Job Description
DiThera Inc. is a biotechnology start-up that actively seeks to develop our proprietary nucleic-acid-dependent protein complementation (NadPC) technology for basic research, diagnostic, and
therapeutic applications. DiThera is located in a state-of-the-art research facility in Costa Mesa, California with access to core technologies and facilities
to rapidly covert ideas into discoveries.
We seek an accomplished protein chemist/biochemist for the position of postdoctoral or senior scientist. The primary duty of the successful candidate will consist of research activities on the
preparation, characterization, and application of protein-DNA conjugates. An initial phase of his/her research project will aim to develop efficient methods for the preparation of covalent conjugates
between split fragments of several proteins, including fluorescent proteins, enzymes, and cytotoxic proteins, and DNA's (oligonucleotides). This will involve recombinant production of split
fragments, their chemical conjugation to DNA's, and purification of the resulting protein-DNA conjugates. Subsequent work will focus on biochemical and biophysical characterization of protein-DNA
conjugates. In particular, the functionality of protein-DNA conjugates will be analyzed quantitatively using in vitro systems. This will include quantitative analysis of the ability to
fluoresce, activity and kinetics of enzymes, and induction of cell death, along with their ability to interact with other macromolecules.
The title will be based on the experience and qualifications of selected individuals and determined at the offer stage.
DiThera offers a competitive salary and benefits program and may provide reallocation support.
Qualifications:
Education: A Ph.D. degree in chemical or biological science is required.
Requirements:
- Expertise in the cloning, expression, purification, refolding, characterization and optimization of recombinant proteins
- Prior experience with chemical modification of proteins and nucleic acids, including experience in the preparation of chemical conjugates between proteins and nucleic acids is desirable, but not
a requirement
- Proficiency in various in vitro characterization methods for proteins and nucleic acids, such as fluorescence emission, enzymatic activity, protein-protein, protein-nucleic acid, and nucleic
acid-nucleic acid interactions, and structural determination
- Proven ability to plan and execute advanced research studies
- A history of relevant publications in peer-reviewed journals
- Creativity and ambition, along with excellent organizational, analytical, collaboration, and communication skills
Start date:As soon as possible.
DiThera is an EOE/AA employer.