Acta gastro-enterologica Belgica Journal Impact Factor & Information

Publisher: Societé Royale Belge de Gastro-Entérologie

Journal description

Current impact factor: 0.58

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2012 Impact Factor 0.581
2011 Impact Factor 0.638
2010 Impact Factor 0.648
2009 Impact Factor 1.01
2008 Impact Factor 0.832
2007 Impact Factor 1.096
2006 Impact Factor 0.736
2005 Impact Factor 0.826
2004 Impact Factor 0.713
2003 Impact Factor 0.67
2002 Impact Factor 0.636
2001 Impact Factor 0.444
2000 Impact Factor 0.605
1999 Impact Factor 0.602
1996 Impact Factor 0.182
1995 Impact Factor 0.857
1994 Impact Factor 0.87
1993 Impact Factor 0.13
1992 Impact Factor 0.059

Impact factor over time

Impact factor

Additional details

5-year impact 0.61
Cited half-life 7.30
Immediacy index 0.08
Eigenfactor 0.00
Article influence 0.17
Website Acta Gastro Enterologica Belgica website
Other titles Acta gastro-enterologica belgica
ISSN 0001-5644
OCLC 1460883
Material type Periodical
Document type Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background Due to the growing use of immunomodulator therapy in inflammatory bowel diseases (IBD), physicians increasingly encounter opportunistic infections in caring for patients with IBD. To the best of our knowledge, there is only one case report of a systemic Bartonella henselae infection in association with Crohn’s disease, which occured during immunosuppressive treatment with infliximab. Aim We describe a case of systemic bartonellosis in a Crohn's disease patient treated by azathioprine. Case report A 61-year-old man had been treated for ileal Crohn's disease since 2004 and had received azathioprine (2.5 mg/kg/day) for 2 years. In January 2014, he was hospitalized for high fever, night sweats and weight loss. Endoscopy disclosed active duodenal Crohn’s disease. The diagnostic work-up revealed serum inflammation, mild cytolytic and cholestatic hepatitis, “biologic” pancreatitis (rapidly resolving) and a suspicion of cholangitis on endoscopic ultrasound (EUS). Common infections were excluded and no improvement was seen with antibiotic treatment (piperacillin/tazobactam). An infectious mononucleosis was suspected since anti-EBV IgM and IgG antibodies were positive, together with splenomegaly on imaging. However, Epstein-Barr Virus (EBV) Polymerase Chain Reaction (PCR) analysis was negative, indicating a false-positive test result. One month later, despite the initial clinical improvement, a necrotic submaxillary adenopathy was diagnosed, suggesting a lymphoma. Cervical node biopsy showed nonspecific subacute inflammation indicating an infectious process. Bone marrow biopsy was negative for lymphoma. Whole body 18F-FDG positron emission tomography/computed tomography (PET/CT) displayed hypermetabolic lesions in both infra- and supra-diaphragmatic lymph nodes, in the spleen and diffusely in the skeleton. Magnetic resonance imaging of the spleen revealed multiple septic lesions. The medical work-up showed doubtful Bartonella henselae serology. EUS-guided fine needle aspiration biopsies of mediastinal lymph nodes were performed and disclosed nonspecific acute adenitis with non-necrotizing granulomas. Systemic bartonellosis was confirmed by PCR analysis of the lymph node tissue. Retrospectively, the patient reported a cat scratch on his nose a few days before the beginning of his symptoms. Serologic cross-reactivity could explain the prior false-positive EBV testing. The symptoms of the patient resolved following discontinuation of azathioprine together with a five-day azithromycin regime. Lesions on 18F-FDG PET/CT imaging disappeared completely, except splenomegaly and the thickening of the common bile duct on abdominal ultrasound. At follow-up 6 months later, the patient was completely asymptomatic. Discussion Bartonella henselae is the agent of cat scratch disease in immunocompetent hosts. In contrast, immunocompromised patients (transplant recipients, patients with acquired immunodeficiency syndrome, cancer patients under chemotherapy, patients treated with tumor necrosis factor-alpha [TNFα] antagonists…) are at risk of developing systemic bartonellosis, with extranodal manifestations including neurologic, hepatic and/or bone involvement. Conclusions Systemic Bartonella henselae infection is a rare complication of immunosuppression in Crohn’s disease patients, even without TNFα blockers, and should be kept in mind in the differential diagnosis of fever of unknown origin and polyadenopathy in this population. Source: (see Case Reports)
    Acta gastro-enterologica Belgica 03/2015; 78(1):112.
