University of Santiago de Compostela

Santiago de Compostela, A Coruña, Spain

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    ABSTRACT: New-born calves depend upon colostrum intake for the acquisition of immunoglobulins (Ig) and other beneficial substances. However, colostrum is also a source of reactive oxygen species (ROS). Intrinsic production of ROS also increases after birth, so the combination of colostral and intrinsic ROS could overwhelm the antioxidant capacity of the calf leading to oxidative stress (OS), a condition that has been shown to play a key role in the initiation and development of several pathological conditions. The aim of this observational study was to assess the effects of the redox balance of colostrum on the oxidative status of calves and on passive immune transfer. Serum samples were taken from 20 calves on their day of birth, every week during their first month of life and at 2 and 3 months of age, and the concentrations of ROS and serum antioxidant capacity (SAC) assayed. The oxidative/anti-oxidative profile and IgG content of the colostrum were also assessed. The redox balance of the colostrum had a significant effect on both calf oxidative status and on passive immune transfer (as measured by calf serum IgG concentration), which indicates that the oxidative/antioxidative profile of colostrum should be measured when colostrum quality is assessed. The highest risk of OS during the study period was found to be when the calves were fed artificial milk replacer; this suggests that calves should be supplemented with antioxidants during this period in order to minimize any harmful consequences of high ROS generation.
    The Veterinary Journal 12/2014;
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    ABSTRACT: This work presents a method for the simultaneous determination of 23 benzodiazepines, metabolites and related pharmaceuticals (zolpidem, methylphenidate and ritalinic acid) by solid-phase extraction (SPE) followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Different SPE cartridges were considered: hydrophilic modified reversed-phase (Oasis HLB) and their modified versions containing also a cationic-exchange group (Oasis MCX) or anionic-exchange (Oasis MAX) funcionalities. Stability of analytes and the impact of the final eluate volume on the matrix effects on LC-MS/MS were also considered. In the final method, 100-200mL of sample are extracted with Oasis MCX (60mg), eluted with 5mL of methanol (1.25% NH3) and the eluate concentrated and analyzed by LC-MS/MS. Under these conditions, LOQs were established between 0.1 and 18ngL(-1) for influent wastewater. The use of surrogated deuterated internal standards allows obtaining recoveries in the 84-122% range. Finally the method was applied to determinate the analytes in wastewater and surface water and 10 compounds were detected in the range of 0.5-170ngL(-1), being the ritalinic acid (the main metabolite of methylphenidate) the analyte detected in the highest concentrations.
    Journal of chromatography. A. 06/2014;
  • Tetrahedron. 05/2014; 70(20):3276–3283.


  • Address
    Colexio de San Xerome, Praza do Obradoiro, s/n., 15782, Santiago de Compostela, A Coruña, Spain
  • Head of Institution
    Juan J. Casares Long
  • Website
  • Phone
    0034881 811 001
  • Fax
    0034881 811 201
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Top publications last week by downloads

Corporate Ownership and Control. 01/2007; 4(4).
Journal of Membrane Science 01/2012; 423-424:348-361.

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