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- SourceAvailable from: Francesco Cappelli[Show abstract] [Hide abstract]
ABSTRACT: Background Few studies have analyzed the clinical and echocardiographic differences between light-chain (AL) and transthyretin (TTR) amyloidosis.HypothesisThe aim of the present research was to compare, in a real-world setting, the clinical and echocardiographic profiles of these kinds of amyloidosis, at the time of diagnosis, using new-generation echocardiography.Methods Seventy-nine patients with AL and 48 patients with TTR amyloidosis were studied.ResultsAccording to the criterion of mean left ventricular (LV) thickness >12 mm, 45 AL (C-AL) and all TTR patients had cardiac amyloidotic involvement, whereas 34 AL patients did not. TTR patients had increased right ventricular (RV) and LV chambers with increased RV and LV wall thickness and reduced LV ejection fraction and fractional shortening. Furthermore, TTR patients showed lower N-terminal pro Brain Natriuretic Peptide concentrations and New York Heart Association functional class when compared with C-AL.Conclusions Our data show that at time of first diagnosis, TTR patients have a more advanced amyloidotic involvement of the heart, despite less severe symptoms and biohumoral signs of heart failure. We can hypothesize that we observed different diseases at different stages. In fact, AL amyloidosis is a multiorgan disease with quick progression rate, that becomes rapidly symptomatic, whereas TTR amyloidosis might have a slow progression rate and might remain poorly symptomatic for a greater amount of time.Clinical Cardiology 02/2015; 38(2). DOI:10.1002/clc.22353
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ABSTRACT: Body dissatisfaction is recognized as a robust risk factor for eating disorders. Despite over 80% of college men are body dissatisfied, not all men report several levels of eating disorder symptoms. In this study, we examined poor impulse control, social anxiety and internalization of media ideals as potential moderators. Data collected from 405 college-aged men were analysed, using latent variable structural equation modelling approach. All variables investigated have been found to moderate the body dissatisfaction-eating disorder symptomatology, such that male body dissatisfaction was strongly related to men's eating disorder symptomatology when each moderator was at its highest level. Practical implications are discussed.Journal of Health Psychology 01/2015; 20(1):80-90. DOI:10.1177/1359105313499198
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ABSTRACT: The Drive for Muscularity Scale and Male Body Dissatisfaction Scale were developed for use with men and correspond to measures of drive for thinness and body dissatisfaction in women. The psychometric properties of these measures were evaluated in a sample of 655 Italian men, who completed other 11 measures also. Both scales demonstrated excellent internal consistency and temporal stability as well as criterion-related and concurrent validity. Both measures distinguished between men with high and low levels of disordered eating. Confirmatory factor analysis replicated the unidimensional factor structure of both scales. Directions for future research are discussed.Journal of Health Psychology 01/2015; 20(1):48-59. DOI:10.1177/1359105313498108
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Rg score distribution
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