Acta Oto-Laryngologica (ACTA OTO-LARYNGOL )

Publisher: Taylor & Francis


Acta Oto-Laryngologica presents original articles of basic research interest regarding clinical questions at hand, as well as clinical studies in the field of otorhinolaryngology and related subdisciplines. Acta Oto-Laryngologica is published by a non-profit society of Swedish otolaryngologists. The journal publishes original papers on basic research as well as clinical studies in the field of otolaryngology and head and neck surgery and related subdisciplines. The aim is not only to present clinical and research data but also to bridge the gap between clinical and basic science research, being an international journal for translational research in otolaryngology and head and neck surgery. Review articles presenting state of the art for a selected topic, and containing an internationally representative bibliography are also published. Letters to the editor, Short communications, recent advances in Commercial technology and their clinical applicability, and well documented Clinical trials are also within the scope of Acta Oto-Laryngologica . Reviews of current books in the field of otolaryngology and head and neck surgery are also published.

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  • Other titles
    Acta oto-laryngologica, Acta otolaryngologica
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    Journal / Magazine / Newspaper, Internet Resource

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Taylor & Francis

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    • STM: Science, Technology and Medicine
    • SSH: Social Science and Humanities
    • Publisher last contacted on 25/03/2014
    • 'Taylor & Francis (Psychology Press)' is an imprint of 'Taylor & Francis'
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Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Conclusion: GelitaSpon gelatin sponge (GS) showed faster reabsorption than gelfoam (GF) in vitro, and GS-packed middle ears resulted in a faster hearing recovery and less inflammation than the ears packed with GF soaked in saline. Soaking GF sponges with boric acid (BA) appeared to offset the inflammatory response of saline-soaked GF, making this inflammatory response comparable to that of GS-packed ears. Objective: To describe the reabsorption and inflammatory effects of absorbable gelatin sponge in the middle ear. Methods: For in vitro evaluation, GF and GS were used as disks immersed in saline solution or 3% BA and placed in gel. Images were captured with a microscope and processed using image processing Toolbox. For in vivo tests, 16 female albino Sprague Dawley rats were divided into four groups: bulla opening; GF + 0.9% saline; GF + BA; and GS + 0.9% saline. An anterior approach to the right bulla was used for surgery. Preoperative and postoperative auditory brainstem response thresholds were measured. Results: In vitro, there was marked degradation of GF by day 14, while GS showed complete degradation by the third day. In vivo, hearing recovery occurred by day 21. GF produced a more severe inflammatory response, which could be reduced by treating the GF with BA.
    Acta Oto-Laryngologica 01/2015; 135(1):14-25.
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    ABSTRACT: Abstract Conclusion: Co-segregation of c.2030T>C mutation with hearing loss in an Iranian family and absence of this mutation in 100 Iranian controls confirms the pathogenicity of this mutation. Allelic heterogeneity among Iranian DFNB7/11 families has been shown by the identification of six different mutations in eight families. Objectives: Transmembrane channel-like 1 (TMC1) gene encodes an integral membrane protein such that its mutations can cause DFNB7/11 hearing loss. To date, several TMC1 mutations have been reported from Iran. Here we report a new DFNB7/11 Iranian family with an unreported TMC1 mutation in Iran. Methods: A total of 66 genes related to hearing loss were analyzed using the OtoSCOPE platform in an affected member of an Iranian deaf family (Irn-Deaf-6866). Sanger sequencing was performed to confirm next-generation sequencing findings. Results: A mutation, c.2030T>C, was identified in exon 21 of the TMC1 gene in the investigated member of the family. Sequencing results in all members of the family confirmed association of this mutation with hearing loss. None of 100 ethnically matched healthy controls had this mutation.