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    ABSTRACT: Pancreatic pseudocysts (PPs) are defined as fluid collections more than 4 weeks old that are surrounded by a nonepithelial wall of fibrous or granulation tissue. Many risk factors have been associated with pseudocyst development but predictive factors remain to be explored. The aim of this study was to investigate the clinical, and biochemical parameters that may predict the development of a PPs after an attack of acute pancreatitis(AP). The medical charts of 102 patients diagnosed with AP enrolled into the study. Demographic, clinical and laboratory details were recorded at admission and at the 48th hour. There were several risk factors on admission and at the 48th hour that is predictive of PPs formation when evaluated by univariate analysis such as: Alanine aminotransferase level at 48hrs, calcium level at admission, base excess at 48hrs, calcium level at 48hrs, and albumin level at 48hrs. In multivariate analysis, calcium level at admission was the only variable that was shown to formation of PPs. Lower serum calcium level may be a predictive factor for the development of PPs after AP attack. We advise that patients with calcium levels below 8mg/dl, after AP should be followed more closely.
    Acta gastro-enterologica Belgica 01/2015; 78.
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    ABSTRACT: Rapamycin reduces hepatic fibrosis by inhibiting hepatic stellate cell activation. The present study investigated whether rapamycin treatment could modify the degree of fibrosis, cellular apoptosis and oxidative stress (OS) in an experimental model of CP. Fifty-five male, Sprague-Dawley rats weighing 200-400g were randomized into four groups. CP was induced by intraductal trinitrobenzene sulfonic acid (TNBS) infusion in group A (n = 15) and group B (n = 15). Group C (n = 15) received intraductal TNBS and was killed for histologic confirmation at four weeks. Group D (n = 10) received intraductal saline instead of TNBS. Group A and group D received oral rapamycin (2 mg/kg/d) for two weeks after CP was induced while group B received oral tap water instead of rapamycin. Blood and pancreatic tissue specimens were collected and oxidative stress parameters, fibrosis and cellular apoptosis were determined. Tissue and blood malondialdehyde (MDA) levels were significantly lower in rapamycin treated group compared to controls (p < 0.001). Superoxide dismutase (SOD) and glutathion peroxidase (GSH-Px) activities were also significantly higher in the active treatment group (p < 0.001 for both). Tissue and blood MDA, SOD, GSH-Px measurements was similar in rapamycin group and pancreatic cannulation group (p > 0.05). Histopathologic fibrosis scores were similar in rapamycin and control groups. Apoptotic cell counts tended to be lower in rapamycin treated animals. Administration of rapamycin alleviated OS and, in part, prevented apoptotic cell death in experimental CP, but did not reduce fibrosis. Copyright© Acta Gastro-Enterologica Belgica.
    Acta gastro-enterologica Belgica 01/2015; 78(1):3-7.
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    ABSTRACT: 3,4-methylenedioxymethamphetamine (MDMA), an amphetamine derivative known as ecstasy, has stimulating and hallucinogenic properties. It has become a substance that is widely used especially by young people. Hepatotoxicity is one of the rare side effects of this substance and can be fatal. Ecstasy-induced fulminant hepatitis has been reported in case reports. The clinical course and the prognosis of the cases may differ. In this article, two cases in whom ecstasy-induced fulminant hepatic failure had developed and who were treated with liver transplantation, and one case which recovered with treatment, have been presented. Copyright© Acta Gastro-Enterologica Belgica.
    Acta gastro-enterologica Belgica 01/2015; 78(1):53-5.
