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Department of Medicine
27
Total Impact Points
3
Members
Department of Pathology
71
Total Impact Points
3
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Department of Oncology
40
Total Impact Points
2
Members

Publication History View all

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background Thyroid hemiagenesis is a rare congenital anomaly in which 1 thyroid lobe fails to develop. Co-occurrence of hemiagenesis and thyroid carcinoma is extremely rare. Here, we report 2 cases of thyroid hemiagenesis with carcinoma. Methods The first patient was referred with a left thyroid mass and absent right lobe. The frozen section examination revealed medullary thyroid carcinoma (MTC); therefore, a left thyroid lobectomy plus neck dissection was performed. Another patient was referred with a right thyroid mass and absent left lobe. Fine-needle aspiration biopsy was suspicious for papillary carcinoma. The patient underwent right thyroid lobectomy plus neck dissection. ResultsThe operative findings confirmed hemiagenesis of the right lobe and MTC in the left lobe for the first case, and hemiagenesis of the left lobe and papillary carcinoma in the right lobe for the second case. Conclusion Our case represents the first reported case of association between thyroid hemiagenesis and MTC. (c) 2014 Wiley Periodicals, Inc. Head Neck 36: E106-E111, 2014
    Head & Neck 11/2014; 36(11). DOI:10.1002/hed.23501
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    ABSTRACT: Background and aims Pancreatic cancer is characterized by inadequate vascularization and considerable tumor hypoxia is prevalent. However, whether hypoxia-inducible factor 1α (HIF-1α) is significantly correlated with clinical prognosis in pancreatic cancer remains unclear. We aimed to determine the value of HIF-1α as a predictor of survival in pancreatic cancer through a meta-analysis of available cohort studies. Methods We performed a literature search of the MEDLINE, Embase, and Cochrane Library databases to identify cohort studies on the prognostic value of HIF-1α in pancreatic cancer. We conducted a meta-analysis to examine the clinical status and overall survival of patients with high HIF-1α expression compared to those with low expression. Results We analyzed eight studies involving 557 patients. HIF-1α was associated with higher rate of lymph node metastasis (odd ratio [OR] = 3.16; 95% confidence interval [CI] = 1.95-5.11; p < 0.05) and advanced tumor stage (OR = 3.66; 95% CI = 2.01-6.69; p < 0.05), while no significant difference was detected for tumor diameter (OR = 1.58; 95% CI = 0.46-5.47; p > 0.05). Notably, HIF-1α overexpression was significantly correlated with poor overall survival (hazard ratio [HR] = 1.88; 95% CI = 1.39-2.56; p < 0.05). Conclusions We believe that HIF-1α overexpression is significantly associated with poor prognosis in pancreatic cancer, and may serve as an important parameter for evaluating the biological behavior and prognosis of pancreatic cancer.
    Pancreatology 09/2014; 14(5). DOI:10.1016/j.pan.2014.06.008
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    ABSTRACT: Objectives To analyze the clinical characteristics, treatment, and outcomes of Kawasaki Disease (KD) patients associated with macrophage activation syndrome (MAS), and compare two diagnostic standards (HLH 2009 and Ravelli’s criteria). Methods All of the studied patients with Kawasaki Disease (KD) were treated at The Children's Hospital, Zhejiang University School of Medicine, during 2007-2010. Clinical and laboratory findings were analyzed. Results In 719 KD patients, eight patients (1.11%, 81.3±49.4 months, all male) were diagnosed by Ravelli’s criteria, but only three (0.42%) patients were diagnosed by HLH 2009 criteria. Aspartate aminotransferase increased significantly in all cases. Alanine aminotransferase, lactate dehydrogenase, and serum ferritin increased significantly in seven cases. Cytopenia and hypertriglyceridemia (>1.5 mmol/L) were found in six and five cases, respectively. Hypofibrinogenemia (<1.5 g/L) was found in two cases. Three cases showed evidence of hemophagocytosis, but only one case met the HLH 2009 criteria. Ectasia of the coronary arteries occurred in two cases. Seven patients were non-responsive to IVIG. One case died after the combined application of DXM, VP16, and CSA. Conclusions MAS may be a frequently under-recognized complication of KD, because the understanding of complications and diagnostic criteria are still in progress. HLH 2009 criteria have low sensitivity and specificity for the diagnosis of MAS complicating KD. When hepatosplenomegaly is present in KD patients with abnormal laboratory findings, such as cytopenia, liver dysfunction, hyperferritinemia, elevated serum LDH, hypofibrinogenemia, and hypertriglyceridemia, the presence of MAS should be considered.
    Seminars in Arthritis and Rheumatism 08/2014; 44(4). DOI:10.1016/j.semarthrit.2014.07.007

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Chinese medical journal 02/2010; 123(3):369-71.
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