeal involvement. Among 9 children included in the study, borreliosis was found in 6 cases. Bilateral facial palsy occurred in 3 of the borrelia-infected patients, as compared with none of the patients without borreliosis. It is suggested that, in areas where the tick vector is present, borreliosis should be regularly sought in patients with facial palsy of otherwise unknown etiology. As regards the serological diagnosis, it is emphasized that normal borrelia antibody titres in serum and cerebrospinal fluid at the time of the first consultation do not exclude the infection. A careful serological follow-up of patients with facial palsy is therefore recommended in order not to miss an underlying borreliosis which, if allowed to go untreated, implies a risk of other organ involvement and a protracted course.
    Acta Oto-Laryngologica 07/2010; 105(1-2):100-7.
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    ABSTRACT: Abstract Conclusions: Selecting patients that are candidates for surgical treatment is important in the work-up of patients with tracheal cancer. Toward this goal, centralization of care concerning tracheal tumors is advised. Centralization may increase long-term survival and decrease operative morbidity and mortality even further. Objective: Primary tracheal tumors pose a diagnostic and therapeutic challenge for the physician when confronted with this mostly malignant tumor. Diagnosis is often delayed for months or years due to its aspecific and asthma-mimicking symptoms. Knowledge from retrospective series is limited and few clinicians have gained experience with this tumor. The available literature on the diagnosis and management of this group of tumors is reviewed to summarize the available knowledge about these uncommon tumors. New diagnostic, staging, and treatment guidelines are proposed. Methods: PubMed was searched for English publications from 1960. The available literature was reviewed and summarized. Results: Surgical resection and primary reconstruction is the best curative treatment modality available at present. In centers of experience, more than half of all patients with tracheal cancer may be candidates for surgical resection, although in population-based studies this treatment is applied in only 10-25% of patients.
    Acta Oto-Laryngologica 06/2010; 130(7):763-772.
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    ABSTRACT: Starting from age 2 up to 7 years, 79 otherwise healthy children underwent nine tympanometric tests. At the age of 7, mastoid X-rays were obtained and the air cell areas measured by planimetry. The mean area was 8.4 cm2, with a left-right mean difference of 1.57 cm2. The children could be divided into three groups: (1) the ears with the smallest cell system associated with abnormal tympanograms (i.e. 'agreement'); (2) the ears with the largest cell system associated with abnormal tympanograms (i.e. 'disagreement'); (3) children with symmetrical cell systems and tympanograms. Significant majority of children showed 'agreement'. The results indicate that the size of the mastoid air cell system is determined by the degree of pathological involvement of the middle ear during childhood.
    Acta Oto-Laryngologica 02/2010; 99(5-6):564-70.
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    ABSTRACT: The medial wall of the bony portion of the Eustachian tube was examined, by anatomical and histological methods, in 150 temporal bones of adults. This wall consists of two parts: posterolateral (labyrinthine) and anteromedial (carotid), whose shapes, sizes and relations depend upon the position of the a. carotis interna. If it is located nearer the tympanic opening of the tube, the labyrinthine part of the wall is smaller and has a triangular shape. The further the artery is removed from the tympanic opening of the tube, the greater and more rectangular the shape of this part of the wall. The part of the medial wall which corresponds to the a. carotis interna can differ in each case and in 69% of the cases this part extended more or less into the lumen of the tube. The average thickness of this part of the wall is 1.5 mm (minimum is wafer-thin and maximum is 3 mm). In 2% of the cases the bony wall above the a. carotis interna was missing, so that the artery projected into the protympanum. Through a bone defect, aneurysm of the artery can develop. In one case, during an operation, it was established that the protrusion of the a. carotis interna into the tympanic cavity was due to a defect in the medial wall of the Eustachian tube.
    Acta Oto-Laryngologica 02/2010; 99(5-6):551-6.
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    ABSTRACT: Cochlear endolymph, scala tympani perilymph, and scala vestibuli perilymph were collected from fetal, neonatal, and mature guinea pigs. The concentrations of Na and K in these fluids were then assessed using a microflame photometer. The electrolyte composition in the endolymph was already characterized by a high concentration of K and a low concentration of Na by the 49th day of gestation.
    Acta Oto-Laryngologica 02/2010; 99(5-6):525-8.
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    ABSTRACT: The effect of histamine was studied on canine nasal blood vessels with an in vitro muscle tension measuring technique. Observations suggest that histamine has at least four different effects: 1) inhibits the contraction induced by nerve terminal stimulation, 2) relaxes the smooth muscle under sustained contraction, 3) contracts the smooth muscle, 4) enhances (nor)epinephrine-induced contraction. Both H1 and H2 histamine receptors were identified in the mucosal blood vessels of the canine nasal septum. H1 receptors were present at the surface of vascular smooth muscle and mediated the contractile response (3) due to opening calcium influx channels. H2 receptors existed at both sympathetic nerve terminals and the muscle cell membrane. Stimulation of either H2 receptor caused muscle relaxation. The presynaptic H2 receptors mediated vasodilation through the inhibition of norepinephrine release from the nerve endings. Postsynaptic H2 receptors caused direct muscle relaxation possibly through an increase in cyclic AMP. Both H1 and H2 antagonists worked well, whereas agonists did not properly produce theoretically expected results in these specimens.
    Acta Oto-Laryngologica 02/2010; 99(5-6):610-9.
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    ABSTRACT: The ultrastructural features of nine laryngeal papillomas of the adult type were examined by transmission and scanning electron microscopy. The surface was covered by numerous microvilli varying in size and shape and often arranged in parallel cords. Although we did not find virus-like particles, the ultrastructural characteristics of the adult type of laryngeal papilloma did not differ from those previously found on the juvenile type. The two types may in nature be one and the same lesion, differing in behaviour because of the different environments.
    Acta Oto-Laryngologica 02/2010; 99(5-6):649-54.