Department of Molecular and Clinical Pharmacology

Publications (82)

• Article: Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity

  B.K. Park, H. Laverty, A. Srivastava, D.J. Antoine, D. Naisbitt, D.P. Williams
  Chemico-Biological Interactions.
• Source

  Available from: Jennifer Pulman

  Article: Assessing the efficacy of different upper limb hemiparesis interventions on improving health-related quality of life in stroke patients: a systematic review.

  Jennifer Pulman, Emily Buckley
  Topics in Stroke Rehabilitation 20(2):171-88. · 0.95 Impact Factor
• Source

  Available from: Jennifer Pulman

  Article: A meta-analysis evaluating the effectiveness of two different upper limb hemiparesis interventions on improving health-related quality of life following stroke.

  Jennifer Pulman, Emily Buckley, David Clark-Carter
  Topics in Stroke Rehabilitation 20(2):189-96. · 0.95 Impact Factor
• Source

  Available from: iasusa.org

  Article: Drug-drug interactions that matter.

  David J Back
  Topics in HIV medicine: a publication of the International AIDS Society, USA 14(2):88-92.
• Article: Clinical pharmacology in the 1990s: a personal perspective.

  A Breckenridge
  Materia medica Polona. Polish journal of medicine and pharmacy 27(4):135-6.
• Article: The role of clinical pharmacology in optimizing antiretroviral therapy.

  David J Back, Saye H Khoo
  British Journal of Clinical Pharmacology 06/2003; 55(5):473-6. · 2.96 Impact Factor
• Article: The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro.

  Becky Chandler, Lisa Almond, Jennifer Ford, Andrew Owen, Patrick Hoggard, Saye Khoo, David Back
  JAIDS Journal of Acquired Immune Deficiency Syndromes 09/2003; 33(5):551-6. · 4.43 Impact Factor
• Article: Pharmacokinetic drug interactions with nevirapine.

  David Back, Sara Gibbons, Saye Khoo
  JAIDS Journal of Acquired Immune Deficiency Syndromes 10/2003; 34 Suppl 1:S8-14. · 4.43 Impact Factor
• Article: Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA.

  Andrew Owen, Becky Chandler, Dave J Back, Saye H Khoo
  Antiviral therapy 11/2004; 9(5):819-21. · 3.16 Impact Factor
• Article: Intracellular pharmacokinetics of antiretroviral agents.

  Andrew Owen, Saye H Khoo
  Journal of HIV therapy 12/2004; 9(4):97-101.
• Article: The implications of P-glycoprotein in HIV: friend or foe?

  Andrew Owen, Becky Chandler, David J Back
  Fundamental and Clinical Pharmacology 07/2005; 19(3):283-96. · 1.80 Impact Factor
• Article: Simultaneous determination of HIV protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir in human plasma by high-performance liquid chromatography-tandem mass spectrometry.

  Laura Dickinson, Lesley Robinson, John Tjia, Saye Khoo, David Back
  Journal of Chromatography B 01/2006; 829(1-2):82-90. · 2.89 Impact Factor
• Article: An update on therapeutic drug monitoring for antiretroviral drugs.

  David Back, Sara Gibbons, Saye Khoo
  Therapeutic Drug Monitoring 07/2006; 28(3):468-73. · 2.49 Impact Factor
• Article: The impact of host pharmacogenetics on antiretroviral drug disposition.

  Andrew Owen
  Current Infectious Disease Reports 10/2006; 8(5):401-8.
• Article: Pharmacogenetics of HIV therapy.

  Andrew Owen, Munir Pirmohamed, Saye H Khoo, David J Back
  Pharmacogenetics and Genomics 11/2006; 16(10):693-703. · 3.48 Impact Factor
• Source

  Available from: Andrew Owen

  Article: Effect of transporter modulation on the emergence of nelfinavir resistance in vitro.

  Becky Chandler, Maria Detsika, Andrew Owen, Sorcha Evans, Ruben C Hartkoorn, Patricia A Cane, David J Back, Saye H Khoo
  Antiviral therapy 02/2007; 12(5):831-4. · 3.16 Impact Factor
• Article: Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein.

  Ruben C Hartkoorn, Becky Chandler, Andrew Owen, Stephen A Ward, S Bertel Squire, David J Back, Saye H Khoo
  Tuberculosis 06/2007; 87(3):248-55. · 3.47 Impact Factor
• Article: Fair pricing for medicines in the UK.

  Tom Walley
  Expert Review of Pharmacoeconomics & Outcomes Research 06/2007; 7(3):207-9.
• Article: Combining resistance and pharmacology for optimum patient care.

  Saye H Khoo, Alan Winston, David J Back
  Current opinion in HIV and AIDS 06/2007; 2(3):157-68. · 4.75 Impact Factor
• Article: Limited-sampling strategy for the prediction of boosted hard-gel saquinavir exposure at a dosage of 1000/100 mg twice daily in human immunodeficiency virus-infected individuals.