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    ABSTRACT: Metaplasia of the esophagus is a precursor of esophageal adenocarcinoma, a cancer with a poor prognosis and an increasing incidence. Guidelines for surveillance are proposed by all professional societies with small differences in timing. However, there is still no consensus on the definition of Barrett's esopaghus (only intestinal metaplasia or all subtypes). The goal of surveillance of esophageal metaplasia has evolved from early detection of cancer to early detection of pre-cancerous metaplasia to allow endoscopic therapy. The endoscopic therapy has the intention to stage, to cure, to prevent progression and to prevent metachronous lesions to develop. Firm indications for endoscopic therapy are high rade dysplasia and mEAC. The actual treatment is EMR/ESD for all visual abnormalities and areas of cancer on biopsies, followed by RFA for the remaining metaplasia. For low grade dysplasia (LGD), surveillance versus RFA is still under discussion. The main reason for this is the wide interobserver variability with large differences in evolution between confirmed and unconfirmed LGD. The endoscopic treatment allows complete remission of dysplasia in most cases and of metaplasia in the majority of cases, with low complication rates and acceptable morbidity (treatable stenosis). However, a median of 3 treatments is usually required to achieve remission, and recurrence is as high as 15% in the following 5 years. Strategies to reduce recurrence like chemotherapy or anti-reflux surgery need to be explored better and can actually not decrease or replace surveillance. Copyright© Acta Gastro-Enterologica Belgica.
    Acta gastro-enterologica Belgica 01/2015; 78(1).
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    ABSTRACT: Until now, "eosinophilic hepatitis" has not been recognized as a separate disease entity. We report a case of a middle-aged women with an acute febrile, severe cholestatic hepatitis accompanied with rash and quincke oedema, and an elevated serum IgE level. Liver biopsy showed lymphocytic inflammation with a remarkably high number of eosinophils. She responded rapidly to methylprednisolone treatment, which could be quickly tapered off and stopped without relapse. The term 'idiopathic acute eosinophilic hepatitis' seems to be the best fitting diagnostic term. Copyright© Acta Gastro-Enterologica Belgica.
    Acta gastro-enterologica Belgica 01/2015; 78(1):65-8.
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    ABSTRACT: In the last years children with chronic hepatitis C (CHC) have been treated with Pegylated Interferon α (PEG-IFNα) and ribavirin (RBV). Treatment can cause several side effects that require reduction or interruption of therapy. The relationship between dose of PEG-IFNα and response to therapy has not been clearly evaluated. Aim of this study was to evaluate the impact of the dose of PEG-IFNα2b and RBV on the efficacy of therapy. All children with CHC treated with PEG-IFNα2b and RBV, observed at the Paediatric Liver Unit of University Federico II of Naples from 1996 to 2006 were evaluated. Sixteen children with CHC treated with combined therapy were enrolled. Seven out of 16 patients (43.7%) achieved rapid virological response; 13/16 patients (81.2%) achieved early virological response; 5/16 patients (31.25%) relapsed; 1 patient resulted non responder. According to percentage of expected dose, our patients were divided into two groups: the first group included 7 patients that performed an overall dosage of PEG-IFNα2b ≥ 75% of the scheduled full dose; the second group included 9 patients that performedm PEG-IFNα2b dose < 75% of scheduled full dose. No difference was noted in terms of sustained virological response. Modifications of therapy due to PEG-IFNα-related adverse events are frequent in children with CHC, but dose adjustments do not seem to impair efficacy of therapy. Copyright© Acta Gastro-Enterologica Belgica.
    Acta gastro-enterologica Belgica 01/2015; 78(1):8-11.
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    ABSTRACT: Duodenal lymphangioma is an extremely rare benign tumor of the gastrointestinal tract. In this case report, we describe the case of a 39-year-old Lebanese female with cystic lymphangioma of the duodenum diagnosed by exploratory laparotomy and immunohistochemical analysis. Herein our findings are described. Copyright© Acta Gastro-Enterologica Belgica.
    Acta gastro-enterologica Belgica 01/2015; 78(1):60-1.
