Vienna, Austria, Austria

Departments View all

Total Impact Points

Recent Publications View all

  • [Show abstract] [Hide abstract]
    ABSTRACT: The Mean Residence Time (MRT) of groundwater is an important factor for the development of hydrogeological concepts influencing the origin, recharge and exchange with the aquifer rocks. In addition, contamination and risk assessment depend strongly on the estimated residence of groundwater.
    12/2015; 13:301-306. DOI:10.1016/j.proeps.2015.07.070
  • [Show abstract] [Hide abstract]
    ABSTRACT: The resection of 5'-DNA ends at a double-strand break (DSB) is an essential step in recombinational repair, as it exposes 3' single-stranded DNA (ssDNA) tails for interaction with a repair template. In mitosis, Exo1 and Sgs1 have a conserved function in the formation of long ssDNA tails, whereas this step in the processing of programmed meiotic DSBs is less well-characterized across model organisms. In budding yeast, which has been most intensely studied in this respect, Exo1 is a major meiotic nuclease. In addition, it exerts a nuclease-independent function later in meiosis in the conversion of DNA joint molecules into ZMM-dependent crossovers. In order to gain insight into the diverse meiotic roles of Exo1, we investigated the effect of Exo1 deletion in the ciliated protist Tetrahymena. We found that Exo1 together with Mre11, but without the help of Sgs1, promotes meiotic DSB end resection. Resection is completely eliminated only if both Mre11 and Exo1 are missing. This is consistent with the yeast model where Mre11 promotes resection in the 3'-5' direction and Exo1 in the opposite 5'-3' direction. However, while the endonuclease activity of Mre11 is essential to create an entry site for exonucleases and hence to start resection in budding yeast, Tetrahymena Exo1 is able to create single-stranded DNA in the absence of Mre11. Excluding a possible contribution of the Mre11 cofactor Sae2 (Com1) as an autonomous endonuclease, we conclude that there exists another unknown nuclease that initiates DSB processing in Tetrahymena. Consistent with the absence of the ZMM crossover pathway in Tetrahymena, crossover formation is independent of Exo1.
    DNA repair 10/2015; 35:137-143. DOI:10.1016/j.dnarep.2015.08.005
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study is to systematically review the literature that explored the association between smoking and suicidal risk among those with serious mental illness and to estimate the risk of suicidal behaviors attributable to smoking among this patient group. Multiple databases (CINAHL, PsycINFO, EMBASE, Informit Health Collection and the Cochrane Library databases) were searched from 1 January 1975 through 15 January 2014, along with references from relevant articles for observational studies that ascertained the association between smoking and suicidal behaviors among patients with psychotic disorders conducted in adult patients. Thirteen studies involving 6813 patients with severe mental illness were included. We found that smoking was significantly associated with suicidality in psychosis with an Odds Ratio of 2.12 (95% CI 1.67–2.7). Smoking is associated with suicidal risk amongst individuals with a severe mental illness; however, it is still unclear whether this represents a true risk factor or a confounder or a mediator via mechanisms, hitherto unknown, needs to be studied further.
    PLoS ONE 09/2015; 10(9). DOI:10.1371/journal.pone.0138147


  • Address
    Universitätsring 1, 1010, Vienna, Austria, Austria
  • Head of Institution
    Heinz W. Engl
  • Website
Information provided on this web page is aggregated encyclopedic and bibliographical information relating to the named institution. Information provided is not approved by the institution itself. The institution’s logo (and/or other graphical identification, such as a coat of arms) is used only to identify the institution in a nominal way. Under certain jurisdictions it may be property of the institution.

4624 Members View all

View all

Top publications last week by reads

Palaeogeography Palaeoclimatology Palaeoecology 11/2015; DOI:10.1016/j.palaeo.2015.10.045
100 Reads
01/2003; Verlag der Österreichischen Akademie der Wissenschaften, Wien.
96 Reads

Top Collaborating Institutions


This map visualizes which other institutions researchers from University of Vienna have collaborated with.

Rg score distribution

See how the RG Scores of researchers from University of Vienna are distributed.