    Acta Oto-Laryngologica 11/2014;
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    ABSTRACT: With the growing acceptance of nonsurgical therapies for laryngeal squamous cell carcinomas (LSCC), it has become important to delineate surgical salvage strategies for disease recurrences. Total laryngectomy (TL) is often recommended but appropriately selected laryngeal recurrences may be treated successfully with partial laryngectomy. Using proper selection criteria for conservative salvage laryngeal surgery, laryngeal function can be preserved with oncological efficacy. The most appealing feature of salvage transoral laser surgery (TLS) is the opportunity to make tumor-tailored excisions without any reconstructive limitations and retaining the option to switch to open partial laryngectomy. A recent detailed review of 11 series found a pooled local control rate of 57% after a first TLS procedure, and 64% after repeated TLS procedures. Supracricoid laryngectomy (SCL) seems to achieve good local control rates in selected cases of recurrent supraglottic-glottic carcinoma: one review considering 7 series calculated that 85% of the patients treated with salvage SCL after radiotherapy experienced no local recurrence; and TL after salvage SCL afforded an overall local control rate of approximately 65%. Neck dissection is mandatory in all cases of local LSCC recurrence with evidence of neck metastases, and routine elective neck dissection is recommended for recurrent supraglottic and transglottic cancers.
    Acta Oto-Laryngologica 09/2014;
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    ABSTRACT: In recent years, it has become clear that HPV affects the development of head and neck cancer, particularly oropharyngeal squamous cell carcinoma (OPSCC). HPV-related OPSCCs are reported to be frequently observed among patients with a relatively younger age and those without smoking habits, and also to show a relatively better prognosis compared with OPSCC patients without HPV infection. In the United States, the incidence of HPV-related OPSCC has been increasing in association with the diversification of sexual activity among young individuals. Similarly, the incidence of HPV-related carcinomas has been increasing in Japan. For instance, uterine cervical cancers have been increasing among younger females, and the incidence of OPSCC has also been gradually increasing in spite of a decreasing trend in smoking habits and alcohol consumption. However, there have been only a few Japanese studies that have examined the incidence and prognostic significance of HPV infection in terms of its impact on the outcomes of OPSCC. Therefore, further analyses are needed to establish an appropriate treatment strategy for Japanese OPSCC patients. The aim of this study was to elucidate the frequency and clinical implications of the HPV infection status in Japanese OPSCC, using both a sequencing analysis and IHC.
    Acta Oto-Laryngologica 07/2014;
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    ABSTRACT: Conclusions: Reconstruction of the ossicular chain differentially affects the motion of the tympanic membrane (TM) and the stapes. Objectives: To determine the effect of different ossicular replacement procedures on the sound-induced motion of the TM and stapes. Methods: A combination of digital stroboscopic holography and laser Doppler vibrometry was used to determine the sound-induced motion of the TM and stapes in cadaveric temporal bones in which the ossicular chain was reconstructed using 12 varied standard techniques. The variations included the use of total or partial ossicular prosthesis, size of cartilage interposed between the TM and the prosthesis, and the length or fit of the prosthesis between the TM and stapes. The measurements were carried out in repeated measures format, so that each manipulation was performed in each temporal bone. Results: The volume displacement of the TM was in general reduced by reconstruction, with the largest reductions occurring with high-frequency stimulation in the reconstructions with a ‘large’ cartilage oval interposed between the TM and the prosthesis. Larger stapes motions in response to low-frequency sound were observed with either ‘loose’ or ‘best’ fit TORP with a ‘small’ cartilage plate between the TM and the prosthesis.
    Acta Oto-Laryngologica 05/2014;
  • Acta Oto-Laryngologica 04/2014; 124(2).
  • Acta Oto-Laryngologica 01/2013; 133(8):874-80.
  • Acta Oto-Laryngologica 01/2012; 132(5):525-32.