  Laura Dickinson, David Back, Anton Pozniak, Saye Khoo, Marta Boffito
  Therapeutic Drug Monitoring 07/2007; 29(3):361-7. · 2.49 Impact Factor
• Article: Factors impacting the expression of membrane-bound proteins in lymphocytes from HIV-positive subjects.

  Becky Chandler, Maria Detsika, Saye H Khoo, Jill Williams, David J Back, Andrew Owen
  Journal of Antimicrobial Chemotherapy 10/2007; 60(3):685-9. · 5.07 Impact Factor
• Article: Pharmacogenetics of antiretroviral agents.

  Andrew Owen, Saye H Khoo
  Current opinion in HIV and AIDS 05/2008; 3(3):288-95. · 4.75 Impact Factor
• Article: Differences in the pharmacokinetics of protease inhibitors between healthy volunteers and HIV-infected persons.

  Laura Dickinson, Saye Khoo, David Back
  Current opinion in HIV and AIDS 06/2008; 3(3):296-305. · 4.75 Impact Factor
• Article: Pharmacogenetics and pharmacogenomics: adverse drug reactions.

  Andrea Jorgensen, Ana Alfirevic
  Pharmacogenomics 11/2008; 9(10):1397-401. · 3.97 Impact Factor
• Source

  Available from: psic.info

  Article: New directly acting antivirals for hepatitis C: potential for interaction with antiretrovirals.

  Kay Seden, David Back, Saye Khoo
  Journal of Antimicrobial Chemotherapy 03/2010; 65(6):1079-85. · 5.07 Impact Factor
• Article: Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.

  Ana Alfirevic, Munir Pirmohamed
  Pharmacogenomics 04/2010; 11(4):497-9. · 3.97 Impact Factor
• Article: Validation of a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay for the simultaneous determination of existing and new antiretroviral compounds.

  Laura Else, Victoria Watson, John Tjia, Andrew Hughes, Marco Siccardi, Saye Khoo, David Back
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 06/2010; 878(19):1455-65. · 2.78 Impact Factor
• Article: Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.

  Nasir S Mirza, Ana Alfirevic, Andrea Jorgensen, Anthony G Marson, Munir Pirmohamed
  Pharmacogenetics and Genomics 01/2011; 21(5):297-302. · 3.48 Impact Factor
• Article: Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the fetal compartment (placenta and amniotic fluid).

  Laura J Else, Stephen Taylor, David J Back, Saye H Khoo
  Antiviral therapy 01/2011; 16(8):1139-47. · 3.16 Impact Factor
• Article: Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract.

  Laura J Else, Stephen Taylor, David J Back, Saye H Khoo
  Antiviral therapy 01/2011; 16(8):1149-67. · 3.16 Impact Factor
• Source

  Available from: Andrew Owen

  Article: Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy.

  Adam Lister, Taoufik Nedjadi, Neil R Kitteringham, Fiona Campbell, Eithne Costello, Bryony Lloyd, Ian M Copple, Samantha Williams, Andrew Owen, John P Neoptolemos, Chris E Goldring, B Kevin Park
  Molecular Cancer 01/2011; 10:37. · 3.99 Impact Factor
• Article: How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

  Hg Laverty, C Benson, Ej Cartwright, Mj Cross, C Garland, T Hammond, C Holloway, N McMahon, J Milligan, Bk Park, [......], P Sager, S Singh, T Suter, W Suter, A Trafford, Pga Volders, R Wallis, R Weaver, M York, Jp Valentin
  British Journal of Pharmacology 02/2011; 163(4):675-93. · 4.41 Impact Factor
• Article: Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine.

  Daniel F Carr, Ana Alfirevic
  Pharmacogenomics 03/2011; 12(3):315-7. · 3.97 Impact Factor
• Article: Assessing the safety of stem cell therapeutics.

  Chris E P Goldring, Paul A Duffy, Nissim Benvenisty, Peter W Andrews, Uri Ben-David, Rowena Eakins, Neil French, Neil A Hanley, Lorna Kelly, Neil R Kitteringham, Jens Kurth, Deborah Ladenheim, Hugh Laverty, James McBlane, Gopalan Narayanan, Sara Patel, Jens Reinhardt, Annamaria Rossi, Michaela Sharpe, B Kevin Park
  Cell stem cell 06/2011; 8(6):618-28. · 23.56 Impact Factor
• Article: Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.

  B K Park, H Laverty, A Srivastava, D J Antoine, D Naisbitt, D P Williams
  Chemico-biological interactions 06/2011; 192(1-2):30-6. · 2.46 Impact Factor
• Article: Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery.

  Nasir Mirza, Olga Vasieva, Anthony Guy Marson, Munir Pirmohamed
  Human Molecular Genetics 08/2011; 20(22):4381-94. · 7.64 Impact Factor
• Article: Intronic tandem repeat in the serotonin transporter gene in Old World monkeys: a new transcriptional regulator?

