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Department of Gastroenterology
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Graduate School of Nanobioscience
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Department of Urology
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    ABSTRACT: Aim microRNAs (miRNAs) are involved in various neoplastic diseases, including prostate cancer (PCs). The aim of this study was to investigate the miRNA profile in PC tissue, to assess their association with clinicopathologic data, and to evaluate the potential of miRNAs as diagnostic and prognostic markers. Materials and Methods From a cohort of 535 patients submitted to radical prostatectomy (RP), a sample of 30 patients (14 patients with rapid biochemical failure (BF) and 16 patients without BF) with Gleason score 7 were analyzed. A total of 1435 miRNAs were quantified by microarray hybridization, and selected miRNAs with the highest Standard deviation (n = 50) were validated by real-time quantitative PCR (qRT-PCR). In situ hybridization (ISH) was used to evaluate the expression of miR-21. Results miR-21 was the only miR that was significantly up-regulated in the BF group (p = 0.045) miR-21 was up-regulated in patients with BF compared with non-BF group (p = 0.05). In univariate analyses, high stromal expression of miR-21 had predictive impact on biochemical failure-free survival (BFFS) and clinical failure-free survival (CFFS) (p = 0.006 and p = 0.04, respectively). In the multivariate analysis, high stromal expression of miR-21 expression was found to be an independent prognostic factor for BFFS in patients with Gleason score 6 (HR 2.41, CI 95% 1.06–5.49, p = 0.037). Conclusion High stromal expression of miR-21 was associated with poor biochemical recurrence-free survival after RP. For patients with Gleason score 6, miR-21 may help predict the risk of future disease progression and thereby help select patients for potential adjuvant treatment or a more stringent follow-up.
    PLoS ONE 11/2014; 9(11):e113039. DOI:10.1371/journal.pone.0113039
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    ABSTRACT: Hemorrhagic ascites due to endometriosis is extremely rare, and its treatment is under discussion. We report a case of recurrent endometriosis related ascites treated with dienogest (DNG). A 35-year-old nulliparous Japanese woman with a history of infertility presented with worsening dysmenorrhea and abdominal distention caused by massive ascites. The patient underwent exploratory laparotomy, and hemorrhagic ascites 5500ml was drained. She had a normal-sized uterus, and the bilateral ovaries could not be observed due to extensive adhesion in the abdominal cavity. Endometriosis was diagnosed by histopathological evaluation of the omentum biopsy and this was considered to be the cause of ascites. After laparotomy she had recurrence of ascites. For the next 8 years, the patient was treated conservatively with gonadotropin-releasing hormone (GnRH) agonist therapy and drainage during the intermittent periods, followed by DNG administration. She has been treated continuously with DNG for 1 year with no recurrence of ascites. DNG could be an effective treatment for recurrent ascites associated with endometriosis, especially when surgical therapy is undesirable.
    Journal of Minimally Invasive Gynecology 11/2014; 21(6). DOI:10.1016/j.jmig.2014.04.014
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    ABSTRACT: Takotsubo cardiomyopathy (TC) is a recently recognized novel cardiac syndrome characterized by transient left ventricular dysfunction without obstructive coronary disease, electrocardiographic (ECG) changes (ST-segment elevation and/or negative T wave) or elevated cardiac enzymes. Because the clinical features and ECG findings of TC mimic those of anterior acute myocardial infarction (AMI) with occlusion of the left anterior descending coronary artery, differential diagnosis has an important role in selecting the most appropriate treatment strategy. Especially in the acute phase, differential diagnosis is essential for deciding whether reperfusion therapy is required. Although it has been suggested that ECG does not allow reliable differentiation between TC and anterior AMI, several ECG criteria distinguishing TC from anterior AMI have been proposed. In this review, we discuss ECG findings of TC, especially in the acute phase, compare them with those of anterior AMI, and identify ECG features that may facilitate early recognition of this disease.
    Journal of electrocardiology 09/2014; 47(5). DOI:10.1016/j.jelectrocard.2014.03.004


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The Japanese Journal of Rehabilitation Medicine 04/2011; 48(4):270-281. DOI:10.2490/jjrmc.48.270

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