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    ABSTRACT: Angiogenesis is a hallmark of cancer, fundamental to its growth. The 'angiogenic switch' occurs when pro-angiogenic factors are not balanced by anti-angiogenic factors. A correlation between angiogenic properties and oncological prognosis (for laryngeal squamous cell carcinoma (LSCC) too) was first hypothesized in the 1990s. An exhaustive literature review was performed to investigate available data on angiogenesis markers and their biological role and therapeutic potential in LSCC. The prognostic significance of microvascular density in LSCC was investigated with endothelial targets, e.g. CD105, CD34, and CD31. Epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), VEGF receptor 2, angiogenin, hypoxia-inducible factor 1, and other biological markers were also studied. Only anti-EGFR therapy has been approved by the USFood and Drug Administration (FDA) for head and neck carcinoma in recent years, while several agents interfering with VEGF and its receptors are being studied. Experimental findings indicate that anti-CD105 monoclonal antibodies efficiently inhibit tumor angiogenesis. There are two main ways to approach the vascular profile of solid malignancies: by inhibiting new vessel formation (anti-angiogenic therapy) or selectively damaging neoplastic vessels (vascular targeting therapy). In advanced LSCC, both these strategies seem promising and warrant further preclinical and clinical investigation.
    Acta Oto-Laryngologica 01/2012; 132(6):574-82.
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    ABSTRACT: Conclusion: Sensorineural hearing loss (SNHL) is a neurological situation and celiac disease (CD) may be seen coincidentally. Children with clinical signs of hearing deficiency of unknown etiology should be assessed for CD. Objective: CD is a chronic inflammatory gluten-dependent intestinal disease and has extraintestinal findings. The aim of this study was to determine the incidence of CD and SNHL in our pediatric patients.Methods: A total of 25 pediatric patients (50 ears) with biopsy-proven CD were diagnosed in the pediatric gastroenterology department; 25 healthy control subjects (50 ears) were also included in the study. All subjects underwent pure tone audiometry at frequencies of 250–8000 Hz and tympanometry. Results: In the patients and controls, normal peak compliance, gradient, peak pressure, ear canal volume, and acoustic reflexes were obtained by tympanometry. There was no air–bone gap in any of the participants. There was a statistically significant difference between the audiometric results in the CD and control groups (right ear and left ear) (p < 0.05).
    Acta Oto-Laryngologica 01/2012; 132:146–151.
  • Acta Oto-Laryngologica 01/2011; 131(11):1220-5..
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    ABSTRACT: Patients with Bell's palsy were investigated with regard to the cellular immune response during the acute and convalescent stages with the purpose of acquiring information concerning the etiology of the condition. In order to ascertain whether there was activation of the immune system, the proportion of activated T cells in the peripheral blood of 14 patients with Bell's palsy was analysed using monoclonal antibodies. A transient increase of these cells occurred in the acute stage, with a return to normal in the convalescent stage. The Leu-7+ cells which play a role in the natural cellular defence against viral infections, were also studied by using monoclonal antibodies in 25 patients. A significant change in the percentage of Leu-7+ cells was not found when the samples from the entire group were analysed. However, 10 patients who were investigated between September and October 1984, when the incidence of Bell's palsy was comparatively high, showed significantly lower percentages of Leu-7+ cells in the acute stage compared with the convalescent stage. The increase in the activated T cells in the acute phase of the palsy suggests a cell-mediated, immuno-regulatory abnormality with primary or secondary immune activation. Similar cellular immune alterations are found also in multiple sclerosis. Further, the differences in the proportions of Leu-7+ cells which occurred in these 10 patients may denote a contribution of various etiological factors to the disease.
    Acta Oto-Laryngologica 07/2010; 105(1-2):108-13.
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    ABSTRACT: During a one-year period, 82 consecutive patients seeking medical attention for facial palsy primarily of unknown etiology were examined for underlying Ixodes ricinus-borne borreliosis. Evidence of the infection was found in 16 (20%) of the patients, most of whom had cerebrospinal fluid findings indicating meningeal involvement. Among 9 children included in the study, borreliosis was found in 6 cases. Bilateral facial palsy occurred in 3 of the borrelia-infected patients, as compared with none of the patients without borreliosis. It is suggested that, in areas where the tick vector is present, borreliosis should be regularly sought in patients with facial palsy of otherwise unknown etiology. As regards the serological diagnosis, it is emphasized that normal borrelia antibody titres in serum and cerebrospinal fluid at the time of the first consultation do not exclude the infection. A careful serological follow-up of patients with facial palsy is therefore recommended in order not to miss an underlying borreliosis which, if allowed to go untreated, implies a risk of other organ involvement and a protracted course.