  Ursula M Paredes, Vivien J Bubb, Kate Haddley, Gabriele A Macho, John P Quinn
  Journal of Molecular Neuroscience 10/2011; 47(2):401-7. · 2.50 Impact Factor
• Article: Reporting of adverse events in randomised controlled trials of antiepileptic drugs using the CONSORT criteria for reporting harms.

  Arif A Shukralla, Catrin Tudur-Smith, Graham A Powell, Paula R Williamson, Anthony G Marson
  Epilepsy research 11/2011; 97(1-2):20-9. · 2.48 Impact Factor
• Source

  Available from: David John Webb

  Article: Circulating microRNAs as potential markers of human drug-induced liver injury.

  Philip J Starkey Lewis, James Dear, Vivien Platt, Kenneth J Simpson, Darren G N Craig, Daniel J Antoine, Neil S French, Neeraj Dhaun, David J Webb, Eithne M Costello, John P Neoptolemos, Jonathan Moggs, Chris E Goldring, B Kevin Park
  Hepatology 11/2011; 54(5):1767-76. · 11.66 Impact Factor
• Article: Improved oral bioavailability of lopinavir in melt-extruded tablet formulation reduces impact of third trimester on lopinavir plasma concentrations.

  L J Else, M Douglas, L Dickinson, D J Back, S H Khoo, G P Taylor
  Antimicrobial Agents and Chemotherapy 11/2011; 56(2):816-24. · 4.84 Impact Factor
• Article: Should we switch to a 50-mg boosting dose of ritonavir for selected protease inhibitors?

  Andrew Hill, Saye Khoo, Marta Boffito, David Back
  JAIDS Journal of Acquired Immune Deficiency Syndromes 12/2011; 58(5):e137-8. · 4.43 Impact Factor
• Article: Differential input to dorsal horn dorsal spinocerebellar tract neurons in mid- and low-lumbar segments from upper cervical spinal cord in the cat.

  Karima Kahlat, Laiche Djouhri
  Neuroscience Research 12/2011; 72(3):227-35. · 2.25 Impact Factor
• Article: Pharmacokinetics of lamivudine and lamivudine-triphosphate after administration of 300 milligrams and 150 milligrams once daily to healthy volunteers: results of the ENCORE 2 study.

  Laura J Else, Akil Jackson, Rebekah Puls, Andrew Hill, Paul Fahey, Enmoore Lin, Alieu Amara, Marco Siccardi, Victoria Watson, John Tjia, Sean Emery, Saye Khoo, David J Back, Marta Boffito
  Antimicrobial Agents and Chemotherapy 12/2011; 56(3):1427-33. · 4.84 Impact Factor
• Article: Genetics and the potential for predictive tests in adverse drug reactions.

  Munir Pirmohamed
  Progress in allergy 01/2012; 97:18-31.
• Article: The Keap1-Nrf2 cell defense pathway--a promising therapeutic target?

  Ian M Copple
  Advances in pharmacology (San Diego, Calif.) 01/2012; 63:43-79.
• Article: Human pluripotent stem cells for modeling toxicity.

  R L C Sison-Young, R Kia, J Heslop, L Kelly, C Rowe, M J Cross, N R Kitteringham, N Hanley, B K Park, C E P Goldring
  Advances in pharmacology (San Diego, Calif.) 01/2012; 63:207-56.
• Article: Mechanism-based urinary biomarkers to identify the potential for aminoglycoside-induced nephrotoxicity in premature neonates: a proof-of-concept study.

  Stephen J McWilliam, Daniel J Antoine, Venkata Sabbisetti, Mark A Turner, Tracey Farragher, Joseph V Bonventre, B Kevin Park, Rosalind L Smyth, Munir Pirmohamed
  PLoS ONE 01/2012; 7(8):e43809. · 4.09 Impact Factor
• Article: Development and validation of a LC-MS/MS assay to quantify intracellular tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP).

  V Watson, L Else, J Tjia, S Khoo, D Back
  Journal of the International AIDS Society 01/2012; 15(6):18336. · 3.26 Impact Factor
• Article: Prediction of drug-drug interactions between various antidepressants and ritonavir using a physiologically based pharmacokinetic model.

  M Siccardi, C Marzolini, K Seden, L Almond, A Kirov, S Khoo, A Owen, D Back
  Journal of the International AIDS Society 01/2012; 15(6):18339. · 3.26 Impact Factor
• Source

  Available from: Rosalind E Jenkins

  Article: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.

  Daniel J Antoine, Rosalind E Jenkins, James W Dear, Dominic P Williams, Mitchell R McGill, Matthew R Sharpe, Darren G Craig, Kenneth J Simpson, Hartmut Jaeschke, B Kevin Park
  Journal of Hepatology 01/2012; 56(5):1070-9. · 9.26 Impact Factor