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    ABSTRACT: The gastrointestinal (GI) tract is the most common extranodal site of lymphoma involvement. Primary lymphomas of the GI tract are rare, while secondary GI involvement is relatively common. Despite their rarity, primary lymphomas of the GI tract are important since their evaluation, diagnosis, management and prognosis are distinct from that of lymphoma at other sites and other cancers of the GI tract. In the last years many improvements have been done in the management of GI lymphomas. The new and more accurate endoscopic techniques enabled to better describe the endoscopic features of GI lymphomas with important contributions in the diagnosis, therapy and follow-up. Moreover, a better insight into GI lymphomas etiology and molecular signaling pathways also allowed an improvement in their management, in particular for the diagnosis and for the treatment strategies. We describe the endoscopic presentation of GI lymphomas according to the involved site and lymphoma subtypes. We also discuss the histo-pathological and molecular aspects of all subtypes of GI lymphomas.
    Acta gastro-enterologica Belgica 01/2015;
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    ABSTRACT: Background : Subepithelial lesions (SEL) on upper gastrointestinal endoscopy are frequently encountered and referred to endoscopic ultrasound (EUS). Management of small gastric hypoechoic SELs of muscularis propria (MP) is controversial since EUS-assisted fine needle aspiration may be inconclusive, and surgical excision may be too invasive. We aimed to analyze our gastric MP-SELs in terms of survival and confounding factors. Methods : Data from gastric hypoechoic MP-SELs suggestive of gastrointestinal stromal tumor (GIST) by EUS were retrospectively reviewed. Surgically resected GISTs were stratified according to the current pathological risk criteria. Results : Sixty-one patients were identified. The mean age was 55.5 ± 13.2 years and 45.6% were male. Mean follow-up duration was 53.4 ± 26.7 (12-110) months. Twenty-eight (45.9%) patients were managed conservatively (diameter 15.3 ± 10.1 mm). There were no metastasis- or tumor-related deaths and no significant size changes (≥ 5 mm) in this group during follow-up. Thirty-three (54.1%) patients underwent complete resection (diameter 34.2 ± 14.1 mm) among which 25 (75.8%) had the final diagnosis of GIST ; 2 (8.0%), 14 (56%) and 6 (24%) patients were classified in no-risk, very-low-risk, low-risk categories respectively, while 2 (8.0%) were in moderate-risk and only 1 (4.0%) was in high-risk category. Conclusions : The excellent survival of patients with small hypoechoic gastric MP-SELs with conservative management represents indolent course of those lesions. We suggest re- consideration of the recommendations in the current guidelines towards extending the follow-up intervals for small MP-SELs.
    Acta gastro-enterologica Belgica 01/2015; 78(1):12-17.
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    ABSTRACT: Colonoscopy is an important endoscopic examination for the diagnosis and treatment of pathological conditions of the colon, like polyps and colorectal cancer. However, several factors determine the quality of colonoscopy and thus the quality of polyp and colorectal cancer detection. The Flemish Society of Gastroenterology (VVGE) performed a voluntary on-line registry among its members to identify quality of colonoscopy in Flanders, Belgium. 64 gastroenterologists voluntarily registered 4276 consecutive colonoscopies performed during a 3 month study period. Colonoscopy quality indicators were prospectively collected and analysed. Results showed a low voluntary participation rate (17%), acceptable overall adenoma detection rate of 20,5% and colorectal cancer interval rate of 5,4%. Complications were low (perforation 0,1% and major bleeding 1,5%). The current study showed that in Flanders, Belgium on-line registration of colonoscopy quality indicators is feasible and that quality of colonoscopy in daily practice meets the expectations of (inter)national guidelines. However, further improvement of the registry and an open debate on the quality control of colonoscopy in Flanders is warranted (Belgian Registry B30020096548). Copyright© Acta Gastro-Enterologica Belgica.
    Acta gastro-enterologica Belgica 01/2015; 78(1):18-25.
  • Acta gastro-enterologica Belgica 01/2015; 78(1):57.