    Acta Oto-Laryngologica 07/2010; 105(1-2):100-7.
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    ABSTRACT: Rats were exposed to toluene (1000 ppm, 16 h/d, 5 d/w, 2 w), or noise (100 dB Leq, 10 h/d, 7 d/w, 4 w) or toluene followed by noise. Auditory function was tested by brainstem audiometry using a 1/3 octave filtered sine wave stimulus at the frequencies 1.6, 3.15, 6.3, 12.5 and 20.0 kHz. A high-frequency auditory impairment was observed after exposure to toluene alone and noise alone. A slight recovery was recorded 1 and 6 months after the toluene exposure. Toluene followed by noise resulted in a higher threshold at all frequencies. A slight recovery was recorded 6 months post-exposure. The threshold shift exceeded the summated loss caused by toluene alone and by noise alone, particularly at 3.15 and 6.3 kHz. The latencies varied only slightly. The results indicate that the major cause of the auditory impairment was cochlear damage and that only minor injury was caused to the auditory pathways.
    Acta Oto-Laryngologica 07/2010; 105(1-2):56-63.
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    ABSTRACT: Abstract Conclusions: Selecting patients that are candidates for surgical treatment is important in the work-up of patients with tracheal cancer. Toward this goal, centralization of care concerning tracheal tumors is advised. Centralization may increase long-term survival and decrease operative morbidity and mortality even further. Objective: Primary tracheal tumors pose a diagnostic and therapeutic challenge for the physician when confronted with this mostly malignant tumor. Diagnosis is often delayed for months or years due to its aspecific and asthma-mimicking symptoms. Knowledge from retrospective series is limited and few clinicians have gained experience with this tumor. The available literature on the diagnosis and management of this group of tumors is reviewed to summarize the available knowledge about these uncommon tumors. New diagnostic, staging, and treatment guidelines are proposed. Methods: PubMed was searched for English publications from 1960. The available literature was reviewed and summarized. Results: Surgical resection and primary reconstruction is the best curative treatment modality available at present. In centers of experience, more than half of all patients with tracheal cancer may be candidates for surgical resection, although in population-based studies this treatment is applied in only 10-25% of patients.
    Acta Oto-Laryngologica 06/2010; 130(7):763-772.
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    ABSTRACT: A case of tracheal dystonia is submitted. In a 44-year-old woman with increasing dyspnoea of predominantly expiratory type, bronchoscopy revealed abnormal yielding and bulging of the right side of the membranous tracheal wall. The bulging was situated in the upper 8 cm of the trachea and varied in extent with the intratracheal pressure. At operation the membranous wall was found to be extremely yielding, in spite of normal width. Adjacent to the abnormal part of the membranous wall there was an enlarged lymph node which on microscopic examination exhibited changes indicating sarcoidosis. The membranous wall was supported by a strip of Teflon, and since the operation the expiratory dyspnoea has improved. The present case is compared with reported cases of tracheobronchial dystonia. It is concluded that the yielding of the membranous wall may have been due to long-lasting pressure by the lymph node, destroying the submucous elastic fibres.
    Acta Oto-Laryngologica 02/2010; 70(5):438-42.
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    ABSTRACT: Some salient problems concerning the diagnosis and prognosis of vocal fold mobility disturbances are briefly outlined. The application of laryngeal electromyography in such cases is recommended. A brief review of EMG findings in the normal and diseased neuro-muscular system is given. In the present study electromyographic investigations of the laryngeal muscles were made of 13 patients (5 males and 8 females) with ages ranging from 22 to 70 years. Their clinical diagnoses included a variety of etiological factors. The posterior crico-arytenoid, thyro-arytenoid and crico-thyroid muscles were routinely examined. A method for the performance of these tests, in the form of an initial sitting and repeated follow-up control studies, is given. The clinical versus EMG findings are analysed. The criteria of neuropathic changes in laryngeal electromyograms are described and their significance is discussed.
    Acta Oto-Laryngologica 02/2010; 70(5):428-37.