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    ABSTRACT: Diverticulosis of the colon is a common disease with an increasing incidence in Western countries. Recent literature has shown some changes in the traditional approach of this disease. The theory that diverticulosis is caused by a reduced intake of dietary fibre, is doubtful. There might be some chemical and histological overlap between diverticulitis, inflammatory bowel disease and irritable bowel disease. High quality clinical study found no effect for antibiotics in acute, uncomplicated diverticulitis. Cyclic administration of mesalazine and rifaximin result in reduced symptoms of diverticular disease. For the treatment of diverticular abscesses, percutaneous drainage shows promising results. Recurrence of acute diverticulitis is rare and most serious complications are linked to the first episode. Recent evidence does not support the traditional recommendation for elective surgery after two episodes of acute diverticulitis any more. This review summarizes the last evidence in diverticular disease and diverticulitis. Copyright© Acta Gastro-Enterologica Belgica.
    Acta gastro-enterologica Belgica 01/2015; 78(1):38-48.
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    ABSTRACT: We describe a case of a patient who presents with jaundice, elevated cholestatic liver enzymes, an extreme weight loss and a midcholedochal stricture very suspect for a cholangiocarcinoma. In the conviction of malignancy, although the absence of anatomopathological prove, the patient underwent a choledochal resection. The anatomopathological specimen revealed no malignancy. In the year following resection, the patient keeps presenting with bile duct strictures and further weight loss. Ultimately the diagnosis of Ig G4-related cholangitis is withheld. Therapy with corticosteroids is initiated with a spectacular clinical, biochemical and radiographical result. IgG4-related cholangitis is the biliary presentation of IgG4-related disease, a recently discovered entity of fibroinflammatory masses which can affect virtually every organ in the body. It is characterized by a dense lymphoplasmacytic infiltrate, storiform fibrosis, obliterative phlebitis and a presence of > 30 IgG4-positive plasma cells per high power field. Main differential diagnosis contains cholangiocarcinoma and primary sclerosing cholangitis. Corticoids are cornerstone of therapy, with azathioprine frequently used as a maintenance in case of relapse. With this case we want to draw the attention to a rather uncommon cause of biliary obstruction, easily mistaken for a cholangiocarcinoma. Copyright© Acta Gastro-Enterologica Belgica.
    Acta gastro-enterologica Belgica 01/2015; 78(1):62-4.
  • Article: Deadly Air.
    Acta gastro-enterologica Belgica 01/2015; 78(1):69.
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    ABSTRACT: Distal intestinal obstruction syndrome (DIOS) - the incomplete of complete intestinal obstruction by intestinal contents in the terminal ileum and proximal colon- is frequently seen in cystic fibrosis (CF) patients. Diagnosis is based on suggestive symptoms of abdominal pain in the right lower quadrant, a palpable mass on examination and signs of obstruction on plain radiography. Treatment consists of intensive laxative treatment with oral laxatives and enemas. Surgery only serves as the last resort for patients not responding to medical therapy, because of the well-known high rate of peri- and postoperative morbidity of surgery in CF patients. In this article we present 3 cases of DIOS, followed by a review of the relevant literature. Copyright© Acta Gastro-Enterologica Belgica.
    Acta gastro-enterologica Belgica 01/2015; 78(1):49-52.
  • Acta gastro-enterologica Belgica 01/2015; 78(1):26-9.
  • Acta gastro-enterologica Belgica 01/2015; 78(1):58-9.
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    ABSTRACT: We report a case of Henoch-Schönlein Purpura in a 83-year old patient. The patient presented with a purpuric rash and arthralgia. During admission, he developed hematochezia and acute kidney injury. Because of protracted gastro-intestinal bleeding after initiating therapy with methylprednisolone and ileocaecal resection, azathioprine was started. Gastro-intestinal bleeding resolved, and renal function normalized. We present the clinical and pathological findings of Henoch-Schönlein Purpura, focusing on gastro-intestinal manifestations.
    Acta gastro-enterologica Belgica 12/2014; 77(4):379-82.